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Volumn 1, Issue 1, 2006, Pages 34-41

Histone deacetylase inhibitors as a potential therapeutic agent for human cancer treatment

Author keywords

Advanced colorectal cancer; Gastric cancer; Gastrointestinal cancer; Hepatocellular carcinoma; Histone deacetylase inhibitors; Pancreatic cancer

Indexed keywords


EID: 33746054902     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-005-0007-9     Document Type: Review
Times cited : (15)

References (89)
  • 2
    • 26444439216 scopus 로고    scopus 로고
    • Prospects: Histone deacetylase inhibitors
    • Dokmanovic M, Marks PA (2005) Prospects: histone deacetylase inhibitors. J Cell Biochem 96:293-304
    • (2005) J Cell Biochem , vol.96 , pp. 293-304
    • Dokmanovic, M.1    Marks, P.A.2
  • 3
    • 0036086135 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and anticancer therapy
    • Kouraklis G, Theocharis S (2002) Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem-ACA 2:477-484
    • (2002) Curr Med Chem-ACA , vol.2 , pp. 477-484
    • Kouraklis, G.1    Theocharis, S.2
  • 4
    • 21844451163 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors, anti-cancerous mechanism and therapy for gastrointestinal cancers
    • Fang JY (2005) Histone deacetylase inhibitors, anti-cancerous mechanism and therapy for gastrointestinal cancers. J Gastroenterol Hepatol 20:988-994
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 988-994
    • Fang, J.Y.1
  • 7
    • 0041347519 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy: Is transcription the primary target?
    • Johnstone RW, Licht JD (2003) Histone deacetylase inhibitors in cancer therapy:Is transcription the primary target? Cancer Cell 4:13-18
    • (2003) Cancer Cell , vol.4 , pp. 13-18
    • Johnstone, R.W.1    Licht, J.D.2
  • 8
    • 0036386359 scopus 로고    scopus 로고
    • Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation
    • Lehrmann H, Pritchard LL, Harel-Bellan A (2002) Histone acetyltransferases and deacetylases in the control of cell proliferation and differentiation. Adv Cancer Res 86:41-65
    • (2002) Adv Cancer Res , vol.86 , pp. 41-65
    • Lehrmann, H.1    Pritchard, L.L.2    Harel-Bellan, A.3
  • 9
    • 13844252820 scopus 로고    scopus 로고
    • Regulation of histone deacetylase activities
    • Sengupta N, Seto E (2004) Regulation of histone deacetylase activities. J Cell Biochem 93:57-67
    • (2004) J Cell Biochem , vol.93 , pp. 57-67
    • Sengupta, N.1    Seto, E.2
  • 10
    • 0038555374 scopus 로고    scopus 로고
    • Short-chain fatty acid inhibitors of histone deacetylases: Promising anticancer therapeutics?
    • Chen JS, Faller DV, Spanjaard RA (2003) Short-chain fatty acid inhibitors of histone deacetylases:promising anticancer therapeutics? Curr Cancer Drug Targets 3:219-236
    • (2003) Curr Cancer Drug Targets , vol.3 , pp. 219-236
    • Chen, J.S.1    Faller, D.V.2    Spanjaard, R.A.3
  • 11
    • 0030480969 scopus 로고    scopus 로고
    • The GBP co-activator is a histone acetyltransferase
    • Bannister AJ, Kouzarides T (1996) The GBP co-activator is a histone acetyltransferase. Nature 384:641-643
    • (1996) Nature , vol.384 , pp. 641-643
    • Bannister, A.J.1    Kouzarides, T.2
  • 12
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276:36734-36741
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 13
    • 0030931494 scopus 로고    scopus 로고
    • The nucleosome core all wrapped up
    • Chromatin structure
    • Rhodes D. Chromatin structure (1997) The nucleosome core all wrapped up. Nature 389:231-233
    • (1997) Nature , vol.389 , pp. 231-233
    • Rhodes, D.1
  • 14
    • 10444282190 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors for the treatment of cancer
    • Lindemann RK, Gabrielli B, Johnstone RW (2004) Histone-deacetylase inhibitors for the treatment of cancer. Cell Cycle 3:779-788
    • (2004) Cell Cycle , vol.3 , pp. 779-788
    • Lindemann, R.K.1    Gabrielli, B.2    Johnstone, R.W.3
  • 16
    • 0029932598 scopus 로고    scopus 로고
    • A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3.p
    • Taunton J, Hassig CA, Scheiber SL (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3.p. Science 272:408-411
    • (1996) Science , vol.272 , pp. 408-411
    • Taunton, J.1    Hassig, C.A.2    Scheiber, S.L.3
  • 17
    • 0033609055 scopus 로고    scopus 로고
    • Three proteins define a class of human histone deacetylases related to yeast Hda1.p
    • USA
    • Grozinger CM, Hassig CA, Schreiber SL (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1.p. Proc Natl Acad Sci USA 96:4868-4873
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 4868-4873
    • Grozinger, C.M.1    Hassig, C.A.2    Schreiber, S.L.3
  • 19
    • 0033964512 scopus 로고    scopus 로고
    • waf1/cip1 promoter activity induced by histone deacetylase inhibitor
    • waf1/cip1 promoter activity induced by histone deacetylase inhibitor. J Biol Chem 275:1371-1376
    • (2000) J Biol Chem , vol.275 , pp. 1371-1376
    • Xiao, H.1    Hasegawa, T.2    Isobe, K.I.3
  • 21
    • 0034105047 scopus 로고    scopus 로고
    • Butarate and Trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: Induction of cyclin D3 and p21 expression
    • Siavoshian S, Segain JP, Kornprobst M, Bonnet C, Cherbut C, Galmiche JP, Blottiere HM (2000) Butarate and Trichostatin A effects on the proliferation/differentiation of human intestinal epithelial cells: induction of cyclin D3 and p21 expression. Gut 46:507-514
    • (2000) Gut , vol.46 , pp. 507-514
    • Siavoshian, S.1    Segain, J.P.2    Kornprobst, M.3    Bonnet, C.4    Cherbut, C.5    Galmiche, J.P.6    Blottiere, H.M.7
  • 22
    • 0038079767 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1
    • Rosato RR, Almenara JA, Grant S (2003) The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Res 63:3637-3645
    • (2003) Cancer Res , vol.63 , pp. 3637-3645
    • Rosato, R.R.1    Almenara, J.A.2    Grant, S.3
  • 23
    • 0035793107 scopus 로고    scopus 로고
    • Potent histone deacetylase inhibitors built from Trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
    • USA
    • Furumai R, Komatsu Y, Nishino N, Khochbin S, Yoshida M, Horinouchi S (2001) Potent histone deacetylase inhibitors built from Trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci USA 98:87-92
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 87-92
    • Furumai, R.1    Komatsu, Y.2    Nishino, N.3    Khochbin, S.4    Yoshida, M.5    Horinouchi, S.6
  • 26
    • 0033561497 scopus 로고    scopus 로고
    • Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase
    • Kim YB, Lee KH, Sugita K, Yoshida M, Horinouchi S (1999) Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene 18:2461-2470
    • (1999) Oncogene , vol.18 , pp. 2461-2470
    • Kim, Y.B.1    Lee, K.H.2    Sugita, K.3    Yoshida, M.4    Horinouchi, S.5
  • 27
    • 0242330341 scopus 로고    scopus 로고
    • A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine
    • Keen JC, Yan L, Mack KM, Petitt C, Smith D, Sharma D, Davidson NE (2003). A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2′-deoxycytidine. Breast Cancer Res Treat 81:177-186
    • (2003) Breast Cancer Res Treat , vol.81 , pp. 177-186
    • Keen, J.C.1    Yan, L.2    Mack, K.M.3    Petitt, C.4    Smith, D.5    Sharma, D.6    Davidson, N.E.7
  • 28
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276:36734-36741
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 29
    • 0000032126 scopus 로고    scopus 로고
    • Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase
    • Kwon HJ, Owa T, Hassig CA, Shimada J, Schreiber SL (1998) Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Proc Natl Acad Sci 95:3356-3361
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 3356-3361
    • Kwon, H.J.1    Owa, T.2    Hassig, C.A.3    Shimada, J.4    Schreiber, S.L.5
  • 31
    • 0035325163 scopus 로고    scopus 로고
    • Histone acetylation and chromatin remodeling
    • Gregory PD, Wagner K, Horz W (2001) Histone acetylation and chromatin remodeling. Exp Cell Res 265:195-202
    • (2001) Exp Cell Res , vol.265 , pp. 195-202
    • Gregory, P.D.1    Wagner, K.2    Horz, W.3
  • 35
    • 7244221565 scopus 로고    scopus 로고
    • Purchase of Aton spotlights HDAC inhibitors
    • Garber K (2004) Purchase of Aton spotlights HDAC inhibitors. Nat Biotechnol 22:364-365
    • (2004) Nat Biotechnol , vol.22 , pp. 364-365
    • Garber, K.1
  • 39
    • 0037279491 scopus 로고    scopus 로고
    • Peroxisome proliferator activated receptor-gamma ligands as potent antineoplastic agents
    • Theocharis S, Margeli A, Kouraklis G (2003) Peroxisome proliferator activated receptor-gamma ligands as potent antineoplastic agents. Curr Med Chem-ACA 3:239-251
    • (2003) Curr Med Chem-ACA , vol.3 , pp. 239-251
    • Theocharis, S.1    Margeli, A.2    Kouraklis, G.3
  • 41
    • 0034086168 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells
    • Qiu L, Burgess A, Fairlie DP, Leonard H, Parsons PG, Gabrielli BG (2000) Histone deacetylase inhibitors trigger a G2 checkpoint in normal cells that is defective in tumor cells. Mol Biol Cell 11:2069-2083
    • (2000) Mol Biol Cell , vol.11 , pp. 2069-2083
    • Qiu, L.1    Burgess, A.2    Fairlie, D.P.3    Leonard, H.4    Parsons, P.G.5    Gabrielli, B.G.6
  • 42
    • 0036280745 scopus 로고    scopus 로고
    • Effects of histone acetylation and DNA methylation on p21 (WAF1) regulation
    • Fang JY, Lu YY (2002) Effects of histone acetylation and DNA methylation on p21 (WAF1) regulation. World J Gastroenterol 8:400-405
    • (2002) World J Gastroenterol , vol.8 , pp. 400-405
    • Fang, J.Y.1    Lu, Y.Y.2
  • 43
    • 0036176617 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer treatment
    • Vigushin DM, Coombes RC (2002) Histone deacetylase inhibitors in cancer treatment. Anticancer Drugs 13:1-13
    • (2002) Anticancer Drugs , vol.13 , pp. 1-13
    • Vigushin, D.M.1    Coombes, R.C.2
  • 44
    • 0038485588 scopus 로고    scopus 로고
    • Role of caspaces, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors Trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA)
    • Henderson C, Mizzau M, Paroni R, Schneider C, Brancolini C (2003) Role of caspaces, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors Trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J Biol Chem 278:12579-12589
    • (2003) J Biol Chem , vol.278 , pp. 12579-12589
