New therapies for hepatocellular carcinoma

Oncogene

Volumn 25, Issue 27, 2006, Pages 3866-3884

  Avila, M A ^a   Berasain, C ^a   Sangro, B ^a,b   Prieto, J ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Hepatocellular carcinoma; Molecular targets; New therapies

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 6 (4 HYDROXYPHENYL) 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AP 23573; ARSENIC TRIOXIDE; BEVACIZUMAB; BORTEZOMIB; CANERTINIB; CETUXIMAB; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; ERLOTINIB; GEFITINIB; HUMV 833; HUMV833; IMATINIB; ISPINESIB; LAPATINIB; LONAFARNIB; MB 07133; MEGESTROL; NOLATREXED; PANITUMUMAB; PELITINIB; PHY 906; SEMAXANIB; SORAFENIB; SUNITINIB; TEMSIROLIMUS; THALIDOMIDE; THYMOSIN ALPHA1; TIPIFARNIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN ANTIBODY; VATALANIB;

CANCER DIAGNOSIS; CANCER GENETICS; CANCER IMMUNOTHERAPY; CANCER STAGING; CANCER SURGERY; CELL GROWTH; CELL SURVIVAL; CHRONIC MYELOID LEUKEMIA; DRUG RECEPTOR BINDING; GASTROINTESTINAL STROMAL TUMOR; HUMAN; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROGNOSIS; REVIEW;

CARCINOMA, HEPATOCELLULAR; HUMANS; LIVER NEOPLASMS;

EID: 33745547361     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209550     Document Type: Review

References (232)

1. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. (1997). EMBO J 16: 3797-3804.
2. Adams J. (2004). Cancer Cell 5: 417-421.
3. Adjei AA, Hidalgo M. (2005). J Clin Oncol 23: 5386-5403.
4. Alexia C, Fallot G, Lasfer M, Schweizer-Groyer G, Groyer A. (2004). Biochem Pharmacol 68: 1003-1015.
5. Algarra I, Cabrera T, Garrido F. (2000). Hum Immunol 61: 65-73.
6. Al-Hajj M, Clarke MF. (2004). Oncogene 23: 7274-7282.
7. Amaravadi R, Thompson CB. (2005). J Clin Invest 115: 2618-2624.
8. Antony PA, Restifo NP. (2005). J Immunother 28: 120-128.
9. Arsura M, Cavin LG. (2005). Cancer Lett 229: 157-169.
10. Avila MA, Berasain C, Torres L, Martín-Duce A, Corrales FJ, Yang H et al. (2000). J Hepatol 33: 907-914.
11. Bachelder RE, Yoon SO, Franci C, García de Herreros A, Mercurio AM. (2005). J Cell Biol 168: 29-33.
12. Barajas M, Mazzolini G, Genove G, Bilbao R, Narvaiza I, Schmitz V et al. (2001). Hepatology 33: 52-61.
13. Baselga J, Arteaga C. (2005). J Clin Oncol 23: 2445-2459.
14. Bedossa P, Peltier E, Terris B, Franco D, Poynard T. (1995). Hepatology 21: 760-766.
15. Berasain C, García-Trevijano ER, Castillo J, Erroba E, Lee DC, Prieto J et al. (2005a). Gastroenterology 128: 424-432.
16. Berasain C, García-Trevijano ER, Castillo J, Erroba E, Santamaria M, Lee DC et al. (2005b). J Biol Chem 280: 19012-19020.
17. Berasain C, Herrero JI, García-Trevijano ER, Avila MA, Esteban JI, Mato JM et al. (2003). Hepatology 38: 148-157.
18. Beurel E, Kornprobst M, Blivet-Van Eggelpoel MJ, Cadoret A, Capeau J, Desbois-Mouthon C. (2005). Int J Oncol 27: 215-222.
19. Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N et al. (2003). Oncogene 22: 2812-2822.
