Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2

International Journal of Cancer

Volumn 97, Issue 5, 2002, Pages 557-561

  Buchholz, Thomas A ^a   Wu, Xifeng ^a   Hussain, Abu ^a   Tucker, Susan L ^a   Mills, Gordon B ^a   Haffty, Bruce ^b   Bergh, Sherry ^a   Story, Michael ^a   Geara, Fady B ^c   Brock, William A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Chromatid breaks; Clonogenic survival; Fibroblasts; Radiation

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER; CANCER CELL; CANCER RISK; CARCINOGENESIS; CLINICAL ARTICLE; GENE MUTATION; HAPLOTYPE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIATION CARCINOGENESIS;

BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CELL SURVIVAL; CELLS, CULTURED; CHROMATIDS; CHROMOSOME BREAKAGE; COLONY-FORMING UNITS ASSAY; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FIBROBLASTS; GERM-LINE MUTATION; HAPLOTYPES; HEAD AND NECK NEOPLASMS; HETEROZYGOTE; HUMANS; LYMPHOCYTES; MALE; OVARIAN NEOPLASMS; RADIATION TOLERANCE;

EID: 0037050741     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10109     Document Type: Article

References (15)

1. BRCA1 required for transcription-coupled repair of oxidative DNA damage
2. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
3. Gamma-radiation-induced single cell DNA damage as a measure of susceptibility to lung cancer: A preliminary report
4. Mutagen sensitivity and risk of gliomas: A case-control analysis
5. Radiation-induced chromatid breaks as a predictor of breast cancer risk
6. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients
7. Cell density dependent plating efficiency affects outcome and interpretation of colony forming assays
8. DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines
9. Association of BRCA1 with Rad51 in mitotic and meiotic cells
10. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage
11. Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2
12. A human BRCA1 gene knockout
13. Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations
14. Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1/2 mutations
15. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. II. BRCA1 and BRCA2