메뉴 건너뛰기




Volumn 93, Issue SPEC. ISS. APR., 2006, Pages 31-40

PI3K and mTOR signalling pathways: Perspectives for rapamycin and its derivatives as antineoplastic targeted therapies;Voies de signalisation de la PI3K et de mTOR: Perspectives de l'utilisation de la rapamycine et de ses dérivés en thérapie antitumorale ciblée

Author keywords

mTOR; PI3K; Rapamycine; Targeted therapies

Indexed keywords

ANTINEOPLASTIC AGENT; AP 23573; EVEROLIMUS; HETERODIMER; IMMUNOSUPPRESSIVE AGENT; MACROLIDE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAPAMYCIN; TEMSIROLIMUS;

EID: 33745459302     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (2)

References (90)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: Its discovery, biological properties, and mechanism of action
    • Sehgal SN. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc 2003; 35: 7S-14S.
    • (2003) Transplant Proc , vol.35
    • Sehgal, S.N.1
  • 3
    • 0038335334 scopus 로고    scopus 로고
    • PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling
    • Paez J, Sellers WR. PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. Cancer Treat Res 2003; 115: 145-67.
    • (2003) Cancer Treat Res , vol.115 , pp. 145-167
    • Paez, J.1    Sellers, W.R.2
  • 4
    • 0034107671 scopus 로고    scopus 로고
    • Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
    • Borlado LR, Redondo C, Alvarez B, et al. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J 2000; 14: 895-903.
    • (2000) FASEB J , vol.14 , pp. 895-903
    • Borlado, L.R.1    Redondo, C.2    Alvarez, B.3
  • 5
    • 0038615946 scopus 로고    scopus 로고
    • Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo
    • Choe G, Horvath S, Cloughesy TF, et al. Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 2003; 63: 2742-6.
    • (2003) Cancer Res , vol.63 , pp. 2742-2746
    • Choe, G.1    Horvath, S.2    Cloughesy, T.F.3
  • 6
    • 0037019186 scopus 로고    scopus 로고
    • Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells
    • Neve RM, Holbro T, Hynes NE. Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells. Oncogene 2002; 21: 4567-76.
    • (2002) Oncogene , vol.21 , pp. 4567-4576
    • Neve, R.M.1    Holbro, T.2    Hynes, N.E.3
  • 7
    • 0035886016 scopus 로고    scopus 로고
    • The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors
    • Philp AJ, Campbell IG, Leet C, et al. The phosphatidylinositol 3′-kinase p85alpha gene is an oncogene in human ovarian and colon tumors. Cancer Res 2001; 61: 7426-9.
    • (2001) Cancer Res , vol.61 , pp. 7426-7429
    • Philp, A.J.1    Campbell, I.G.2    Leet, C.3
  • 8
    • 0036479747 scopus 로고    scopus 로고
    • Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival
    • Grant S, Qiao L, Dent P. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival. Front Biosci 2002; 7: 376-89.
    • (2002) Front Biosci , vol.7 , pp. 376-389
    • Grant, S.1    Qiao, L.2    Dent, P.3
  • 9
    • 0033628571 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase dependent pathways: The role in control of cell growth, survival, and malignant transformation
    • Krasilnikov MA. Phosphatidylinositol-3 kinase dependent pathways: the role in control of cell growth, survival, and malignant transformation. Biochemistry 2000; 65: 59-67.
    • (2000) Biochemistry , vol.65 , pp. 59-67
    • Krasilnikov, M.A.1
  • 10
    • 0036007421 scopus 로고    scopus 로고
    • Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
    • Kozma SC, Thomas G. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioassays 2002; 24: 65-71.
    • (2002) Bioassays , vol.24 , pp. 65-71
    • Kozma, S.C.1    Thomas, G.2
  • 11
    • 10744230205 scopus 로고    scopus 로고
    • MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells
    • Mhashilkar AM, Stewart AL, Sieger K, et al. MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells. Mol Ther 2003; 8: 207-19.
    • (2003) Mol Ther , vol.8 , pp. 207-219
    • Mhashilkar, A.M.1    Stewart, A.L.2    Sieger, K.3
  • 12
    • 0036320205 scopus 로고    scopus 로고
    • Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    • Edinger AL, Thompson CB. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell 2002; 13: 2276-88.