20. Bissell DM. (2001). Exp Mol Med 33: 179-190.
21. Blobel CP. (2005). Nat Rev Mol Cell Biol 6: 32-43.
22. Bosch FX, Ribes J, Diaz M, Cleries R. (2004). Gastroenterology 127: S5-S16.
23. Bréchot C. (2004). Gastroenterology 127: S56-S61.
24. Bristol JA, Zhu M, Ji H, Mina M, Xie Y, Clarke L et al. (2003). Mol Ther 7: 755-764.
25. Buendia MA. (2000). Semin Cancer Biol 10: 185-200.
26. Calvisi DF, Factor V, Loi R, Thorgeirsson SS. (2001). Cancer Res 61: 2085-2091.
27. Calvisi DF, Ladu S, Conner EA, Factor V, Thorgeirsson SS. (2004). Lab Invest 84: 1137-1147.
28. Camirand A, Zakikhani M, Young F, Pollak M. (2005). Breast Cancer Res 7: R570-R579.
29. Camp ER, Summy J, Bauer T, Liu W, Gallick GE, Ellis LM. (2005). Clin Cancer Res 11: 397-405.
30. Carloni V, Mazzocca A, Pantaleo P, Cordella C, Laffi G, Gentilini P. (2001). Hepatology 34: 42-19.
31. Carloni V, Vizzuti F, Pantaleo P. (2005). Clin Cancer Res 11: 4266-4274.
32. Chan KT, Lung ML. (2004). Cancer Chemother Pharmacol 53: 519-526.
33. Chung YH, Kim JA, Song BC, Lee GC, Koh MS, Lee SG et al. (2000). Cancer 89: 977-982.
34. Clarke MF. (2005). Biol Blood Marrow Transplant 11: 14-16.
35. Coleman WB. (2003). Curr Mol Med 3: 573-588.
36. Dean M, Fojo T, Bates S. (2005). Nat Rev Cancer 5: 275-284.
37. Deane NG, Parker MA, Aramandla R, Diehl L, Lee W-J, Washington MK et al. (2001). Cancer Res 61: 5389-5395.
38. Desbois-Mouthon C, Cadoret A, Blivet-Van Eggelpoël M-J, Bertrand F, Cherqui G, Perret C et al. (2001). Oncogene 20: 252-259.
39. Dihlmann S, von Knebel Doeberitz M. (2005). Int J Cancer 113: 515-524.
40. Dikmen ZG, Gellert GC, Jackson S, Gryaznov S, Tressler R, Dogan P et al. (2005). Cancer Res 65: 7866-7873.
41. Ding Q, Xia W, Liu J-C, Yang J-Y, Lee D-F, Xia J et al. (2005). Mol Cell 19: 159-170.
42. Ding X, Yang LY, Huang GW, Wang W, Lu WQ. (2004). World J Gastroenterol 10: 2735-2739.
43. Djojosubroto MW, Chin AC, Go N, Schaetzlein S, Manns MP, Gryaznov S et al. (2005). Hepatology 42: 1127-1136.
44. Dranoff G. (2004). Nat Rev Cancer 4: 11-22.
45. Drozdzik M, Qian C, Xie X, Peng D, Bilbao R, Mazzolini G et al. (2000). J Hepatol 32: 279-286.
46. Ebert O, Shinozaki K, Huang TG, Savontaus MJ, Garcia-Sastre A, Woo SL. (2003). Cancer Res 63: 3605-3611.
47. Edamoto Y, Hara A, Biernat W, Terracciano L, Cathomas G, Riehle H-M et al. (2003). Int J Cancer 106: 334-341.
48. Eger A, Stockinger A, park J, Langkopf E, Mikula M, Gotzmann J et al. (2004). Oncogene 23: 2672-2680.
49. Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M et al. (2004). Proc Natl Acad Sci USA 101: 12682-12687.
50. Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA. (2002). Cancer Res 62: 5443-5450.
51. Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM et al. (2005). J Pharmacol Exp Ther 312: 554-560.
