-
1
-
-
0030026679
-
Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase
-
Hannigan, G. E. et al. Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase. Nature 379, 91-96 (1996). First report of the identification of ILK. Demonstration of an interaction with β1-integrin cytoplasmic domain and function in the regulation of anchorage-dependent growth of epithelial cells.
-
(1996)
Nature
, vol.379
, pp. 91-96
-
-
Hannigan, G.E.1
-
2
-
-
0035809918
-
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
-
Zervas, C. G., Gregory, S. L. & Brown, N. H. Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane. J. Cell Biol. 152, 1007-1018 (2001).
-
(2001)
J. Cell Biol.
, vol.152
, pp. 1007-1018
-
-
Zervas, C.G.1
Gregory, S.L.2
Brown, N.H.3
-
3
-
-
0037076211
-
Elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes
-
Mackinnon, A. C., Qadota, H., Norman, K. R., Moerman, D. G. & Williams, B. D. C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes. Curr. Biol. 12, 787-797 (2002). References 2 and 3 provide genetic evidence in model oganisms for the integrin-ILK connection and show conserved evolutionary function of ILK.
-
(2002)
Curr. Biol.
, vol.12
, pp. 787-797
-
-
Mackinnon, A.C.1
Qadota, H.2
Norman, K.R.3
Moerman, D.G.4
Williams, B.D.C.5
-
4
-
-
0345103747
-
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation
-
Sakai, T. et al. Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation. Genes Dev. 17, 926-940 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 926-940
-
-
Sakai, T.1
-
5
-
-
0037904987
-
The integrin-actin connection, an eternal love affair
-
Brakebusch, C. & Fassler, R. The integrin-actin connection, an eternal love affair. EMBO J. 22, 2324-2333 (2003).
-
(2003)
EMBO J.
, vol.22
, pp. 2324-2333
-
-
Brakebusch, C.1
Fassler, R.2
-
6
-
-
3042708179
-
The PINCH-ILK-parvin complexes: Assembly, functions and regulation
-
Wu, C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim. Biophys. Acta 1692, 55-62 (2004).
-
(2004)
Biochim. Biophys. Acta
, vol.1692
, pp. 55-62
-
-
Wu, C.1
-
7
-
-
0035969233
-
Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes
-
Wu, C. & Dedhar, S. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. J. Cell Biol. 155, 505-510 (2001).
-
(2001)
J. Cell Biol.
, vol.155
, pp. 505-510
-
-
Wu, C.1
Dedhar, S.2
-
8
-
-
2542468783
-
Affixin interacts with α-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction
-
Yamaji, S. et al. Affixin interacts with α-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. J. Cell Biol. 165, 539-551 (2004).
-
(2004)
J. Cell Biol.
, vol.165
, pp. 539-551
-
-
Yamaji, S.1
-
9
-
-
18644372487
-
Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation
-
Yamaji, S. et al. Possible role of ILK-affixin complex in integrin-cytoskeleton linkage during platelet aggregation. Biochem. Biophys. Res. Commun. 297, 1324-1331 (2002).
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.297
, pp. 1324-1331
-
-
Yamaji, S.1
-
10
-
-
0038724824
-
The role of integrin-linked kinase (ILK) in cancer progression
-
Persad, S. & Dedhar, S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev. 22, 375-384 (2003).
-
(2003)
Cancer Metastasis Rev.
, vol.22
, pp. 375-384
-
-
Persad, S.1
Dedhar, S.2
-
11
-
-
1642587815
-
Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase
-
Oloumi, A., McPhee, T. & Dedhar, S. Regulation of E-cadherin expression and β-catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim. Bophys. Acta 1691, 1-15 (2004).
-
(2004)
Biochim. Bophys. Acta
, vol.1691
, pp. 1-15
-
-
Oloumi, A.1
McPhee, T.2
Dedhar, S.3
-
12
-
-
0035844257
-
2+-independent smooth muscle contraction, a novel function for integrin-linked kinase
-
2+-independent smooth muscle contraction, a novel function for integrin-linked kinase. J. Biol. Chem. 276, 16365-16373 (2001). An unbiased approach providing biochemical data demonstrating that ILK is a bona fide serine/threonine protein kinase.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 16365-16373
-
-
Deng, J.T.1
Van Lierop, J.E.2
Sutherland, C.3
Walsh, M.P.4
-
13
-
-
4644322059
-
ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells
-
Vouret-Craviari, V., Boulter, E., Grall, D., Matthews, C. & Van Obberghen-Schilling, E. ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells. J. Cell Sci. 117, 4539-4569 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4539-4569
-
-
Vouret-Craviari, V.1
Boulter, E.2
Grall, D.3
Matthews, C.4
Van Obberghen-Schilling, E.5
-
14
-
-
4444305175
-
Integrin-linked kinase regulates endothelial cell survival and vascular develpment
-
Friedrich, E. B. et al. Integrin-linked kinase regulates endothelial cell survival and vascular develpment. Mol. Cell. Biol. 24, 8134-8144 (2004). Endothelial-cell-specific knockout demonstrating an essential role of ILK in vascular development and angiogenesis. Demonstrates an essential role of ILK in the control of endothelial-cell survival.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8134-8144
-
-
Friedrich, E.B.1
-
15
-
-
9144270454
-
Regulation of tumor angiogenesis by integrin-linked kinase (ILK)
-
Tan, C. et al. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 5, 79-90 (2004). Shows that ILK can promote the expression and synthesis of VEGF by prostate cancer cells, and also that ILK is required for VEGF-induced angiogenic response. Also shows the efficacy of ILK inhibitors in suppressing tumour angiogenesis and growth in vivo, and provides a framework for ILK as a two-hit therapeutic target for tumour angiogenesis.
