Synthesis of apicidin-derived quinolone derivatives: Parasite-selective histone deacetylase inhibitors and antiproliferative agents

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4919-4922

  Meinke, P T ^a   Colletti, S L ^a   Doss, G ^a   Myers, R W ^a   Gurnett, A M ^a   Dulski, P M ^a   Darkin Rattray, S J ^a   Allocco, J J ^a   Galuska, S ^a   Schmatz, D M ^a   Wyvratt, M J ^a   Fisher, M H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APICIDIN; HISTONE DEACETYLASE INHIBITOR; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CELL PROLIFERATION; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; BINDING, COMPETITIVE; CELL DIVISION; CELL EXTRACTS; CHICKENS; EIMERIA TENELLA; ENZYME INHIBITORS; HELA CELLS; HISTONE DEACETYLASES; HUMANS; INDOLES; LIVER; PEPTIDES, CYCLIC; PLASMODIUM FALCIPARUM; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034649616     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0001976     Document Type: Article

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