52. Eskens FA. (2004). Br J Cancer 90: 1-7.
53. Ezquerro IJ, Lasarte JJ, Dotor J, Castilla-Cortazar I, Bustos M, Penuelas I et al. (2003). Cytokine 22: 12-20.
54. Feijoo E, Alfaro C, Mazzolini G, Serra P, Penuelas I, Arina A et al. (2005). Int J Cancer 116: 275-281.
55. Feitelson MA. (2005). Cancer Lett [E-pub ahead of print].
56. Feitelson MA, Sun B, Satiroglu Tufan NL, Liu J, Pan J, Lian Z. (2002). Oncogene 21: 2593-2604.
57. Fillat C, Carrio M, Cascante A, Sangro B. (2003). Curr Gene Ther 3: 13-26.
58. Fischer AN, Herrera B, Mikula M, Proell V, Fuchs E, Gotzmann J et al. (2005). Carcino genesis 26: 931-942.
59. Folkman J. (2003). Cancer Biol Ther 2: S127-S133.
60. Fujii T, Koshikawa K, Nomoto S, Okochi O, Kaneko T, Inoue S et al. (2004). J Hepatol 41: 104-111.
61. Ganten TM, Koschny R, Haas TL, Sykora J, Li-Webber M, Herzer K et al. (2005). Hepatology 42: 588-597.
62. Geschwind JF, Salem R, Carr BI, Soulen MC, Thurston KG, Goin KA et al. (2004). Gastroenterology 127: S194-S205.
63. Giannelli G, Azzariti A, Fransvea E, Porcelli L, Antonaci S, Paradiso A. (2004). Br J Cancer 91: 1964-1969.
64. Giannelli G, Fransvea E, Bergamini C, Marinosci F, Antonaci S. (2003). Clin Cancer Res 9: 3684-3691.
65. Giles RH, van Es JH, Clevers H. (2003). Biochim Biophys Acta 1653: 1-24.
66. Goin JE, Salem R, Carr BI, Dancey JE, Soulen MC, Geschwind JF et al. (2005a). J Vasc Interv Radiol 16: 195-203.
67. Goin JE, Salem R, Carr BI, Dancey JE, Soulen MC, Geschwind JF et al. (2005b). J Vasc Interv Radiol 16: 205-213.
68. Goldman CK, Kendall RL, Cabrera G, Soroceanu L, Heike Y, Gillespie GY et al. (1998). Proc Natl Acad Sci USA 95: 8795-8800.
69. Gotzmann J, Huber H, Thallinger C, Wolschek M, Jansen B, Schulte-Hermann R et al. (2001). J Cell Sci 115: 1189-1202.
70. Graaf MR, Richel DJ, Van Noorden CJF, Guchelaar H-J. (2004). Cancer Treat Rev 30: 609-641.
71. Griscelli F, Li H, Bennaceur-Griscelli A, Soria J, Opolon P, Soria C et al. (1998). Proc Natl Acad Sci USA 95: 6367-6372.
72. Habib N, Salama H, Abd El Latif Abu Median A, Isac Anis I, Abd Al Aziz RA, Sarraf C et al. (2002). Cancer Gene Ther 9: 254-259.