-
(2004)
Cancer Cell
, vol.5
, pp. 79-90
-
-
Tan, C.1
-
16
-
-
0842280613
-
Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor
-
Kaneko, Y., Kitazato, K., & Basaki, Y. Integrin-linked kinase regulates vascular morphogenesis induced by vascular endothelial growth factor. J. Cell Sci. 117, 407-415 (2004).
-
(2004)
J. Cell Sci.
, vol.117
, pp. 407-415
-
-
Kaneko, Y.1
Kitazato, K.2
Basaki, Y.3
-
17
-
-
0035920145
-
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: Critical roles for kinase activity and amino adds arginine 211 and serine 343
-
Persad, S. et al. Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino adds arginine 211 and serine 343. J. Biol. Chem. 276, 27462-27469 (2001). In depth biochemical analysis of ILK as a Ser473 kinase for AKT. Characterization of critical amino acids involved in the regulation of ILK activity, and characterization of small-molecule ILK inhibitors.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 27462-27469
-
-
Persad, S.1
-
18
-
-
0035804215
-
-/- human colon carcinoma cells
-
-/- human colon carcinoma cells. Oncogene 20, 133-140 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 133-140
-
-
Tan, C.1
-
19
-
-
0141533044
-
Integrin signaling to the actin cytoskeleton
-
DeMali, K. A., Wennerberg, K. & Burridge, K. Integrin signaling to the actin cytoskeleton. Curr. Opin. Cell Biol. 15, 572-582 (2003).
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 572-582
-
-
DeMali, K.A.1
Wennerberg, K.2
Burridge, K.3
-
20
-
-
0015266211
-
Cytochalasin B: Effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments- glycoproteins-embryonic cells-sorting-out)
-
Sanger, J. W. & Holtzer, H. Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out). Proc. Natl Acad. Sci. USA 69, 253-257 (1972).
-
(1972)
Proc. Natl. Acad. Sci. USA
, vol.69
, pp. 253-257
-
-
Sanger, J.W.1
Holtzer, H.2
-
21
-
-
0027454485
-
Mapping of the α-actinin binding site within the β1 integrin cytoplasmic domain
-
Otey, C. A., Vasquez, G. B., Burridge, K. & Erickson, B. W. Mapping of the α-actinin binding site within the β1 integrin cytoplasmic domain. J. Biol. Chem. 268, 21193-21197 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 21193-21197
-
-
Otey, C.A.1
Vasquez, G.B.2
Burridge, K.3
Erickson, B.W.4
-
22
-
-
0027172919
-
Mechanotransduction across the cell surface and through the cytoskeleton
-
Wang, N., Butler, J. P. & Ingber, D. E. Mechanotransduction across the cell surface and through the cytoskeleton. Science 260, 1124-1127 (1993).
-
(1993)
Science
, vol.260
, pp. 1124-1127
-
-
Wang, N.1
Butler, J.P.2
Ingber, D.E.3
-
23
-
-
0343576503
-
Dual control of cell growth by somatomedins and platelet-derived growth factor
-
Stiles, C. D. et al. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc. Natl Acad Sci. USA 76, 1279-1283 (1979).
-
(1979)
Proc. Natl. Acad Sci. USA
, vol.76
, pp. 1279-1283
-
-
Stiles, C.D.1
-
24
-
-
0027176804
-
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown
-
McNamee, H. P., Ingber, D. E. & Schwartz, M. A. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J. Cell Biol. 121, 673-678 (1993).
-
(1993)
J. Cell Biol.
, vol.121
, pp. 673-678
-
-
McNamee, H.P.1
Ingber, D.E.2
Schwartz, M.A.3
-
25
-
-
0025946283
-
Signal transduction by integrins: Increased protein tyrosine phosphorylation caused by clustering of β1 integrins
-
Kornberg, L. J., Earp, H. S., Turner, C. E., Prockop, C. & Juliano, R. L. Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of β1 integrins. Proc. Natl Acad Sci. USA 88, 8392-8396 (1991).
-
(1991)
Proc. Natl. Acad Sci. USA
, vol.88
, pp. 8392-8396
-
-
Kornberg, L.J.1
Earp, H.S.2
Turner, C.E.3
Prockop, C.4
Juliano, R.L.5
-
26
-
-
0027055575
-
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase
-
Kornberg, L., Earp, H. S., Parsons, J. T., Schaller, M. & Juliano, R. L. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem. 267, 23439-23442 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 23439-23442
-
-
Kornberg, L.1
Earp, H.S.2
Parsons, J.T.3
Schaller, M.4
Juliano, R.L.5
-
27
-
-
0028238346
-
Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed β1 integrin cytoplasmic domain
-
Lukashev, M. E., Sheppard, D. & Pytela, R. Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed β1 integrin cytoplasmic domain. J. Biol. Chem. 269, 18311-18314 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18311-18314
-
-
Lukashev, M.E.1
Sheppard, D.2
Pytela, R.3
-
28
-
-
0008584962
-
Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15. 5-p15.4
-
Hannigan, G. E. et al. Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15. 5-p15.4. Genomes 42, 177-179 (1997).
-
(1997)
Genomes
, vol.42
, pp. 177-179
-
-
Hannigan, G.E.1
-
29
-
-
0033020670
-
The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
-
Tu, Y., Li, F., Goicoechea, S. & Wu, C. The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol. Cell. Biol. 19, 2425-2434 (1999). First identification of the interaction of ILK with PINCH, an evolutionary conserved protein required for various ILK functions.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 2425-2434
-
-
Tu, Y.1
Li, F.2
Goicoechea, S.3
Wu, C.4
-
30
-
-
0035341207
-
Modulation of integrin signa transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1
-
Leung-Hagestejn, C., Mahendra, A., Naruszewicz, I. & Hannigan, G. E. Modulation of integrin signa transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1. EMBO J. 20, 2160-2170 (2001). Important finding identifying a negative regulator of ILK activity.
-
(2001)
EMBO J.
