Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 22, Issue 6, 2002, Pages 961-968

  Bernal Mizrachi, Carlos ^a   Weng, Sherry ^a   Li, Bing ^a   Nolte, Lorraine A ^a   Feng, Chu ^a   Coleman, Trey ^a   Holloszy, John O ^a   Semenkovich, Clay F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Energy metabolism; Hypertension; Insulin resistance; Type 2 diabetes; Uncoupling proteins

Indexed keywords

CATECHOLAMINE; CHOLESTEROL; GLUCOSE; INSULIN; LEPTIN; TRIACYLGLYCEROL; UNCOUPLING PROTEIN;

ADRENERGIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BLOOD PRESSURE; BREATHING; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; ENERGY METABOLISM; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; THERMOREGULATION; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR DISEASE;

ANIMALS; BLOOD PRESSURE; BODY COMPOSITION; BODY WEIGHT; BREEDING; CARRIER PROTEINS; DIET; ENERGY METABOLISM; FEMALE; GLUCOSE; INFUSIONS, PARENTERAL; ION CHANNELS; LEPTIN; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OBESITY; OXYGEN CONSUMPTION;

EID: 0036078412     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000019404.65403.71     Document Type: Article

References (43)

1. Annual deaths attributable to obesity in the United States
2. Body mass index and the prevalence of hypertension and dyslipidemia
3. Insulin resistance and cardiovascular disease
4. Incidence and precursors of hypertension in young adults: The Framingham Offspring Study
5. The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients
6. Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ
7. Free fatty acids and pathogenesis of type 2 diabetes mellitus
8. Insulin sensitivity of blood glucose versus insulin sensitivity of blood free fatty acids in normal, obese, and obese-diabetic subjects
9. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
10. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
11. Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk
12. Obesity and the regulation of energy balance
13. Obesity hypertension: Role of leptin and sympathetic nervous system
14. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
15. Leptin induces direct vasodilation through distinct endothelial mechanisms
16. Human leptin has natriuretic activity in the rat
17. Uncoupling proteins: Their roles in adaptive thermogenesis and substrate metabolism reconsidered
18. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
19. Dietinduced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice
20. Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency: Islet LPL regulates insulin secretion
21. PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE null mice
22. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
23. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
24. The disease burden associated with overweight and obesity
25. Emerging epidemic of type 2 diabetes in youth
26. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
27. Melancortin-4 receptor mutations are a frequent and heterogeneous case of morbid obesity
28. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
29. Thyroid hormone-sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform-specific
30. Effects of central leptin administration on blood pressure in normotensive rats
31. Chronic leptin infusion increases arterial pressure
32. Pathophysiological role of leptin in obesity-related hypertension
33. Cardiovascular consequences of obesity: Role of leptin
34. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
35. Leptin enhances the calcification of vascular cells: Artery wall as a target of leptin
36. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity
37. Plasma leptin and the risk of cardiovascular disease in the West of Scotland Coronary Prevention Study (WOSCOPS)
38. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
39. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function
40. Resting metabolic rate, fat-free mass and catecholamine excretion during weight loss in female obese patients
41. Antihypertensive and volume-depleting effects of mild exercise on essential hypertension
42. Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
43. Efficacy of atenolol and captopril in reducing the risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39