73. Habib NA, Sarraf CE, Mitry RR, Havlik R, Nicholls J, Kelly M et al. (2001). Hum Gene Ther 12: 219-226.
74. Hannigan G, Troussard AA, Dedahr S. (2005). Nat Rev Cancer 5: 51-63.
75. Harada K, Shiota G, Kawasaki H. (1999). Liver 19: 318-325.
76. Harris TJC, Peifer M. (2005). Trends in Cell Biol 15: 234-237.
77. He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY et al. (2005). Oncogene 24: 3054-3058.
78. Herraiz M, Beraza N, Solano A, Sangro B, Montoya J, Qian C et al. (2003). Hum Gene Ther 14: 463-472.
79. Higashitsuji H, Higashitsuji H, Itoh K, Sakurai T, Nagao T, Sumitomo H et al. (2005). Cancer Cell 8: 75-87.
80. Higashitsuji H, Itoh K, Nagao T, Dawson S, Nonoguchi K, Kido T et al. (2000). Nat Med 6: 96-99.
81. Horie Y, Suzuki A, Kataoka E, Sasaki T, Hamada K, Sasaki J et al. (2004). J Clin Invest 113: 1774-1783.
82. Höpfner m, Sutter AP, Huether A, Schuppan D, Zeitz M, Scherübl H. (2004). J Hepatol 41: 1008-1016.
83. Hu KQ. (2002). J Lab Clin Med 139: 234-243.
84. Hu TH, Huang CC, Lin PR, Chang HW, Ger LP, Lin YW et al. (2003). Cancer 97: 1929-1940.
85. Huang TB, Ebert O, Shinozaki K, García-Sastre A, Woo SL. (2003b). Mol Ther 8: 434-440.
86. Huang TG, Savontaus MJ, Shinozaki K, Sauter BV, Woo SL. (2003a). Gene Therapy 10: 1241-1247.
87. Huether A, Höpfner M, Sutter AP, Schuppan D, Scherübl H. (2005). J Hepatol 43: 661-669.
88. Humphreys MJ, Ghaneh P, Greenhalf W, Campbell F, Clayton TM, Everett P et al. (2001). Gene Therapy 8: 1241-1247.
89. Huynh H, Do PT, Nguyen TH, Chow P, Tan PH, Quach TH et al. (2004). Int J Oncol 25: 1839-1847.
90. Hwang YH, Choi JY, Kim S, Chung ES, Kim T, Koh SS et al. (2004). Hepatol Res 29: 113-121.
91. Hynes RO. (1992). Cell 69: 11-25.
92. Inui Y, Higashiyama S, Kawata S, Tamura S, Miyagawa J, Taniguchi N et al. (1994). Gastroenterology 107: 1799-1804.
93. Irving J, Wang Z, Powell S, O'Sullivan C, Mok M, Murphy B et al. (2004). Cancer Gene Ther 11: 174-185.
94. Ishikawa N, Daigo Y, Takano A, Taniwaki M, Kato T, Hayama S et al. (2005). Cancer Res 65: 9176-9184.
95. Itoh S, Maeda T, Shimada M, Aishima S, Shirabe K, Tanaka S et al. (2004). Clin Cancer Res 10: 2812-2817.
96. Izzo F, Marra P, Beneduce G, Castello G, Vallone P, De Rosa V et al. (2004). J Clin Oncol 22: 1815-1822.
97. Jakubczak JL, Ryan P, Gorziglia M, Clarke L, Hawkins LK, Hay C et al. (2003). Cancer Res 63: 1490-1499.
98. Jarnagin WR, Zager JS, Klimstra D, Delman KA, Malhotra S, Ebright M et al. (2003). Cancer Gene Ther 10: 215-223.
99. Kakiuchi S, Daigo Y, Ishikawa N, Furukawa C, Tsunoda T, Yano S et al. (2004). Hum Mol Genet 13: 3029-3043.
100. Kalinichenko VV, Major ML, Wang X, Petrovic V, Kuechle J, Yoder HM et al. (2004). Genes Dev 18: 830-850.
101. Kawashima M, Furuse J, Nishio T, Konishi M, Ishii H, Kinoshita T et al. (2005). J Clin Oncol 23: 1839-1846.
102. Kennedy AS, Nutting C, Coldwell D, Gaiser J, Drachenberg C. (2004). Int J Radiat Oncol Biol Phys 60: 1552-1563.
103. Kianmanesh AR, Perrin H, Panis Y, Fabre M, Nagy HJ, Houssin D et al. (1997). Hum Gene Ther 8: 1807-1814.
104. Kim Y, Sills RC, Houle CD. (2005). Toxicol Pathol 33: 175-180.
105. Kirn D. (2001). Expert Opin Biol Ther 1: 525-538.
