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Volumn 296, Issue 7, 2006, Pages 815-826

Biology of CCR5 and its role in HIV infection and treatment

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZOYL 1 [(4 METHOXY 1H PYRROLO[2,3 B]PYRIDIN 3 YL)OXOACETYL] 2 METHYLPIPERAZINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; ENFUVIRTIDE; EOTAXIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 3; PROTEIN HCC 1; PROTEIN HCC 4; RANTES; UNCLASSIFIED DRUG;

EID: 33747132429     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.296.7.815     Document Type: Review
Times cited : (219)

References (113)
  • 1
    • 0028868139 scopus 로고
    • Host-directed and immune-based therapies for human immunodeficiency virus infection
    • Lederman MM. Host-directed and immune-based therapies for human immunodeficiency virus infection. Ann Intern Med. 1995;122:218-222.
    • (1995) Ann Intern Med , vol.122 , pp. 218-222
    • Lederman, M.M.1
  • 2
    • 23844558948 scopus 로고    scopus 로고
    • Tumour necrosis factor inhibitors
    • Nash PT, Florin TH. Tumour necrosis factor inhibitors. Med J Aust. 2005;183:205-208.
    • (2005) Med J Aust , vol.183 , pp. 205-208
    • Nash, P.T.1    Florin, T.H.2
  • 3
    • 21644468434 scopus 로고    scopus 로고
    • The evolving clinical profile of abatacept (CTLA4-Ig): A novel co-stimulatory modulator for the treatment of rheumatoid arthritis
    • Ruderman EM, Pope RM. The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis. Arthritis Res Ther. 2005;7(suppl 2):S21-S25.
    • (2005) Arthritis Res Ther , vol.7 , Issue.2 SUPPL.
    • Ruderman, E.M.1    Pope, R.M.2
  • 4
    • 33744762212 scopus 로고    scopus 로고
    • Biological therapies directed against cells in autoimmune disease
    • Hasler P. Biological therapies directed against cells in autoimmune disease. Springer Semin Immunopathol. 2006;27:443-456.
    • (2006) Springer Semin Immunopathol , vol.27 , pp. 443-456
    • Hasler, P.1
  • 5
    • 0037413467 scopus 로고    scopus 로고
    • A controlled trial of natalizumab for relapsing multiple sclerosis
    • Miller DH, Khan OA, Sheremata WA, et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2003;348:15-23.
    • (2003) N Engl J Med , vol.348 , pp. 15-23
    • Miller, D.H.1    Khan, O.A.2    Sheremata, W.A.3
  • 6
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and metaanalysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and metaanalysis of rare harmful effects in randomized controlled trials. JAMA. 2006;295:2275-2285.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 7
    • 33644605483 scopus 로고    scopus 로고
    • Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    • Yousry TA, Major EO, Ryschkewitsch C, et al. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med. 2006;354:924-933.
    • (2006) N Engl J Med , vol.354 , pp. 924-933
    • Yousry, T.A.1    Major, E.O.2    Ryschkewitsch, C.3
  • 8
    • 11144270580 scopus 로고    scopus 로고
    • Chemokines
    • Paul WE, ed. Philadelphia, Pa: Lippincott Williams & Wilkins
    • Murphy PM. Chemokines. In: Paul WE, ed. Fundamental Immunology. 5th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2003:801-840.
    • (2003) Fundamental Immunology. 5th Ed. , pp. 801-840
    • Murphy, P.M.1
  • 9
    • 0034604451 scopus 로고    scopus 로고
    • Crystal structure of rhodopsin: A G protein-coupled receptor
    • Palczewski K, Kumasaka T, Hori T, et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science. 2000;289:739-745.
    • (2000) Science , vol.289 , pp. 739-745
    • Palczewski, K.1    Kumasaka, T.2    Hori, T.3
  • 10
    • 0033523018 scopus 로고    scopus 로고
    • Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 co-receptor and ligand binding function
    • Howard OM, Shirakawa AK, Turpin JA, et al. Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 co-receptor and ligand binding function. J Biol Chem. 1999;274:16228-16234.
    • (1999) J Biol Chem , vol.274 , pp. 16228-16234
    • Howard, O.M.1    Shirakawa, A.K.2    Turpin, J.A.3
  • 11
    • 4444246007 scopus 로고    scopus 로고
    • Chemokine receptor CCR5: Insights into structure, function, and regulation
    • Oppermann M. Chemokine receptor CCR5: insights into structure, function, and regulation. Cell Signal. 2004;16:1201-1210.
    • (2004) Cell Signal , vol.16 , pp. 1201-1210
    • Oppermann, M.1
  • 12
    • 0030812438 scopus 로고    scopus 로고
    • Molecular mechanism of desensitization of the chemokine receptor CCR-5: Receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor
    • Aramori I, Ferguson SS, Bieniasz PD, Zhang J, Cullen B, Cullen MG. Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor. EMBO J. 1997;16:4606-4616.
