Medicinal chemistry applied to a synthetic protein: Development of highly potent HIV entry inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 47, 2004, Pages 16460-16465

  Hartley, Oliver ^a   Gaertner, Hubert ^a,e   Wilken, Jill ^b,f   Thompson, Darren ^b,g   Fish, Richard ^a   Ramos, Alejandra ^c   Pastore, Cristina ^c   Dufour, Brigitte ^a   Cerini, Fabrice ^a   Melotti, Astrid ^a   Heveker, Nikolaus ^d,h   Picard, Laurent ^d,i   Alizon, Marc ^d   Mosier, Donald ^c   Kent, Stephen ^b,j   Offord, Robin ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b Gryphon Therapeutics   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d INSTITUT COCHIN   (France)

^e Geneva Proteomics Inc   (Switzerland)

^f Department of Research   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITÉ DE MONTRÉAL   (Canada)

ⁱ Université de Montréal ^*  (Netherlands)

^j UNIVERSITY OF CHICAGO   (United States)

more..

Author keywords

AIDS; CCR5; Chemokines

Indexed keywords

CHEMOKINE RECEPTOR CCR5; HYDROXYL GROUP; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; OXIME; PROTEIN; RANTES; VIRUS RNA;

ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG POTENCY; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; MASS SPECTROMETRY; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CHO CELLS; CRICETINAE; DRUG DESIGN; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, SCID; RANTES; RECEPTORS, CCR5; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 9344239350     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404802101     Document Type: Article

References (38)