    • (2002) Mol Biol Cell , vol.13 , pp. 2276-2288
    • Edinger, A.L.1    Thompson, C.B.2
  • 13
    • 0032402201 scopus 로고    scopus 로고
    • Deletions in the long arm of chromosome 10 in lymphomas with t (14; 18): A pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1?
    • Siebert R, Gesk S, Harder S, et al. Deletions in the long arm of chromosome 10 in lymphomas with t (14; 18): a pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1? Blood 1998; 92: 4487-9.
    • (1998) Blood , vol.92 , pp. 4487-4489
    • Siebert, R.1    Gesk, S.2    Harder, S.3
  • 14
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • Liaw D, Marsh DJ, Li J, et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997; 16: 64-7.
    • (1997) Nat Genet , vol.16 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3
  • 15
    • 6844252284 scopus 로고    scopus 로고
    • Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
    • Marsh DJ, Coulon V, Lunetta KL, et al. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum Mol Genet 1998; 7: 507-15.
    • (1998) Hum Mol Genet , vol.7 , pp. 507-515
    • Marsh, D.J.1    Coulon, V.2    Lunetta, K.L.3
  • 16
    • 0032403139 scopus 로고    scopus 로고
    • Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis
    • Davies MA, Lu Y, Sano T, et al. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res 1998; 58: 5285-90.
    • (1998) Cancer Res , vol.58 , pp. 5285-5290
    • Davies, M.A.1    Lu, Y.2    Sano, T.3
  • 17
    • 17944377486 scopus 로고    scopus 로고
    • Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
    • Neshat MS, Mellinghoff IK, Tran C, et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci USA 2001; 98: 10314-9.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10314-10319
    • Neshat, M.S.1    Mellinghoff, I.K.2    Tran, C.3
  • 18
    • 0029118603 scopus 로고
    • Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
    • Ui M, Okada T, Hazeki K, et al. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem Sci 1995; 20: 303-7.
    • (1995) Trends Biochem Sci , vol.20 , pp. 303-307
    • Ui, M.1    Okada, T.2    Hazeki, K.3
  • 19
    • 0030250021 scopus 로고    scopus 로고
    • Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events
    • Hazeki O, Hazeki K, Katada T, et al. Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events. J Lipid Mediat Cell Signal 1996; 14: 259-61.
    • (1996) J Lipid Mediat Cell Signal , vol.14 , pp. 259-261
    • Hazeki, O.1    Hazeki, K.2    Katada, T.3
  • 20
    • 0028950217 scopus 로고
    • Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
    • Sabers CJ, Martin MM, Brunn GJ, et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995; 270: 815-22.
    • (1995) J Biol Chem , vol.270 , pp. 815-822
    • Sabers, C.J.1    Martin, M.M.2    Brunn, G.J.3
  • 21
    • 0028825698 scopus 로고
    • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
    • Lorenz MC, Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem 1995; 270: 27531-7.
    • (1995) J Biol Chem , vol.270 , pp. 27531-27537
    • Lorenz, M.C.1    Heitman, J.2
  • 22
    • 0029418483 scopus 로고
    • Mechanism of action of rapamycin: New insights into the regulation of G1-phase progression in eukaryotic cells
    • Wiederrecht GJ, Sabers CJ, Brunn GJ, et al. Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells. Prog Cell Cycle Res 1995; 1: 53-71.
    • (1995) Prog Cell Cycle Res , vol.1 , pp. 53-71
    • Wiederrecht, G.J.1    Sabers, C.J.2    Brunn, G.J.3
  • 23
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Dos Sarbassov D, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14: 1296-302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Dos Sarbassov, D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6
  • 24
    • 0035798097 scopus 로고    scopus 로고
    • Mammalian TOR: A homeostatic ATP sensor
    • Dennis PB, Jaeschke A, Saitoh M, et al. Mammalian TOR: a homeostatic ATP sensor. Science 2001; 294: 1102-5.
    • (2001) Science , vol.294 , pp. 1102-1105
    • Dennis, P.B.1    Jaeschke, A.2    Saitoh, M.3
  • 25
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway
    • Gingras AC, Kennedy SG, O'Leary MA, et al. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Dev 1998; 12: 502-13.
