Apical-basal polarity, Wnt signaling and vertebrate organogenesis

Seminars in Cell and Developmental Biology

Volumn 17, Issue 2, 2006, Pages 214-222

  Karner, Courtney ^a   Wharton, Keith A ^a,b   Carroll, Thomas J ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Non canonical; Organogenesis; Planar cell polarity, Tissue polarity; Wnt

Indexed keywords

WNT PROTEIN;

APICAL MEMBRANE; BASEMENT MEMBRANE; BRAIN; BRAIN DEVELOPMENT; CELL FUNCTION; CELL POLARITY; DIGESTIVE SYSTEM; EMBRYO DEVELOPMENT; EPIDERMIS; EPITHELIUM CELL; HEART; HEART DEVELOPMENT; HUMAN; METAZOON; NONHUMAN; ORGANOGENESIS; POLARIZATION; PROTEIN FUNCTION; RETINA; RETINA DEVELOPMENT; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

METAZOA; VERTEBRATA;

EID: 33745896194     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2006.05.007     Document Type: Review

References (95)

1. Giles R.H., van Es J.H., and Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653 1 (2003) 1-24
2. Polakis P. Wnt signaling and cancer. Genes Dev 14 15 (2000) 1837-1851
3. Cadigan K.M., and Liu Y.I. Wnt signaling: complexity at the surface. J Cell Sci 119 Pt 3 (2006) 395-402
4. Veeman M.T., Axelrod J.D., and Moon R.T. A second canon. Functions and mechanisms of beta-catenin-independent Wnt signalling. Dev Cell 5 3 (2003) 367-377
5. Miller J.R. The Wnts. Genome Biol 3 1 (2002) (REVIEWS3001)
6. Axelrod J.D. Unipolar membrane association of dishevelled mediates frizzled planar cell polarity signaling. Genes Dev 15 10 (2001) 1182-1187
7. Wu J., Klein T.J., and Mlodzik M. Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol 2 7 (2004) E158
8. Wharton Jr. K.A. Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. Dev Biol 253 1 (2003) 1-17
9. Strutt H., and Strutt D. Long-range coordination of planar polarity in Drosophila. Bioessays 27 12 (2005) 1218-1227
10. Matter K., and Balda M.S. Signalling to and from tight junctions. Nat Rev Mol Cell Biol 4 3 (2003) 225-236
11. Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev 18 16 (2004) 1909-1925
12. Matter K., et al. Mammalian tight junctions in the regulation of epithelial differentiation and proliferation. Curr Opin Cell Biol 17 5 (2005) 453-458
13. Kemphues K.J., et al. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52 3 (1988) 311-320
14. Spicer J., et al. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22 30 (2003) 4752-4756
15. Ossipova O., et al. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol 5 10 (2003) 889-894
16. Lin-Marq N., Borel C., and Antonarakis S.E. Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Mol Genet Genomics 273 2 (2005) 184-196
17. Martin S.G., and Daniel A.S.J. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421 (2003) 379-384
18. Baas A.F., Smit L., and Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol 14 6 (2004) 312-319
19. Spicer J., and Ashworth A. LKB1 kinase: master and commander of metabolism and polarity. Curr Biol 14 10 (2004) R383-R385
20. Tiainen M., Ylikorkala A., and Makela T.P. Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest. Proc Natl Acad Sci USA 96 16 (1999) 9248-9251
21. Shaw R.J., et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6 1 (2004) 91-99
22. Baas A.F., et al. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116 3 (2004) 457-466
23. Lizcano J.M., et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23 4 (2004) 833-843
24. Hawley S.A., et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2 4 (2003) 28
25. Shaw R.J., et al. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101 10 (2004) 3329-3335
26. Woods A., et al. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13 22 (2003) 2004-2008
27. Guo S., and Kemphues K.J. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 81 4 (1995) 611-620
28. Shulman J.M., Benton R., and St Johnston D. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell 101 4 (2000) 377-388
29. Cox D.N., et al. Drosophila par-1 is required for oocyte differentiation and microtubule organization. Curr Biol 11 2 (2001) 75-87
30. Drewes G., et al. MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89 2 (1997) 297-308
31. Cohen D., et al. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J Cell Biol 164 5 (2004) 717-727
32. Elbert M., Rossi G., and Brennwald P. The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery. Mol Biol Cell 16 2 (2005) 532-549
33. Sun T.Q., et al. PAR-1 is a dishevelled-associated kinase and a positive regulator of Wnt signaling. Nat Cell Biol 3 7 (2001) 628-636
34. Ossipova O., et al. Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell 8 6 (2005) 829-841
35. Le Bivic A. E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila. Trends Cell Biol 15 5 (2005) 237-240
36. Harris T.J., and Peifer M. Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. J Cell Biol 167 1 (2004) 135-147
37. Itoh M., et al. Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol 154 3 (2001) 491-497
38. Ebnet K., et al. The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity. J Cell Sci 116 Pt 19 (2003) 3879-3891
39. Widberg C.H., et al. Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation. J Biol Chem 278 37 (2003) 35093-35101
40. Lehman K., et al. Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9. J Cell Biol 146 1 (1999) 125-140
41. Zhang X., et al. Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis. J Cell Biol 170 2 (2005) 273-283
42. Musch A., et al. Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells. Mol Biol Cell 13 1 (2002) 158-168
43. Dollar G.L., et al. Regulation of lethal giant larvae by dishevelled. Nature 437 7063 (2005) 1376-1380
44. Etienne-Manneville S. Cdc42-the centre of polarity. J Cell Sci 117 Pt 8 (2004) 1291-1300
45. Joberty G., et al. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol 2 8 (2000) 531-539
46. Lin D., et al. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2 8 (2000) 540-547
