Rationalizing membrane protein overexpression

Trends in Biotechnology

Volumn 24, Issue 8, 2006, Pages 364-371

  Wagner, Samuel ^a   Bader, Mirjam Lerch ^a   Drew, David ^b   de Gier, Jan Willem ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BIOLOGICAL MEMBRANES; BIOTECHNOLOGY;

OVEREXPRESSION HOST; PROTEIN FOLDING; PROTEIN INSERTION;

PROTEINS;

MEMBRANE PROTEIN;

AMINO TERMINAL SEQUENCE; BIOGENESIS; GLYCOSYLATION; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN MODIFICATION; REVIEW; STATISTICAL SIGNIFICANCE;

ANIMALS; BACTERIAL PROTEINS; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MEMBRANE PROTEINS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS;

EID: 33745894174     PISSN: 01677799     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibtech.2006.06.008     Document Type: Review

References (79)

1. Wallin E., et al. Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms. Protein Sci. 7 (1998) 1029-1038
2. von Heijne G. Recent advances in the understanding of membrane protein assembly and structure. Q. Rev. Biophys. 32 (1999) 285-307
3. Bannwarth M., et al. The expression of outer membrane proteins for crystallization. Biochim. Biophys. Acta 1610 (2003) 37-45
4. Kiefer H. In vitro folding of α-helical membrane proteins. Biochim. Biophys. Acta 1610 (2003) 57-62
5. Korepanova A., et al. Cloning and expression of multiple integral membrane proteins from Mycobacterium tuberculosis in Escherichia coli. Protein Sci. 14 (2005) 148-158
6. Daley D.O., et al. Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 (2005) 1321-1323
7. Huang Y., et al. Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 301 (2003) 616-620
8. Tate, C.G. and Grisshammer, R.K. (eds) (2003) Overexpression of integral membrane proteins. Biochim. Biophys. Acta 1610, 1-152
9. Wickner W., et al. Protein translocation across biological membranes. Science 310 (2005) 1452-1456
10. Luirink J., et al. Biogenesis of inner membrane proteins in Escherichia coli. Annu. Rev. Microbiol. 59 (2005) 329-355
11. Raine A., et al. Targeting and insertion of heterologous membrane proteins in E. coli. Biochimie 85 (2003) 659-668
12. Kunji E.R., et al. Eukaryotic membrane protein overproduction in Lactococcus lactis. Curr. Opin. Biotechnol. 16 (2005) 546-551
13. Baneyx F., et al. Recombinant protein folding and misfolding in Escherichia coli. Nat. Biotechnol. 22 (2004) 1399-1408
14. Sorensen H.P., et al. Advanced genetic strategies for recombinant protein expression in Escherichia coli. J. Biotechnol. 115 (2005) 113-128
15. Tate C.G. Overexpression of mammalian integral membrane proteins for structural studies. FEBS Lett. 504 (2001) 94-98
16. Goder V., et al. Sec61p contributes to signal sequence orientation according to the positive-inside rule. Mol. Biol. Cell 15 (2004) 1470-1478
17. Bowie J.U. Solving the membrane protein folding problem. Nature 438 (2005) 581-589
18. Valent Q.A., et al. Nascent membrane and presecretory proteins synthesized in Escherichia coli associate with signal recognition particle and trigger factor. Mol. Microbiol. 25 (1997) 53-64
19. Kota J., et al. Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J. Cell Biol. 168 (2005) 79-88
20. Nagamori S., et al. Role of YidC in folding of polytopic membrane proteins. J. Cell Biol. 165 (2004) 53-62
21. Matsumoto H., et al. Gene encoding cytoskeletal proteins in Drosophila rhabdomeres. Proc. Natl. Acad. Sci. U. S. A. 84 (1987) 985-989
22. Helenius A., et al. Roles of N-linked glycans in the endoplasmic reticulum. Annu. Rev. Biochem. 73 (2004) 1019-1049
23. Yeliseev A.A., et al. Expression of human peripheral cannabinoid receptor for structural studies. Protein Sci. 14 (2005) 2638-2653
