Latent transforming growth factor-β activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation

American Journal of Pathology

Volumn 160, Issue 6, 2002, Pages 2081-2093

  Ewan, Kenneth B ^a   Shyamala, Gopalan ^a   Ravani, Shraddha A ^a   Tang, Yang ^b   Akhurst, Rosemary ^b   Wakefield, Lalage ^c   Barcellos Hoff, Mary Helen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; ESTROGEN; PROGESTERONE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BREAST CANCER; BREAST DEVELOPMENT; BREAST EPITHELIUM; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ESTRUS CYCLE; GENE ACTIVATION; HETEROZYGOSITY; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PREGNANCY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PUBERTY; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 0036081239     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61158-3     Document Type: Article

References (66)

1. Transforming growth factor β regulation of cell proliferation
2. Molecular and cell biology of TGF-beta
3. TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest
4. TGF-beta stabilizes p15INK4B protein, increases p15INK4B/cdk4 complexes and inhibits cyclin D1/cdk4 association in human mammary epithelial cells
5. Resistance to inhibition of cell growth by transforming growth factor-β and its role in oncogenesis
6. TGF-β induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects
7. Mammary tumor suppression by transforming growth factor β1 transgene expression
8. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
9. TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
10. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
11. Transforming growth factor-β and breast cancer: Tumor promoting effects of transforming growth factor-β
12. Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
13. 1 (Ser223, 225)
14. Transforming growth factor β1 stimulates contrasting responses in metastatic versus primary mouse prostate cancer-derived cell lines in vitro
15. Regulation of immune responses by TGF-β
16. Gradual phenotypic conversion associated with immortalization of cultured mammary epithelial cells
17. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: Implications for tumor invasion
18. TGF-b signaling in tumor suppression and cancer progression
19. 1 in developing bleomycin-induced pulmonary fibrosis in rats
20. Induction of extracellular matrix gene expression in normal human keratinocytes by transforming growth factor β is altered by cellular differentiation
21. Transforming growth factor-β in breast cancer: A working hypothesis
22. Regulation of mammary growth and function by TGF-β
23. The role of TGF-β in patterning and growth of the mammary ductal tree
24. Regulated expression and growth inhibitory effects of transforming growth factor-β isoforms in mouse mammary gland development
25. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-β 1
26. Reversible inhibition of mammary gland growth by transforming growth factor-β
27. The pro domain of pre-pro-transforming growth factor β1 when independently expressed is a functional binding protein for the mature growth factor
28. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells
29. The extracellular regulation of growth factor action
30. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung
31. Immunohistochemical detection of active TGF-β in situ using engineered tissue
32. Latency and activation in the regulation of TGF-β
33. Transforming growth factor-β activation in irradiated murine mammary gland
34. Latent transforming growth factor-β activation in situ: Quantitative and functional evidence following low dose irradiation
35. Immunocytochemical detection of latent transforming growth factor-β activation in cultured macrophages
36. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
37. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
38. Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population
39. Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice
40. Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-β1 and TGF-β2)
41. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
42. Roles of estrogen and progesterone in normal mammary gland development: Insights from progesterone null receptor mutant mice and in situ localization of receptor
43. Postnatal development of the rodent mammary gland
44. TGFβ suppresses casein synthesis in mouse mammary explants and may play a role in controlling milk levels
45. Apoptosis in the terminal endbud of the murine mammary gland: A mechanism of ductal morphogenesis
46. Laminin and β1 integrins are crucial for normal mammary gland development in the mouse
47. Dominant-negative interference of the transforming growth factor-beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice
48. Overexpression of a kinase-deficient transforming growth factor-β type II receptor in mouse mammary stroma results in increased epithelial branching
49. Role of the stroma in mammary development
50. Murine progesterone receptor expression in proliferating mammary epithelial cells during normal pubertal development and adult estrous cycle. Association with ERα and ERβ status
51. Targeting expression of a transforming growth factor β1 transgene to the pregnant mammary gland inhibits alveolar development and lactation
52. Topography of DNA synthesis in the mammary gland of the C3H mouse and its control by ovarian hormones: An autoradiographic study
53. Progesterone signaling and mammary gland morphogenesis
54. Dissociation between steroid receptor expression and cell proliferation in the human breast
55. Estrogen receptor-positive proliferating cells in the normal and precancerous breast
56. Site-directed mutagenesis of cysteine residues in the pro region of the transforming growth factor β 1 precursor
57. Effect of transforming growth factor-β1 on proliferation and death of rat prostatic cells
58. Coordinated regulation of apoptosis and cell proliferation by transforming growth factor β 1 in cultured uterine epithelial cells
59. Transforming growth factor b3 induces cell death during the first stage of mammary gland involution
60. Apoptotic cell death and tissue remodeling during mouse mammary gland involution
61. Roles for transforming growth factors-β in the genesis, prevention and treatment of breast cancer
62. TGF-β and breast cancer: Lessons learned from genetically altered mouse models
63. TGF-β signaling in growth control, cancer, and heritable disorders
64. Association between the T29->C polymorphism in the transforming growth factor beta1 gene and breast cancer among elderly white women: The study of osteoporotic fractures
65. Regulation of transforming growth factor-β subtypes by members of the steroid hormone superfamily
66. Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts