HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling

Blood

Volumn 98, Issue 10, 2001, Pages 2909-2916

  Del Corno, Manuela ^a,b,c,d   Liu, Qing Hua ^a,b,c,d   Schols, Dominique ^a,b,c,d   De Clercq, Erik ^a,b,c,d   Gessani, Sandra ^a,b,c,d   Freedman, Bruce D ^a,b,c,d   Collman, Ronald G ^a,b,c,d,e  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e 522 Johnson Pavilion   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; EGTAZIC ACID; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 2; GLYCOPROTEIN GP 120; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PERTUSSIS TOXIN; STRESS ACTIVATED PROTEIN KINASE; STROMAL CELL DERIVED FACTOR 1ALPHA; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ARTICLE; CALCIUM TRANSPORT; CELL FUNCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; NORMAL HUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TARGET CELL;

EID: 0035892099     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.10.2909     Document Type: Article

References (77)

1. Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV-1 coreceptors: roles n viral entry, tropism, and disease. Annu Rev Immunol. 1999;17:657-700
2. Popik W, Pitha PM. Exploitation of cellular signaling by HIV-1: unwelcome guests with master keys that signal their entry. Virology. 2000;276:1-6.
3. Weissman D, Rabin RL, Arthos J et al. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature. 1997;389:981-985
4. Cicala C, Arthos J, Ruiz M, et al. Induction of pohosphorylation and intracellular association of CC chemokine receptor 5 and focal adhesion kinase in primary human CD4+ T cells by macrophage-tropic HIV envelope. J Immunol. 1999:163:420-426
5. Davis CB, Dikic I, Unutmaz D, et al. Signal transduction due to HIV-1 enve ope interactions with-chemokine receptors CXCR4 or CCR5. J Exp Med 1997:186:1793-1798.
6. Missé D, Cerutti M, Noraz N. et al. A CD4-independent interaction of human immunodeficiency virus-1 gp120 with CXCR4 induces their cointernalization, cell signaling, and T-cell chermotaxis. Blood 1999;93:2454-2462.
7. Popik W, Hesselgesser JE, Pitha PM Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol. 1998;72:6406-6413
8. Popik W, Pitha PM. Early activation of mitogen-activated protein kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein-kinase, and c-Jun N-terminal kinase in response to binding of simian immunodeficiency virus to Jurkat T cells expressing CCR5 receptor. Virology. 1998;252:210-217.
9. Igarashi T, Brown CR, Endo Y, et al. Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus, HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans. Proc Natl Acad Sci U S A. 2001;98:658-663.
10. Kolson DL, Lavi E, González-Scarano F The effects of human immunodeficiency virus in the central nervous system. Adv Virus Res 1998;50:1-47.
11. Martin JC, Bandres JC. Cells of the monocyte-macrophage lineage and pathogenesis of HIV-1 infection. J Acquir Immune Defic Syndr. 1999;22:413-429
12. Orenstein JM, Fox C, Wahl SM. Macrophages as a source of HIV during opportunistic infections. Science. 1997;276:857-1861
13. Borghi P, Fantuzzi, L Varano B, et al. Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages. J Virol 1995;69:1284-1287
14. Koziel H, Eichbaum O, Kruskal BA, et al. Reduced binding and phagocytosis of Pneumocystis carini by alveolar macrophages from persons infected with HIV-1 Correlates with mannose receptor downregulation. J Clin Invest 1998;102:1332-1344.
15. Shiratsuchi H, Johnson JL, Toossi Z, Ellner JJ. Modulation of the effector function of human monocytes for Mycobacterium a avium by human immunodeficiency virus-1 envelope glycoprotein-gp120. J Clin Invest 1994;93:885-891.
16. Simmons G, Reeves JD, McKnignt A, et al. CXCR4 as a functional coreceptor for human immunodeficiency virus type infection of primary macrophages. J Virol. 1998;72:8453-8457.
17. Verani A, Pesenti E, Polo S, et al. CXCR4 is a functional coreceptor for infection of human macrophages by CXCR4-dependent primary HIV-1 isolates. J Immunol. 1998;161:2084-2088