, vol.20
, pp. 2160-2170
-
-
Leung-Hagestejn, C.1
Mahendra, A.2
Naruszewicz, I.3
Hannigan, G.E.4
-
31
-
-
0035844879
-
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction
-
Yamaji, S. et al. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction. J. Cell Biol. 153, 1251-1264 (2001).
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1251-1264
-
-
Yamaji, S.1
-
32
-
-
0035972170
-
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
-
Tu, Y., Huang, Y., Zhang, Y., Hua, Y. & Wu, C. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading, J. Cell Biol. 153, 585-598 (2001). References 31 and 32 describe the identification and interactions with ILK of β-parvin and α-parvin, respectively, and the roles of their interactions with ILK on cell spreading.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 585-598
-
-
Tu, Y.1
Huang, Y.2
Zhang, Y.3
Hua, Y.4
Wu, C.5
-
33
-
-
0029020282
-
Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks, S. K. & Hunter, T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 9, 576-596 (1995).
-
(1995)
FASEB J.
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
34
-
-
0026345394
-
Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members
-
Hanks, S. K. & Quinn, A. M. Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol. 200, 38-62 (1991).
-
(1991)
Methods Enzymol.
, vol.200
, pp. 38-62
-
-
Hanks, S.K.1
Quinn, A.M.2
-
35
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning, G., Whyte, D. B., Martinez, R., Hunter, T. & Sudarsanam, S. The protein kinase complement of the human genome. Science 298, 1912-1934 (2002).
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
36
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
Jenne, D. E. et al. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genet. 18, 38-43 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
-
37
-
-
0032471851
-
Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
-
Mehenni, H. et al. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am. J. Hum. Genet. 63, 1641-1650 (1998).
-
(1998)
Am. J. Hum. Genet.
, vol.63
, pp. 1641-1650
-
-
Mehenni, H.1
-
38
-
-
18344405643
-
Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients
-
Boudeau, J. et al. Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients. Hum. Mutat. 21, 172 (2003).
-
(2003)
Hum. Mutat.
, vol.21
, pp. 172
-
-
Boudeau, J.1
-
39
-
-
0037076484
-
Integrin adhesion: When is a kinase a kinase?
-
Zervas, C. G. & Brown, N. H. Integrin adhesion: when is a kinase a kinase? Curr. Biol. 12, R350-R351 (2002).
-
(2002)
Curr. Biol.
, vol.12
-
-
Zervas, C.G.1
Brown, N.H.2
-
40
-
-
0034601436
-
The integrin-linked kinase (ILK) suppresses anoikis
-
Attwel, S., Roskelley, C. & Dedhar, S. The integrin-linked kinase (ILK) suppresses anoikis. Oncogene 19, 3811-3815 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 3811-3815
-
-
Attwel, S.1
Roskelley, C.2
Dedhar, S.3
-
41
-
-
0030999580
-
Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression
-
Radeva, G. et al. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J. Biol. Chem. 272, 13937-13944 (1997). This study showed that ILK can coordinate adhesion-dependent cell-cycle regulation.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 13937-13944
-
-
Radeva, G.1
-
42
-
-
0141534266
-
Integrin-linked kinase is a positive mediator of L6 myoblast differentiation
-
Miller, M. G., Naruszewicz, I., Kumar, A. S., Ramlal, T. & Hannigan, G. E. Integrin-linked kinase is a positive mediator of L6 myoblast differentiation. Biochem. Biophys. Res. Commun. 310, 796-803 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.310
, pp. 796-803
-
-
Miller, M.G.1
Naruszewicz, I.2
Kumar, A.S.3
Ramlal, T.4
Hannigan, G.E.5
-
43
-
-
0344012484
-
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN
-
Attwel, S., Mills, J., Troussard, A., Wu, C. & Dedhar, S. Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol. Biol. Cell 14, 4813-4825 (2003). This work shows the integrated function of ILK as a kinase and an adaptor in focal adhesions.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 4813-4825
-
-
Attwel, S.1
Mills, J.2
Troussard, A.3
Wu, C.4
Dedhar, S.5
-
44
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H. & Downward, J. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16, 2783-2793 (1997).
-
(1997)
EMBO J.
, vol.16
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
45
-
-
0032530482
-
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
-
Delcommenne, M. et al. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc. Natl Acad. Sci. USA 95, 11211-11216 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 11211-11216
-
-
Delcommenne, M.1
-
46
-
-
0033599029
-
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism
-
Lynch, D. K., Ellis, C. A., Edwards, P. A. & Hiles, I. D. Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism. Oncogene 18, 8024-8032 (1999). References 45 and 46 showed that ILK activity is regulated in a PI3K-dependent manner, and that ILK regulates AKT Ser473 phosphorylation in a PI3K-dependent manner.
-
(1999)
Oncogene
, vol.18
, pp. 8024-8032
-
-
Lynch, D.K.1
Ellis, C.A.2
Edwards, P.A.3
Hiles, I.D.4
-
47
-
-
0034724443
-
Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells
-
Persad, S. et al. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc. Natl Acad. Sci. USA 97, 3207-3212 (2000). References 47 and 56 show that PTEN negatively regulates ILK activity and that loss of PTEN results in constitutively activated ILK. Inhibition of ILK in PTEN-negative cells inhibits tumour-cell growth and inhibits AKT activation.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3207-3212
-
-
Persad, S.1
-
48
-
-
0037457047
-
α integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells
-
Cruet-Hennequart, S. et al. α integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells. Oncogene 22, 1688-1702 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 1688-1702
-
-
Cruet-Hennequart, S.1
-
49
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama, T. & Dixon, J. E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273, 13375-13378 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
50
-
-
0036181869
-
PTEN: The down side of PI 3-kinase signaling
-
Leslie, N. R. & Downes, C. P. PTEN: The down side of PI 3-kinase signaling. Cell Signal. 14, 285-295 (2002).
-
(2002)
Cell Signal.
