Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone

European Journal of Pharmaceutical Sciences

Volumn 14, Issue 1, 2001, Pages 47-52

  Hutzler, J Matthew ^a   Frye, Reginald F ^b,c   Korzekwa, Kenneth R ^c,e   Branch, Robert A ^c   Huang, S M ^d   Tracy, Timothy S ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b Universigy of Pittsburgh   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e Camitro Corporation   (United States)

Author keywords

Activation; CYP2C9; Dapsone; Flurbiprofen; Metabolism

Indexed keywords

ENZYMES; HYDROXYLATION; METABOLISM; PHARMACOKINETICS;

HUMAN LIVER MICROSOMES;

DRUG PRODUCTS;

ACETYLDAPSONE; CYTOCHROME P450 2C9; DAPSONE; DRUG METABOLITE; FLURBIPROFEN;

ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG ACTIVATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG HYDROXYLATION; DRUG METABOLISM; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DAPSONE; ENZYME ACTIVATION; ENZYME ACTIVATORS; FLURBIPROFEN; INDICATORS AND REAGENTS; KINETICS; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES;

EID: 0034934070     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(01)00144-0     Document Type: Article

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