18. Yi, Y, Isaacs SN, Williams DA, et al. Role of CXCR4 in cell-cell fusion and infection of monocyte-derived macrophages by primary human immunodeficiency virus type 1 (HIV-1) strains: two distinct mechanisms of HIV-1 dual tropism. J Virol. 1999;73:7117-7125
19. Arai H, Charo IF. Differential regulation of G-protein-mediated signaling by cnemokine receptors. J Biol Chem. 1996;271:21814-21819.
20. Liu QH, Williams DA, McManus C, et al. HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. Proc Natl Acad Sci U S A. 2000;97:4832-4837
21. Collman R, Hassan, NF, Walker, R, et al. Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types. J Exp Med. 1989;170:1149-1163.
22. Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection of Caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene. Nature 1996;352:722-725
23. Edinger AL, Blanpaln C, Kunstman KJ, et al. Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains. J Virol 1999;73:4062-4073
24. Avraham S, London R, Fu Y, et al. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem. 1995;270:27742-27751.
25. Lev S, Moreno H, Matinez R, et al. Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature 1995;376:737-745.
26. Sasaki H, Nagura K, Ishino M, et al. Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J Biol Chem. 1995;270:21206-21219
27. Dikic I, Dikic I, Schlessinger J. Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J Biol Chem. 1998;273:14301-14308.
28. Dikic I, Tokiwa G, Lev S, Courtniedge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 1996;383:547-550.
29. Ganju RK, Dutt P, Wu L, et al. Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. Blood 1998;9:791-797.
30. 2+]i elevation can substitute for receptor activation. J Biol Chem. 1998;273:23110-23117.
31. Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science. 1996;273:792-794.
32. Li X, Hunter D, Morris J, Haskill JS, Earp HS. A calcium-dependent tyrosine kinase spice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. J Biol Chem. 1998;273:19361- 9364.
33. Oberlin E, Amara A, Bachelerie F, et al. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature. 1996;382:833-835.
34. Schols D, Struyf S, Van Damme J, et al. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J Exp Med. 1997;186:1383-1388.
35. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-377.
36. Yu H, Li X, Marchetto GS, et al. Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. J Biol Chem. 1996;271:29993-29998.
37. Arthos J, Rubbert A, Rabin RL, et al. CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes. J Virol. 2000;74:6418-6424.
38. Aussel C, Marhaba R, Pelassy C, Breittmayer JP. Submicromolar La3+ concentrations block the calcium release-activated channel, and impair CD69 and CD25 expression in CD3- or thapsigargin-activated Jurkat cells. Biochem J. 1996;313 (pt 3):909-913.
39. Floto RA, Mahaut-Smith MP, Allen JM, Somasundaram B. Differentiation of the human monocytic cell line U937 results in an upregulation of the calcium release-activated current, ICRAC. J Physiol. 1996;495:331-338.
40. Ui M, Katada T. Bacterial toxins as probe for receptor-Gi coupling. Adv Second Messenger Phosphoprotein Res. 1990;24:63-69.
41. Cobb MH, Goldsmith EJ, How MAP kinases are regulated. J Biol Chem. 1995;270:14843-14846.
42. Della Rocca GJ, van Biesen T, Daaka Y, et al. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. J Biol Chem. 1997;272:19125-19132.
43. Pandey P, Avraham S, Kumar S, et al. Activation of p38 mitogen-activated protein kinase by PYK2/related adhesion focal tyrosine kinase-dependent mechanism. J Biol Chem. 1999;274:10140-10144.
44. Baggiolini M. Chemokines and leukocyte traffic. Nature. 1998;392:565-568.
45. Cinque P, Vago L, Mengozzi M, et al. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS. 1998;12:1327-1332.
46. Kelder W, McArthur JC, Nance-Sproson T, McClernon D, Griffin DE. β-Chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann Neurol. 1998;44:831-835.
47. Sasseville VG, Smith MM, Mackay CR, et al. Chemokine expression in simian immunodeficiency virus-induced AIDS encephalitis. Am J Pathol. 1996;149:1459-1467.
48. Canque B, Rosenzwajg M, Gey A, et al. Macrophage inflammatory protein-1α is induced by human immunodeficiency virus infection of monocyte-derived macrophages. Blood. 1996;87:2011-2019.