47. Garrard S.M., et al. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. EMBO J 22 5 (2003) 1125-1133
48. Betschinger J., Eisenhaber F., and Knoblich J.A. Phosphorylation-induced autoinhibition regulates the cytoskeletal protein lethal (2) giant larvae. Curr Biol 15 3 (2005) 276-282
49. Betschinger J., Mechtler K., and Knoblich J.A. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature 422 6929 (2003) 326-330
50. Chen X., and Macara I.G. Par-3 controls tight junction assembly through the Rac exchange factor Tiam1. Nat Cell Biol 7 3 (2005) 262-269
51. Nishimura T., et al. PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol 7 3 (2005) 270-277
52. Bilder D., Schober M., and Perrimon N. Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol 5 1 (2003) 53-58
53. Fogg V.C., Liu C.J., and Margolis B. Multiple regions of crumbs3 are required for tight junction formation in MCF10A cells. J Cell Sci 118 Pt 13 (2005) 2859-2869
54. Hurd T.W., et al. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol 5 2 (2003) 137-142
55. Roh M.H., et al. The crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci 116 Pt 14 (2003) 2895-2906
56. Grawe F., et al. The Drosophila genes crumbs and stardust are involved in the biogenesis of adherens junctions. Development 122 3 (1996) 951-959
57. Bilder D., Li M., and Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289 5476 (2000) 113-116
58. Yaffe M.B. How do 14-3-3 proteins work? Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett 513 1 (2002) 53-57
59. Hurd T.W., et al. Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia. Curr Biol 13 23 (2003) 2082-2090
60. Benton R., and St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell 115 6 (2003) 691-704
61. Kusakabe M., and Nishida E. The polarity-inducing kinase Par-1 controls Xenopus gastrulation in cooperation with 14-3-3 and aPKC. EMBO J 23 21 (2004) 4190-4201
62. Suzuki A., et al. aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol 14 16 (2004) 1425-1435
63. Simmonds A.J., et al. Apical localization of wingless transcripts is required for wingless signaling. Cell 105 2 (2001) 197-207
64. Marois E., Mahmoud A., and Eaton S. The endocytic pathway and formation of the Wingless morphogen gradient. Development 133 (2005) 307-317
65. Strutt D. Frizzled signalling and cell polarisation in Drosophila and vertebrates. Development 130 19 (2003) 4501-4513
66. Etienne-Manneville S., and Hall A. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature 421 6924 (2003) 753-756
67. Malliri A., et al. The RAC activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumour development. J Biol Chem (2005)
68. Tao W., et al. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15 14 (2001) 1796-1807
69. Deng W.M., et al. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development 130 1 (2003) 173-184
70. Lechler T., and Fuchs E. Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 437 7056 (2005) 275-280
71. Gradl D., Kuhl M., and Wedlich D. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 19 8 (1999) 5576-5587
72. Hanson C.A., and Miller J.R. Non-traditional roles for the adenomatous polyposis coli (APC) tumor suppressor protein. Gene 361 (2005) 1-12
73. Gotz M., and Huttner W.B. The cell biology of neurogenesis. Nat Rev Mol Cell Biol 6 10 (2005) 777-788
74. Roegiers F., and Jan Y.N. Asymmetric cell division. Curr Opin Cell Biol 16 2 (2004) 195-205
75. Malicki J., et al. Mutations affecting development of the zebrafish retina. Development 123 (1996) 263-273
76. Horne-Badovinac S., et al. Positional cloning of heart and soul reveals multiple roles for PKC lambda in zebrafish organogenesis. Curr Biol 11 19 (2001) 1492-1502
77. Peterson R.T., et al. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Curr Biol 11 19 (2001) 1481-1491
78. Wei X., and Malicki J. nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina. Nat Genet 31 2 (2002) 150-157
79. Lu B., et al. Adherens junctions inhibit asymmetric division in the Drosophila epithelium. Nature 409 6819 (2001) 522-525
80. Horne-Badovinac S., Rebagliati M., and Stainier D.Y. A cellular framework for gut-looping morphogenesis in zebrafish. Science 302 5645 (2003) 662-665
81. Rohr S., Bit-Avragim N., and Abdelilah-Seyfried S. Heart and soul/PRKCi and nagie oko/Mpp5 regulate myocardial coherence and remodeling during cardiac morphogenesis. Development 133 1 (2006) 107-115
82. Trinh L.A., and Stainier D.Y. Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev Cell 6 3 (2004) 371-382
83. Sakai T., Larsen M., and Yamada K.M. Fibronectin requirement in branching morphogenesis. Nature 423 6942 (2003) 876-881
84. Lowery L.A., and Sive H. Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products. Development 132 9 (2005) 2057-2067
85. Klezovitch O., et al. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev 18 5 (2004) 559-571
86. Hemminki A., et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391 6663 (1998) 184-187
87. Carretero J., et al. Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene. Oncogene 23 22 (2004) 4037-4040
88. Kim C.J., et al. Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas. Eur J Cancer 40 1 (2004) 136-141
89. Sonawane M., et al. Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis. Development 132 14 (2005) 3255-3265
90. Jho E.H., et al. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol Cell Biol 22 4 (2002) 1172-1183
91. Leung J.Y., et al. Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalling. J Biol Chem 277 24 (2002) 21657-21665
92. Lustig B., et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22 4 (2002) 1184-1193
93. Maretto S., et al. Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci USA 100 6 (2003) 3299-3304
94. DasGupta R., and Fuchs E. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development 126 20 (1999) 4557-4568
95. Nelson W.J., and Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303 5663 (2004) 1483-1487