    • (1998) Genes Dev , vol.12 , pp. 502-513
    • Gingras, A.C.1    Kennedy, S.G.2    O'Leary, M.A.3
  • 26
    • 0032849890 scopus 로고    scopus 로고
    • Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
    • Heesom KJ, Denton RM. Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase. FEBS Lett 1999; 457: 489-93.
    • (1999) FEBS Lett , vol.457 , pp. 489-493
    • Heesom, K.J.1    Denton, R.M.2
  • 27
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K, Yonezawa K, Weng QP, et al. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 1998; 273: 14484-94.
    • (1998) J Biol Chem , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3
  • 28
    • 0037145807 scopus 로고    scopus 로고
    • ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling
    • McLeod LE, Proud CG. ATP depletion increases phosphorylation of elongation factor eEF2 in adult cardiomyocytes independently of inhibition of mTOR signalling. FEBS Lett 2002; 531: 448-52.
    • (2002) FEBS Lett , vol.531 , pp. 448-452
    • McLeod, L.E.1    Proud, C.G.2
  • 29
    • 85047697574 scopus 로고    scopus 로고
    • A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis
    • Li B, Desai SA, MacCorkle-Chosnek RA, et al. A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis. Gene Ther 2002; 9: 233-44.
    • (2002) Gene Ther , vol.9 , pp. 233-244
    • Li, B.1    Desai, S.A.2    MacCorkle-Chosnek, R.A.3
  • 30
    • 18444416812 scopus 로고    scopus 로고
    • Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
    • Castedo M, Roumier T, Blanco J, et al. Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J 2002; 21: 4070-80.
    • (2002) EMBO J , vol.21 , pp. 4070-4080
    • Castedo, M.1    Roumier, T.2    Blanco, J.3
  • 31
    • 0032911889 scopus 로고    scopus 로고
    • Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70 (S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts
    • Takuwa N, Fukui Y, Takuwa Y. Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70 (S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts. Mol Cell Biol 1999; 19: 1346-58.
    • (1999) Mol Cell Biol , vol.19 , pp. 1346-1358
    • Takuwa, N.1    Fukui, Y.2    Takuwa, Y.3
  • 32
    • 0037179847 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
    • Pene F, Claessens YE, Muller O, et al. Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 2002; 21: 6587-97.
    • (2002) Oncogene , vol.21 , pp. 6587-6597
    • Pene, F.1    Claessens, Y.E.2    Muller, O.3
  • 33
    • 0035145602 scopus 로고    scopus 로고
    • Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells
    • Xu G, Kwon G, Cruz WS, et al. Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic beta-cells. Diabetes 2001; 50: 353-60.
    • (2001) Diabetes , vol.50 , pp. 353-360
    • Xu, G.1    Kwon, G.2    Cruz, W.S.3
  • 34
    • 0037039358 scopus 로고    scopus 로고
    • A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    • Tang SJ, Reis G, Kang H, et al. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci USA 2002; 99: 467-72.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 467-472
    • Tang, S.J.1    Reis, G.2    Kang, H.3
  • 35
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot 1975; 28: 721-6.
    • (1975) J Antibiot , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 36
    • 0018606537 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. IV Mechanism of action
    • Singh K, Sun S, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic. IV Mechanism of action. J Antibiot 1979; 32: 630-45.
    • (1979) J Antibiot , vol.32 , pp. 630-645
    • Singh, K.1    Sun, S.2    Vezina, C.3
  • 37
    • 0018101547 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation
    • Baker H, Sidorowicz A, Sehgal SN, et al. Rapamycin (AY-22,989), a new antifungal antibiotic. III. In vitro and in vivo evaluation. J Antibiot 1978; 31: 539-45.
    • (1978) J Antibiot , vol.31 , pp. 539-545
    • Baker, H.1    Sidorowicz, A.2    Sehgal, S.N.3
  • 38
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J Antibiot 1975; 28: 727-32.
    • (1975) J Antibiot , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 39
    • 0028923877 scopus 로고
    • FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells
    • Fruman DA, Wood MA, Gjertson CK, et al. FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells. Eur J Immunol 1995; 25: 563-71.
    • (1995) Eur J Immunol , vol.25 , pp. 563-571
    • Fruman, D.A.1    Wood, M.A.2    Gjertson, C.K.3
  • 40
    • 0027430173 scopus 로고
    • Therapeutic monitoring of rapamycin: A new immunosuppressive drug
    • Yatscoff RW, LeGatt DF, Kneteman NM. Therapeutic monitoring of rapamycin: a new immunosuppressive drug. Ther Drug Monit 1993; 15: 478-82.
