The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells

Journal of Hepatology

Volumn 36, Issue 2, 2002, Pages 233-240

  Herold, Christoph ^a   Ganslmayer, Marion ^a   Ocker, Matthias ^a   Hermann, Martin ^a   Geerts, Albert ^b   Hahn, Eckhart G ^a   Schuppan, Detlef ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Bax; Bcl 2; Caspase 3; Cell cycle; Hepatocellular carcinoma; P21; P27; Proliferation

Indexed keywords

CASPASE 3; CYCLIN A; HISTONE DEACETYLASE INHIBITOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P27; TRICHOSTATIN A;

APOPTOSIS; ARTICLE; CALORIMETRY; CELL CYCLE; CELL DENSITY; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASES; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; LIVER NEOPLASMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0036171675     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00257-4     Document Type: Article

References (37)

1. Resection or transplantation for hepatocellular carcinoma in cirrhotic patients: Outcomes based on indicated treatment strategy
2. Treatment of small hepatocellular carcinoma in cirrhotic patients: A cohort study comparing surgical resection and percutaneous ethanol injection
3. Multimodality treatment for patients with hepatocellular carcinoma: A single institution retrospective series
4. Adjuvant oral chemotherapy to prevent recurrence after curative resection for hepatocellular carcinoma
5. Hepatocellular carcinoma: Treatment with percutaneous ethanol injection and transcatheter arterial chemoembolization
6. Ultrasonically controlled percutaneous high frequency thermotherapy of liver tumor with perfused needle electrodes
7. Prospektive randomized controlled trial comparing percutaneous acid injection and percutaneous ethanol injection for small hepatocellular carcinoma
8. Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histonedeacetylase inhibitors
9. Mutation and expression of the p27KIP1 and p57KIP2 genes in human gastric cancer
10. Inhibitors of histone deacetylase suppress the growth of MCF-7 breast cancer cells
11. The biological role of histone acetylation
12. A new antifungal antibiotic, Trichostatin
13. Induction of caspase-protease activity and apoptosis by Butyrate and Trichostatin A (inhibitors of histone deacetylase): Dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway
14. Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylases in human carcinoma cell lines
15. Modulating IGFBP-3 expression by trichostatin A: Potential therapeutic role in the treatment of hepatocellular carcinoma
16. IBF-II enhances trichostatin A-induced TGFβ1 and p21 (Waf1,Cip1,sdi1) expression in Hep3B cells
17. Differential expression of human histone deacetylase mRNAs in response to immune cell apoptosis induction by trichostatin A and butyrate
18. Sodium butyrate induces apoptosis in human renal cell carcinoma cells and synergistically enhances their sensitivity to anti-Fas-mediated cytotoxicity
19. Interaction between dexamethasone and butyrate in apoptosis induction: Non-additive in thymocytes and synergistic in a T cell-derived leukemia cell line
20. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
21. Trichostatin A modulates expression of p21 waf1/cip1, Bcl-xl, ID1, ID2, ID3, CRAB2, GATA-2, hsp86 and TFI1D/TAFII31 mRna in human lung adenocarcinoma cells
22. A histone-deacetylase inhibitor, Trichostatin A, inhibits transdifferentiation of hepatic stellate cells into myofibroblast-like cells
23. Effect of Trichostatin A on cell growth and expression of cell cycle-and apoptosis-related molecules in human gastric and oral carcinoma cell lines
24. Protein complexes activate distinct caspase cascades in death receptor and stress induced apoptosis
25. Reversible arrest of proliferation or rat 3Y1 fibroblasts in both G1 and G2 phases by Trichostatin A
26. Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines
27. No induction of apoptosis by IFN-beta in human antigen-specific T cells
28. Differentiation status modulates transcription factor NF-kappaB activity in unstimulated human hepatocellular carcinoma cell lines
29. Effect of oxidative stress by iron on 4-hydroxynonenal formation and proliferative activity in hepatomas of different degrees of differentiation
30. S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid
31. Cyclins, cyclin-dependent kinases and cdk-inhibitors: Implications in cell cycle control and cancer
32. Fenretinidine: Induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells
33. Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA-replication
34. IGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21 (WAF-1) expression
35. Control of cell cycle progression in human mesothelioma cells treated with gamma interferon
36. Translocation of Bax to mitochondria during apoptosis measured by laser scanning cytometry
37. IGF-betal-induces apoptosis independently of p53 and selectively reduces expression of bcl-2 in hematopoietic multipotent cells