, vol.14
, pp. 285-295
-
-
Leslie, N.R.1
Downes, C.P.2
-
51
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
-
Li, J. et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 1943-1947 (1997).
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
-
52
-
-
15444349266
-
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
-
Cairns, P. et al. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res. 57, 4997-5000 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4997-5000
-
-
Cairns, P.1
-
53
-
-
0032574718
-
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
-
Whang, Y. E. et al. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl Acad. Sci. USA 95, 5246-5250 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 5246-5250
-
-
Whang, Y.E.1
-
54
-
-
0032506011
-
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
-
Myers, M. P. et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc. Natl Acad. Sci. USA 95, 13513-13518 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13513-13518
-
-
Myers, M.P.1
-
55
-
-
0032475861
-
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
-
Stambolic, V. et al. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39 (1998).
-
(1998)
Cell
, vol.95
, pp. 29-39
-
-
Stambolic, V.1
-
56
-
-
0034642547
-
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity
-
Morimoto, A. M. et al. The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity. Oncogene 19, 200-209 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 200-209
-
-
Morimoto, A.M.1
-
57
-
-
0035844886
-
Tumor suppressor PTEN inhibits nuclear accumulation of β-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation
-
Persad, S., Troussard, A. A., McPhee, T. R., Mulholland, D. J. & Dedhar, S. Tumor suppressor PTEN inhibits nuclear accumulation of β-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J. Cell Biol. 153, 1161-1174 (2001).
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1161-1174
-
-
Persad, S.1
Troussard, A.A.2
McPhee, T.R.3
Mulholland, D.J.4
Dedhar, S.5
-
58
-
-
11144227278
-
Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398
-
Obara, S. et al. Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398. Cancer Lett. 208, 115-122 (2004).
-
(2004)
Cancer Lett.
, vol.208
, pp. 115-122
-
-
Obara, S.1
-
59
-
-
7144261716
-
DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer
-
Mok, S. C. et al. DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. Oncogene 16, 2381-2387 (1998).
-
(1998)
Oncogene
, vol.16
, pp. 2381-2387
-
-
Mok, S.C.1
-
60
-
-
0036734416
-
Down-regulation of DOC-2 in colorectal cancer points to is role as a tumor suppressor in this malignancy
-
Kleeff, J. et al. Down-regulation of DOC-2 in colorectal cancer points to is role as a tumor suppressor in this malignancy. Dis. Colon Rectum 45, 1242-1248 (2002).
-
(2002)
Dis. Colon Rectum
, vol.45
, pp. 1242-1248
-
-
Kleeff, J.1
-
61
-
-
3442894137
-
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
-
Hoek, K. et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 64, 5270-5282 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 5270-5282
-
-
Hoek, K.1
-
62
-
-
0141891463
-
Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival
-
Dai, D. L. et al. Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival. Clin. Cancer Res. 9, 4409-4414 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 4409-4414
-
-
Dai, D.L.1
-
63
-
-
0037072821
-
Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1
-
Takada, T. et al. Induction of apoptosis by stomach cancer-associated protein-tyrosine phosphatase-1. J. Biol. Chem. 277, 34359-34366 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 34359-34366
-
-
Takada, T.1
-
64
-
-
0037338529
-
Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge
-
Fumoto, K., Uchimura, T., Iwasaki, T., Ueda, K. & Hosoya, H. Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edge. Biochem. J. 370, 551-556 (2003).
-
(2003)
Biochem. J.
, vol.370
, pp. 551-556
-
-
Fumoto, K.1
Uchimura, T.2
Iwasaki, T.3
Ueda, K.4
Hosoya, H.5
-
65
-
-
0037004888
-
Spatial localization of mono-and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cells
-
Uchimura, T., Fumoto, K., Yamamoto, Y., Ueda, K. & Hosoya, H. Spatial localization of mono-and diphosphorylated myosin II regulatory light chain at the leading edge of motile HeLa cells. Cell Struct. Funct. 27, 479-486 (2002).
-
(2002)
Cell Struct. Funct.
, vol.27
, pp. 479-486
-
-
Uchimura, T.1
Fumoto, K.2
Yamamoto, Y.3
Ueda, K.4
Hosoya, H.5
-
66
-
-
0031917782
-
Specific localization of serine 19 phosphorated myosin II during cell locomotion and mitosis of cultured cells
-
Matsumura, F., Ono, S., Yamakita, Y., Totsukawa, G. & Yamashino, S. Specific localization of serine 19 phosphorated myosin II during cell locomotion and mitosis of cultured cells. J. Cell Biol. 140, 119-129 (1998).
-
(1998)
J. Cell Biol.
, vol.140
, pp. 119-129
-
-
Matsumura, F.1
Ono, S.2
Yamakita, Y.3
Totsukawa, G.4
Yamashino, S.5
-
67
-
-
0037109063
-
Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase
-
Deng, J. T., Sutherland, C., Brautigan, D. L., Eto, M. & Walsh, M. P. Phosphorylation of the myosin phosphatase inhibitors, CPI-17 and PHI-1, by integrin-linked kinase. Biochem. J. 367, 517-524 (2002).
-
(2002)
Biochem. J.
, vol.367
, pp. 517-524
-
-
Deng, J.T.1
Sutherland, C.2
Brautigan, D.L.3
Eto, M.4
Walsh, M.P.5
-
68
-
-
0037532608
-
Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases
-
Erdodi, F. et al. Phosphorylation of protein phosphatase type-1 inhibitory proteins by integrin-linked kinase and cyclic nucleotide-dependent protein kinases. Biochem. Biophys. Res. Commun. 306, 382-387 (2003).