106. Kojiro M, Roskams T. (2005). Semin Liver Dis 25: 133-142.
107. Kuhns MS, Epshteyn V, Sobel RA, Allison JP. (2000). Proc Natl Acad Sci USA 97: 12711-12716.
108. Kulik LM, Mulcahy MF, Hunter RD, Nemcek Jr AA, Abecassis MM, Salem R. (2005). Liver Transpl 11: 1127-1131.
109. Lai CL, Lau JY, Wu PC, Ngan H, Chung HT, Mitchell SJ et al. (1993). Hepatology 17: 389-394.
110. Lambert B, Bacher K, De Keukeleire K, Smeets P, Colle I, Jeong JM et al. (2005). J Nucl Med 46: 1326-1332.
111. Lan M, Kojima T, Osanai M, Chiba H, Sawada N. (2004). Carcinogenesis 25: 2385-2395.
112. Lee JO, Kwun HJ, Jung JK, Choi KH, Min DS, Jang KL. (2005). Oncogene 24: 6617-6625.
113. Lee JS, Thorgeirsson SS. (2004). Gastroenterology 127: S51-S55.
114. Lee JS, Thorgeirsson SS. (2005). Semin Liver Dis 25: 125-132.
115. Lee RG, Tsamandas AC, Demetris AJ. (1997). Hepatology 26: 1415-1422.
116. Lee WC, Wang HC, Hung CF, Huang PF, Lia CR, Chen MF. (2005). J Immunother 28: 496-504.
117. Lepourcelet M, Chen YN, France DS, Wang H, Crews P, Petersen F et al. (2004). Cancer Cell 5: 91-102.
118. Liang TJ, Heller T. (2004). Gastroenterology 127: S62-S71.
119. Libbrecht L, Roskams T. (2002). Semin Cell Dev Biol 13: 389-396.
120. Lin P, Buxton JA, Acheson A, Radziejewski C, Maisonpierre PC, Yancopoulos GD et al. (1998). Proc Natl Acad Sci USA 95: 8829-8834.
121. Liu MD, Uaje MB, Al-Ghazi MS, Fields D, Herman J, Kuo JV et al. (2004). Am Surg 70: 947-953.
122. Liu Y, Poon RT, Li Q, Kok TW, Lau C, Fan ST. (2005). Cancer Res 65: 3691-3699.
123. Llovet JM, Burroughs A, Bruix J. (2003). Lancet 362: 1907-1917.
124. Llovet JM, Bustamante J, Castells A, Vilana R, Ayuso Mdel C, Sala M et al. (1999). Hepatology 29: 62-67.
125. LoRusso PM, Adjei AA, Varterasian M, Gadgeel S, Reid J, Mitchell DY et al. (2005). J Clin Oncol 23: 5281-5293.
126. Lowe SW, Cepero E, Evan G. (2004). Nature 432: 307-315.
127. Lozano G, Zambetti GP. (2005). Cancer Cell 8: 3-4.
128. Luo J-L, Kamata H, Karin M. (2005). J Clin Invest 115: 2625-2632.
129. Makower D, Rozenblit A, Kaufman H, Edelman M, Lane ME, Zwiebel J et al. (2003). Clin Cancer Res 9: 693-702.
130. Mani A, Gelmann EP. (2005). J Clin Oncol 23: 4776-4789.
131. Masaki T, Okada M, Shiratori Y, Rengifo W, Matsumoto K, Maeda S et al. (1998). Hepatology 27: 1257-1264.
132. Masaki T, Shiratori Y, Rengifo W, Igarashi K, Yamagata M, Kurokohchi K et al. (2003). Hepatology 37: 534-543.
133. Matsumura T, Makino R, Mitamura K. (2001). Clin Cancer Res 7: 594-599.
134. Mazzolini G, Alfaro C, Sangro B, Feijoo E, Ruiz J, Benito A et al. (2005). J Clin Oncol 23: 999-1010.
135. Mazzolini G, Narvaiza I, Martinez-Cruz LA, Arina A, Barajas M, Galofre JC et al. (2003a). Gene Therapy 10: 1067-1078.
136. Mazzolini G, Prieto J, Melero I. (2003b). Curr Pharm Des 9: 1981-1991.
137. Mazzolini G, Qian C, Narvaiza I, Barajas M, Borras-Cuesta F, Xie X et al. (2000). Hum Gene Ther 11: 113-125.
138. McCormick F. (2003). Cancer Biol Ther 2: S157-S160.
139. Melero I, Duarte M, Ruiz J, Sangro B, Galofre J, Mazzolini G et al. (1999). Gene Therapy 6: 1779-1784.
140. Merle P, de la Monte SM, Kim M, Herrmann M, Tanaka S, von dem Bussche A et al. (2004). Gastroenterology 127: 1110-1122.
