Cyclin-dependent kinase inhibitor p27Kip1 is required for mouse mammary gland morphogenesis and function

Journal of Cell Biology

Volumn 153, Issue 5, 2001, Pages 917-931

  Muraoka, Rebecca S ^a   Lenferink, Anne E G ^b   Simpson, Jean ^a,d   Brantley, Dana M ^b   Renee Roebuck, L ^b   Michael Yakes, F ^b   Arteaga, Carlos L ^a,b,c,d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

Author keywords

Apoptosis; Cyclin D1; Growth; Mammary gland; P27

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; PROTEIN P27; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST DEVELOPMENT; BREAST DUCT; BREAST EPITHELIUM; BREAST HYPOPLASIA; CELL DIFFERENTIATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; ENZYME REGULATION; LACTATION; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACTIVE TRANSPORT, CELL NUCLEUS; ADIPOSE TISSUE; ALLELES; ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; EPITHELIAL CELLS; FEMALE; GENE DELETION; GENOTYPE; LACTATION; MAMMARY GLANDS, ANIMAL; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MORPHOGENESIS; ORGAN CULTURE TECHNIQUES; PHENOTYPE; PREGNANCY; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0035947771     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.5.917     Document Type: Article

References (48)

1. Dynamic expression and activity of NF-κB during post-natal mammary gland morphogenesis
2. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D dependent kinases in murine fibroblasts
3. New insights into the tumor suppression function of p27Kip1
4. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
5. 1 to S transition in Drosophila: Cyclin E is a limiting downstream target of E2F
6. Genetic manipulation of mammary epithelium by transplantation
7. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
8. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female in p27(Kip1)-deficient mice
9. The murine gene p27Kip1 is haplo-insufficient for tumor suppression
10. High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers
11. Cyclin D1 and prognosis in human breast cancer
12. Developing a mammary gland is a stat affair
13. Expression of transcription factor E2F1 induces quiescent cells to enter S phase
14. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4
15. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
16. Blockade of EGF receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGFa bigenic mice
17. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
18. Cyclin E induced S-phase without activation of the Rb/E2F pathway
19. The mammary gland: A unique organ for the study of development and tumorigenesis
20. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
21. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
22. Interleukin-2-mediated elimination of p27Kip1 cyclin dependent kinase inhibitor prevented by rapamycin
23. Null mutation of the prolactin receptor produces multiple reproductive defects in the mouse
24. Role of the ubiquitin-proteosome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
25. Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias
26. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
27. Expression of cell cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
28. Hormone-induced proliferation and differentiation of granulosa cells: A coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1
29. Cyclin E-CDK2 is a regulator of p27Kip1
30. Cancer cell cycles
31. CDK inhibitors: Positive and negative regulators of G1-phase progression
32. A specific role for cyclin D1 in mammary gland development
33. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
34. Formation of p27-CDK complexes during the human mitotic cell cycle
35. p27/Kip1 mutation found in breast cancer
36. Apoptotic cell death and tissue remodeling during mouse mammary gland involution
37. Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors
38. Differential expression and regulation of cyclin D1 protein in normal and malignant human tumor cells: Association with Cdk4 is required for cyclin D1 function and G1 progression
39. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinoma
40. Genetic evidence for the interaction of cyclin D1 and p27kip1 in mice
41. The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during granulosa-luteal transition
42. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
43. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
44. Retinoblastoma protein switches the E2F site from positive to negative element
45. Mechanism of active transcriptional repression by the retinoblastoma protein
46. Low p27 expression predicts poor disease-free survival in patients with prostate cancer
47. The cleared mammary fat pad and the transplantation of mammary gland morphological structures and cells
48. CDK-independent activation of estrogen receptor by cyclinD1