    • Henderson, C.1    Mizzau, M.2    Paroni, R.3    Schneider, C.4    Brancolini, C.5
  • 45
    • 0038677606 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation
    • Shin HJ, Baek KH, Jeon AH, Kim SJ, Jang KL, Sung YC, Kim CM, Lee CW (2003) Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation. Oncogene 22:3853-3858
    • (2003) Oncogene , vol.22 , pp. 3853-3858
    • Shin, H.J.1    Baek, K.H.2    Jeon, A.H.3    Kim, S.J.4    Jang, K.L.5    Sung, Y.C.6    Kim, C.M.7    Lee, C.W.8
  • 47
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21:103-107
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 49
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone RW, Ruefli AA, Lowe SW (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108:153-164
    • (2002) Cell , vol.108 , pp. 153-164
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 50
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1:287-299
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 51
    • 0035845541 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
    • USA
    • Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ, Johnstone RW (2001) The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci USA 98:10833-10838
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 10833-10838
    • Ruefli, A.A.1    Ausserlechner, M.J.2    Bernhard, D.3    Sutton, V.R.4    Tainton, K.M.5    Kofler, R.6    Smyth, M.J.7    Johnstone, R.W.8
  • 52
    • 15244343927 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines
    • Sonnemann J, Gange J, Kumar KS, Muller C, Bader P, Beck JF (2005) Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines. Invest New Drugs 23:99-109
    • (2005) Invest New Drugs , vol.23 , pp. 99-109
    • Sonnemann, J.1    Gange, J.2    Kumar, K.S.3    Muller, C.4    Bader, P.5    Beck, J.F.6
  • 53
    • 0033767848 scopus 로고    scopus 로고
    • Mechanism of cell cycle arrest caused by histone deacetylase inhibitors inhuman carcinoma cells
    • Kim YB, Ki SW, Yoshida M, Horinouchi S (2000) Mechanism of cell cycle arrest caused by histone deacetylase inhibitors inhuman carcinoma cells. J Antibiot 53:1191-1200
    • (2000) J Antibiot , vol.53 , pp. 1191-1200
    • Kim, Y.B.1    Ki, S.W.2    Yoshida, M.3    Horinouchi, S.4
  • 54
    • 0035313802 scopus 로고    scopus 로고
    • The ins and outs of nucleosome assembly
    • Mello JA, Almouzni G (2001) The ins and outs of nucleosome assembly. Curr Opin Genet Dev 11:136-141
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 136-141
    • Mello, J.A.1    Almouzni, G.2
  • 55
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulatory pathway of cellular degradation
    • Klionsky DJ, Emr SD (2000) Autophagy as a regulatory pathway of cellular degradation. Science 290:1717-1721
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 56
    • 4544352237 scopus 로고    scopus 로고
    • Cell biology: Regulated self-cannibalism
    • Klionsky DJ (2004) Cell biology: regulated self-cannibalism. Nature 431:31-32
    • (2004) Nature , vol.431 , pp. 31-32
    • Klionsky, D.J.1
  • 57
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • Gozuacik D, Kimchi A (2004) Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23:2891-2896
    • (2004) Oncogene , vol.23 , pp. 2891-2896
    • Gozuacik, D.1    Kimchi, A.2
  • 58
    • 0038309329 scopus 로고    scopus 로고
    • The molecular mechanism of autophagy
    • Wang CW, Klionsky DJ (2003) The molecular mechanism of autophagy. Mol Med 9:65-76
    • (2003) Mol Med , vol.9 , pp. 65-76
    • Wang, C.W.1    Klionsky, D.J.2
  • 59
    • 1542513774 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
    • USA
    • Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS (2004) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci USA 101:3438-3443
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 3438-3443
