Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice

Cancer Research

Volumn 61, Issue 14, 2001, Pages 5389-5395

  Deane, Natasha G ^a   Parker, Monica A ^b   Aramandla, Radhika ^a   Diehl, Lisa ^a   Lee, Woo Jung ^a   Washington, M Kay ^a   Nanney, Lillian B ^a,b   Shyr, Yu ^a   Beauchamp, R Daniel ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; FATTY ACID BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER NODULE; MALE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; RNA SYNTHESIS; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CYCLIN D1; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOMEGALY; INTESTINES; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RATS; SEX FACTORS; TIME FACTORS; TRANSGENES;

EID: 0035879040     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. D-type cyclins
2. Mammalian G1 cyclins
3. Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts
4. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
5. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
6. NFκ-B function in growth control. Regulation of cyclin D1 expression and G0/G1-to-S-Phase transition
7. Glycogen synthase kinase-3β regulates cyclin D1 proteotysis and subcellular localization
8. Oncogenic Ras-mediated cell growth arrest, and apoptosis is associated with increased ubiquitin-dependent cyclin D1 degradation
9. Cyclin D1 is a nuclear protein required for cell cycle progression in G1
10. Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes
11. The hallmarks of cancer
12. Cyclins and cancer
13. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma
14. A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene
15. Prognostic role of cyclin D1 in lung cancer. Relationship to proliferating cell nuclear antigen
16. Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma
17. Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis
18. The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas
19. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
20. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach
21. Hepatocellular carcinoma
22. Expression and prognostic roles of the G1-S modulators in hepatocellular carcinoma: P27 independently predicts the recurrence
23. Alteration of cell cycle-related genes in hepatocarcinogenesis
24. β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
25. β-Catenin signaling and cancer
26. Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
27. Mechanisms underlying generation of gradients in gene expression within the intestine: An analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes
28. A morphologic classification of proliferative, and neoplastic hepatic lesions in mice
29. Cell cycle regulators and human hepatocarcinogenesis
30. Transgenic animals as models for hepatocarcinogenesis
31. Oncogene-induced liver neoplasia in transgenic mice
32. Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor α
33. T antigen expression and tumorigenesis in transgenic mice containing a mouse major urinary protein/SV40 T antigen hybrid gene
34. Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large Tag transgenic mice
35. Cell proliferation kinetics in the gastrointestinal tract of man. I. Cell renewal in colon and rectum
36. Suppression of intestinal polyposis in Apc δ716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
37. Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells