Chemical fate of the nicotinic acetylcholinergic radiotracer [123I]5-IA-85380 in baboon brain and plasma

Nuclear Medicine and Biology

Volumn 33, Issue 4, 2006, Pages 549-554

  Baldwin, Ronald M ^a,b   Zoghbi, Sami S ^a   Staley, Julie K ^a,b   Brenner, Eric ^a,b   Al Tikriti, Mohammed S ^a,b   Amici, Louis ^a,b   Fujita, Masahiro ^a,b   Innis, Robert B ^a,b   Tamagnan, Gilles ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

Author keywords

(S) 5 123I iodo 3 (2 azetidinylmethoxy)pyridine; 5 iodo 3 pyridinol; 123I 5 IA 85380; Metabolites; Nicotinic acetylcholine receptor; Pharmacokinetics; SPECT tracer validation

Indexed keywords

5 IODO 3 (2 AZETIDINYLMETHOXY)PYRIDINE I 123; 5 IODO 3 PYRIDINOL; ACETONITRILE; CHOLINERGIC RECEPTOR; DRUG METABOLITE; NICOTINIC RECEPTOR; PENTOBARBITAL; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BABOON; BRAIN TISSUE; CEREBELLUM; CHEMICAL COMPOSITION; CONTROLLED STUDY; DENATURATION; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG SYNTHESIS; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; THALAMUS;

ANIMALS; AZETIDINES; BRAIN; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; PAPIO ANUBIS; PYRIDINES; RADIOPHARMACEUTICALS; RECEPTORS, NICOTINIC; TISSUE DISTRIBUTION;

EID: 33646542645     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2006.03.002     Document Type: Article

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