The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility

Science

Volumn 307, Issue 5714, 2005, Pages 1434-1440

  Gonzalez, Enrique ^a   Kulkarni, Hemant ^a   Bolivar, Hector ^a,k   Mangano, Andrea ^b   Sanchez, Racquel ^a   Catano, Gabriel ^a   Nibbs, Robert J ^c   Freedman, Barry I ^d   Quinones, Marlon P ^a   Bamshad, Michael J ^e   Murthy, Krishna K ^f   Rovin, Brad H ^g   Bradley, William ^h,i   Clark, Robert A ^a   Anderson, Stephanie A ^h,i   O'Connell, Robert J ⁱ   Agan, Brian K ⁱ   Ahuja, Seema S ^a   Bologna, Rosa ^b   Sen, Luisa ^b   Dolan, Matthew J ^i,j   Ahuja, Sunil K ^a   more..

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b HOSPITAL DE PEDIATRÍA PROF DR JUAN P GARRAHAN   (Argentina)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^g OHIO STATE UNIVERSITY   (United States)

^h HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

ⁱ WILFORD HALL MEDICAL CENTER   (United States)

^j USAF   (United States)

^k UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE CONTROL; IMMUNOLOGY; MOLECULAR STRUCTURE; VIRUSES;

ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS); GENE ENCODING; HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV-1); SEGMENTAL DUPLICATIONS;

GENETIC ENGINEERING;

CHEMOKINE; CHEMOKINE RECEPTOR CCR5; LIGAND;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; GENOME;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CCL3L1 GENE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE; GENE DOSAGE; GENE DUPLICATION; GENE NUMBER; GENETIC CODE; GENETIC SUSCEPTIBILITY; GENOTYPE; HOST RESISTANCE; HUMAN; HUMAN GENOME; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNITY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANIMALS; CHEMOKINES, CC; CHILD; COHORT STUDIES; CONTINENTAL POPULATION GROUPS; DISEASE PROGRESSION; ETHNIC GROUPS; FEMALE; GENE DOSAGE; GENE DUPLICATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; PAN TROGLODYTES; PHENOTYPE; PUBLIC HEALTH; RECEPTORS, CCR5; SELECTION (GENETICS);

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 20044377204     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101160     Document Type: Article

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23. We thank the Board members and reviewers, including the statistical referee, for critically reviewing various aspects of this work and for very valuable suggestions; G. Crawford, B. Kasinath, G. Nabel, J. Burns, B. Cherniak, members of the Infectious Diseases division for helpful discussions and critical reading of the manuscript; E. Fattig and M. Hildebrand for technical assistance; N. Chopra and J. Sharron for graphic work; and A. S. Ahuja for forbearance. The Henry H. Jackson Foundation and the Military HIV Program, Walter Reed Army Institute of Research contributed support for the WHMC patient cohort as part of the Tri-Service HIV Program. Supported by the Veterans Administration Center on AIDS and HIV-1 infection, and grants from NIH (AIO46326, AIO43279, and MH069270) (S.K.A.). S.K.A. is a recipient of the Elizabeth Glaser Scientist Award and the Burroughs Wellcome Clinical Scientist Award in Translational Research. Because of space constraints, we regret our inability to cite additional excellent work. The views expressed herein are those of the authors and do not reflect the official policy of the Department of Defense or other departments of the U.S. government.