    • Mills, K.R.1    Reginato, M.2    Debnath, J.3    Queenan, B.4    Brugge, J.S.5
  • 60
    • 0037225763 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1 alpha activity
    • Mie Lee Y, Kim SH, Kim HS, Jin Son M, Nakajima H, Jeong Kwon H, Kim KW (2003) Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1 alpha activity. Biochem Biophys Res Commun 300:241-246
    • (2003) Biochem Biophys Res Commun , vol.300 , pp. 241-246
    • Mie Lee, Y.1    Kim, S.H.2    Kim, H.S.3    Jin Son, M.4    Nakajima, H.5    Jeong Kwon, H.6    Kim, K.W.7
  • 62
    • 20444479514 scopus 로고    scopus 로고
    • Drug insight: Histone deacetylase inhibitors development of the new targeted anticancer agent suberolyanilide hydroxyamic acid
    • Kelly WK, Marks AP (2005) Drug insight:Histone deacetylase inhibitors development of the new targeted anticancer agent suberolyanilide hydroxyamic acid. Nat Clin Prac 2:1-8
    • (2005) Nat Clin Prac , vol.2 , pp. 1-8
    • Kelly, W.K.1    Marks, A.P.2
  • 65
    • 0036252352 scopus 로고    scopus 로고
    • The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation
    • Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA (2002) The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr 132:1012-1017
    • (2002) J Nutr , vol.132 , pp. 1012-1017
    • Hinnebusch, B.F.1    Meng, S.2    Wu, J.T.3    Archer, S.Y.4    Hodin, R.A.5
  • 66
    • 0141996376 scopus 로고    scopus 로고
    • Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma
    • Kraker AJ, Mizzen CA, Hartl BG, Miin J, Allis CD, Meriman RL (2003) Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol Cancer Ther 2:401-408
    • (2003) Mol Cancer Ther , vol.2 , pp. 401-408
    • Kraker, A.J.1    Mizzen, C.A.2    Hartl, B.G.3    Miin, J.4    Allis, C.D.5    Meriman, R.L.6
  • 67
    • 2342564962 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3- yl-methoxycarbomyl)amino-methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells
    • Zhang Y, Adachi M, Zhao X, Kawamura R, Imai K (2004) Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbomyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells. Int J Cancer 110:301-308
    • (2004) Int J Cancer , vol.110 , pp. 301-308
    • Zhang, Y.1    Adachi, M.2    Zhao, X.3    Kawamura, R.4    Imai, K.5
  • 68
    • 0035863313 scopus 로고    scopus 로고
    • Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412
    • Zaugg K, Rocha S, Resch H, Hegyi I, Oehler C, Glanzmann C, Fabbro D, Bodis S, Pruschy M (2001) Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412. Cancer Res 61:732-738
    • (2001) Cancer Res , vol.61 , pp. 732-738
    • Zaugg, K.1    Rocha, S.2    Resch, H.3    Hegyi, I.4    Oehler, C.5    Glanzmann, C.6    Fabbro, D.7    Bodis, S.8    Pruschy, M.9
  • 69
    • 0035127288 scopus 로고    scopus 로고
    • The role of apoptosis in 2′, 2′-difluoro-2′- Deoxycytidine (gemcitabine)-mediated radiosensitization
    • Lawrence TS, Davis MA, Hough A, Rehemtulla A (2001) The role of apoptosis in 2′, 2′-difluoro-2′- deoxycytidine (gemcitabine)-mediated radiosensitization. Clin Cancer Res 7:314-319
    • (2001) Clin Cancer Res , vol.7 , pp. 314-319
    • Lawrence, T.S.1    Davis, M.A.2    Hough, A.3    Rehemtulla, A.4
  • 70
    • 0035831031 scopus 로고    scopus 로고
    • Nuclear visions, functional flexibility form structural instability
    • Wolffe AP, Hansen JC (2001) Nuclear visions, functional flexibility form structural instability. Cell 104:631-634
    • (2001) Cell , vol.104 , pp. 631-634
    • Wolffe, A.P.1    Hansen, J.C.2
  • 71
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1:287-299
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 72
    • 24744445352 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors for the treatment of hepatocellular carcinoma
    • Coradini D, Speranza A (2005) Histone deacetylase inhibitors for the treatment of hepatocellular carcinoma. Acta Pharmacol Sin 26:1025-1033
