Competition between neighboring topogenic signals during membrane protein insertion into the ER

FEBS Journal

Volumn 272, Issue 1, 2005, Pages 28-36

  Monné, Magnus ^a,b   Hessa, Tara ^a   Thissen, Laura ^a   Von Heijne, Gunnar ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Endoplasmic reticulum; Kinetics; Membrane protein; Positive inside rule; Topology

Indexed keywords

MEMBRANE PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; DNA DETERMINATION; ENDOPLASMIC RETICULUM; KINETICS; MEMBRANE STRUCTURE; MICROSOME MEMBRANE; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ENDOPLASMIC RETICULUM; KINETICS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 11444249293     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04394.x     Document Type: Article

References (29)

1. Johnson AE & van Waes MA (1999) The translocon: a dynamic gateway at the ER membrane. Annu Rev Cell Dev Biol 15, 799-842.
2. de Gier JW & Luirink J (2001) Biogenesis of inner membrane proteins in Escherichia coli. Mol Microbiol 40, 314-322.
3. Goder V & Spiess M (2001) Topogenesis of membrane proteins: determinants and dynamics. FEBS Lett 504, 87-93.
4. von Heijne G (2000) Recent advances in the understanding of membrane protein assembly and structure. Quart Rev Biophys 32, 285-307.
5. Blobel G (1980) Intracellular protein topogenesis. Proc Natl Acad Sci USA 77, 1496-1500.
6. Dale H, Angevine CM & Krebs MP (2000) Ordered membrane insertion of an archaeal opsin in vivo. Proc Natl Acad Sci USA 97, 7847-7852.
7. Nilsson I, Witt S, Kiefer H, Mingarro I & von Heijne G (2000) Distant downstream sequence determinants can control N-tail translocation during protein insertion into the endoplasmic reticulum membrane. J Biol Chem 275, 6207-6213.
8. Monné M, Gafvelin G, Nilsson R. & von Heijne G (1999) N-tail translocation in a eukaryotic polytopic membrane protein - Synergy between neighboring transmembrane segments. Eur J Biochem 263, 264-269.
9. Goder V, Bieri C & Spiess M (1999) Glycosylation can influence topogenesis of membrane proteins and reveals dynamic reorientation of nascent polypeptides within the translocon. J Cell Biol 147, 257-266.
10. Anthony V & Skach WR (2002) Molecular mechanism of P-glycoprotein assembly into cellular membranes. Curr Protein Pept Sci 3, 485-501.
11. Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS & Skach WR (2000) Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Mol Biol Cell 11, 2973-2985.
12. Carveth K, Buck T, Anthony V & Skach WR (2002) Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue. J Biol Chem 277, 39507-39514.
13. Tvrdik P, Asadi A, Kozak L, Nedergaard J, Cannon B & Jacobsson A (1997) Cig30, a mouse member of a novel membrane protein gene family is involved in the recruitement of brown adipose tissue. J Biol Chem 272, 31738-31746.
14. Garoff H, Huylebroeck D, Robinson A, Tillman U, Liljetröm & P (1990) The signal sequence of the p62-protein of Semliki Forest virus is involved in initiation but not in completing chain translocation. J Cell Biol 111, 867-876.
15. Rothman J & Lodish H (1977) Synchronised transmembrane insertion and glycosylation of a nascent membrane protein. Nature 269, 775-780.
16. Whitley P, Nilsson IM & von Heijne G (1996) A nascent secretory protein may traverse the ribosome/ER translocase complex as an extended chain. J Biol Chem 271, 6241-6244.
17. Hessa T, Monné, M & von Heijne G (2003) Stop-transfer efficiency of marginally hydrophobic stop-transfer segments depends on the length of the C-terminal tail. EMBO Report 4, 178-183.
18. Goder V & Spiess M (2003) Molecular mechanism of signal sequence orientation in the endoplasmic reticulum. EMBO J 22, 3645-3653.
19. Goder V, Crottet P & Spiess M (2000) In vivo kinetics of protein targeting to the endoplasmic reticulum determined by site-specific phosphorylation. EMBO J 19, 6704-6712.
20. Ota K, Sakaguchi M, von Heijne G, Hamasaki N & Mihara K (1998) Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning membrane proteins. Mol Cell 2, 495-503.
21. von Heijne G (1986) The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology. EMBO J 5, 3021-3027.
22. Mothes W, Heinrich S, Graf R., Nilsson I, von Heijne G, Brunner J & Rapoport T (1997) Molecular mechanisms of membrane protein integration into the endoplasmic reticulum. Cell 89, 523-533.
23. Heinrich S, Mothes W, Brunner J & Rapoport T (2000) The Sec61p complex mediates the integration of a membrane protein by allowing lipid partitioning of the transmembrane domain. Cell 102, 233-244.
24. McCormick PJ, Miao Y, Shao Y, Lin J & Johnson AE (2003) Cotranslational protein integration into the ER membrane Is mediated by the binding of nascent chains to translocon proteins. Mol Cell 12, 329-341.
25. Wahlberg JM & Spiess M (1997) Multiple determinants direct the orientation of signal-anchor proteins: the topogenic role of the hydrophobic signal domain. J Cell Biol. 137, 555-562.
26. Kozak M (1999) Initiation of translation in prokaryotes and eukaryotes. Gene 234, 187-208.
27. Kunkel TA (1987) Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol 154, 367-382.
28. Geisselsoder J, Witney F & Yuckenberg P (1987) Efficient site-directed in vitro mutagenesis. Biotechniques 5, 786-791.
29. Liljeström P & Garoff H (1991) Internally located cleavable signal sequences direct the formation of Semlíkí Forest virus membrane proteins from a polyprotein precursor. J Virol 65, 147-154.