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.306
, pp. 382-387
-
-
Erdodi, F.1
-
69
-
-
0037016703
-
A critical role of the PINCH-integrin-tinked kinase interaction in the regulation of cell shape change and migration
-
Zhang, Y., Guo, L., Chen, K. & Wu, C. A critical role of the PINCH-integrin-tinked kinase interaction in the regulation of cell shape change and migration. J. Biol. Chem. 277, 318-326 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 318-326
-
-
Zhang, Y.1
Guo, L.2
Chen, K.3
Wu, C.4
-
70
-
-
0035895898
-
Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain
-
Velyvis, A., Yang, Y., Wu, C. & Qin, J. Solution structure of the focal adhesion adaptor PINCH LIM1 domain and characterization of its interaction with the integrin-linked kinase ankyrin repeat domain. J. Biol. Chem. 276, 4932-4939 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 4932-4939
-
-
Velyvis, A.1
Yang, Y.2
Wu, C.3
Qin, J.4
-
71
-
-
0033378656
-
Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats
-
Li, F., Zhang, Y. & Wu, C. Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats. J. Cell Sci. 112, 4589-4599 (1999).
-
(1999)
J. Cell Sci.
, vol.112
, pp. 4589-4599
-
-
Li, F.1
Zhang, Y.2
Wu, C.3
-
72
-
-
0345803932
-
PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival
-
Fukuda, T., Chen, K., Shi, X. & Wu, C. PINCH-1 is an obligate partner of integrin-linked kinase (ILK) functioning in cell shape modulation, motility, and survival. J. Biol. Chem. 278, 51324-51333 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 51324-51333
-
-
Fukuda, T.1
Chen, K.2
Shi, X.3
Wu, C.4
-
73
-
-
0037064063
-
Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration
-
Zhang, Y., Chen, K., Guo, L. & Wu, C. Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. J. Biol. Chem. 277, 38328-38338 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38328-38338
-
-
Zhang, Y.1
Chen, K.2
Guo, L.3
Wu, C.4
-
74
-
-
0037377167
-
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions
-
Braun, A. et al. PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions. Exp. Cell Res. 284, 239-250 (2003).
-
(2003)
Exp. Cell Res.
, vol.284
, pp. 239-250
-
-
Braun, A.1
-
75
-
-
0035126590
-
Parvin, a 42 kDa focal adhesion protein, related to the α-actinin superfamily
-
Olski, T. M., Noegel, A. A. & Korenbaum, E. Parvin, a 42 kDa focal adhesion protein, related to the α-actinin superfamily. J. Cell Sci. 114, 525-538 (2001).
-
(2001)
J. Cell Sci.
, vol.114
, pp. 525-538
-
-
Olski, T.M.1
Noegel, A.A.2
Korenbaum, E.3
-
76
-
-
0037059789
-
Molecular dissection of actopaxin-integrin-linked kinase-paxillin interactions and their role in subcellular localization
-
Nikolopoulos, S. N. & Turner, C. E. Molecular dissection of actopaxin-integrin-linked kinase-paxillin interactions and their role in subcellular localization. J. Biol. Chem. 277, 1568-1575 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1568-1575
-
-
Nikolopoulos, S.N.1
Turner, C.E.2
-
77
-
-
10644244400
-
β-parvin inhibits integrin linked kinase signaling and is down-regulated in breast cancer
-
Mongroo, P. et al. β-parvin inhibits integrin linked kinase signaling and is down-regulated in breast cancer. Oncogene 23, 8959-8970 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 8959-8970
-
-
Mongroo, P.1
-
78
-
-
0037417416
-
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt
-
Fukuda, T., Guo, L., Shi, X. & Wu, C. CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. J. Cell Biol. 160, 1001-1008 (2003).
-
(2003)
J. Cell Biol.
, vol.160
, pp. 1001-1008
-
-
Fukuda, T.1
Guo, L.2
Shi, X.3
Wu, C.4
-
79
-
-
4744340477
-
Distinct roles of two structurally closely related focal adhesion proteins, α-parvins and β-parvins, in regulation of cell morphology and survival
-
Zhang, Y., Chen, K., Tu, Y. & Wu, C. Distinct roles of two structurally closely related focal adhesion proteins, α-parvins and β-parvins, in regulation of cell morphology and survival. J. Biol. Chem. 279, 41695-41705 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41695-41705
-
-
Zhang, Y.1
Chen, K.2
Tu, Y.3
Wu, C.4
-
80
-
-
0037115611
-
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites
-
Zhang, Y. et al. Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J. Cell Sci. 115, 4777-4786 (2002).
-
(2002)
J. Cell Sci.
, vol.115
, pp. 4777-4786
-
-
Zhang, Y.1
-
81
-
-
0036673109
-
Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex
-
Guo, L. & Wu, C. Regulation of fibronectin matrix deposition and cell proliferation by the PINCH-ILK-CH-ILKBP complex. FASEB J. 16, 1298-1300 (2002).
-
(2002)
FASEB J.
, vol.16
, pp. 1298-1300
-
-
Guo, L.1
Wu, C.2
-
82
-
-
0035968234
-
Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions
-
Nikolopoulos, S. N. & Turner, C. E. Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions. J. Biol. Chem. 276, 23499-23505 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 23499-23505
-
-
Nikolopoulos, S.N.1
Turner, C.E.2
-
83
-
-
0028057613
-
Disruption of epithelial cell-matrix interactions induces apoptosis
-
Frish, S. M. & Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124, 619-626 (1984).
-
(1984)
J. Cell Biol.
, vol.124
, pp. 619-626
-
-
Frish, S.M.1
Francis, H.2
-
84
-
-
0027752979
-
A link between cyclin A expression and adhesion-dependent cell cycle progression
-
Guadagno, T. M., Ohtsubo, M., Roberts, J. M. & Assoian, R. K. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262, 1572-1575 (1993).
-
(1993)
Science
, vol.262
, pp. 1572-1575
-
-
Guadagno, T.M.1
Ohtsubo, M.2
Roberts, J.M.3
Assoian, R.K.4
-
85
-
-
0029876639
-
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
-
Zhu, X., Ohtsubo, M., Bohmer, R. M., Roberts, J. M. & Assoian, R. K. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J.Cell Biol. 133, 391-403 (1996).
