Constitutional genomic instability with inversions, duplications, and amplifications in 9p23-24 in BRCA2 mutation carriers

Cancer Research

Volumn 61, Issue 13, 2001, Pages 5179-5185

  Savelyeva, Larissa ^a   Claas, Andreas ^a   Matzner, Isabel ^a   Schwab, Manfred ^a   Schlag, Peter ^b   Hofmann, Wera ^c   Scherneck, Siegfried ^c   Weber, Barbara ^d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Section of Pathology   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN;

ARTICLE; BREAST CANCER; CHROMOSOME 9P; CHROMOSOME INVERSION; CHROMOSOME MAP; CHROMOSOME REARRANGEMENT; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL CANCER; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DUPLICATION; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; KARYOTYPE; MALE; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL;

ADULT; AGED; BRCA2 PROTEIN; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 9; FEMALE; GENE AMPLIFICATION; GENE REARRANGEMENT; GERM-LINE MUTATION; HETEROZYGOTE; HUMANS; INVERSION, CHROMOSOME; LYMPHOCYTES; MALE; NEOPLASM PROTEINS; PEDIGREE; PHYSICAL CHROMOSOME MAPPING; TRANSCRIPTION FACTORS;

EID: 0035393630     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13
2. Identification of the breast cancer susceptibility gene, BRCA2
3. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
4. Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12-13
5. Different tumor types from BRCA2 carriers show wild-type chromosome deletions on 13q12-q13
6. Involvement of Brca2 in DNA repair
7. Absence of Brca2 causes genome instability by chromosome breakage and loss associated with centrosome amplification
8. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation
9. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
10. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation
11. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair
12. Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
13. Insight into the functions of BRCA1 and BRCA2
14. An interstitial tandem duplication of 9p23-24 coexists with a mutation in the BRCA2 gene in the germ line of three brothers with breast cancer
15. MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells
16. Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells
17. Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents
18. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments
19. A metric map of humans: 23,500 loci in 850 bands
20. High incidence of loss of heterozygosity in breast tumors from carriers of the BRCA2 999de15 mutation
21. Genomic instability and human malignancies
22. FISH analysis in detecting 9p duplication (p22p24)
23. Amplification of oncogenes revisited: From expression profiling to clinical application
24. Retention of polysomy at 9p23-24 during karyotypic evolution in human breast cancer cell line COLO 824
25. Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in κ transgenic mice
26. Expression of immunoglobulin δ gene causes allelic exclusion in transgenic mice