Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice

Genes Chromosomes and Cancer

Volumn 36, Issue 4, 2003, Pages 317-331

  Donoho, Greg ^a,f   Brenneman, Mark A ^b   Cui, Tracy X ^c,g   Donoviel, Dorit ^a   Vogel, Hannes ^d   Goodwin, Edwin H ^c   Chen, David J ^e   Hasty, Paul ^a,h  

^a LEXICON PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^f PFIZER INC   (United States)

^g UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^h UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; MITOMYCIN C; RAD51 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER; CHROMOSOME ABERRATION; DNA CROSS LINKING; DNA STRAND; EMBRYO; EXON; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; HYPERSENSITIVITY; LIFESPAN; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; SEPSIS;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

ANIMALS; BRCA2 PROTEIN; BREEDING; CELL LINE; CELL LINE, TRANSFORMED; CELL SURVIVAL; CHROMOSOME FRAGILITY; CROSS-LINKING REAGENTS; DNA ADDUCTS; DNA DAMAGE; DNA-BINDING PROTEINS; EXONS; GAMMA RAYS; GENES, BRCA2; LONGEVITY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOMYCIN; RAD51 RECOMBINASE; SEQUENCE DELETION;

ANIMALIA;

EID: 0037375905     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10148     Document Type: Article

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