Transforming growth factor-β1 stimulated protein kinase B serine-473 and focal adhesion kinase tyrosine phosphorylation dependent on cell adhesion in human hepatocellular carcinoma SMMC-7721 cells

Biochemical and Biophysical Research Communications

Volumn 312, Issue 2, 2003, Pages 388-396

  Xu, Zhen ^a   Ma, Dong Zhu ^a   Wang, Li Ying ^a   Su, Jian Min ^a   Zha, Xi Liang ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cell adhesion; FAK Tyr phosphorylation; Integrin linked kinase; PKB Ser 473 phosphorylation; TGF 1

Indexed keywords

FOCAL ADHESION KINASE; INTEGRIN LINKED KINASE; PROTEIN KINASE; PROTEIN KINASE B; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SERINE; TYROSINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL SUSPENSION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN DETERMINATION; UPREGULATION;

EID: 0345276468     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.10.130     Document Type: Article

References (34)

1. Derynck R., Feng X.H. TGF-β receptor signaling. Biochem. Biophys. Acta. 1333:1997;F105-F150.
2. Attisano L., Wrana J.L. Signal transduction by TGF-β superfamily. Science. 296:2002;1646-1647.
3. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature. 371:1994;257-261.
4. Perlman R., Schiemann W.P., Brooks M.W., Lodish H.F., Weinberg R.A. TGF-β-induced apoptosis is mediated by the adaptor protein DAXX that facilitates JNK activation. Nat. Cell Biol. 3:2001;708-714.
5. Akhurst R.J., Derynck R. TGF-β signaling in cancer- a double-edged sword. Trends Cell Biol. 11:2001;S44-S51.
6. Markowitz S., Wang J., Myeroff L., Parsons R., et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science. 268:1995;1336-1338.
7. Massague J., Blain S.W., Lo R.S. TGF-β signaling in growth control, cancer, and heritable disorders. Cell. 103:2000;295-309.
8. Mulder K.M. Role of Ras and Mapks in TGFbeta signaling. Cytokine Growth Factor Rev. 11:2000;23-35.
9. Filmus J., Zhao J., Buick R.N. Overexpression of H-ras oncogene induces resistance to the growth-inhibitory action of transforming growth factor beta-1 (TGF-. β1 ) and alters the number and type of TGF- β1 receptors in rat intestinal epithelial cell clones Oncogene. 7:1992;521-526.
10. Fukuda K., Kawata S., Tamura S., Matsuda Y. Altered regulation of Src tyrosine kinase by transforming growth factor. β1 in a human hepatoma cell line Hepatology. 28:1998;797-804.
11. Nicholson K.M., Anderson N.G. The protein kinase B/Akt signaling pathway in human malignancy. Cell. Signal. 14:2002;381-395.
12. Giancotti F.G., Ruoslahti E. Integrin signaling. Science. 285:1999;1028-1032.
13. Kim L.T., Yamada K.M. The regulation of expression of integrin receptors. Protein. Sci. Exp. Biol. Med. 214:1997;123-131.
14. Huang R.C., Zhou R.H., Lu F.D. Establishment and some biological characteristics of SMMC-7721 human hepatocellular carcinoma cell line. Acta. Shanghai No.2 Military Med. Univ. 1:1980;5-9.
15. Folkman J., Moscona A. Role of cell shape in growth control. Nature. 273:1978;345-349.
16. Busk M., Pytela R., Sheppard D. Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein. J. Biol. Chem. 267:1992;5790-5796.
17. Lin J.K., Chou C.K. In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor beta 1. Cancer Res. 52:1992;385-388.
18. Inagaki M., Moustakas A., Lin H.Y., Lodish H.F., Carr B.I. Growth inhibition by transforming growth factor beta (TGF-beta) type I is restored in TGF-beta-resistant hepatoma cells after expression of TGF-beta receptor type II cDNA. Proc. Natl. Acad. Sci. USA. 90:1993;5359-5363.
19. Freathy C., Brown D.G., Roberts R.A., Cain K. Transforming growth factor-beta(1) induces apoptosis in rat Fao hepatoma cells via cytochrome c release and oligomerization of Apaf-1 to form a approximately 700kd apoptosome caspase-processing complex. Hepatology. 32:2000;750-760.
20. Jong H.S., Lee H.S., Kim T.Y., Im Y.H., et al. Attenuation of transforming growth factor beta-induced growth inhibition in human hepatocellular carcinoma cell lines by cyclin D1 overexpression. Biochem. Biophys. Res. Commun. 292:2002;383-389.
21. Heino J., Ignotz R.A., Hemler M.E., Crouse C., Massague J. Regulation of cell adhesion receptors by transforming growth factor-β. Concomitant regulation of integrins that share a common. β1 subunit J. Biol. Chem. 264:1989;380-388.
22. Bellis S.L., Newman E., Friedman E.A. Steps in integrin. β1 chain glycosylation mediated by TGF β1 signaling through Ras J. Cell Physiol. 181:1999;33-44.
23. Yan Z., Chen M., Perucho M., Friedman E. Oncogenic Ki-ras but not oncogenic Ha-ras blocks integrin. β1 -chain maturation in colon epithelial cells J. Biol. Chem. 272:1997;30928-30936.
24. Dedhar S., Williams B., Hannigan G. Integrin-linked kinase (ILK): a regulator of integrin and growth factor signaling. Trends Cell Biol. 9:1999;319-323.
25. Dedhar S. Cell-substrate interactions and signaling through ILK. Curr. Opin. Cell Biol. 12:2000;250-256.
26. Atfi A., Drobetsky E., Boissonneault M., Chapdelaine A., Chevalier S. Transforming growth factor beta down-regulates Src family protein tyrosine kinase signaling pathways. J. Biol. Chem. 269:1994;30688-30693.
27. Kim J.T., Joo C.K. Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1. J. Biol. Chem. 277:2002;31938-31948.
28. Lhuillier L., Dryer S.E. Developmental regulation of neuronal Kca channels by TGF-. β1: an essential role for PI-3 kinase signaling and membrane insertion J. Neurophysiol. 88:2002;954-964.
29. Valderrama-Carvajal H., Cocolakis E., Lacerte A., Lee E.H., et al. Activin/ TGF-β-beta induce apoptosis is through Smad-dependent expression of the lipid phosphatase SHIP. Nat. Cell Biol. 4:2002;963-969.
30. Balendran A., Casamayor A., Deak M., Paterson A., et al. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr. Biol. 9:1999;393-404.
31. Toker A., Newton A.C. Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site. J. Biol. Chem. 275:2002;8271-8274.
32. Kroner C., Eybrechts K., Akkerman J.W. Dual regulation of platelet protein kinase B. J. Biol. Chem. 275:2000;27790-27798.
33. Persad S., Attwell S., Gray V., Mawji N., et al. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343. J. Biol. Chem. 276:2001;27462-27469.
34. Hynes R.O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:1995;11-25.