24. Bogdanov M., et al. A phospholipid acts as a chaperone in assembly of a membrane transport protein. J. Biol. Chem. 271 (1996) 11615-11618
25. Bogdanov M., et al. Phospholipid-assisted refolding of an integral membrane protein. Minimum structural features for phosphatidylethanolamine to act as a molecular chaperone. J. Biol. Chem. 274 (1999) 12339-12345
26. Lee A.G. How lipids affect the activities of integral membrane proteins. Biochim. Biophys. Acta 1666 (2004) 62-87
27. Hunte C. Specific protein-lipid interactions in membrane proteins. Biochem. Soc. Trans. 33 (2005) 938-942
28. (o) ATP synthase. FEBS Lett. 482 (2000) 215-219
29. Kihara A., et al. FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 4532-4536
30. Griffith D.A., et al. A novel yeast expression system for the overproduction of quality-controlled membrane proteins. FEBS Lett. 553 (2003) 45-50
31. Kaufman R.J., et al. The unfolded protein response in nutrient sensing and differentiation. Nat. Rev. Mol. Cell Biol. 3 (2002) 411-421
32. Bonander N., et al. Design of improved membrane protein production experiments: quantitation of the host response. Protein Sci. 14 (2005) 1729-1740
33. Tolia N.H., et al. Strategies for protein coexpression in Escherichia coli. Nat. Methods 3 (2006) 55-64
34. Chen Y., et al. DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli. Protein Expr. Purif. 32 (2003) 221-231
35. 2+ transporter. Nature 440 (2006) 833-837
36. Tate C.G., et al. Molecular chaperones stimulate the functional expression of the cocaine-sensitive serotonin transporter. J. Biol. Chem. 274 (1999) 17551-17558
37. Weiss H.M., et al. Expression of an integral membrane protein, the 5HT5A receptor. Methods Mol. Biol. 103 (1998) 227-239
38. Andre N., et al. Enhancing functional production of G protein-coupled receptors in Pichia pastoris to levels required for structural studies via a single expression screen. Protein Sci. 15 (2006) 1115-1126
39. Stimpson H.E., et al. Transferrin receptor-like proteins control the degradation of a yeast metal transporter. EMBO J. 25 (2006) 662-672
40. Miroux B., et al. Over-production of proteins in Escherichia coli: Mutant hosts that allow synthesis of some membrane proteins and globular proteins at high levels. J. Mol. Biol. 260 (1996) 289-298
41. Dumon-Seignovert L., et al. The toxicity of recombinant proteins in Escherichia coli: a comparison of overexpression in BL21(DE3), C41(DE3), and C43(DE3). Protein Expr. Purif. 37 (2004) 203-206
42. Drew D., et al. Optimization of membrane protein overexpression and purification using GFP fusions. Nat. Methods 3 (2006) 303-313
43. Eshaghi S., et al. An efficient strategy for high-throughput expression screening of recombinant integral membrane proteins. Protein Sci. 14 (2005) 676-683
44. Eroglu C., et al. Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye. EMBO Rep. 3 (2002) 491-496
45. Kuruma Y., et al. Development of a minimal cell-free translation system for the synthesis of presecretory and integral membrane proteins. Biotechnol. Prog. 21 (2005) 1243-1251
46. Klammt C., et al. High level cell-free expression and specific labeling of integral membrane proteins. Eur. J. Biochem. 271 (2004) 568-580
47. Elbaz Y., et al. In vitro synthesis of fully functional EmrE, a multidrug transporter, and study of its oligomeric state. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 1519-1524
48. Pornillos O., et al. X-ray structure of the EmrE multidrug transporter in complex with a substrate. Science 310 (2005) 1950-1953
49. Wallin E., et al. Properties of N-terminal tails in G-protein coupled receptors: a statistical study. Protein Eng. 8 (1995) 693-698