    • (1993) Ther Drug Monit , vol.15 , pp. 478-482
    • Yatscoff, R.W.1    LeGatt, D.F.2    Kneteman, N.M.3
  • 41
    • 0027280944 scopus 로고
    • Effect of a short course of rapamycin, cyclosporin A, and donor-specific transfusion on rat cardiac allograft survival
    • Davies CB, Madden RL, Alexander JW, et al. Effect of a short course of rapamycin, cyclosporin A, and donor-specific transfusion on rat cardiac allograft survival. Transplantation 1993; 55: 1102-7.
    • (1993) Transplantation , vol.55 , pp. 1102-1107
    • Davies, C.B.1    Madden, R.L.2    Alexander, J.W.3
  • 42
    • 0027162462 scopus 로고
    • Optimization of cyclosporine therapy
    • Kahan BD. Optimization of cyclosporine therapy. Transplant Proc 1993; 25: 5-9.
    • (1993) Transplant Proc , vol.25 , pp. 5-9
    • Kahan, B.D.1
  • 43
    • 0032128447 scopus 로고    scopus 로고
    • Rapamycin: Distribution, pharmacokinetics and therapeutic range investigations: An update
    • Trepanier DJ, Gallant H, Legatt DF, et al. Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update. Clin Biochem 1998; 31: 345-51.
    • (1998) Clin Biochem , vol.31 , pp. 345-351
    • Trepanier, D.J.1    Gallant, H.2    Legatt, D.F.3
  • 44
    • 0027268303 scopus 로고
    • Effects of rapamycin in experimental organ allografting
    • Ochiai T, Gunji Y, Nagata M, et al. Effects of rapamycin in experimental organ allografting. Transplantation 1993; 56: 15-9.
    • (1993) Transplantation , vol.56 , pp. 15-9
    • Ochiai, T.1    Gunji, Y.2    Nagata, M.3
  • 45
    • 18244423842 scopus 로고    scopus 로고
    • Effect of tacrolimus (FK506) and sirolimus (rapamycin) mono- and combination therapy in prolongation of renal allograft survival in the monkey
    • Qi S, Xu D, Peng J, et al. Effect of tacrolimus (FK506) and sirolimus (rapamycin) mono- and combination therapy in prolongation of renal allograft survival in the monkey. Transplantation 2000; 69: 1275-83.
    • (2000) Transplantation , vol.69 , pp. 1275-1283
    • Qi, S.1    Xu, D.2    Peng, J.3
  • 46
    • 0033609090 scopus 로고    scopus 로고
    • Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle
    • Gallo R, Padurean A, Jayaraman T, et al. Inhibition of intimal thickening after balloon angioplasty in porcine coronary arteries by targeting regulators of the cell cycle. Circulation 1999; 99: 2164-70.
    • (1999) Circulation , vol.99 , pp. 2164-2170
    • Gallo, R.1    Padurean, A.2    Jayaraman, T.3
  • 47
    • 0037961732 scopus 로고    scopus 로고
    • Use of rapamycin-impregnated stents in coronary arteries
    • Sousa JE, Sousa AG, Costa MA, et al. Use of rapamycin-impregnated stents in coronary arteries. Transplant Proc 2003; 35: 165S-170S.
    • (2003) Transplant Proc , vol.35
    • Sousa, J.E.1    Sousa, A.G.2    Costa, M.A.3
  • 48
    • 0029845013 scopus 로고    scopus 로고
    • Rapamycin inhibits vascular smooth muscle cell migration
    • Poon M, Marx SO, Gallo R, et al. Rapamycin inhibits vascular smooth muscle cell migration. J Clin Invest 1996; 98: 2277-83.
    • (1996) J Clin Invest , vol.98 , pp. 2277-2283
    • Poon, M.1    Marx, S.O.2    Gallo, R.3
  • 49
    • 0030756152 scopus 로고    scopus 로고
    • Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet-derived growth factor or endothelial cell growth factor
    • Mohacsi PJ, Tuller D, Hulliger B, et al. Different inhibitory effects of immunosuppressive drugs on human and rat aortic smooth muscle and endothelial cell proliferation stimulated by platelet-derived growth factor or endothelial cell growth factor. J Heart Lung Transplant 1997; 16: 484-92.
