Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication

AIDS

Volumn 17, Issue 16, 2003, Pages

  Quiñones Mateu, Miguel E ^a,b   Lederman, Michael M ^b   Feng, Zhimin ^c   Chakraborty, Bikram ^a   Weber, Jan ^a   Rangel, Hector R ^a   Marotta, Michael L ^a   Mirza, Muneer ^a   Jiang, Bin ^c   Kiser, Patti ^a   Medvik, Kathy ^b   Sieg, Scott F ^b   Weinberg, Aaron ^b,c,d  

^a LERNER RESEARCH INSTITUTE   (United States)

^b Center for Vision Research   (United States)

^c UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

HIV 1; Human beta defensins; Oral epithelial cells; Receptors; Viral transmission

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BETA DEFENSIN 1; BETA DEFENSIN 2; BETA DEFENSIN 3; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA; RECOMBINANT BETA DEFENSIN 1; RECOMBINANT BETA DEFENSIN 2; RECOMBINANT BETA DEFENSIN 3; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; ELECTRON MICROSCOPY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOUTH MUCOSA; MUCOSAL IMMUNITY; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; VIRION; VIRUS CELL INTERACTION; VIRUS INFECTIVITY; VIRUS INHIBITION; VIRUS ISOLATION; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TRANSMISSION;

BETA-DEFENSINS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HIV-1; HUMANS; MOUTH MUCOSA; RECEPTORS, CCR5; RECEPTORS, CXCR4; RECOMBINANT PROTEINS; RNA, MESSENGER; VIRUS REPLICATION;

EID: 9144240994     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200311070-00001     Document Type: Article

References (48)