    • (2005) Acta Pharmacol Sin , vol.26 , pp. 1025-1033
    • Coradini, D.1    Speranza, A.2
  • 73
    • 0036171675 scopus 로고    scopus 로고
    • The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells
    • Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, Schuppan D (2002) The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. J Hepatol 36:233-240
    • (2002) J Hepatol , vol.36 , pp. 233-240
    • Herold, C.1    Ganslmayer, M.2    Ocker, M.3    Hermann, M.4    Geerts, A.5    Hahn, E.G.6    Schuppan, D.7
  • 76
    • 0036386341 scopus 로고    scopus 로고
    • Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells: Alteration of the Sp1/Sp3/HDAC1 multiprotein complex
    • Choi HS, Lee JH, Park JG, Lee YI (2002) Trichostatin A, a histone deacetylase inhibitor, activates the IGFBP-3 promoter by upregulating Sp1 activity in hepatoma cells:alteration of the Sp1/Sp3/HDAC1 multiprotein complex. Biochem Biophys Res Commun 296:1005-1012
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 1005-1012
    • Choi, H.S.1    Lee, J.H.2    Park, J.G.3    Lee, Y.I.4
  • 79
    • 6044264858 scopus 로고    scopus 로고
    • FR901228, a novel histone deacetylase inhibitor, induces cell-cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells
    • Sato N, Ohta T, Kitagawa H, Kayahara M, Ninomiya I, Fushida S, Fujimura T, Nishimura G, Shimizu K, Miwa K (2004) FR901228, a novel histone deacetylase inhibitor, induces cell-cycle arrest and subsequent apoptosis in refractory human pancreatic cancer cells. Int J Oncol 24:679-685
    • (2004) Int J Oncol , vol.24 , pp. 679-685
    • Sato, N.1    Ohta, T.2    Kitagawa, H.3    Kayahara, M.4    Ninomiya, I.5    Fushida, S.6    Fujimura, T.7    Nishimura, G.8    Shimizu, K.9    Miwa, K.10
  • 80
    • 0027065034 scopus 로고
    • Human gastric carcinogenesis: A multi-step and multi-factorial process: First American Cancer Society award lecture on cancer epidemiology and prevention
    • Correa P (1992). Human gastric carcinogenesis: a multi-step and multi-factorial process: first American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res 52:6735-6740
    • (1992) Cancer Res , vol.52 , pp. 6735-6740
    • Correa, P.1
  • 81
    • 1342310915 scopus 로고    scopus 로고
    • Downregulation of gelsolin and retinoic acid receptor beta expression in gastric cancer tissues through histone deacetylase 1
    • Kim JH, Choi YK, Kwon HJ, Yang HK, Choi JH, Kim DY (2004) Downregulation of gelsolin and retinoic acid receptor beta expression in gastric cancer tissues through histone deacetylase 1. J Gastroenterol Hepatol 19:218-224
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 218-224
    • Kim, J.H.1    Choi, Y.K.2    Kwon, H.J.3    Yang, H.K.4    Choi, J.H.5    Kim, D.Y.6
  • 83
    • 0038364156 scopus 로고    scopus 로고
    • Cathelicidins - A family of multifunctional antimicrobial peptides
    • Bals R, Wilson JM (2003) Cathelicidins - a family of multifunctional antimicrobial peptides. Cell Mol Life Sci 60:711-720
    • (2003) Cell Mol Life Sci , vol.60 , pp. 711-720
    • Bals, R.1    Wilson, J.M.2
  • 85
    • 4544323749 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Understanding a new wave of anticancer agents
    • Villar-Garea A, Esteller M (2004) Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer 112:171-178
    • (2004) Int J Cancer , vol.112 , pp. 171-178
    • Villar-Garea, A.1    Esteller, M.2
  • 87
    • 0027463032 scopus 로고
    • Butyrate production from dietary fibers and protection against large bowel cancer in a rat model
    • McIntyne A, Gibson PR, Young GP (1993) Butyrate production from dietary fibers and protection against large bowel cancer in a rat model. Gut 34:386-391
    • (1993) Gut , vol.34 , pp. 386-391
    • McIntyne, A.1    Gibson, P.R.2    Young, G.P.3


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