    • (1997) EMBO J , vol.16 , pp. 4606-4616
    • Aramori, I.1    Ferguson, S.S.2    Bieniasz, P.D.3    Zhang, J.4    Cullen, B.5    Cullen, M.G.6
  • 13
    • 0032188973 scopus 로고    scopus 로고
    • Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization
    • Zhao J, Ma L, Wu YL, Wang P, Hu W, Pei G. Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization. J Cell Biochem. 1998;71:36-45.
    • (1998) J Cell Biochem , vol.71 , pp. 36-45
    • Zhao, J.1    Ma, L.2    Wu, Y.L.3    Wang, P.4    Hu, W.5    Pei, G.6
  • 14
    • 0032522970 scopus 로고    scopus 로고
    • Macrophage inflammatory protein-1β induces migration and activation of human thymocytes
    • Dairaghi DJ, Franz-Bacon K, Callas E, et al. Macrophage inflammatory protein-1β induces migration and activation of human thymocytes. Blood. 1998;91:2905-2913.
    • (1998) Blood , vol.91 , pp. 2905-2913
    • Dairaghi, D.J.1    Franz-Bacon, K.2    Callas, E.3
  • 15
    • 0035892099 scopus 로고    scopus 로고
    • HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxininsensitive chemokine receptor signaling
    • Del Corno M, Liu QH, Schols D, et al. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxininsensitive chemokine receptor signaling. Blood. 2001;98:2909-2916.
    • (2001) Blood , vol.98 , pp. 2909-2916
    • Del Corno, M.1    Liu, Q.H.2    Schols, D.3
  • 16
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by β-arrestins
    • Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by β-arrestins. Science. 2005;308:512-517.
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 18
    • 0033567969 scopus 로고    scopus 로고
    • CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist
    • Blanpain C, Migeotte I, Lee B, et al. CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999;94:1899-1905.
    • (1999) Blood , vol.94 , pp. 1899-1905
    • Blanpain, C.1    Migeotte, I.2    Lee, B.3
  • 19
    • 0036467505 scopus 로고    scopus 로고
    • The role of chemokines in linking innate and adaptive immunity
    • Luster AD. The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol. 2002;14:129-135.
    • (2002) Curr Opin Immunol , vol.14 , pp. 129-135
    • Luster, A.D.1
  • 20
    • 0035260758 scopus 로고    scopus 로고
    • Chemokines as regulators of T cell differentiation
    • Luther SA, Cyster JG. Chemokines as regulators of T cell differentiation. Nat Immunol. 2001;2:102-107.
    • (2001) Nat Immunol , vol.2 , pp. 102-107
    • Luther, S.A.1    Cyster, J.G.2
  • 21
    • 0032193205 scopus 로고    scopus 로고
    • Roles of chemokines and receptor polarization in NKtarget cell interactions
    • Nieto M, Navarro F, Perez-Villar JJ, et al. Roles of chemokines and receptor polarization in NKtarget cell interactions. J Immunol. 1998;161:3330-3339.
    • (1998) J Immunol , vol.161 , pp. 3330-3339
    • Nieto, M.1    Navarro, F.2    Perez-Villar, J.J.3
  • 22
    • 22244448718 scopus 로고    scopus 로고
    • Regulation of protein function by glycosaminoglycans-as exemplified by chemokines
    • Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. Regulation of protein function by glycosaminoglycans-as exemplified by chemokines. Annu Rev Biochem. 2005;74:385-410.
    • (2005) Annu Rev Biochem , vol.74 , pp. 385-410
    • Handel, T.M.1    Johnson, Z.2    Crown, S.E.3    Lau, E.K.4    Proudfoot, A.E.5
  • 23
    • 0032904627 scopus 로고    scopus 로고
    • Mechanisms that regulate the function of the selectins and their ligands
    • Vestweber D, Blanks JE. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev. 1999;79:181-213.
    • (1999) Physiol Rev , vol.79 , pp. 181-213
    • Vestweber, D.1    Blanks, J.E.2
  • 24
    • 0037300378 scopus 로고    scopus 로고
    • Chemokines: Attractive mediators of the immune response
    • Wong MM, Fish EN. Chemokines: attractive mediators of the immune response. Semin Immunol. 2003;15:5-14.
    • (2003) Semin Immunol , vol.15 , pp. 5-14
    • Wong, M.M.1    Fish, E.N.2
  • 25
    • 18244389686 scopus 로고    scopus 로고
    • T cell costimulation by chemokine receptors
    • Molon B, Gri G, Bettella M, et al. T cell costimulation by chemokine receptors. Nat Immunol. 2005;6:465-471.
    • (2005) Nat Immunol , vol.6 , pp. 465-471
    • Molon, B.1    Gri, G.2    Bettella, M.3
  • 27
    • 0026017498 scopus 로고
    • Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides
    • Jasin M, Page KA, Littman DR. Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides. J Virol. 1991;65:440-444.
    • (1991) J Virol , vol.65 , pp. 440-444
    • Jasin, M.1    Page, K.A.2    Littman, D.R.3
  • 28
    • 0024544365 scopus 로고
    • Human immunodeficiency virus infection studied in CD4-expressing human-murine T-cell hybrids
    • Tersmette M, van Dongen JJ, Clapham PR, et al. Human immunodeficiency virus infection studied in CD4-expressing human-murine T-cell hybrids. Virology. 1989;168:267-273.