1. Rothenberg RB, Scarlett M, del Rio C, Reznik D, O'Daniels C. Oral transmission of HIV. AIDS 1998, 12:2095-2105.
2. Fenyo EM, Schuitemaker B, Asjo B, McKeating J. The History of HIV-1 Biological Phenotypes Past, Present and Future. Los Alamos: Theoretical Biology and Biophysics Group; 1997.
3. Weinberg A, Krisanaprakornkit S, Dale BA. Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med 1998, 9:399-414.
4. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415:389-395.
5. Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA. Expression of the peptide antibiotic human beta-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 1998, 66:4222-4228.
6. Krisanaprakornkit S, Kimball JR, Weinberg A, Darveau RP, Bainbridge BW, Dale BA. Inducible expression of human beta-defensin 2 by Fusobacterium nucleatum in oral epithelial cells: multiple signaling pathways and role of commensal bacteria in innate immunity and the epithelial barrier. Infect Immun 2000, 68:2907-2915.
7. Dunsche A, Acil Y, Dommisch H, Siebert R, Schroder JM, Jepsen S. The novel human beta-defensin-3 is widely expressed in oral tissues. Eur J Oral Sci 2002, 110:121-124.
8. Biragyn A, Ruffini PA, Leifer CC, Klyushnenkova E, Shakhov A, Chertov O, et al. Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 2002, 298:1025-1029.
9. Gropp R, Frye M, Wagner TO, Bargon J. Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy. Hum Gene Ther 1999, 10:957-964.
10. Pauwels R, Balzarini J, Baba M, et al. Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J Virological Methods 1988, 20:309-321.
11. Quinones-Mateu ME, Ball SC, Marozsan AJ, et al. A dual infection/competition assay shows a correlation between ex vivo human immunodeficiency virus type 1 fitness and disease progression. J Virol 2000, 74:9222-9233.
12. Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB, Jr., Ganz T. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 1998, 101:1633-1642.
13. Harder J, Bartels J, Christophers E, Schroder JM. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 2001, 276:5707-5713.
14. Weber J, Rangel HR, Chakraborty B, et al. A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy. J Gen Virol 2003, 84:2217-2228.
15. Morner A, Bjorndal A, Albert J, et al. Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage. J Virol 1999, 73:2343-2349.
16. Salkowitz JR, Purvis SF, Meyerson H, et al. Characterization of high-risk HIV-1 seronegative hemophiliacs. Clin Immunol 2001, 98:200-211.
17. Iyer SB, Hultin LE, Zawadzki JA, Davis KA, Giorgi JV. Quantitation of CD38 expression using QuantiBRITE beads. Cytometry 1998, 33:206-212.
18. Briquet S, Vaquero C. Immunolocalization studies of an antisense protein in HIV-1-infected cells and viral particles. Virology 2002, 292:177-184.
19. Yahi N, Baghdiguian S, Moreau H, Fantini J. Galactosyl ceramide (or a closely related molecule) is the receptor for human immunodeficiency virus type 1 on human colon epithelial HT29 cells. J Virol 1992, 66:4848-4854.
20. Han Y, Ventura CL, Black KP, Cummins JE, Jr., Hall SD, Jackson S. Productive human immunodeficiency virus-1 infection of epithelial cell lines of salivary gland origin. Oral Microbiol Immunol 2000, 15:82-88.
21. Fotopoulos G, Harari A, Michetti P, Trono D, Pantaleo G, Kraehenbuhl JP. Transepithelial transport of HIV-1 by M cells is receptor-mediated. Proc Natl Acad Sci USA 2002, 99:9410-9414.
22. Mandel ID. Saliva. St. Louis: C.V. Mosby Co, 1972.
23. Rogers MF, White CR, Sanders R, et al. Lack of transmission of human immunodeficiency virus from infected children to their household contacts. Pediatrics 1990, 85:210-214.
24. Moore BE, Flaitz CM, Coppenhaver DH, Nichols M, Kalmaz GD, Bessman JD, et al. HIV recovery from saliva before and after dental treatment: inhibitors may have critical role in viral inactivation. J Am Dental Assoc 1993, 124:67-74.
25. Goto Y, Yeh CK, Notkins AL, Prabhakar BS. Detection of proviral sequences in saliva of patients infected with human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 1991, 7:343-347.
26. Baron S, Poast J, Cloyd MW. Why is HIV rarely transmitted by oral secretions? Saliva can disrupt orally shed, infected leukocytes. Arch Intern Med 1999, 159:303-310.
27. Barr CE, Miller LK, Lopez MR, et al. Recovery of infectious HIV-1 from whole saliva. J Am Dental Assoc 1992, 123:36-37.
28. Coppenhaver DH, Sriyuktasuth-Woo P, Baron S, Barr CE, Qureshi MN. Correlation of nonspecific antiviral activity with the ability to isolate infectious HIV-1 from saliva. New Engl J Med 1994, 330:1314-1315.
29. Herz AM, Robertson MN, Lynch JB, Schmidt A, Rabin M, Sherbert C, et al. Viral dynamics of early HIV infection in neonatal macaques after oral exposure to HIV-2287: an animal model with implications for maternal-neonatal HIV transmission. J Med Primatol 2002, 31:29-39.
30. Smith PD, Li L, Meng G. Mucosal events in the pathogenesis of human immunodeficiency virus type 1 infection. J Infect Dis 1999, 179 Suppl 3:5436-440.
31. Shugars DC, Wahl SM. The role of the oral environment in HIV-1 transmission. J Am Dental Assoc 1998, 129:851-858.
32. O'Neil DA, Porter EM, Elewaut D, et al. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999, 163:6718-6724.
33. Wehkamp J, Fellermann K, Herrlinger KR, et al. Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol 2002, 14:745-752.
34. Bajaj-Elliott M, Fedeli P, Smith GV, Domizio P, Maher L, Ali RS, et al. Modulation of host antimicrobial peptide (beta-defensins 1 and 2) expression during gastritis. Gut 2002, 51:356-361.
35. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. [see comments] New Engl J Med 2002, 347:1151-1160.
36. Liu L, Wang L, Jia HP, Zhao C, Heng HHQ, Schutte BC, et al. Structure and mapping of the human beta-defensin HBD-2 gene and its expression at sites of inflammation. Gene 1998, 222:237-244.
37. Dale BA, Kimball JR, Krisanaprakornkit S, Roberts F, Robinovitch M, O'Neal R, et al. Localized antimicrobial peptide expression in human gingiva. J Periodontal Res 2001, 36:285-294.
38. Sawaki K, Mizukawa N, Yamaai T, Yoshimoto T, Nakano M, Sugahara T. High concentration of beta-defensin-2 in oral squamous cell carcinoma. Anticancer Res 2002, 22:2103-2107.
39. Liu X, Zha J, Chen H, Nishitani J, Camargo P, Cole SW, et al. Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes. J Virol 2003, 77:3470-3476.
40. Cole AM, Hong T, Boo LM, Nguyen T, Zhao C, Bristol G, et al. Retrocyclin: a primate peptide that protects cells from infection by T-and M-tropic strains of HIV-1. Proc Natl Acad Sci USA 2002, 99:1813-1818.
41. Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, et al. Contribution of human alfa-defensin 1, 2, and 3 to the anti-HIV-1 activity of CD8 antiviral factor. Science 2002, 298:995-1000.
42. Wu Z, Hoover DM, Yang D, Baulegne C, Santamaria F, Oppenheim JJ, et al. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci USA 2003, 100:8880-8885.
43. Schols D, Pauwels R, Desmyter J, De Clercq E. Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1. Virology 1990, 175:556-561.
44. Witvrouw M, Este JA, Quinones-Mateu ME, Reymen D, Andrei G, Snoeck R, et al. Activity of a sulfated polysaccharide extracted from the red seaweed Aghardhiella tenera against human immunodificiency virus and other enveloped viruses. Antiviral Chem Chemother 1994, 5:297-303.
45. De Clercq E. New developments in anti-HIV chemotherapy. Biochim Biophys Acta 2002, 1587:258-275.
46. Wang W, Cole AM, Hong T, Waring AJ, Lehrer RI. Retrocyclin, an antiretroviral theta-defensin, Is a Lectin. J Immunol 2003, 170:4708-4716.
47. Duits LA, Ravensbergen B, Rademaker M, Hiemstra PS, Nibbering PH. Expression of beta-defensin 1 and 2 mRNA by human monocytes, macrophages and dendritic cells. Immunology 2002, 106:517-525.
48. Fang XM, Shu Q, Chen QX, Dercksen MW, de Goede RE, van Steenwijk RP, et al. Differential expression of alpha-and beta-defensins in human peripheral blood. Eur J Clin Invest 2003, 33:82-87.