Role of Expression of Focal Adhesion Kinase in Progression of Hepatocellular Carcinoma

Clinical Cancer Research

Volumn 10, Issue 8, 2004, Pages 2812-2817

  Itoh, Shinji ^a   Maeda, Takashi ^a   Shimada, Mitsuo ^a   Aishima, Shin Ichi ^a   Shirabe, Ken ^a   Tanaka, Shinji ^a   Maehara, Yoshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AGED; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DISEASE PROGRESSION; FEMALE; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTEIN-TYROSINE KINASES; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 1942534181     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-1046-03     Document Type: Article

References (38)

1. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease study. Lancet 1997;349:1269-76.
2. Simonetti RG, Camma C, Fiorello F, et al. Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig Dis Sci 1991;36:962-72.
3. Scudamore CH, Ragaz J, Kluftinger AM, Owen DA. Hepatocellular carcinoma: a comparison of oriental and Caucasian patients. Am J Surg 1988;155:659-62.
4. The Liver Cancer Study Group of Japan. Primary liver cancer in Japan. Clinicopathologic features and results of surgical treatment. Ann Surg 1990;211:277-87.
5. Yamanaka N, Okamoto E, Toyosaka A, et al. Prognostic factor after hepatectomy for hepatocellular carcinomas. A univariate and multivariate analysis. Cancer (Phila) 1990;65:1104-10.
6. Kornberg LJ, Earp HS, Parsons JT, Schaller M, Juliano RL. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem 1992;267:23439-42.
7. Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science (Wash DC) 1995;268:233-9.
8. Sieg DJ, Hauck CR, Ilic D, et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2000;2:249-56.
9. Hungerford JE, Compton MT, Matter ML, Hoffstrom BG, Otey CA. Inhibition of pp125 FAK in cultured fibroblasts results in apoptosis. J Cell Biol 1996;135:1383-90.
10. Xu LH, Owens LV, Sturge GC, et al. Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 1996;7:413-8.
11. Ilic D, Almeida EA, Schlaepfer DD, et al. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis. J Cell Biol 1998;143:547-60.
12. Xing Z, Chen HC, Nowlen JK, et al. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. Mol Biol Cell 1994;5:413-21.
13. Cobb BS, Schaller MD, Leu TH, Parsons JT. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol 1994;14:147-55.
14. Schaller MD, Hildebrand JD, Shannon JD, et al. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol Cell Biol 1994;14:1680-8.
15. Chan PY, Kanner SB, Whitney G, Aruffo A. A transmembrane-anchored chimeric focal adhesion kinase is constitutively activated and phosphorylated at tyrosine residues identical to pp125FAK. J Biol Chem 1994;269:20567-74.
16. Chen HC, Guan JL. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 1994;91:10148-52.
17. Zhang X, Chattopadhyay A, Ji QS, et al. Focal adhesion kinase promotes phospholipase C-γ1 activity. Proc Natl Acad Sci USA 1999;96:9021-6.
18. Han DC, Guan JL. Association of focal adhesion kinase with Grb7 and its role in cell migration. J Biol Chem 1999;274:24425-30.
19. Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993;342:1024-5.
20. Owens LV, Xu L, Craven RJ, et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 1995;55:2752-5.
21. Kornberg LJ. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck 1998;20:745-52.
22. Cance WG, Harris JE, Iacocca MV, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res 2000;6:2417-23.
23. Judson PL, He X, Cance WG, Van Le L. Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer (Phila) 1999;86:1551-6.
24. Tanaka S, Mori M, Akiyoshi T, et al. A novel variant of human Grb7 is associated with invasive esophageal carcinoma. J Clin Investig 1998;102:821-7.
25. Masuda T-a, Inoue H, Sonoda H, et al. Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res 2002;62:3819-25.
26. The Liver Cancer Study Group of Japan. The general rules for clinical and pathological study of primary liver cancer, 4th ed. Tokyo: Kanehara Co. Ltd.; 2000.
27. The Liver Cancer Study Group of Japan. Predictive factors for long-term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer (Phila) 1994;74:2772-80.
28. Masutani S, Sasaki Y, Imaoka S, et al. The prognostic significance of surgical margin in liver resection of patients with hepatocellular carcinoma. Arch Surg 1994;129:1025-30.
29. Jwo SC, Chiu JH, Chau GY, Loong CC, Lin WY. Risk factors linked to tumor recurrence of human hepatocellular carcinoma after hepatic resection. Hepatology 1992;16:1367-71.
30. Okada S, Shimada K, Yamamoto J, et al. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 1994;106:1618-24.
31. Sasaki Y, Imaoka S, Ishiguro S, et al. Clinical features of small hepatocellular carcinomas as assessed by histologic grades. Surgery 1996;119:252-60.
32. Shirabe K, Shimada M, Kajiyama K, et al. Clinicopathologic features of patients with hepatocellular carcinoma survivng > 10 years after hepatic resection. Cancer (Phila) 1998;83:2312-6.
33. Adachi E, Maeda T, Matsumata T, et al. Risk factors for intrahepatic recurrence in human small hepatocellular carcinoma. Gastroenterology 1995;108:768-75.
34. Schneider GB, Kurago Z, Zaharias R, et al. Elevated focal adhesion kinase expression facilitates oral tumor cell invasion. Cancer (Phila.) 2002;95:2508-15.
35. Lark AL, Livasy CA, Calvo B, et al. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res 2003;9:215-22.
36. Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium. Cancer Res 1982;42:3853-63.
37. Owen JD, Ruest PJ, Fry DW, Hanks SK. Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of pyk2. Mol Cell Biol 1999;19:4806-18.
38. 1, is necessary for the matrix-dependent activation of FAK and MAP kinase and the migration of human hepatocarcinoma cells. Hepatology 2001;34:42-9.