    • (1989) Virology , vol.168 , pp. 267-273
    • Tersmette, M.1    Van Dongen, J.J.2    Clapham, P.R.3
  • 29
    • 0025797437 scopus 로고
    • Human genes other than CD4 facilitate HIV-1 infection of murine cells
    • Weiner DB, Huebner K, Williams WV, Greene MI. Human genes other than CD4 facilitate HIV-1 infection of murine cells. Pathobiology. 1991;59:361-371.
    • (1991) Pathobiology , vol.59 , pp. 361-371
    • Weiner, D.B.1    Huebner, K.2    Williams, W.V.3    Greene, M.I.4
  • 30
    • 0029417004 scopus 로고
    • Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells
    • Cocchi F, DeVico AL, Garzino DA, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995;270:1811-1815.
    • (1995) Science , vol.270 , pp. 1811-1815
    • Cocchi, F.1    DeVico, A.L.2    Garzino, D.A.3    Arya, S.K.4    Gallo, R.C.5    Lusso, P.6
  • 31
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 1996;272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3
  • 33
    • 0029775576 scopus 로고    scopus 로고
    • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
    • Bleul CC, Farzan M, Choe H, et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996;382:829-833.
    • (1996) Nature , vol.382 , pp. 829-833
    • Bleul, C.C.1    Farzan, M.2    Choe, H.3
  • 34
    • 0005014748 scopus 로고    scopus 로고
    • The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    • Choe H, Farzan M, Sun Y, et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 1996;85:1135-1148.
    • (1996) Cell , vol.85 , pp. 1135-1148
    • Choe, H.1    Farzan, M.2    Sun, Y.3
  • 35
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major co-receptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature. 1996;381:661-666.
    • (1996) Nature , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 36
    • 15844389650 scopus 로고    scopus 로고
    • HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    • Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996;381:667-673.
    • (1996) Nature , vol.381 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.P.3
  • 37
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996;272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 38
    • 0032104378 scopus 로고    scopus 로고
    • G protein-coupled receptors in HIV and SIV entry: New perspectives on lentivirus-host interactions and on the utility of animal models
    • Unutmaz D, KewalRamani VN, Littman DR. G protein-coupled receptors in HIV and SIV entry: new perspectives on lentivirus-host interactions and on the utility of animal models. Semin Immunol. 1998;10:225-236.
    • (1998) Semin Immunol , vol.10 , pp. 225-236
    • Unutmaz, D.1    KewalRamani, V.N.2    Littman, D.R.3
  • 39
    • 16144365317 scopus 로고    scopus 로고
    • CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5
    • Trkola A, Dragic T, Arthos J, et al. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature. 1996;384:184-187.
    • (1996) Nature , vol.384 , pp. 184-187
    • Trkola, A.1    Dragic, T.2    Arthos, J.3
  • 40
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature. 1998;393:648-659.
    • (1998) Nature , vol.393 , pp. 648-659
    • Kwong, P.D.1    Wyatt, R.2    Robinson, J.3    Sweet, R.W.4    Sodroski, J.5    Hendrickson, W.A.6
  • 41
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-377.
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 42
    • 0001633495 scopus 로고    scopus 로고
    • Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene: Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study
    • Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene: Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science. 1996;273:1856-1862.
    • (1996) Science , vol.273 , pp. 1856-1862
    • Dean, M.1    Carrington, M.2    Winkler, C.3
  • 43
    • 17344372255 scopus 로고    scopus 로고
    • Dating the origin of the CCR5-Δ32 AIDS-resistance allele by the coalescence of haplotypes
    • Stephens JC, Reich DE, Goldstein DB, et al. Dating the origin of the CCR5-Δ32 AIDS-resistance allele by the coalescence of haplotypes. Am J Hum Genet. 1998;62:1507-1515.
    • (1998) Am J Hum Genet , vol.62 , pp. 1507-1515
    • Stephens, J.C.1    Reich, D.E.2    Goldstein, D.B.3
  • 44
    • 0035126472 scopus 로고    scopus 로고
    • Characterization of high-risk HIV-1 seronegative hemophiliacs
    • Salkowitz JR, Purvis SF, Meyerson H, et al. Characterization of high-risk HIV-1 seronegative hemophiliacs. Clin Immunol. 2001;98:200-211.
    • (2001) Clin Immunol , vol.98 , pp. 200-211
    • Salkowitz, J.R.1    Purvis, S.F.2    Meyerson, H.3
  • 45
    • 0037172396 scopus 로고    scopus 로고
    • Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Δ32 allele
    • Gorry PR, Zhang C, Wu S, et al. Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Δ32 allele. Lancet. 2002;359:1832-1834.
    • (2002) Lancet , vol.359 , pp. 1832-1834
    • Gorry, P.R.1    Zhang, C.2    Wu, S.3
  • 46
    • 17544384752 scopus 로고    scopus 로고
    • Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 Δ32
    • Michael NL, Nelson JA, Kewal Ramani VN, et al. Exclusive and persistent use of the entry coreceptor CXCR4 by human immunodeficiency virus type 1 from a subject homozygous for CCR5 Δ32. J Virol. 1998;72:6040-6047.