-
(1996)
J.Cell Biol.
, vol.133
, pp. 391-403
-
-
Zhu, X.1
Ohtsubo, M.2
Bohmer, R.M.3
Roberts, J.M.4
Assoian, R.K.5
-
86
-
-
0034692686
-
The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways
-
D'Amico, M. et al. The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3β and cAMP-responsive element-binding protein-dependent pathways. J. Biol. Chem. 275, 32649-32657 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 32649-32657
-
-
D'Amico, M.1
-
87
-
-
0030786162
-
Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase
-
Li, F., Liu, J., Mayne, R. & Wu, C. Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim. Biophys. Acta 1358, 215-220 (1997).
-
(1997)
Biochim. Biophys. Acta
, vol.1358
, pp. 215-220
-
-
Li, F.1
Liu, J.2
Mayne, R.3
Wu, C.4
-
88
-
-
0038148536
-
Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes
-
Terpstra, L. et al. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J. Cell Biol. 162, 139-148 (2003).
-
(2003)
J. Cell Biol.
, vol.162
, pp. 139-148
-
-
Terpstra, L.1
-
89
-
-
0038323946
-
Integrin-linked kinase regulates chondrocyte shape and proliferation
-
Grashoff, C., Aszodi, A., Sakai, T., Hunziker, E. B. & Fassler, R. Integrin-linked kinase regulates chondrocyte shape and proliferation. EMBO Rep. 4, 432-138 (2003).
-
(2003)
EMBO Rep.
, vol.4
, pp. 432-1138
-
-
Grashoff, C.1
Aszodi, A.2
Sakai, T.3
Hunziker, E.B.4
Fassler, R.5
-
90
-
-
0032746701
-
Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner
-
Troussard, A. A., Tan, C., Yoganathan, T. N. & Dedhar, S. Cell-extracellular matrix interactions stimulate the AP-1 transcription factor in an integrin-linked kinase- and glycogen synthase kinase 3-dependent manner. Mol. Cell. Biol. 19, 7420-7427 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 7420-7427
-
-
Troussard, A.A.1
Tan, C.2
Yoganathan, T.N.3
Dedhar, S.4
-
91
-
-
2442702768
-
ILKAP regulates ILK signaling and inhibits anchorage-independent growth
-
Kumar, A. S., Naruszewicz, I., Wang, P., Leung-Hagesteijn, C. & Hannigan, G. E. ILKAP regulates ILK signaling and inhibits anchorage-independent growth. Oncogene 23, 3454-3461 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 3454-3461
-
-
Kumar, A.S.1
Naruszewicz, I.2
Wang, P.3
Leung-Hagesteijn, C.4
Hannigan, G.E.5
-
92
-
-
6344280968
-
Integrin-linked kinase (ILK) regulates the nuclear entry of the c-JUN coactivator αNAC and its coactivation potency
-
Quelo, I., Gauthier, C., Hannigan, G. E., Dedhar, S. & St-Arnaud, R. Integrin-linked kinase (ILK) regulates the nuclear entry of the c-JUN coactivator αNAC and its coactivation potency. J. Biol. Chem. 279, 43893-43899 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 43893-43899
-
-
Quelo, I.1
Gauthier, C.2
Hannigan, G.E.3
Dedhar, S.4
St-Arnaud, R.5
-
93
-
-
0037666792
-
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
-
Troussard, A. A. et al. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J. Biol. Chem. 278, 22374-22378 (2003). Genetic approach showing that ILK is essential for promoting phosphorylation of AKT on Ser473.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22374-22378
-
-
Troussard, A.A.1
-
94
-
-
0037315101
-
Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons
-
Gary, D. S., Milhavet, O., Camandola, S. & Mattson, M. P. Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. J. Neurochem. 84, 878-890 (2003).
-
(2003)
J. Neurochem.
, vol.84
, pp. 878-890
-
-
Gary, D.S.1
Milhavet, O.2
Camandola, S.3
Mattson, M.P.4
-
95
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson, K. M. & Anderson, N. G. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 14, 381-395 (2002).
-
(2002)
Cell Signal.
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
96
-
-
0036479113
-
Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-κS-dependent manner
-
Tan, C., Mui, A. & Dedhar, S. Integrin-linked kinase regulates inducible nitric oxide synthase and cyclooxygenase-2 expression in an NF-κS-dependent manner. J. Biol. Chem. 277, 3109-3116 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3109-3116
-
-
Tan, C.1
Mui, A.2
Dedhar, S.3
-
97
-
-
2342641439
-
Upregulation of IKKα/IKKβ by integrin-linked kinase is required for HER2/neu-induced NF-κB antiapoptotic pathway
-
Makino, K., Day, C. P., Wang, S. C., Li, Y. M. & Hung, M. C. Upregulation of IKKα/IKKβ by integrin-linked kinase is required for HER2/neu-induced NF-κB antiapoptotic pathway. Oncogene 23, 3883-3887 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 3883-3887
-
-
Makino, K.1
Day, C.P.2
Wang, S.C.3
Li, Y.M.4
Hung, M.C.5
-
98
-
-
0035977036
-
Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: Mechanism for ganglioside-induced apoptosis
-
Wang, X. Q., Sun, P. & Paller, A. S. Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis. J. Biol. Chem. 276, 44504-44511 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 44504-44511
-
-
Wang, X.Q.1
Sun, P.2
Paller, A.S.3
-
99
-
-
0037162291
-
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1
-
Hill, M. M., Feng, J. & Hemmings, B. A. Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. Curr. Biol. 12, 1251-1255 (2002).
-
(2002)
Curr. Biol.