    • (1997) J Heart Lung Transplant , vol.16 , pp. 484-492
    • Mohacsi, P.J.1    Tuller, D.2    Hulliger, B.3
  • 50
    • 0028886999 scopus 로고
    • Rapamycin: Distribution, pharmacokinetics, and therapeutic range investigations
    • Yatscoff RW, Wang P, Chan K, et al. Rapamycin: distribution, pharmacokinetics, and therapeutic range investigations. Ther Drug Monit 1995; 17: 666-71.
    • (1995) Ther Drug Monit , vol.17 , pp. 666-671
    • Yatscoff, R.W.1    Wang, P.2    Chan, K.3
  • 51
    • 0029929678 scopus 로고    scopus 로고
    • Pharmacokinetics of rapamycin
    • Yatscoff RW. Pharmacokinetics of rapamycin. Transplant Proc 1996; 28: 970-3.
    • (1996) Transplant Proc , vol.28 , pp. 970-973
    • Yatscoff, R.W.1
  • 52
    • 0031001611 scopus 로고    scopus 로고
    • Clinically significant drug interactions with new immunosuppressive agents
    • Mignat C. Clinically significant drug interactions with new immunosuppressive agents. Drug Saf 1997; 16: 267-78.
    • (1997) Drug Saf , vol.16 , pp. 267-278
    • Mignat, C.1
  • 53
    • 0034870203 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of sirolimus
    • Mahalati K, Kahan BD. Clinical pharmacokinetics of sirolimus. Clin Pharmacokinet 2001; 40: 573-85.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 573-585
    • Mahalati, K.1    Kahan, B.D.2
  • 54
    • 0029922065 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients
    • Brattstrom C, Tyden G, Sawe J, et al. A randomized, double-blind, placebo-controlled study to determine safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients. Transplant Proc 1996; 28: 985-6.
    • (1996) Transplant Proc , vol.28 , pp. 985-986
    • Brattstrom, C.1    Tyden, G.2    Sawe, J.3
  • 55
    • 0035886032 scopus 로고    scopus 로고
    • Rapamycin: Clinical results and future opportunities
    • Kahan BD, Camardo JS. Rapamycin: clinical results and future opportunities. Transplantation 2001; 72: 1181-93.
    • (2001) Transplantation , vol.72 , pp. 1181-1193
    • Kahan, B.D.1    Camardo, J.S.2
  • 56
    • 0034786155 scopus 로고    scopus 로고
    • Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: A randomized controlled trial
    • Reitamo S, Spuls P, Sassolas B, et al. Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trial. Br J Dermatol 2001; 145: 438-45.
    • (2001) Br J Dermatol , vol.145 , pp. 438-445
    • Reitamo, S.1    Spuls, P.2    Sassolas, B.3
  • 57
    • 0029775645 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/p70 (S6)-kinase pathway induces B16 melanoma cell differentiation
    • Busca R, Bertolotto C, Ortonne JP, et al. Inhibition of the phosphatidylinositol 3-kinase/p70 (S6)-kinase pathway induces B16 melanoma cell differentiation. J Biol Chem 1996; 271: 31824-30.
    • (1996) J Biol Chem , vol.271 , pp. 31824-31830
    • Busca, R.1    Bertolotto, C.2    Ortonne, J.P.3
  • 58
    • 0021164348 scopus 로고
    • Activity of rapamycin (AY-22,989) against transplanted tumors
    • Eng CP, Sehgal SN, Vezina C. Activity of rapamycin (AY-22,989) against transplanted tumors. J Antibiot 1984; 37: 1231-7.
    • (1984) J Antibiot , vol.37 , pp. 1231-1237
    • Eng, C.P.1    Sehgal, S.N.2    Vezina, C.3
  • 59
    • 0033178702 scopus 로고    scopus 로고
    • Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells
    • Grewe M, Gansauge F, Schmid RM, et al. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res 1999; 59: 3581-7.
    • (1999) Cancer Res , vol.59 , pp. 3581-3587
    • Grewe, M.1    Gansauge, F.2    Schmid, R.M.3
  • 60
    • 0033557578 scopus 로고    scopus 로고
    • Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells
    • Hosoi H, Dilling MB, Shikata T, et al. Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. Cancer Res 1999; 59: 886-94.