    • (1998) J Virol , vol.72 , pp. 6040-6047
    • Michael, N.L.1    Nelson, J.A.2    Kewal Ramani, V.N.3
  • 47
    • 33645046393 scopus 로고    scopus 로고
    • Selective transmission of CCR5-utilizing HIV-1: The 'gatekeeper' problem resolved?
    • Margolis L, Shattock R. Selective transmission of CCR5-utilizing HIV-1: the 'gatekeeper' problem resolved? Nat Rev Microbiol. 2006;4:312-317.
    • (2006) Nat Rev Microbiol , vol.4 , pp. 312-317
    • Margolis, L.1    Shattock, R.2
  • 48
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382:722-725.
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 49
    • 0035881173 scopus 로고    scopus 로고
    • Homozygous and heterozygous CCR5-Δ32 genotypes are associated with resistance to HIV infection
    • Marmor M, Sheppard HW, Donnell D, et al. Homozygous and heterozygous CCR5-Δ32 genotypes are associated with resistance to HIV infection. J Acquir Immune Defic Syndr. 2001;27:472-481.
    • (2001) J Acquir Immune Defic Syndr , vol.27 , pp. 472-481
    • Marmor, M.1    Sheppard, H.W.2    Donnell, D.3
  • 50
    • 0035818402 scopus 로고    scopus 로고
    • Effects of CCR5-Δ32, CCR2-64I, and SDF-13′A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data
    • Ioannidis JP, Rosenberg PS, Goedert JJ, et al. Effects of CCR5-Δ32, CCR2-64I, and SDF-13′A alleles on HIV-1 disease progression: an international meta-analysis of individual-patient data. Ann Intern Med. 2001;135:782-795.
    • (2001) Ann Intern Med , vol.135 , pp. 782-795
    • Ioannidis, J.P.1    Rosenberg, P.S.2    Goedert, J.J.3
  • 51
    • 8244227329 scopus 로고    scopus 로고
    • Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: Studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk
    • Zimmerman PA, Buckler-White A, Alkhatib G, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med. 1997;3:23-36.
    • (1997) Mol Med , vol.3 , pp. 23-36
    • Zimmerman, P.A.1    Buckler-White, A.2    Alkhatib, G.3
  • 52
    • 0027537480 scopus 로고
    • Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS
    • Koot M, Keet IP, Vos AH, et al. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med. 1993;118:681-688.
    • (1993) Ann Intern Med , vol.118 , pp. 681-688
    • Koot, M.1    Keet, I.P.2    Vos, A.H.3
  • 53
    • 0031575431 scopus 로고    scopus 로고
    • Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals
    • Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR. Change in coreceptor use coreceptor use correlates with disease progression in HIV-1-infected individuals. J Exp Med. 1997;185:621-628.
    • (1997) J Exp Med , vol.185 , pp. 621-628
    • Connor, R.I.1    Sheridan, K.E.2    Ceradini, D.3    Choe, S.4    Landau, N.R.5
  • 54
    • 17044452367 scopus 로고    scopus 로고
    • HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene
    • Quillent C, Oberlin E, Braun J, et al. HIV-1-resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet. 1998;351:14-18.
    • (1998) Lancet , vol.351 , pp. 14-18
    • Quillent, C.1    Oberlin, E.2    Braun, J.3
  • 55
    • 20044377204 scopus 로고    scopus 로고
    • The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility
    • Gonzalez E, Kulkarni H, Bolivar H, et al. The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science. 2005;307:1434-1440.
    • (2005) Science , vol.307 , pp. 1434-1440
    • Gonzalez, E.1    Kulkarni, H.2    Bolivar, H.3
  • 56
  • 57
    • 3242877388 scopus 로고    scopus 로고
    • Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection
    • Elvin SJ, Williamson ED, Scott JC, et al. Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection. Nature. 2004;430:417.
    • (2004) Nature , vol.430 , pp. 417
    • Elvin, S.J.1    Williamson, E.D.2    Scott, J.C.3
  • 59
    • 0033521155 scopus 로고    scopus 로고
    • Use of chemokine receptors by poxviruses
    • Lalani AS, Masters J, Zeng W, et al. Use of chemokine receptors by poxviruses. Science. 1999;286:1968-1971.
    • (1999) Science , vol.286 , pp. 1968-1971
    • Lalani, A.S.1    Masters, J.2    Zeng, W.3
  • 60
    • 0034625771 scopus 로고    scopus 로고
    • Timing the ancestor of the HIV-1 pandemic strains
    • Korber B, Muldoon M, Theiler J, et al. Timing the ancestor of the HIV-1 pandemic strains. Science. 2000;288:1789-1796.
    • (2000) Science , vol.288 , pp. 1789-1796
    • Korber, B.1    Muldoon, M.2    Theiler, J.3
  • 61
    • 0035796003 scopus 로고    scopus 로고
    • CC chemokine receptor 5 and renal-transplant survival
    • Fischereder M, Luckow B, Hocher B, et al. CC chemokine receptor 5 and renal-transplant survival. Lancet. 2001;357:1758-1761.
