Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas

European Journal of Cancer

Volumn 40, Issue 1, 2004, Pages 136-141

  Kim, C J ^a   Cho, Y G ^a   Park, J Y ^a   Kim, T Y ^a   Lee, J H ^a   Kim, H S ^a   Lee, J W ^a   Song, Y H ^a   Nam, S W ^a   Lee, S H ^a   Yoo, N J ^a   Lee, J Y ^a   Park, W S ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; Hepatocellular carcinoma; Loss of heterozygosity; Mutation; p53; STK11 LKB1

Indexed keywords

PHOSPHOTRANSFERASE; PROTEIN P53;

ADULT; ALLELE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CHROMOSOME 19P; CODON; FEMALE; GENE MAPPING; GENETIC ANALYSIS; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; MISSENSE MUTATION; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; TUMOR GROWTH; TUMOR SUPPRESSOR GENE;

EID: 10744223577     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(03)00659-2     Document Type: Article

References (33)

1. Suh C.I., Suh K.A., Park S.H., Chang H.J., Ko J.W., Ahn D.H. Annual report of the central cancer registry in Korea - 1998. J. Korean Cancer Assoc. 32:2000;827-834.
2. Sakamoto M., Hirohashi S., Shimosato Y. Early stages of multistep hepatocarcinogenesis. adenomatous hyperplasia and early hepatocellular carcinoma Hum. Pathol. 22:1991;172-178.
3. Kumar V., Cotran R.S., Robbins S.L. Neoplasia. Robbins Basic Pathology. 7th ed. 2003;165-210 Saunders, Philadelphia.
4. Okabe H., Ikai I., Matsuo K.et al. Comprehensive allelotype study of hepatocellular carcinoma. potential differences in pathways to hepatocellular carcinoma between hepatitis B virus-positive and -negative tumors Hepatology. 31:2000;1073-1079.
5. Qin L.X., Tang Z.Y., Ye S.L.et al. Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared. J. Cancer Res. Clin. Oncol. 127:2001;482-488.
6. Guan X.Y., Fang Y., Sham J.S.T.et al. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridisation. Genes Chromosomes Cancer. 29:2000;110-116.
7. Aaltonen LA, Peutz-Jeghers syndrome. In Vogelstein B, Kinzler KW, eds. The Genetic Basis of Human Cancer, 2nd ed. 337-341. New York, McGraw-Hill.
8. Hemminki A., Tomlinson I.P., Markie D.et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nat. Genet. 15:1997;87-90.
9. Amos C.I., Bali D., Thil T.J.et al. Fine mapping of a genetic locus for Peutz-Jeghers syndrome on chromosome 19p. Cancer Res. 57:1997;3653-3656.
10. Hemminki A., Markie D., Tomlinson P.et al. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature. 391:1998;184-187.
11. 1 cell cycle arrest. Proc. Natl. Acad. Sci. U.S.A. 96:1999;9248-9251.
12. Marignani P.A., Kanai F., Carpenter C.L. LKB1 associates with Brg1 and is necessary for Brg-1 induced growth arrest. J. Biol. Chem. 276:2001;32415-32418.
13. Nakau M., Miyoshi H., Seldin M.F., Imamura M., Oshima M., Taketo M.M. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res. 62:2002;4549-4553.
14. Sugo H., Takamori S., Kojima K., Beppu T., Futagawa S. The significance of p53 mutations as an indicator of the biological behavior of recurrent hepatocellular carcinomas. Surg. Today. 29:1999;849-855.
15. Lee S.N., Park C.K., Sung C.O.et al. Correlation of mutation and immunohistochemistry of p53 in hepatocellular carcinomas in Korean people. J. Korean Med. Sci. 17:2002;801-805.
16. El-Deiry W.S. Regulation of p53 downstream genes. Semin. Cancer Biol. 8:1998;345-357.
17. Karuman P., Gozani O., Odze R.D.et al. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol. Cell. 7:2001;1307-1319.
18. Park W.S., Lee H.K., Lee J.Y.et al. p53 mutations in solar keratoses. Hum. Pathol. 27:1996;1180-1184.
19. Ylikorkala A., Avizienyte E., Tomlinson I.P.et al. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum. Mol. Genet. 8:1999;45-51.
20. Nakagawa H., Koyama K., Miyoshi Y.et al. Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome. Hum. Genet. 103:1998;168-172.
21. Nishioka Y., Kobayashi K., Sagae S.et al. Mutational analysis of STK11 gene in ovarian carcinomas. Jpn. J. Cancer Res. 90:1999;629-632.
22. Sheffield V.C., Beck J.S., Kwitek A.E., Sandstrom D.W., Stone E.M. The sensitivity of single-strand conformation polymorphism anlaysis for the detection of single base substitutions. Genomics. 6:1993;325-332.
23. Avizienyte E., Roth S., Loukola A.et al. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. Cancer Res. 58:1998;2087-2090.
24. Park W.S., Moon Y.W., Yang Y.M.et al. Mutations of the STK11 gene in sporadic gastric carcinoma. Int. J. Oncol. 13:1998;601-604.
25. Wang Z.J., Taylor F., Churchman M., Norbury G., Tomlinson I. Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes. Am. J. Pathol. 153:1998;363-366.
26. Avizienyte E., Loukola A., Roth S.et al. LKB1 somatic mutations in sporadic tumors. Am. J. Pathol. 154:1999;677-681.
27. Bignell G.R., Barfoot R., Seal S., Collins N., Warren W., Stratton M.R. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer. Cancer Res. 58:1998;1384-1386.
28. Esteller M., Avizienyte E., Corn P.G.et al. Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene. 19:2000;164-168.
29. Robbins W.S. Molecular events in the pathogenesis of hepadnavirus associated hepatocellular carcinoma. Annu. Rev. Med. 45:1994;297-323.
30. Ogata N., Tokino T., Kamimura T., Asakura H. A comparison of the molecular structure of integrated hepatitis B virus genomes in hepatocellular carcinoma cells and hepatocytes derived from the same patient. Hepatology. 11:1990;1017-1023.
31. Hino O., Shows T.B., Rogler C.E. Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17:18 translocation. Proc. Natl. Acad. Sc. USA. 83:1986;8338-8342.
32. Nakamura T., Tokino T., Nagaya T., Matsubara K. Microdeletion associated with the integration process of hepatitis B virus DNA. Nucleic Acids Res. 16:1988;4865-4873.
33. Wyllie A.H., Bellamy C.O., Bubb V.J.et al. Apoptosis and carcinogenesis. Br. J. Cancer (Suppl.). 80:1999;34-37.