49. Fantuzzi L, Canini I, BeJardelli F, Gessani S. HIV-1 gp120 stimulates the production of beta-chemokines in human peripheral blood monocytes through a CD4-independent mechanism. J Immunol. 2001;166:5381-5387.
50. Schmidtmayerova H, Nottet HSLM, Nuovo G, et al. Human immunodeficiency virus type 1 infection alters chemokine β peptice expression in human monocytes: Implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci U S A. 1996;93:700-704.
51. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000;351:95-105.
52. Cocchi F, De Vico AL, Garzino-Demo A, et al. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995;270:1811-1815.
53. Avraham H, Park SY, Schinkmann K, Avraham S. RAFTK/Pyk2-mediated cellular signalling. Cell Signal. 2000;12:123-133.
54. Ganju RK, Brubaker SA, Meyer J, et al. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem. 1998;273:23169-23175.
55. Farzan M, Choe H, Martin KA, et al. HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem. 1997;272:6854-6857.
56. Wong M, Fish EN. RANTES and MIP-1alpha activate STATs in T cells. J Biol Chem. 1998;273:309-314.
57. Zhao J, Ma L, Wu YL et al. Chemokine receptor CCR5 functionally couples to inhibitory G proteins and undergoes desensitization. J Cell Biochem. 1998;71:36-45.
58. Hall RA, Spurney RF, Premont RT, et al. G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. J Biol Chem. 1999;274:24328-24334.
59. Heuss C, Gerber U. G-protein-independent signaling by G-protein-coupled receptors. Trends Neurosci. 2000;23:469-475.
60. Cohen PS, Schmidtmayerova H, Dennis J, et al. The critical role of p38 MAP kinase in T cell HIV-1 replication. Mol Med. 1997;3:339-346.
61. Shapiro L, Heidenreich KA, Meintzer MK, Dinarello CA. Role of p38 mitogen-activated protein kinase in HIV type 1 production in vitro. Proc Natl Acad Sci U S A. 1998;95:7422-7426.
62. Sugden PH, Clerk A. Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell Signal. 1997;9:337-351.
63. Kutsch O, Oh J, Nath A, Benveniste EN. Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes. J Virol. 2000;74:9214-9221.
64. Means TK, Pavlovich RP, Roca D, Vermeulen MW, Fenton MJ. Activation of TNF-alpha transcription utilizes distinct MAP kinase pathways in different macrophage populations. J Leukoc Biol. 2000;67:885-893.
65. Park IW, Wang JF, Groopman JE. HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. Blood. 2001;97:352-358.
66. Sodhi A, Montaner S, Patel V, et al. The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha. Cancer Res. 2000;60:4873-4880.
67. Gessani S, Borghi P, Fantuzzi L, et al. Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation. J Leukoc Biol. 1997;62:49-53.
68. Atchison RE, Gosling J, Monteclaro FS, et al. Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines. Science. 1996;274:1924-1926.
69. Alfano M, Sehmidtmayerova H, Amella CA, Pushkarsky T, Bukrinsky M. The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains. J Exp Med. 1999;190:597-605.
70. Jones MV, Bell JE, Nath A. Immunolocalization of HIV envelope gp120 in HIV encephalitis with dementia. AIDS. 2000;14:2709-2713.
71. Oh SK, Cruikshank WW, Raina J, et al. Identification of HIV-1 envelope glycoprotein in the serum of AIDS and ARC patients. J Acquir Immune Defic Syndr. 1992;5:251-256.
72. Merrill JE, Koyanagi Y, Zack J, et al. Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J Virol. 1992;66:2217-2225.
73. Tedla N, Palladinetti P, Kelly M, et al. Chemokines and T lymphocyte recruitment to lymph nodes in HIV infection. Am J Pathol. 1996;148:1367-1373.
74. Glass JD, Fedor H, Wesselingh SL, McArthur JC. Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol. 1995;38:755-762.
75. Sanders VJ, Pittman CA, White MC, et al. Chemokines and receptors in HIV encephalitis. AIDS. 1998;12:1021-1026.
76. Galasso JM, Liu Y, Szaflarski J, Warren JS, Silverstein FS. Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain. Neuroscience. 2000;101:737-744.
77. Persidsky Y, Ghorpade A, Rasmussen J, et al. Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am J Pathol. 1999;155:1599-1611.