    • (1999) Cancer Res , vol.59 , pp. 886-894
    • Hosoi, H.1    Dilling, M.B.2    Shikata, T.3
  • 61
    • 0028925744 scopus 로고
    • Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro
    • Shi Y, Frankel A, Radvanyi LG, et al. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res 1995; 55: 1982-8.
    • (1995) Cancer Res , vol.55 , pp. 1982-1988
    • Shi, Y.1    Frankel, A.2    Radvanyi, L.G.3
  • 62
    • 0035959805 scopus 로고    scopus 로고
    • Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase
    • Calastretti A, Bevilacqua A, Ceriani C, et al. Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase. Oncogene 2001; 20: 6172-80.
    • (2001) Oncogene , vol.20 , pp. 6172-6180
    • Calastretti, A.1    Bevilacqua, A.2    Ceriani, C.3
  • 63
    • 0036275356 scopus 로고    scopus 로고
    • Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling
    • Humar R, Kiefer FN, Berns H, et al. Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 2002; 16: 771-80.
    • (2002) FASEB J , vol.16 , pp. 771-780
    • Humar, R.1    Kiefer, F.N.2    Berns, H.3
  • 64
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8 : 128-35.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3
  • 65
    • 0035866358 scopus 로고    scopus 로고
    • Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy
    • Geoerger B, Kerr K, Tang CB, et al. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. Cancer Res 2001; 61: 1527-32.
    • (2001) Cancer Res , vol.61 , pp. 1527-1532
    • Geoerger, B.1    Kerr, K.2    Tang, C.B.3
  • 66
    • 0000375616 scopus 로고    scopus 로고
    • The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenograft in vivo
    • Gibbons JJ, Discafani C, Peterson R. The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenograft in vivo. Proc Am Assoc Cancer Res 2000; 40: 301.
    • (2000) Proc Am Assoc Cancer Res , vol.40 , pp. 301
    • Gibbons, J.J.1    Discafani, C.2    Peterson, R.3
  • 67
    • 12844270274 scopus 로고    scopus 로고
    • mTOR, a novel target in pancreatic cancer: The effect of CCI-779 in preclinical models
    • abstract 3886
    • Ito D, Fujimoto K, Doi R, et al. mTOR, a novel target in pancreatic cancer: The effect of CCI-779 in preclinical models. Proc Am Assoc Cancer Res 2004: 45; (abstract 3886).
    • (2004) Proc Am Assoc Cancer Res , pp. 45
    • Ito, D.1    Fujimoto, K.2    Doi, R.3
  • 68
    • 12844252844 scopus 로고    scopus 로고
    • Effects of the mTOR inhibitor CCI-779 used alone or during chemotherapy on human prostate cancer xenografts
    • abstract 3849
    • Wu L, Birle D, Tannock I. Effects of the mTOR inhibitor CCI-779 used alone or during chemotherapy on human prostate cancer xenografts. Proc Am Assoc Cancer Res 2004; 45; (abstract 3849).
    • (2004) Proc Am Assoc Cancer Res , vol.45
    • Wu, L.1    Birle, D.2    Tannock, I.3
  • 69
    • 18144406958 scopus 로고    scopus 로고
    • In vivo and in vitro effect of CCI-779 a rapamycin analogue on HNSCC
    • abstract 3688
    • Nathan C-A, Amirghahari N, Sibley D, et al. In vivo and in vitro effect of CCI-779 a rapamycin analogue on HNSCC. Proc Am Assoc Cancer Res 2004; 45; (abstract 3688).
    • (2004) Proc Am Assoc Cancer Res , vol.45
    • Nathan, C.-A.1    Amirghahari, N.2    Sibley, D.3
  • 70
    • 0034790016 scopus 로고    scopus 로고
    • mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001; 8: 249-58.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3
  • 72
    • 0036225178 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic
    • Huang S, Houghton PJ. Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr Opin Investig Drugs 2002; 3: 295-304.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 295-304
    • Huang, S.1    Houghton, P.J.2
  • 73
    • 0003166055 scopus 로고    scopus 로고
    • CCI-779, a rapamycin analog with antitumor activity: A phase I study utilizing a weekly schedule
    • abstract 728
    • Raymond E, Alexandre J, Depenbrock H, et al. CCI-779, a rapamycin analog with antitumor activity: a phase I study utilizing a weekly schedule. Proc Am Soc Clin Onco 2000; (abstract 728).
