E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors

Human Gene Therapy

Volumn 12, Issue 3, 2001, Pages 219-226

  Habib, N A ^a   Sarraf, C E ^a   Mitry, R R ^a   Havlik R ^a   Nicholls, J ^a   Kelly, M ^a   Vernon, C C ^a   Gueret Wardle, D ^a   El Masry, R ^b   Salama, H ^c   Ahmed, R ^c   Michail, N ^d   Edward, E ^d   Jensen, S L ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b El Hyatt Hospital   (Egypt)

^c CAIRO UNIVERSITY   (Egypt)

^d THEODOR BILHARZ RESEARCH INSTITUTE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; GENE PRODUCT; PROTEIN DL1520; UNCLASSIFIED DRUG;

ADENOVIRUS; ADULT; AGED; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GENE THERAPY; HUMAN; LIVER TUMOR; MALE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; TOXICITY TESTING; VIRUS RECOMBINANT;

ADENOVIRIDAE; ADENOVIRUS E1B PROTEINS; ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL NUCLEUS; CHROMATIN; COMBINED MODALITY THERAPY; CYTOPLASM; FEMALE; FLUOROURACIL; GENE DELETION; GENE THERAPY; HUMANS; LIVER NEOPLASMS; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; NECROSIS; NEOPLASM METASTASIS;

ADENOVIRIDAE;

EID: 0035835373     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340150218369     Document Type: Article

References (21)

1. Apoptosis as a gene-directed program of cell death
2. Adenovirus proteins from both E1B reading frames are required for the transformation of rodent cells by viral infection and DNA transfection
3. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
4. The molecular genetics of cancer
5. Phase II trial of intratumoral injection with an E1B-deleted adenovirus in patients with recurrent refractory head and neck cancer
6. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
7. Stepwise dismantling of adenovirus 2 during entry into cells
8. p53-dependent cell death/apoptosis is required for a productive adenovirus infection
9. p53-independent and dependent requirements for E1B-55K in adenovirus type 5 replication
10. Targeting the replication of adenoviral gene therapy vectors to lung cancer cells: The importance of the adenoviral E1b-55kD gene
11. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
12. Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumor efficacy
13. ONYX-015: Clinical data are encouraging
14. Killing tumor cells with viruses - A question of specificity
15. Progress of the smart bomb cancer virus
16. Replication of ONYX-015, a potential anticancer adenovirus, is independent of p53 status in tumor cells
17. Studies on the use of viruses in the treatment of carcinoma of the cervix
18. Adenovirus-mediated p53 gene transfer in advanced non-small-cell cancer
19. p53 selective and nonselective replication of an E1B-deleted adenovirus in hepatocellular carcinoma
20. A retrospective study of the natural history of patients with liver metastases from colorectal cancer
21. Cell death is a new classification separating apoptosis from necrosis