141. Mesnil M, Yamasaki H. (2000). Cancer Res 60: 3989-3999.
142. Mohr L, Shankara S, Yoon SK, Krohne TU, Geissler M, Roberts B et al. (2000). Hepatology 31: 606-614.
143. Monga SP, Pediaditakis P, Mule K, Stolz DB, Michalopoulos GK. (2001). Hepatology 33: 1098-1109.
144. Morgan D, McLean AJ. (1995). Clin Pharmacokinet 29: 370-391.
145. Mosesson Y, Yarden Y. (2004). Semin Cancer Biol 14: 262-270.
146. Müller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, Li-Weber M et al. (2005). J Exp Med 188: 2033-2045.
147. Murillo O, Arina A, Tirapu I, Alfaro C, Mazzolini G, Palencia B et al. (2003). Clin Cancer Res 9: 5454-5464.
148. Nakanishi K, Sakamoto M, Yasuda J, Takamura M, Fujita N, Tsuruo T et al. (2002). Cancer Res 62: 2971-2975.
149. Narvaiza I, Mazzolini G, Barajas M, Duarte M, Zaratiegui M, Qian C et al. (2000). J Immunol 164: 3112-3122.
150. Nejjari M, Hafdi Z, Gouysse G, Fiorentino M, Bëatrix O, Dumortier J et al. (2002). Hepatology 36: 418-426.
151. Nelson WJ, Nusse R. (2004). Science 303: 1483-1487.
152. O'Neal WK, Zhou H, Morral N, Langston C, Parks RJ, Graham FL et al. (2000). Mol Med 6: 179-195.
153. Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB. (2000). Oncogene 19: 6043-6052.
154. Ohwada A, Hirschowitz EA, Crystal RG. (1996). Hum Gene Ther 7: 1567-1576.
155. Okabe H, Satoh S, Kato T, Kitahara O, Yanagawa R, Yamaoka Y et al. (2001). Cancer Res 61: 2129-2137.
156. Osada S, Kanematsu M, Imai H, Goshima S, Suguiyama Y. (2005). J Am Coll Surg 201: 405-411.
157. Osaki M, Oshimura M, Ito H. (2004). Apoptosis 9: 667-676.
158. Palmer DH, Mautner V, Mirza D, Oliff S, Gerritsen W, van der Sijp JR et al. (2004). J Clin Oncol 22: 1546-1552.
159. Palmieri G, Montella L, Milo M, Fiore R, Biondi E, Bianco AR et al. (2002). Am J Clin Oncol 25: 224-226.
160. Park W, Lim do H, Paik SW, Koh KC, Choi MS, Park CK et al. (2005). Int J Radiat Oncol Biol Phys 61: 1143-1150.
161. Pawlik TM, Nakamura H, Yoon SS, Mullen JT, Chandrasekhar S, Chiocca EA et al. (2000). Cancer Res 60: 2790-2795.
162. Pei Z, Chu L, Zou W, Zhang Z, Qiu S, Qi R et al. (2004). Hepatology 39: 1371-1381.
163. Penuelas I, Mazzolini G, Boan JF, Sangro B, Marti-Climent J, Ruiz M et al. (2005). Gastroenterology 128: 1787-1795.
164. Philip PA, Mahoney MR, Allmer C, Thomas J, Pitot HC, Kim G et al. (2005). J Clin Oncol 23: 6657-6663.
165. Pikarski E, Porat RM, Stein h, Abramovitch R, Amit S, Kasem S et al. (2004). Nature 431: 461-466.
166. Pinzani M, Rombutus K, Colagrande S. (2005). J Hepatol 42: S22-S36.
167. Prieto J, Qian C, Hernandez-Alcoceba R, Gonzalez-Aseguinolaza G, Mazzolini G, Sangro B et al. (2004). Expert Opin Biol Ther 4: 1073-1091.
