Dapsone activation of cyp2c9-mediated metabolism: Evidence for activation of multiple substrates and a two-site model

Drug Metabolism and Disposition

Volumn 29, Issue 7, 2001, Pages 1029-1034

  Hutzler, J Matthew ^a   Hauer, Michael J ^b   Tracy, Timothy S ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C9; DAPSONE; FLURBIPROFEN;

ARTICLE; DRUG ACTIVATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVATION; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 ENZYME SYSTEM; DAPSONE; ENZYME ACTIVATION; FLURBIPROFEN; HYDROXYLATION; MODELS, CHEMICAL; NAPROXEN; PIROXICAM; STEROID 16-ALPHA-HYDROXYLASE; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 0034956877     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

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19. Evidence that the biotransformation of dapsone and monoacetyldapsone to their respective hydroxylamine metabolites in rat liver microsomes is mediated by cytochrome P450 2C6/2C11 and 3A1
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21. Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of Warfarin, flurbiprofen, and diclofenac by human liver microsomes
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