Sigmoidal kinetics of CYP3A substrates: An approach for scaling dextromethorphan metabolism in hepatic microsomes and isolated hepatocytes to predict in vivo clearance in rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 1, 1999, Pages 58-65

  Witherow, Lynn E ^a   Houston, J Brian ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHOXYMORPHINAN; CYTOCHROME P450; CYTOCHROME P450 3A; DEXTROMETHORPHAN; DEXTRORPHAN; MORPHINAN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; LIVER CELL; LIVER MICROSOME; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; RAT; STEADY STATE;

ANIMALS; ANTITUSSIVE AGENTS; ARYL HYDROCARBON HYDROXYLASES; BLOOD PROTEINS; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; ERYTHROCYTES; KINETICS; LIVER; MALE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; OXIDOREDUCTASES, N-DEMETHYLATING; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032968065     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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