Kinetics of small molecule inhibitor binding to p38 kinase

European Journal of Biochemistry

Volumn 268, Issue 22, 2001, Pages 5747-5754

  Thurmond, Robin L ^a   Wadsworth, Scott A ^a   Schafer, Peter H ^a,b   Zivin, Robert A ^a   Siekierka, John J ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b CELGENE CORPORATION   (United States)

Author keywords

BIAcore; Kinetics; p38 kinase; Surface plasmon resonance; TNF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (4 FLUOROPHENYL) 1 (3 PHENYLPROPYL) 5 (4 PYRIDINYL) 1H IMIDAZOL 2 YL] 3 BUTYN 1 OL; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE RELEASE; DISSOCIATION CONSTANT; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; KINETICS; MOLECULAR WEIGHT; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE;

ANIMALS; DROSOPHILA; ENZYME INHIBITORS; HUMANS; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; SURFACE PLASMON RESONANCE;

EID: 0035171919     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02512.x     Document Type: Article

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