1. UNAIDS/World Health Organizarion (2003) AIDS Epidemic Update (UNAIDS/World Health Organization, Geneva).
2. Shattock, R. J. & Moore, J. P. (2003) Nat. Rev. Microbiol. 1, 25-34.
3. Robertson, D. (2003) Nat. Biotechnol. 21, 470-471.
4. Michael, N. L. & Moore, J. P. (1999) Nat. Med. 5, 740-742.
5. Berger, E. A., Murphy, P. M. & Farber, J. M. (1999) Annu. Rev. Immunol. 17, 657-700.
6. Dean, M., Carrington, M., Winkler, C., Huttley, G. A., Smith, M. W., Allikmets, R., Goedert, J. J., Buchbinder, S. P., Vittinghoff, E., Gomperts, E., et al. (1996) Science 273, 1856-1862.
7. Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A. & Landau, N. R. (1996) Cell 86, 367-377.
8. Samson, M., Libert, F., Doranz, B. J., Rucker, J., Liesnard, C., Farber, C. M., Saragosti, S., Lapoumeroulie, C., Cognaux, J., Forceille, C., et al. (1996) Nature 382, 722-725.
9. Cocchi, F., DeVico, A. L., Garzino, D. A., Arya, S. K., Gallo, R. C. & Lusso, P. (1995) Science 270, 1811-1815.
10. Blanpain, C, Migeotte, I., Lee, B., Vakili, J., Doranz, B. J., Govaerts, C., Vassart, G., Doms, R. W. & Parmentier, M. (1999) Blood 94, 1899-1905.
11. Zlotnik, A. & Yoshie, O. (2000) Immunity 12, 121-127.
12. Siciliano, S. J., Rollins, T. E., DeMartino, J., Konteatis, Z., Malkowitz, L., Van, R. G., Bondy, S., Rosen, H. & Springer, M. S. (1994) Proc. Natl. Acad. Sci. USA 91, 1214-1218.
13. Wells, T., Proudfoot, A., Power, C. A., Lusti-Narasimhan, M., Alouani, S., Hoogewerf, A. J. & Peitsch, M. C. (1996) Methods 10, 126-134.
14. Blanpain, C., Doranz, B. J., Bondue, A., Govaerts, C., De Leener, A., Vassart, G., Doms, R. W., Proudfoot, A. & Parmentier, M. (2002) J. Biol. Chem. 278, 5179-5187.
15. Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, M. M., Schwartz, T. W., Buser, R., Wells, T. N. C. & Proudfoot, A. E. (1997) Science 276, 276-279.
16. Proudfoot, A. E., Power, C. A., Hoogewerf, A. J., Montjovent, M. O., Borlat, F., Offord, R. E. & Wells, T. N. (1996) J. Biol. Chem. 271, 2599-2603.
17. Mosier, D. E., Picchio, G. R., Gulizia, R. J., Sabbe, R., Poignard, P., Picard, L., Offord, R. E., Thompson, D. A. & Wilken, J. (1999) J. Virol. 73, 3544-3550.
18. Townson, J. R., Graham, G. J., Landau, N. R., Rasala, B. & Nibbs, R. J. (2000) J. Biol. Chem. 275, 39254-39261.
19. Polo, S., Nardese, V., Santis, C. D., Arcelloni, C., Paroni, R., Sironi, F., Verani, A., Rizzi, M., Bolognesi, M. & Lusso, P. (2000) Eur. J. Immunol 30, 3190-3198.
20. Pastore, C., Picchio, G. R., Galimi, F., Fish, R., Hartley, O., Offord, R. E. & Mosier, D. E. (2003) Antimicrob. Agents Chemother. 47, 509-517.
21. Hartley, O., Dorgham, K., Perez-Bercoff, D., Cerini, F., Heimann, A., Gaertner, H., Offord, R. E., Pancino, G., Debre, P. & Gorochov, G. (2003) J. Virol. 77, 6637-6644.
22. Mack, M., Luckow, B., Nelson, P. J., Cihak, J., Simmons, G., Clapham, P. R., Signoret, N., Marsh, M., Stangassinger, M., Borlat, F., et al. (1998) J. Exp. Med. 187, 1215-1224.
23. Sabbe, R., Picchio, G. R., Pastore, C., Chaloin, O., Hartley, O., Offord, R. & Mosier, D. E. (2001) J. Virol. 75, 661-671.
24. Brandt, S. M., Mariani, R., Holland, A. U., Hope, T. J. & Landau, N. R. (2002) J. Biol. Chem. 277, 17291-17299.
25. Dower, W. J. & Mattheakis, L. C. (2002) Curr. Opin. Chem. Biol. 6, 390-398.
26. Wilken, J. & Kent, S. B. (1998) Curr. Opin. Biotechnol. 9, 412-426.
27. Wilken, J., Hoover, D., Thompson, D. A., Barlow, P. N., McSparron, H., Picard, L., Wlodawer, A., Lubkowski, J. & Kent, S. B. (1999) Chem. Biol. 6, 43-51.
28. Dawson, P. E., Muir, T. W., Clark-Lewis, I. & Kent, S. B. (1994) Science 266, 776-779.
29. Naldini, L., Blomer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M. & Trono, D. (1996) Science 272, 263-267.
30. Olson, W. C., Rabut, G. E., Nagashima, K. A., Tran, D. N., Anselma, D. J., Monard, S. P., Segal, J. P., Thompson, D. A., Kajumo, F., Guo, Y., et al. (1999) J. Virol. 73, 4145-4155.
31. Chesebro, B., Wehrly, K., Nishio, J. & Perryman, S. (1996) J. Virol. 70, 9055-9059.
32. Signoret, N., Pelchen-Matthews, A., Mack, M., Proudfoot, A. E. & Marsh, M. (2000) J. Cell Biol. 151, 1281-1294.
33. Hoogewerf, A. J., Kuschert, G. S., Proudfoot, A. E., Borlat, F., Clark-Lewis, I., Power, C. A. & Wells, T. N. (1997) Biochemistry 36, 13570-13578.
34. Yang, O. O., Swanberg, S. L., Lu, Z., Dziejman, M., McCoy, J., Luster, A. D., Walker, B. D. & Herrmann, S. H. (1999) J. Virol. 73, 4582-4589.
35. Pakianathan, D. R., Kuta, E. G., Artis, D. R., Skelton, N. J. & Hebert, C. A. (1997) Biochemistry 36, 9642-9648.
36. Ferguson, S. S. (2001) Pharmacol. Rev. 53, 1-24.
37. Kawamura, T., Bruce, S. E., Abraha, A., Sugaya, M., Hartley, O., Offord, R. E., Arts, E. J., Zimmerman, P. A. & Blauvelt, A. (2004) J. Virol. 78, 7602-7609.
38. Lederman, M. M., Veazey, R. S., Offord, R. E., Mosier, D. E., Dufour, J., Mefford, M., Piatak, M., Lifson, J. D., Salkowitz, J. R., Rodriguez, B., et al. (2004) Science, 306, 485-487.