Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair

Cancer Letters

Volumn 243, Issue 1, 2006, Pages 90-100

  Arnold, Katrin ^a   Kim, Min Kyoung ^a   Frerk, Katrin ^a   Edler, Lutz ^a   Savelyeva, Larissa ^a   Schmezer, Peter ^a   Wiedemeyer, Ruprecht ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

BRCA2; Chromosomal instability; Haploinsufficiency; Homologous recombination

Indexed keywords

BRCA2 PROTEIN; MESSENGER RNA; MITOMYCIN C;

ADULT; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; FEMALE; GAMMA IRRADIATION; GENE MUTATION; GENOMIC INSTABILITY; HETEROZYGOTE DETECTION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE LEVEL; WILD TYPE;

ANALYSIS OF VARIANCE; BASE SEQUENCE; BRCA2 PROTEIN; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; CELL CYCLE; CELL LINE; COMET ASSAY; DNA; DNA DAMAGE; DNA MUTATIONAL ANALYSIS; DNA REPAIR; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GAMMA RAYS; HAPLOTYPES; HETEROZYGOTE; HUMANS; MALE; MITOMYCIN; MUTATION; PEDIGREE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33749249540     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.11.041     Document Type: Article

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