50. Monne M., et al. Competition between neighboring topogenic signals during membrane protein insertion into the ER. FEBS J 272 (2005) 28-36
51. Monne M., et al. Functional expression of eukaryotic membrane proteins in Lactococcus lactis. Protein Sci. 14 (2005) 3048-3056
52. Andersson H., et al. Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail. Mol. Pharmacol. 64 (2003) 570-577
53. Sarramegna V., et al. Solubilization, purification, and mass spectrometry analysis of the human μ-opioid receptor expressed in Pichia pastoris. Protein Expr. Purif. 43 (2005) 85-93
54. Weiss H.M., et al. Purification and characterization of the human adenosine A(2a) receptor functionally expressed in Escherichia coli. Eur. J. Biochem. 269 (2002) 82-92
55. Tucker J., et al. Purification of a rat neurotensin receptor expressed in Escherichia coli. Biochem. J. 317 (1996) 891-899
56. Roosild T.P., et al. NMR structure of Mistic, a membrane-integrating protein for membrane protein expression. Science 307 (2005) 1317-1321
57. Dalbey R.E., et al. Directionality in protein translocation across membranes: the N-tail phenomenon. Trends Cell Biol. 5 (1995) 380-383
58. Feilmeier B.J., et al. Green fluorescent protein functions as a reporter for protein localization in Escherichia coli. J. Bacteriol. 182 (2000) 4068-4076
59. Drew D., et al. Rapid topology mapping of Escherchia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 2690-2695
60. Ito K., et al. Cellular functions, mechanism of action, and regulation of Ftsh protease. Annu. Rev. Microbiol. 59 (2005) 211-231
61. White J.F., et al. Automated large-scale purification of a G protein-coupled receptor for neurotensin. FEBS Lett. 564 (2004) 289-293
62. Drew D., et al. A scalable, GFP-based pipeline for membrane protein overexpression screening and purification. Protein Sci. 14 (2005) 2011-2017
63. Auer M., et al. High-yield expression and functional analysis of Escherichia coli glycerol-3-phosphate transporter. Biochemistry 40 (2001) 6628-6635
64. Cohen S.L., et al. Mass spectrometry as a tool for protein crystallography. Annu. Rev. Biophys. Biomol. Struct. 30 (2001) 67-85
65. + channels heterologously expressed in Pichia pastoris. J. Mol. Biol. 333 (2003) 103-116
66. Han M.J., et al. Engineering Escherichia coli for increased productivity of serine-rich proteins based on proteome profiling. Appl. Environ. Microbiol. 69 (2003) 5772-5781
67. Lee S.Y., et al. Systems biotechnology for strain improvement. Trends Biotechnol. 23 (2005) 349-358
68. DiTullio P., et al. Production of cystic fibrosis transmembrane conductance regulator in the milk of transgenic mice. Biotechnology 10 (1992) 74-77
69. Pedelacq J.D., et al. Engineering soluble proteins for structural genomics. Nat. Biotechnol. 20 (2002) 927-932
70. + channel. Science 309 (2005) 897-903
71. Tornroth-Horsefield S., et al. Structural mechanism of plant aquaporin gating. Nature 439 (2006) 688-694
72. Ellgaard L., et al. Quality control in the endoplasmic reticulum. Nat. Rev. Mol. Cell Biol. 4 (2003) 181-191
73. Wang D.N., et al. Practical aspects of overexpressing bacterial secondary membrane transporters for structural studies. Biochim. Biophys. Acta 1610 (2003) 23-36
74. 1B-adrenergic receptor: effects on receptor expression and function. Biochemistry 41 (2002) 4281-4291
75. Drew D.E., et al. Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli. FEBS Lett. 507 (2001) 220-224
76. Kawate T., et al. Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. Structure 14 (2006) 673-681
77. Jiang Y., et al. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417 (2002) 515-522
78. Wacker M., et al. N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science 298 (2002) 1790-1793
79. + conduction and selectivity. Science 280 (1998) 69-77