, vol.12
, pp. 1251-1255
-
-
Hill, M.M.1
Feng, J.2
Hemmings, B.A.3
-
100
-
-
4644359805
-
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
-
Feng, J., Park, J., Cron, P., Hess, D. & Hemmings, B. A. Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J. Biol. Chem. 279, 41189-41196 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41189-41196
-
-
Feng, J.1
Park, J.2
Cron, P.3
Hess, D.4
Hemmings, B.A.5
-
101
-
-
0242266910
-
Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination
-
Chun, S. J., Rasband, M. N., Sidman, R. L., Habib, A. A. & Vartanian, T. Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination. J. Cell Biol. 163, 397-408 (2003).
-
(2003)
J. Cell Biol.
, vol.163
, pp. 397-408
-
-
Chun, S.J.1
Rasband, M.N.2
Sidman, R.L.3
Habib, A.A.4
Vartanian, T.5
-
102
-
-
0032516094
-
Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways
-
Novak, A. et al. Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways. Proc. Natl Acad. Sci. USA 95, 4374-4379 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 4374-4379
-
-
Novak, A.1
-
103
-
-
0031962084
-
Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity
-
Wu, C. et al. Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity. J. Biol. Chem. 273, 528-536 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 528-536
-
-
Wu, C.1
-
104
-
-
0141720342
-
Role for integrin-linked kinase in mediating tubular epithelial to mesenchyma transition and renal interstitial fibrogenesis
-
Li, Y., Yang, J., Dai, C., Wu, C. & Liu, Y. Role for integrin-linked kinase in mediating tubular epithelial to mesenchyma transition and renal interstitial fibrogenesis. J. Clin. Invest. 112, 503-516 (2003).
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 503-516
-
-
Li, Y.1
Yang, J.2
Dai, C.3
Wu, C.4
Liu, Y.5
-
105
-
-
0035067120
-
Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells
-
Somasiri, A., Howarth, A., Goswami, D., Dedhar, S. & Roskelley, C. D. Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells. J. Cell Sci. 114, 1125-1136 (2001).
-
(2001)
J. Cell Sci.
, vol.114
, pp. 1125-1136
-
-
Somasiri, A.1
Howarth, A.2
Goswami, D.3
Dedhar, S.4
Roskelley, C.D.5
-
106
-
-
0035950544
-
Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice
-
White, D. E., Cardiff, R. D., Dedhar, S. & Muller, W. J. Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20, 7064-7072 (2001). This study provided in vivo demonstration that increased expression of ILK in breast epithelial cells promotes hyperplasia and tumour formation.
-
(2001)
Oncogene
, vol.20
, pp. 7064-7072
-
-
White, D.E.1
Cardiff, R.D.2
Dedhar, S.3
Muller, W.J.4
-
107
-
-
6044231839
-
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
-
Barbera, M. J. et al. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene 23, 7345-7354 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 7345-7354
-
-
Barbera, M.J.1
-
108
-
-
1642307942
-
Integrin-linked kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition
-
Lee, Y. I., Kwon, Y. J. & Joo, C. K. Integrin-linked kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition. Biochem. Biophys. Res. Commun. 316, 997-1001 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.316
, pp. 997-1001
-
-
Lee, Y.I.1
Kwon, Y.J.2
Joo, C.K.3
-
109
-
-
0036086409
-
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
-
Muraoka, R. S. et al. Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases. J. Clin. Invest. 109, 1551-1559 (2002).
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 1551-1559
-
-
Muraoka, R.S.1
-
110
-
-
0034676338
-
The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9)
-
Troussard, A. A. et al. The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9). Oncogene 19, 5444-5452 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 5444-5452
-
-
Troussard, A.A.1
-
111
-
-
0037439424
-
Interaction of αPIX (ARHGEF6) with β-parvin (PARVB) suggests an involvement of αPIX in integrin-mediated signaling
-
Rosenberger, G., Jantke, I., Gal, A. & Kutsche, K. Interaction of αPIX (ARHGEF6) with β-parvin (PARVB) suggests an involvement of αPIX in integrin-mediated signaling. Hum. Mol. Genet. 12, 155-167 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 155-167
-
-
Rosenberger, G.1
Jantke, I.2
Gal, A.3
Kutsche, K.4
-
112
-
-
0037103743
-
Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase
-
Muranyi, A. et al. Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. Biochem. J. 366, 211-216 (2002).
-
(2002)
Biochem. J.
, vol.366
, pp. 211-216
-
-
Muranyi, A.1
-
113
-
-
12144286634
-
Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and β-catenin-TCF/Lef signaling pathways
-
Xie, D. et al. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and β-catenin-TCF/Lef signaling pathways. Cancer Res. 64, 1987-1996 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 1987-1996
-
-
Xie, D.1
-
114
-
-
0034782943
-
Integrin-linked kinase expression increases with prostate tumor grade
-
Graff, J. R. et al. Integrin-linked kinase expression increases with prostate tumor grade. Clin. Cancer Res. 7, 1987-1991 (2001).
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1987-1991
-
-
Graff, J.R.1
-
115
-
-
0842308778
-
Integrin-linked kinase (ILK) expression in human colon cancer
-
Bravou, V., Klironomos, G., Papadaki, E., Stefanou, D. & Varakis, J. Integrin-linked kinase (ILK) expression in human colon cancer. Br. J. Cancer 89, 2340-2341 (2003).
-
(2003)
Br. J. Cancer
, vol.89
, pp. 2340-2341
-
-
Bravou, V.1
Klironomos, G.2
Papadaki, E.3
Stefanou, D.4
Varakis, J.5
-
116
-
-
0038604840
-
Characterisation of integrin-linked kinase signailing in sporadic human colon cancer
-
Marotta, A., Parhar, K., Owen, D., Dedhar, S. & Salh, B. Characterisation of integrin-linked kinase signailing in sporadic human colon cancer. Br. J. Cancer 88, 1755-1762 (2003).