    • (2001) Lancet , vol.357 , pp. 1758-1761
    • Fischereder, M.1    Luckow, B.2    Hocher, B.3
  • 62
    • 23744505807 scopus 로고    scopus 로고
    • A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection
    • Akashi S, Sho M, Kashizuka H, et al. A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection. Transplantation. 2005;80:378-384.
    • (2005) Transplantation , vol.80 , pp. 378-384
    • Akashi, S.1    Sho, M.2    Kashizuka, H.3
  • 63
    • 0040945723 scopus 로고    scopus 로고
    • Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: Blocking monocyte arrest and recruitment
    • Grone HJ, Weber C, Weber KS, et al. Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J. 1999;13:1371-1383.
    • (1999) FASEB J , vol.13 , pp. 1371-1383
    • Grone, H.J.1    Weber, C.2    Weber, K.S.3
  • 64
    • 31344465937 scopus 로고    scopus 로고
    • CCR5 deficiency increases risk of symptomatic West Nile virus infection
    • Glass WG, McDermott DH, Lim JK, et al. CCR5 deficiency increases risk of symptomatic West Nile virus infection. J Exp Med. 2006;203:35-40.
    • (2006) J Exp Med , vol.203 , pp. 35-40
    • Glass, W.G.1    McDermott, D.H.2    Lim, J.K.3
  • 65
    • 26844529383 scopus 로고    scopus 로고
    • Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection
    • Glass WG, Lim JK, Cholera R, Pletnev AG, Gao JL, Murphy PM. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med. 2005;202:1087-1098.
    • (2005) J Exp Med , vol.202 , pp. 1087-1098
    • Glass, W.G.1    Lim, J.K.2    Cholera, R.3    Pletnev, A.G.4    Gao, J.L.5    Murphy, P.M.6
  • 66
    • 22544457921 scopus 로고    scopus 로고
    • Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2
    • Ank N, Petersen K, Malmgaard L, Mogensen SC, Paludan SR. Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2. J Virol. 2005;79:9831-9841.
    • (2005) J Virol , vol.79 , pp. 9831-9841
    • Ank, N.1    Petersen, K.2    Malmgaard, L.3    Mogensen, S.C.4    Paludan, S.R.5
  • 67
    • 13444283754 scopus 로고    scopus 로고
    • CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi
    • Machado FS, Koyama NS, Carregaro V, et al. CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi. J Infect Dis. 2005;191:627-636.
    • (2005) J Infect Dis , vol.191 , pp. 627-636
    • Machado, F.S.1    Koyama, N.S.2    Carregaro, V.3
  • 68
    • 4344588778 scopus 로고    scopus 로고
    • CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration
    • Algood HM, Flynn JL. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol. 2004;173:3287-3296.
    • (2004) J Immunol , vol.173 , pp. 3287-3296
    • Algood, H.M.1    Flynn, J.L.2
  • 69
    • 0038819121 scopus 로고    scopus 로고
    • CCR5 deficiency decreases susceptibility to experimental cerebral malaria
    • Belnoue E, Kayibanda M, Deschemin JC, et al. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood. 2003;101:4253-4259.
    • (2003) Blood , vol.101 , pp. 4253-4259
    • Belnoue, E.1    Kayibanda, M.2    Deschemin, J.C.3
  • 71
    • 0035885037 scopus 로고    scopus 로고
    • Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus
    • Glass WG, Liu MT, Kuziel WA, Lane TE. Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus. Virology. 2001;288:8-17.
    • (2001) Virology , vol.288 , pp. 8-17
    • Glass, W.G.1    Liu, M.T.2    Kuziel, W.A.3    Lane, T.E.4
  • 72
    • 24744462346 scopus 로고    scopus 로고
    • Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5Δ32 gene deletion
    • Barr EL, Ouburg S, Igietseme JU, et al. Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5Δ32 gene deletion. J Microbiol Immunol Infect. 2005;38:244-254.
    • (2005) J Microbiol Immunol Infect , vol.38 , pp. 244-254
    • Barr, E.L.1    Ouburg, S.2    Igietseme, J.U.3
  • 73
    • 0037308259 scopus 로고    scopus 로고
    • Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C
    • Promrat K, McDermott DH, Gonzalez CM, et al. Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology. 2003;124:352-360.
    • (2003) Gastroenterology , vol.124 , pp. 352-360
    • Promrat, K.1    McDermott, D.H.2    Gonzalez, C.M.3
  • 74
    • 22644440543 scopus 로고    scopus 로고
    • The CCR5-Δ32 mutation: Impact on disease outcome in individuals with hepatitis C infection from a single source
    • Goulding C, McManus R, Murphy A, et al. The CCR5-Δ32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. Gut. 2005;54:1157-1161.
    • (2005) Gut , vol.54 , pp. 1157-1161
    • Goulding, C.1    McManus, R.2    Murphy, A.3
  • 75
    • 3042601653 scopus 로고    scopus 로고
    • CC-chemokine receptor 5 (CCR5) in hepatitis C: At the crossroads of the antiviral immune response?
