Crystal structure of the CorA Mg2+ transporter

Nature

Volumn 440, Issue 7085, 2006, Pages 833-837

  Lunin, Vladimir V ^a   Dobrovetsky, Elena ^b   Khutoreskaya, Galina ^b   Zhang, Rongguang ^c   Joachimiak, Andrzej ^c   Doyle, Declan A ^d   Bochkarev, Alexey ^a,b,e   Maguire, Michael E ^f   Edwards, Aled M ^a,b,c,e   Koth, Christopher M ^b,g  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITY OF TORONTO   (Canada)

^f CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CRYSTAL STRUCTURE; CYTOLOGY; HYDROPHOBIC CHROMATOGRAPHY; MONOMERS;

BIOLOGICAL ION; CYTOPLASMIC DOMAIN; PROKARYOTES; TRANSMEMBRANE HELICES;

POSITIVE IONS;

MAGNESIUM;

BIOCHEMICAL PHENOMENA; CRYSTAL STRUCTURE; CYTOPLASM; HYDROPHOBICITY; ION EXCHANGE; MAGNESIUM; MEMBRANE;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; ELECTRICITY; ION TRANSPORT; MEMBRANE TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; SIGNAL TRANSDUCTION; THERMOTOGA MARITIMA;

CORA; EUKARYOTA; THERMOTOGA;

EID: 33645748904     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04642     Document Type: Article

References (25)

1. Nelson, D. L. & Kennedy, E. P. Magnesium transport in Escherichia coli. Inhibition by cobaltous ion. J. Biol. Chem. 246, 3042-3049 (1971).
2. Hmiel, S. P., Snavely, M. D., Miller, C. G. & Maguire, M. E. Magnesium transport in Salmonella typhimurium: Characterization of magnesium influx and cloning of a transport gene. J. Bacteriol. 168, 1444-1450 (1986).
3. Bui, D. M., Gregan, J., Jarosch, E., Ragnini, A. & Schweyen, R. J. The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J. Biol. Chem. 274, 20438-20443 (1999).
4. Kehres, D. G. & Maguire, M. E. Structure, properties and regulation of magnesium transport proteins. Biometals 15, 261-270 (2002).
5. Kehres, D. G., Lawyer, C. H. & Maguire, M. E. The CorA magnesium transporter gene family. Microb. Compar. Genom. 43, 151-169 (1998).
6. 2+ transporter in Salmonella enterica serovar Typhimurium. J. Bacteriol. 184, 4369-4373 (2002).
7. Gardner, R. C. Genes for magnesium transport. Curr. Opin. Plant Biol. 6, 263-267 (2003).
8. Cordes, F. S., Bright, J. N. & Sansom, M. S. Proline-induced distortions of transmembrane helices. J. Mol. Biol. 323, 951-960 (2002).
9. Tieleman, D. P., Shrivastava, I. H., Ulmschneider, M. R. & Sansom, M. S. Proline-induced hinges in transmembrane helices: possible roles in ion channel gating. Proteins 44, 63-72 (2001).
10. Knoop, V., Groth-Malonek, M., Gebert, M., Eifler, K. & Weyand, K. Transport of magnesium and other divalent cations: evolution of the 2-TM-GxN proteins in the MIT superfamily. Mol. Genet. Genom. 274, 205-216 (2005).
11. Doyle, D. A. Molecular insights into ion channel function. Mol. Membr. Biol. 21, 221-225 (2004).
12. + channel: electrostatic stabilization of monovalent cations. Science 285, 100-102 (1999).
13. + conduction and selectivity. Science 280, 69-77 (1998).
14. Kuo, A. et al. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300, 1922-1926 (2003).
15. Chang, G., Spencer, R. H., Lee, A. T., Barclay, M. T. & Rees, D. C. Structure of the MscL homolog from Mycobacterium tuberculosis: A gated mechanosensitive ion channel. Science 282, 2220-2226 (1998).
16. Miyazawa, A., Fujiyoshi, Y. & Unwin, N. Structure and gating mechanism of the acetylcholine receptor pore. Nature 423, 949-955 (2003).
17. MacKinnon, R. Potassium channels and the atomic basis for selective ion conduction. Biosci. Rep. 24, 75-100 (2004).
18. 2+ chemistry and biochemistry. Biometals 15, 203-210 (2002).
19. 2+ transport by the CorA, MgtA, and MgtB systems. J. Bacteriol. 171, 4761-4766 (1989).
20. Kucharski, L. M., Lubbe, W. J. & Maguire, M. E. Cation hexaammines are selective and potent inhibitors of the CorA magnesium transport system. J. Biol. Chem. 275, 16767-16773 (2000).
21. 2+ transport protein of Salmonella typhimurium. Mutagenesis of conserved residues in the second membrane domain. J. Biol. Chem. 274, 36973-36979 (1999).
22. Langosch, D., Thomas, L. & Betz, H. Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer. Proc. Natl Acad. Sci. USA 85, 7394-7398 (1988).
23. Lester, H. A. The permeation pathway of neurotransmitter-gated ion channels. Annu. Rev. Biophys. Biomol. Struct. 21, 267-292 (1992).
24. Delano, W. L. PyMOL 〈http://pymol.sourceforge.net/〉 (cited 19 October 2005).
25. Korolev, S. et al. The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nature Struct. Biol. 9, 27-31 (2002).