-
(2003)
Br. J. Cancer
, vol.88
, pp. 1755-1762
-
-
Marotta, A.1
Parhar, K.2
Owen, D.3
Dedhar, S.4
Salh, B.5
-
117
-
-
0035959870
-
Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
-
Marotta, A. et al. Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene 20, 6250-6257 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 6250-6257
-
-
Marotta, A.1
-
118
-
-
0037295608
-
Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma
-
Ito, R. et al. Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma. Virchows Arch. 442, 118-123 (2003).
-
(2003)
Virchows Arch.
, vol.442
, pp. 118-123
-
-
Ito, R.1
-
119
-
-
0141995796
-
Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritonea tumour fluid
-
Ahmed, N. et al. Integrin-linked kinase expression increases with ovarian tumour grade and is sustained by peritonea tumour fluid. J. Pathol. 201, 229-237 (2003).
-
(2003)
J. Pathol.
, vol.201
, pp. 229-237
-
-
Ahmed, N.1
-
120
-
-
1842531077
-
Cell-free 59 kDa immunoreactive integrin-linked kinase: A novel marker for ovarian carcinoma
-
Ahmed, N., Oliva, K., Rice, G. E. &, Quinn, M. A. Cell-free 59 kDa immunoreactive integrin-linked kinase: a novel marker for ovarian carcinoma. Clin. Cancer Res. 10, 2415-2420 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 2415-2420
-
-
Ahmed, N.1
Oliva, K.2
Rice, G.E.3
Quinn, M.A.4
-
121
-
-
0031595969
-
ILK (β1-integrin-linked protein kinase): A novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour
-
Chung, D. H. et al. ILK (β1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumour. Virchows Arch. 433, 113-117 (1998).
-
(1998)
Virchows Arch.
, vol.433
, pp. 113-117
-
-
Chung, D.H.1
-
122
-
-
4143113653
-
Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase
-
Chen, P., Shen, W. Z. & Karnik, P. Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase. Int. J. Cancer 111, 881-891 (2004).
-
(2004)
Int. J. Cancer
, vol.111
, pp. 881-891
-
-
Chen, P.1
Shen, W.Z.2
Karnik, P.3
-
123
-
-
0036771764
-
Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway
-
Di-Poi, N., Tan, N. S., Michalik, L., Wahli, W. & Desvergne, B. Antiapoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol. Cell 10, 721-733 (2002).
-
(2002)
Mol. Cell
, vol.10
, pp. 721-733
-
-
Di-Poi, N.1
Tan, N.S.2
Michalik, L.3
Wahli, W.4
Desvergne, B.5
-
124
-
-
0033615352
-
PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
-
He, T. C., Chan, T. A., Vogelstein, B. & Kinzler, K. W. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99, 335-345 (1999).
-
(1999)
Cell
, vol.99
, pp. 335-345
-
-
He, T.C.1
Chan, T.A.2
Vogelstein, B.3
Kinzler, K.W.4
-
125
-
-
0035956850
-
Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells
-
Park, B. H., Vogelstein, B. & Kinzler, K. W. Genetic disruption of PPARδ decreases the tumorigenicity of human colon cancer cells. Proc. Natl Acad. Sci. USA 98, 2598-2603 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 2598-2603
-
-
Park, B.H.1
Vogelstein, B.2
Kinzler, K.W.3
-
126
-
-
1942470331
-
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth
-
Gupta, R. A. et al. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth. Nature Med. 10, 245-247 (2004).
-
(2004)
Nature Med.
, vol.10
, pp. 245-247
-
-
Gupta, R.A.1
-
127
-
-
2342640982
-
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines
-
Stephen, R. L. et al. Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines. Cancer Res. 64, 3162-3170 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 3162-3170
-
-
Stephen, R.L.1
-
128
-
-
4143127943
-
Overexpression of hyperactive integrin-linked kinase leads to increased ceuular radiosensitivity
-
Cordes, N. Overexpression of hyperactive integrin-linked kinase leads to increased ceuular radiosensitivity. Cancer Res. 64, 5683-5692 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 5683-5692
-
-
Cordes, N.1
-
129
-
-
2942694338
-
Integrin-linked kinase (ILK) in combination molecular targeting
-
Edwards, L. A., Shabbits, J. A., Bally, M. & Dedhar, S. Integrin-linked kinase (ILK) in combination molecular targeting. Cancer Treat. Res. 119, 59-75 (2004).
-
(2004)
Cancer Treat. Res.
, vol.119
, pp. 59-75
-
-
Edwards, L.A.1
Shabbits, J.A.2
Bally, M.3
Dedhar, S.4
-
130
-
-
5144226211
-
PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients
-
Nagata, Y. et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 6, 117-127 (2004).
-
(2004)
Cancer Cell
, vol.6
, pp. 117-127
-
-
Nagata, Y.1
-
131
-
-
0037850992
-
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo
-
Lin, X., Qadota, H., Moerman, D. G. & Williams, B. D. C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo. Curr. Biol. 13, 922-932 (2003).
-
(2003)
Curr. Biol.
, vol.13
, pp. 922-932
-
-
Lin, X.1
Qadota, H.2
Moerman, D.G.3
Williams, B.D.4
-
132
-
-
19944411156
-
Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumour growth
-
in the press
-
Edwards, L. et al. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumour growth. Oncogene (in the press).
-
Oncogene
-
-
Edwards, L.1
-
133
-
-
11144230947
-
Inhibition of integrin-linked kinase(ILK) by a selective small molecule inhibitor, QLT054 inhibits the PI3K/PKB/mTOR, STAT-3 and FKHR pathways, tumour growth and enhances gemdtabine-induced apoptosis in human primary pancreatic cancer xenografts
-
in the press
-
Yau, C. et al. Inhibition of integrin-linked kinase(ILK) by a selective small molecule inhibitor, QLT054 inhibits the PI3K/PKB/mTOR, STAT-3 and FKHR pathways, tumour growth and enhances gemdtabine-induced apoptosis in human primary pancreatic cancer xenografts. Cancer Res. (in the press).
-
Cancer Res.
-
-
Yau, C.1
|