aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

Current Biology

Volumn 14, Issue 16, 2004, Pages 1425-1435

  Suzuki, Atsushi ^a   Hirata, Maki ^a   Kamimura, Katsusi ^a   Maniwa, Rika ^a   Yamanaka, Tomoyuki ^a   Mizuno, Keiko ^a   Kishikawa, Masaru ^a   Hirose, Hiroko ^a   Amano, Yoshiko ^a   Izumi, Natsuko ^a   Miwa, Yoshihiro ^b   Ohno, Shigeo ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MARK2 PROTEIN, HUMAN; PKC 3 PROTEIN; PKC-3 PROTEIN; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE;

ANIMAL; ARTICLE; CELL CULTURE; CELL FRACTIONATION; CELL POLARITY; COMPARATIVE STUDY; DNA SEQUENCE; DOG; EPITHELIUM CELL; EPSTEIN BARR VIRUS; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOLECULAR CLONING; MUTATION; PHYSIOLOGY; RNA INTERFERENCE; SERODIAGNOSIS; TIGHT JUNCTION;

ANIMALS; CELL FRACTIONATION; CELL POLARITY; CELLS, CULTURED; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOGS; EPITHELIAL CELLS; GENETIC VECTORS; HERPESVIRUS 4, HUMAN; HUMANS; MUTATION; PRECIPITIN TESTS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SEQUENCE ANALYSIS, DNA; TIGHT JUNCTIONS; TRANSFECTION;

ANIMALIA; CANIS FAMILIARIS; HUMAN HERPESVIRUS 4; MAMMALIA; RICKETTSIA SP. PAR;

EID: 4344699150     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2004.08.021     Document Type: Article

References (42)