    • Ahlenstiel G, Woitas RP, Rockstroh J, Spengler U. CC-chemokine receptor 5 (CCR5) in hepatitis C: at the crossroads of the antiviral immune response? J Antimicrob Chemother. 2004;53:895-898.
    • (2004) J Antimicrob Chemother , vol.53 , pp. 895-898
    • Ahlenstiel, G.1    Woitas, R.P.2    Rockstroh, J.3    Spengler, U.4
  • 76
    • 0027378573 scopus 로고
    • A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
    • Muster T, Steindl F, Purtscher M, et al. A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1. J Virol. 1993;67:6642-6647.
    • (1993) J Virol , vol.67 , pp. 6642-6647
    • Muster, T.1    Steindl, F.2    Purtscher, M.3
  • 77
    • 0028291731 scopus 로고
    • Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1
    • Roben P, Moore JP, Thali M, Sodroski J, Barbas CF III, Burton DR. Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1. J Virol. 1994;68:4821-4828.
    • (1994) J Virol , vol.68 , pp. 4821-4828
    • Roben, P.1    Moore, J.P.2    Thali, M.3    Sodroski, J.4    Barbas III, C.F.5    Burton, D.R.6
  • 78
    • 0031936306 scopus 로고    scopus 로고
    • Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage
    • Trkola A, Ketas T, Kewalramani VN, et al. Neutralization sensitivity of human immunodeficiency virus type 1 primary isolates to antibodies and CD4-based reagents is independent of coreceptor usage. J Virol. 1998;72:1876-1885.
    • (1998) J Virol , vol.72 , pp. 1876-1885
    • Trkola, A.1    Ketas, T.2    Kewalramani, V.N.3
  • 79
    • 0034759882 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies targeted to the membraneproximal external region of human immunodeficiency virus type 1 glycoprotein gp41
    • Zwick MB, Labrijn AF, Wang M, et al. Broadly neutralizing antibodies targeted to the membraneproximal external region of human immunodeficiency virus type 1 glycoprotein gp41. J Virol. 2001;75:10892-10905.
    • (2001) J Virol , vol.75 , pp. 10892-10905
    • Zwick, M.B.1    Labrijn, A.F.2    Wang, M.3
  • 80
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • Trkola A, Kuster H, Rusert P, et al. Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat Med. 2005;11:615-622.
    • (2005) Nat Med , vol.11 , pp. 615-622
    • Trkola, A.1    Kuster, H.2    Rusert, P.3
  • 81
    • 0026662175 scopus 로고
    • Phase I study of continuous-infusion soluble CD4 as a single agent and in combination with oral dideoxyinosine therapy in children with symptomatic human immunodeficiency virus infection
    • Husson RN, Chung Y, Mordenti J, et al. Phase I study of continuous-infusion soluble CD4 as a single agent and in combination with oral dideoxyinosine therapy in children with symptomatic human immunodeficiency virus infection. J Pediatr. 1992;121:627-633.
    • (1992) J Pediatr , vol.121 , pp. 627-633
    • Husson, R.N.1    Chung, Y.2    Mordenti, J.3
  • 82
    • 0027976755 scopus 로고
    • The effects of high-dose recombinant soluble CD4 on human immunodeficiency virus type 1 viremia
    • Schacker T, Coombs RW, Collier AC, et al. The effects of high-dose recombinant soluble CD4 on human immunodeficiency virus type 1 viremia. J Infect Dis. 1994;169:37-40.
    • (1994) J Infect Dis , vol.169 , pp. 37-40
    • Schacker, T.1    Coombs, R.W.2    Collier, A.C.3
  • 83
    • 9144250171 scopus 로고    scopus 로고
    • Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542
    • Jacobson JM, Israel RJ, Lowy I, et al. Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542. Antimicrob Agents Chemother. 2004;48:423-429.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 423-429
    • Jacobson, J.M.1    Israel, R.J.2    Lowy, I.3
  • 84
    • 2442455279 scopus 로고    scopus 로고
    • A novel class of HIV-1 inhibitors that targets the viral envelope and inhibits CD4 receptor binding
    • Wang HG, Williams RE, Lin PF. A novel class of HIV-1 inhibitors that targets the viral envelope and inhibits CD4 receptor binding. Curr Pharm Des. 2004;10:1785-1793.
    • (2004) Curr Pharm Des , vol.10 , pp. 1785-1793
    • Wang, H.G.1    Williams, R.E.2    Lin, P.F.3
  • 85
    • 27744496272 scopus 로고    scopus 로고
    • Drug firms donate compounds for anti-HIV gel
    • Towie N. Drug firms donate compounds for anti-HIV gel. Nature. 2005;438:6-7.
    • (2005) Nature , vol.438 , pp. 6-7
    • Towie, N.1
  • 86
    • 27744571425 scopus 로고    scopus 로고
    • Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
    • Veazey RS, Klasse PJ, Schader SM, et al. Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature. 2005;438:99-102.