    • (2000) Proc Am Soc Clin Onco
    • Raymond, E.1    Alexandre, J.2    Depenbrock, H.3
  • 74
    • 0000183432 scopus 로고    scopus 로고
    • CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: A phase I study
    • abstract 726
    • Hidalgo M, Rowinsky EK, Erlichman C, et al. CCI-779, a rapamycin analog and multifaceted inhibitor of signal transduction: a phase I study. Proc Am Soc Clin Oncol 2000; 19; (abstract 726).
    • (2000) Proc Am Soc Clin Oncol , vol.19
    • Hidalgo, M.1    Rowinsky, E.K.2    Erlichman, C.3
  • 75
    • 2942735384 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
    • Raymond E, Alexandre J, Faivre S, et al. Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. J Clin Oncol 2004; 22: 2336-47.
    • (2004) J Clin Oncol , vol.22 , pp. 2336-2347
    • Raymond, E.1    Alexandre, J.2    Faivre, S.3
  • 76
    • 0041662261 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients
    • Peralba JM, DeGraffenried L, Friedrichs W, et al. Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clin Cancer Res 2003; 9: 2887-92.
    • (2003) Clin Cancer Res , vol.9 , pp. 2887-2892
    • Peralba, J.M.1    Degraffenried, L.2    Friedrichs, W.3
  • 77
    • 0030832514 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative: Pharmacological properties in vitro and in vivo
    • Schuler W, Sedrani R, Cottens S, et al. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation 1997; 64: 36-42.
    • (1997) Transplantation , vol.64 , pp. 36-42
    • Schuler, W.1    Sedrani, R.2    Cottens, S.3
  • 78
    • 0030814696 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative: Synergism with cyclosporine
    • Schuurman HJ, Cottens S, Fuchs S, et al. SDZ RAD, a new rapamycin derivative: synergism with cyclosporine. Transplantation 1997; 64: 32-5.
    • (1997) Transplantation , vol.64 , pp. 32-35
    • Schuurman, H.J.1    Cottens, S.2    Fuchs, S.3
  • 79
    • 0042804378 scopus 로고    scopus 로고
    • In vivo activity of RAD 001, an orally active rapamycin derivative, in experimental tumor models
    • abstract 359
    • O'Reilly T, Vaxelaire J, Muller M, et al. In vivo activity of RAD 001, an orally active rapamycin derivative, in experimental tumor models. Proc Am Assoc Cancer Res 2002: 43; (abstract 359).
    • (2002) Proc Am Assoc Cancer Res , vol.43
    • O'Reilly, T.1    Vaxelaire, J.2    Muller, M.3
  • 80
    • 0042303286 scopus 로고    scopus 로고
    • Antiangiogenetic activity of RAD 001, an orally active anticancer agent
    • abstract 922
    • Lane H, Schnell C, Theuer A, et al. Antiangiogenetic activity of RAD 001, an orally active anticancer agent. Proc Am Assoc Cancer Res 2002; 43; (abstract 922).
    • (2002) Proc Am Assoc Cancer Res , vol.43
    • Lane, H.1    Schnell, C.2    Theuer, A.3
  • 81
    • 0038054547 scopus 로고    scopus 로고
    • Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses
    • Majewski M, Korecka M, Joergensen J, et al. Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses. Transplantation 2003; 75: 1710-7.
    • (2003) Transplantation , vol.75 , pp. 1710-1717
    • Majewski, M.1    Korecka, M.2    Joergensen, J.3
  • 82
    • 0034636055 scopus 로고    scopus 로고
    • The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders
    • Majewski M, Korecka M, Kossev P, et al. The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: a potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc Natl Acad Sci USA 2000; 97: 4285-90.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 4285-4290
    • Majewski, M.1    Korecka, M.2    Kossev, P.3
  • 83
    • 0033610455 scopus 로고    scopus 로고
    • A phase I study of a 4-week course of SDZ-RAD (RAD) quiescent cyclosporine-prednisone-treated renal transplant recipients
    • Kahan BD, Wong RL, Carter C, et al. A phase I study of a 4-week course of SDZ-RAD (RAD) quiescent cyclosporine-prednisone-treated renal transplant recipients. Transplantation 1999; 68: 1100-6.