1. Rodriguez-Boulan E., Nelson W.J. Morphogenesis of the polarized epithelial cell phenotype. Science. 245:1989;718-725
2. Nelson W.J. Adaptation of core mechanisms to generate cell polarity. Nature. 422:2003;766-774
3. Guo S., Kemphues K.J. Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo. Curr. Opin. Genet. Dev. 6:1996;408-415
4. Ohno S. Intercellular junctions and cellular polarity. the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity Curr. Opin. Cell Biol. 13:2001;641-648
5. Wodarz A., Ramrath A., Grimm A., Knust E. Drosophila atypical protein kinase C associates with bazooka and controls polarity of epithelia and neuroblasts. J. Cell Biol. 150:2000;1361-1374
6. Petronczki M., Knoblich J.A. DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat. Cell Biol. 3:2001;43-49
7. Suzuki A., Ishiyama K., Hashiba K., Shimizu M., Ebnet K., Ohno S. aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J. Cell Sci. 115:2002;3565-3573
8. Johnson K., Wodarz A. A genetic hierarchy controlling cell polarity. Nat. Cell Biol. 5:2003;12-14
9. Roh M.H., Margolis B. Composition and function of PDZ protein complexes during cell polarization. Am. J. Physiol. Renal Physiol. 285:2003;F377-F387
10. Yamanaka T., Horikoshi Y., Sugiyama Y., Ishiyama C., Suzuki A., Hirose T., Iwamatsu A., Shinohara A., Ohno S. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Curr. Biol. 13:2003;734-743
11. Guo S., Kemphues K.J. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 81:1995;611-620
12. Cox D.N., Lu B., Sun T.Q., Williams L.T., Jan Y.N. Drosophila par-1 is required for oocyte differentiation and microtubule organization. Curr. Biol. 11:2001;75-87
13. Huynh J.R., Shulman J.M., Benton R., St Johnston D. PAR-1 is required for the maintenance of oocyte fate in Drosophila. Development. 128:2001;1201-1209
14. Tomancak P., Piano F., Riechmann V., Gunsalus K.C., Kemphues K.J., Ephrussi A. A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation. Nat. Cell Biol. 2:2000;458-460
15. Shulman J.M., Benton R., St Johnston D. The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell. 101:2000;377-388
16. Doerflinger H., Benton R., Shulman J.M., St Johnston D. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development. 130:2003;3965-3975
17. Espinosa L., Navarro E. Human serine/threonine protein kinase EMK1. genomic structure and cDNA cloning of isoforms produced by alternative splicing Cytogenet. Cell Genet. 81:1998;278-282
18. Kato T., Satoh S., Okabe H., Kitahara O., Ono K., Kihara C., Tanaka T., Tsunoda T., Yamaoka Y., Nakamura Y., et al. Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis. Neoplasia. 3:2001;4-9
19. Drewes G., Ebneth A., Mandelkow E.M. MAPs, MARKs and microtubule dynamics. Trends Biochem. Sci. 23:1998;307-311
20. Peng C.Y., Graves P.R., Ogg S., Thoma R.S., Byrnes M.J. 3rd, Wu Z., Stephenson M.T., Piwnica-Worms H. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 9:1998;197-208
21. Bohm H., Brinkmann V., Drab M., Henske A., Kurzchalia T.V. Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity. Curr. Biol. 7:1997;603-606
22. Benton R., St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell. 115:2003;691-704
23. Vaccari T., Ephrussi A. The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein. Curr. Biol. 12:2002;1524-1528
24. Etemad-Moghadam B., Guo S., Kemphues K.J. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell. 83:1995;743-752
25. Boyd L., Guo S., Levitan D., Stinchcomb D.T., Kemphues K.J. PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos. Development. 122:1996;3075-3084
26. Benton R., Palacios I.M., St Johnston D. Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation. Dev. Cell. 3:2002;659-671
27. Yamanaka T., Horikoshi Y., Suzuki A., Sugiyama Y., Kitamura K., Maniwa R., Nagai Y., Yamashita A., Hirose T., Ishikawa H., et al. PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells. 6:2001;721-731
28. Suzuki A., Yamanaka T., Hirose T., Manabe N., Mizuno K., Shimizu M., Akimoto K., Izumi Y., Ohnishi T., Ohno S. Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J. Cell Biol. 152:2001;1183-1196
29. Hurov J.B., Watkins J.L., Piwnica-Worms H. Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Curr. Biol. 14:2004;736-741
30. Tanaka J., Miwa Y., Miyoshi K., Ueno A., Inoue H. Construction of Epstein-Barr virus-based expression vector containing mini-oriP. Biochem. Biophys. Res. Commun. 264:1999;938-943
31. Cohen D., Brennwald P.J., Rodriguez-Boulan E., Musch A. Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton. J. Cell Biol. 164:2004;717-727
32. Vega-Salas D.E., Salas P.J., Gundersen D., Rodriguez-Boulan E. Formation of the apical pole of epithelial (Madin-Darby canine kidney) cells. polarity of an apical protein is independent of tight junctions while segregation of a basolateral marker requires cell-cell interactions J. Cell Biol. 104:1987;905-916
33. Morton D.G., Shakes D.C., Nugent S., Dichoso D., Wang W., Golden A., Kemphues K.J. The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo. Dev. Biol. 241:2002;47-58
34. Tzivion G., Shen Y.H., Zhu J. 14-3-3 proteins; bringing new definitions to scaffolding. Oncogene. 20:2001;6331-6338
35. Betschinger J., Mechtler K., Knoblich J.A. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature. 422:2003;326-330
36. Hutterer A., Betschinger J., Petronczki M., Knoblich J.A. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev. Cell. 6:2004;845-854
37. Drewes G., Ebneth A., Preuss U., Mandelkow E.M., Mandelkow E. MARK, a novel family of protein kinases that phosphorylate microtubule- associated proteins and trigger microtubule disruption. Cell. 89:1997;297-308
38. Pepperkok R., Bre M.H., Davoust J., Kreis T.E. Microtubules are stabilized in confluent epithelial cells but not in fibroblasts. J. Cell Biol. 111:1990;3003-3012
39. Ohno S., Akita Y., Konno Y., Imajoh S., Suzuki K. A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family. Cell. 53:1988;731-741
40. Brummelkamp T.R., Bernards R., Agami R. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553
41. Standaert M.L., Bandyopadhyay G., Sajan M.P., Cong L., Quon M.J., Farese R.V. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut. 4(translocation and glucose transport. J. Biol. Chem. 274):1999;14074-14078
42. Van Der Hoeven P.C., Van Der Wal J.C., Ruurs P., Van Dijk M.C., Van Blitterswijk J. 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1. negative regulation by 14-3-3 phosphorylation Biochem. J. 345:2000;297-306