    • (2005) Nature , vol.438 , pp. 99-102
    • Veazey, R.S.1    Klasse, P.J.2    Schader, S.M.3
  • 87
    • 33646342770 scopus 로고    scopus 로고
    • Microbicides and other topical strategies to prevent vaginal transmission of HIV
    • Lederman MM, Offord RE, Hartley O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol. 2006;6:371-382.
    • (2006) Nat Rev Immunol , vol.6 , pp. 371-382
    • Lederman, M.M.1    Offord, R.E.2    Hartley, O.3
  • 89
    • 14844333093 scopus 로고    scopus 로고
    • Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection
    • Moyle GJ, Wildfire A, Mandalia S, et al. Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J Infect Dis. 2005;191:866-872.
    • (2005) J Infect Dis , vol.191 , pp. 866-872
    • Moyle, G.J.1    Wildfire, A.2    Mandalia, S.3
  • 90
    • 9344239350 scopus 로고    scopus 로고
    • Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors
    • Hartley O, Gaertner H, Wilken J, et al. Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors. Proc Natl Acad Sci U S A. 2004;101:16460-16465.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16460-16465
    • Hartley, O.1    Gaertner, H.2    Wilken, J.3
  • 91
    • 33645784598 scopus 로고    scopus 로고
    • Preclinical evaluation of synthetic-2 RANTES as a candidate vaginal microbicide to target CCR5
    • Kish-Catalone TM, Lu W, Gallo RC, Devico AL. Preclinical evaluation of synthetic-2 RANTES as a candidate vaginal microbicide to target CCR5. Antimicrob Agents Chemother. 2006;50:1497-1509.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1497-1509
    • Kish-Catalone, T.M.1    Lu, W.2    Gallo, R.C.3    Devico, A.L.4
  • 92
    • 0030951442 scopus 로고    scopus 로고
    • Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
    • Simmons G, Clapham PR, Picard L, et al. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science. 1997;276:276-279.
    • (1997) Science , vol.276 , pp. 276-279
    • Simmons, G.1    Clapham, P.R.2    Picard, L.3
  • 93
    • 5644247983 scopus 로고    scopus 로고
    • Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    • Lederman MM, Veazey RS, Offord R, et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science. 2004;306:485-487.
    • (2004) Science , vol.306 , pp. 485-487
    • Lederman, M.M.1    Veazey, R.S.2    Offord, R.3
  • 94
    • 33745851881 scopus 로고    scopus 로고
    • Cutting edge: Human beta defensin 3: A novel antagonist of the HIV-1 co-receptor CXCR4
    • Feng Z, Dubyak GR, Lederman MM, Weinberg A. Cutting edge: human beta defensin 3: a novel antagonist of the HIV-1 co-receptor CXCR4. J Immunol. 2006;177:782-786.
    • (2006) J Immunol , vol.177 , pp. 782-786
    • Feng, Z.1    Dubyak, G.R.2    Lederman, M.M.3    Weinberg, A.4
  • 95
    • 9144240994 scopus 로고    scopus 로고
    • Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication
    • Quinones-Mateu ME, Lederman MM, Feng Z, et al. Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication. AIDS. 2003;17:F39-F48.
    • (2003) AIDS , vol.17
    • Quinones-Mateu, M.E.1    Lederman, M.M.2    Feng, Z.3
  • 96
    • 33750337778 scopus 로고    scopus 로고
    • Characterization of a panel of novel human monoclonal antibodies that specifically antagonize CCR5 and block HIV-1 entry
    • October 30-November 2, Washington, DC. Abstract 2871
    • Roschke V, Clark S, Branco L, et al. Characterization of a panel of novel human monoclonal antibodies that specifically antagonize CCR5 and block HIV-1 entry. Presented at: 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy; October 30-November 2, 2004; Washington, DC. Abstract 2871.
    • (2004) 44th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Roschke, V.1    Clark, S.2    Branco, L.3
  • 97
    • 15744391870 scopus 로고    scopus 로고
    • The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor
    • Watson C, Jenkinson S, Kazmierski W, Kenakin T. The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor. Mol Pharmacol. 2005;67:1268-1282.
    • (2005) Mol Pharmacol , vol.67 , pp. 1268-1282
    • Watson, C.1    Jenkinson, S.2    Kazmierski, W.3    Kenakin, T.4
  • 98
    • 20644453529 scopus 로고    scopus 로고
    • Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)
    • Marozsan AJ, Kuhmann SE, Morgan T, et al. Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D). Virology. 2005;338:182-199.
    • (2005) Virology , vol.338 , pp. 182-199
    • Marozsan, A.J.1    Kuhmann, S.E.2    Morgan, T.3
  • 99
    • 28544434492 scopus 로고    scopus 로고
    • CCR5 antagonists: Hosttargeted antivirals for the treatment of HIV infection
    • Westby M, van der Ryst E. CCR5 antagonists: hosttargeted antivirals for the treatment of HIV infection. Antivir Chem Chemother. 2005;16:339-354.