168. Putzer BM, Stiewe T, Rodicker F, Schildgen O, Ruhm S, Dirsch O et al. (2001). J Natl Cancer Inst 93: 472-479.
169. Qian C, Sangro B, Prieto J. (2002). Gastroenterology 123: 639-642.
170. Ranges GE, Figari IS, Espevik T, Palladino Jr MA. (1987). J Exp Med 166: 991-998.
171. Raoul JL, Guyader D, Bretagne JF, Heautot JF, Duvauferrier R, Bourguet P et al. (1997). Hepatology 26: 1156-1161.
172. Raskopf E, Dzienisowicz C, Hilbert T, Rabe C, Leifeld L, Wernert N et al. (2005). Hepatology 41: 1233-1240.
173. Reya T, Clevers H. (2005). Nature 434: 843-850.
174. Robert C, Soria JC, Spatz A, Le Cesne A, Malka D, Pautier P et al. (2005). Lancet Oncol 6: 491-500.
175. Roberts LR, Gores GJ. (2005). Semin Liver Dis 25: 212-225.
176. Rumpold H, Wolf D, Koeck R, Gunsilius E. (2004). J Cell Mol Med 8: 509-518.
177. Rust C, Gores GJ. (2000). Am J Med 108: 567-574.
178. Ryan AJ, Wedge SR. (2005). Br J Cancer 92(Suppl. 1): S6-S13.
179. Sahin F, Kannangai R, Adegbola O, Wang J, Su G, Torbenson M. (2004). Clin Cancer Res 10: 8421-8425.
180. Sangro B, Bilbao I, Herrero I, Corella C, Longo J, Beloqui O et al. (1993). Hepatology 18: 309-414.
181. Sangro B, Herraiz M, Martinez-Gonzalez MA, Bilbao I, Herrero I, Beloqui O et al. (1998). Surgery 124: 575-583.
182. Sangro B, Mazzolini G, Ruiz J, Herraiz M, Quiroga J, Herrero I et al. (2004). J Clin Oncol 22: 1389-1397.
183. Satyanarayana A, Manns MP, Rudolph KL. (2004). Hepatology 40: 276-283.
184. Sawai Y, Tamura S, Fukui K, Ito N, Imanaka K, Saeki A et al. (2003). J Hepatol 39: 991-996.
185. Schiffer E, Housset C, Cacheux W, Wendum D, Desbois-Mouthon C, Rey C et al. (2005). Hepatology 41: 307-314.
186. Schmitz V, Barajas M, Wang L, Peng D, Duarte M, Prieto J et al. (2001). Hepatology 34: 72-81.
187. Schmitz V, Wang L, Barajas M, Peng D, Prieto J, Qian C. (2002). Gene Therapy 9: 1600-1606.
188. Schuppan D, Ocker M. (2003). Hepatology 38: 289-291.
189. Sell S. (2002). Semin Cell Dev Biol 13: 419-424.
190. Sgadari C, Angiolillo AL, Tosato G. (1996). Blood 87: 3877-3882.
191. Shachaf CM, Kopelman A, Arvanitis C, Karlsson A, Beer S, Mandl S et al. (2004). Nature 431: 1112-1117.
192. Sridhar SS, Hedley D, Siu LL. (2005). Mol Cancer Ther 4: 677-685.
193. Strand S, Hofmann WJ, Hug H, Muller M, Otto G, Strand D et al. (1996). Nat Med 2: 1361-1366.
194. Street A, Macdonald A, McCormick C, Harris M. (2005). J Virol 79: 5006-5016.
195. Strumberg D, Richly H, Hilger RA, Schleucher N, Korfee S, Tewes M et al. (2005). J Clin Oncol 23: 965-972.
196. Stuart K, Tessitore J, Rudy J, Clendennin N, Johnston A. (1999). Cancer 86: 410-414.
197. Stupack DG, Cheresh DA. (2004). Curr Top Dev Biol 64: 207-308.
198. Su M-C, Lien H-C, Jeng Y-M. (2005). Cancer Lett 224: 117-121.
199. Sundram F, Chau TC, Onkhuudai P, Bernal P, Padhy AK. (2004). Eur J Nucl Med Mol Imaging 31: 250-257.
200. Sutter AP, Maaser K, Höpfner M, Huether A, Schuppan D, Scherübl H. (2005). J Hepatol 43: 808-816.
201. Takayama T, Sekine T, Makuuchi M, Yamasaki S, Kosuge T, Yamamoto J et al. (2000). Lancet 356: 802-807.Erratum in: Lancet (2000) 356; 1690.
