A novel conditional Akt ‘survival switch’ reversibly protects cells from apoptosis

Gene Therapy

Volumn 9, Issue 4, 2002, Pages 233-244

  Li, B ^a   Desai, S A ^a   MacCorkle Chosnek, R A ^a   Fan, L ^a   Spencer, D M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Akt; Apoptosis; CID; Conditional signaling protein; Inducible Akt; Survival switch

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 9; ETOPOSIDE; FAS ANTIBODY; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE LIPID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PLECKSTRIN; PROTEIN BAD; PROTEIN KINASE B; RAPAMYCIN; STAUROSPORINE; TACROLIMUS; TRANSCRIPTION FACTOR; WORTMANNIN;

APOPTOSIS; ARTICLE; BINDING SITE; CELL MEMBRANE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DIMERIZATION; DRUG BINDING; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; ISCHEMIA; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL MEMBRANE; CELL SURVIVAL; CELLS, CULTURED; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; JURKAT CELLS; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS;

EID: 85047697574     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301641     Document Type: Article

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