    • (2005) Antivir Chem Chemother , vol.16 , pp. 339-354
    • Westby, M.1    Van Der Ryst, E.2
  • 101
    • 33644653540 scopus 로고    scopus 로고
    • Late virologic breakthrough in treatment-naïve patients on a regimen of combivir plus vicriviroc
    • February 5-8, Denver, Colo. Abstract 161LB
    • Greaves W, Landovitz R, Fatkenheuer G, et al. Late virologic breakthrough in treatment-naïve patients on a regimen of combivir plus vicriviroc. Presented at: XIII Conference on Retroviruses and Opportunistic Infections; February 5-8, 2006; Denver, Colo. Abstract 161LB.
    • (2006) XIII Conference on Retroviruses and Opportunistic Infections
    • Greaves, W.1    Landovitz, R.2    Fatkenheuer, G.3
  • 103
    • 17444393539 scopus 로고    scopus 로고
    • Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-Δ32 mutation
    • Dean M, Jacobson LP, McFarlane G, et al. Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-Δ32 mutation. Cancer Res. 1999;59:3561-3564.
    • (1999) Cancer Res , vol.59 , pp. 3561-3564
    • Dean, M.1    Jacobson, L.P.2    McFarlane, G.3
  • 104
    • 18644369147 scopus 로고    scopus 로고
    • The appealing story of HIV entry inhibitors: from discovery of biological mechanisms to drug development
    • Castagna A, Biswas P, Beretta A, Lazzarin A. The appealing story of HIV entry inhibitors: from discovery of biological mechanisms to drug development. Drugs. 2005;65:879-904.
    • (2005) Drugs , vol.65 , pp. 879-904
    • Castagna, A.1    Biswas, P.2    Beretta, A.3    Lazzarin, A.4
  • 105
    • 4143090383 scopus 로고    scopus 로고
    • Immune restoration disease after antiretroviral therapy
    • French MA, Price P, Stone SF. Immune restoration disease after antiretroviral therapy. AIDS. 2004;18:1615-1627.
    • (2004) AIDS , vol.18 , pp. 1615-1627
    • French, M.A.1    Price, P.2    Stone, S.F.3
  • 106
    • 0037702193 scopus 로고    scopus 로고
    • The immune reconstitution inflammatory syndrome
    • Shelburne SA III, Hamill RJ. The immune reconstitution inflammatory syndrome. AIDS Rev. 2003;5:67-79.
    • (2003) AIDS Rev , vol.5 , pp. 67-79
    • Shelburne III, S.A.1    Hamill, R.J.2
  • 107
    • 4644342929 scopus 로고    scopus 로고
    • CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
    • Brenchley JM, Schacker TW, Ruff LE, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749-759.
    • (2004) J Exp Med , vol.200 , pp. 749-759
    • Brenchley, J.M.1    Schacker, T.W.2    Ruff, L.E.3
  • 108
    • 0027549618 scopus 로고
    • Distribution of SIV infection in the gastrointestinal tract of rhesus macaques at early and terminal stages of AIDS
    • Heise C, Vogel P, Miller CJ, Lackner A, Dandekar S. Distribution of SIV infection in the gastrointestinal tract of rhesus macaques at early and terminal stages of AIDS. J Med Primatol. 1993;22:187-193.
    • (1993) J Med Primatol , vol.22 , pp. 187-193
    • Heise, C.1    Vogel, P.2    Miller, C.J.3    Lackner, A.4    Dandekar, S.5
  • 109
    • 17844374605 scopus 로고    scopus 로고
    • Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection
    • Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature. 2005;434:1093-1097.
    • (2005) Nature , vol.434 , pp. 1093-1097
    • Mattapallil, J.J.1    Douek, D.C.2    Hill, B.3    Nishimura, Y.4    Martin, M.5    Roederer, M.6
  • 110
    • 0032540418 scopus 로고    scopus 로고
    • Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection
    • Veazey RS, DeMaria M, Chalifoux LV, et al. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science. 1998;280:427-431.
    • (1998) Science , vol.280 , pp. 427-431
    • Veazey, R.S.1    DeMaria, M.2    Chalifoux, L.V.3
  • 111
    • 0142030023 scopus 로고    scopus 로고
    • Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection
    • Lange CG, Lederman MM, Medvik K, et al. Nadir CD4+ T-cell count and numbers of CD28+ CD4+ T-cells predict functional responses to immunizations in chronic HIV-1 infection. AIDS. 2003;17:2015-2023.
    • (2003) AIDS , vol.17 , pp. 2015-2023
    • Lange, C.G.1    Lederman, M.M.2    Medvik, K.3
  • 112
    • 0033985563 scopus 로고    scopus 로고
    • Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitorcontaining regimen
    • Valdez H, Smith KY, Landay A, et al; ACTG 375 Team and AIDS Clinical Trials Group. Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitorcontaining regimen. AIDS. 2000;14:11-21.
    • (2000) AIDS , vol.14 , pp. 11-21
    • Valdez, H.1    Smith, K.Y.2    Landay, A.3
  • 113
    • 33644658900 scopus 로고    scopus 로고
    • Challenges of developing R5 inhibitors in antiretroviral naive HIV-infected patients
    • Deeks SG. Challenges of developing R5 inhibitors in antiretroviral naive HIV-infected patients. Lancet. 2006;367:711-713.
    • (2006) Lancet , vol.367 , pp. 711-713
    • Deeks, S.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.