    • (1999) Transplantation , vol.68 , pp. 1100-1106
    • Kahan, B.D.1    Wong, R.L.2    Carter, C.3
  • 84
    • 18144397895 scopus 로고    scopus 로고
    • Structure-based design of AP23573, a phosphorus-containing analog of rapamycin for anti-tumor therapy
    • abstract 2476
    • Metcalf C, Bohacek R, Rozamus L, et al. Structure-based design of AP23573, a phosphorus-containing analog of rapamycin for anti-tumor therapy. Proc Am Assoc Cancer Res 2004; 45; (abstract 2476).
    • (2004) Proc Am Assoc Cancer Res , vol.45
    • Metcalf, C.1    Bohacek, R.2    Rozamus, L.3
  • 85
    • 12844258508 scopus 로고    scopus 로고
    • Anti-proliferative activity of the mTOR inhibitor AP23573 in combination with cytotoxic and targeted agents
    • abstract 3887
    • Rivera V, Tang H, Metcalf C, et al. Anti-proliferative activity of the mTOR inhibitor AP23573 in combination with cytotoxic and targeted agents. Proc Am Assoc Cancer Res 2004; 45; (abstract 3887).
    • (2004) Proc Am Assoc Cancer Res , vol.45
    • Rivera, V.1    Tang, H.2    Metcalf, C.3
  • 86
    • 16444379884 scopus 로고    scopus 로고
    • Bcl-2 and CCND1/CDK4 as molecular markers of the cellular effects of mTOR inhibitors in human ovarian carcinomas cells
    • Aguirre D, Boya P, Bellet D, et al. Bcl-2 and CCND1/CDK4 as molecular markers of the cellular effects of mTOR inhibitors in human ovarian carcinomas cells. Apoptosis 2004; 9: 797-805.
    • (2004) Apoptosis , vol.9 , pp. 797-805
    • Aguirre, D.1    Boya, P.2    Bellet, D.3
  • 87
    • 4243892438 scopus 로고    scopus 로고
    • The mTOR inhibitor, CCI-779, restores tamoxifen response in breast cancer cells with high Akt activity. Proc 14th NCI-EORTC-AACR symposium on molecular targets and cancer therapeutics
    • abstract 528
    • Degrafenried L, Friedrichs W, Fulcher L, et al. The mTOR inhibitor, CCI-779, restores tamoxifen response in breast cancer cells with high Akt activity. Proc 14th NCI-EORTC-AACR symposium on molecular targets and cancer therapeutics. Eur J Cancer 2002: S158; (abstract 528).
    • (2002) Eur J Cancer , vol.158
    • Degrafenried, L.1    Friedrichs, W.2    Fulcher, L.3
  • 88
    • 4544388665 scopus 로고    scopus 로고
    • The mTOR pathway in estrogen response: A potential for combining the rapamycin derivative RAD001 with the aromatase inhibitor Letrozole (Femara®) in breast carcinoma
    • abstract 5619
    • Rudloff J, Boulay A, Zumstein-Mecker S, et al. The mTOR pathway in estrogen response: A potential for combining the rapamycin derivative RAD001 with the aromatase inhibitor Letrozole (Femara®) in breast carcinoma. Proc Am Assoc Cancer Res 2004: 45; (abstract 5619).
    • (2004) Proc Am Assoc Cancer Res , vol.45
    • Rudloff, J.1    Boulay, A.2    Zumstein-Mecker, S.3
  • 89
    • 0037616593 scopus 로고    scopus 로고
    • Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
    • Bianco R, Shin I, Ritter CA, et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 2003; 22: 2812-22.
    • (2003) Oncogene , vol.22 , pp. 2812-2822
    • Bianco, R.1    Shin, I.2    Ritter, C.A.3
  • 90
    • 8344253460 scopus 로고    scopus 로고
    • Combination signal transduction inhibition: A phase I/II trial of the oral mTOR-inhibitor everolimus (RAD001) and imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM
    • abstract 3002
    • Van Oosterom A, Dumez H, Desai J, et al. Combination signal transduction inhibition: a phase I/II trial of the oral mTOR-inhibitor everolimus (RAD001) and imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to IM. Proc Am Soc Clin Oncol 2004; (abstract 3002).
    • (2004) Proc Am Soc Clin Oncol
    • Van Oosterom, A.1    Dumez, H.2    Desai, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.