202. Taub R. (2004). Nat Rev Mol Cell Biol 5: 836-847.
203. Thiery IP. (2003). Curr Opin Cell Biol 15: 740-746.
204. Thompson N, Lyons J. (2005). Curr Opin Pharmacol 5: 350-356.
205. Thompson EW, Newgreen DF, Tarin D. (2005). Cancer Res 65: 5991-5995.
206. Thorgeirsson SS, Grisham JW. (2002). Nat Genet 31: 339-346.
207. Tirapu I, Arina A, Mazzolini G, Duarte M, Alfaro C, Feijoo E et al. (2004). Int J Cancer 110: 51-60.
208. Tirapu I, Rodriguez-Calvillo M, Qian C, Duarte M, Smerdou C, Palencia B et al. (2002). Curr Gene Ther 2: 79-89.
209. Trinchieri G. (1998). Adv Immunol 70: 83-243.
210. Valdés F, Alvarez AM, Locascio A, Vega S, Herrera B, Fernández M et al. (2002). Mol Cancer Res 1: 68-78.
211. Vignot S, Faivre S, Aguirre D, Raymond E. (2005). Ann Oncol 16: 525-537.
212. Von Sengbusch A, Gassmann P, Fisch KM, Enns A, Nicolson GL, Haier J. (2005). Am J Pathol 166: 585-596.
213. Wallace HM, Fraser AV. (2003). Biochem Soc Trans 31: 393-396.
214. Wang L, Schmitz V, Perez-Mediavilla A, Izal I, Prieto J, Qian C. (2003). Mol Ther 8: 72-79.
215. Warren RS, Kirn DH. (2002). Surg Oncol Clin N Am 11: 571-588.
216. Wiessenauer CA, Yip-Schneider MT, Wang Y, Schmidt M. (2004). J Am Coll Surg 198: 410-421.
217. Wirth T, Zender L, Schulte B, Mundt B, Plentz R, Rudolph KL et al. (2003). Cancer Res 63: 3181-3188.
218. Wong CM, Fan ST, Ng IO. (2001). Cancer 92: 136-145.
219. Xu GW, Sun ZT, Forrester K, Wang XW, Coursen J, Harris CC. (1996). Hepatology 24: 1264-1268.
220. Xu Z, Ma D, Wang L, Su J, Zha X. (2003). Biochem Biophys Res Commun 312: 388-396.
221. Yang C, Zeisberg M, Lively JC, Nyberg P, Afdhal N, Kalluri R. (2003). Cancer Res 63: 8312-8317.
222. Yarden Y. (2001). Eur J Cancer 37: S3-S8.
223. Yau CYF, Wheeler JJ, Sutton KL, Hedley DW. (2005). Cancer Res 65: 1497-1504.
224. You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N et al. (2004). Cancer Res 64: 5385-5389.
225. Zacharoulis D, Hatzitheofilou C, Athanasiou E, Zacharoulis S. (2005). Expert Rev Anticancer Ther 5: 645-656.
226. Zavadil J, Böttinger EP. (2005). Oncogene 24: 5764-5774.
227. Zender L, Kock R, Eckhard M, Frericks B, Gosling T, Gebhardt T et al (2002). Gastroenterology 123: 608-618.
228. Zhang H, Ozaki I, Mizuta T, Matsuhashi S, Yoshimura T, Hisatomi A et al. (2002). Cancer 95: 896-906.
229. Zhang H, Ozaki I, Mizuta T, Yoshimura T, Matsuhashi S, Eguchi Y et al. (2004). Cancer Sci 95: 878-886.
230. Zhang H, Ozaki I, Mizuta T, Yoshimura T, Matsuhasi S, Hisatomi A et al. (2003). Hepatology 38: 305-313.
231. Zhang Y, Xiong Y, Yarbrough WG. (1998). Cell 92: 725-734.
232. Zou W, Luo C, Zhang Z, Liu J, Gu J, Pei Z et al. (2004). Oncogene 23: 457-464.