Synthesis and characterization of radioiodinated (S)-5-iodonicotine: A new ligand for potential imaging of brain nicotinic cholinergic receptors by single photon emission computer tomography

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 2, 1997, Pages 284-290

  Saji, Hideo ^a   Watanabe, Akira ^a   Magata, Yasuhiro ^a   Ohmomo, Yoshiro ^b   Kiyono, Yasushi ^a   Yamada, Yoshihisa ^a   Iida, Yasuhiko ^a   Yonekura, Yoshiharu ^a   Konishi, Junji ^a   Yokoyama, Akira ^a  

^a KYOTO UNIVERSITY   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

(S) 5 iodonicotine; autoradiography; central nicotine receptor; radiopharmaceutical; single photon emission computed tomography; stereoisomer

Indexed keywords

5 IODONICOTINE I 125; CYTISINE; LIGAND; NICOTINE; NICOTINE DERIVATIVE; NICOTINIC RECEPTOR; RADIOPHARMACEUTICAL AGENT; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; MALE; MOUSE; NONHUMAN; RADIOIODINATION; RADIOISOTOPE DISTRIBUTION; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE DISTRIBUTION;

EID: 0030894487     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.284     Document Type: Article

References (40)

1. Nordberg A., Winblad B., Neurosci. Lett., 72, 115-119 (1986).
2. Whitehouse P. J., Martino A. M., Antuono P. G., Lowenstein P. R., Coyle J. T., Price D. L., Kellar K. J., Brain Res., 371, 146-151 (1986).
3. London E. D., Ball M. J., Waller S. B., Neurochem. Res., 14, 745-750 (1989).
4. Aquilonius S-M., "Nicotinic Receptors in the CNS Their Role in Synaptic Transmission," ed. by Nordberg A., Fuxe K., Holmstedt B., Elsevier Science Publishers, Amsterdam, 1989, pp. 329-333.
5. Giacobini E., J. Neurosci. Res., 27, 548-560 (1990).
6. Benwell M. E., Balfour D. J. K., Anderson J. M., J. Neurochem., 50, 1243-1247 (1988).
7. Maziere M., Comar D., Marazano C., Berger G., Eur. J. Nucl. Med., 1, 255-258 (1976).
8. Nyback H., Nordberg A., Langstrom B., Halldin C., Hartvig P., Ahlin A., Swahn C-G., Sedvall G., "Nicotinic Receptors in the CNS Their Role in Synaptic Transmission" ed. by Nordberg A., Fuxe K., Holmstedt B., Elsevier Science Publishers, Amsterdam, 1989, pp. 313-319.
9. Nordberg A., Hartvig P., Lundqvist H., Antoni G., Ulin J., Langstrom B., J. Neural Transm. [P-D Sect]., 1, 195-205 (1989).
10. Nordberg A., Hartvig P., Lilja A., Viitanen M., Amberla K., Lundqvist H., Andersson Y., Ulin J., Winblad B., Langstrom B., J. Neural Transm. [P-D Sect]., 2, 215-224 (1990).
11. Nordberg A., Lilja A., Lundqvist H., Hartvig P., Amberla K., Viitanen M., Warpman U., Johansson M., Hellastrom-lindahl E., Bjurling P., Fasth K-J., Langstrom B., Winblad B., Neurobiol. Aging, 13, 747-758 (1992).
12. Saji H., Magata Y., Yamada Y., Tajima K., Yonekura Y., Konishi J., Ohmomo Y., Yokoyama A., Chem. Pharm. Bull., 40, 734-736 (1992).
13. Sheridan R. P., Nilakantan R., Dixon J. S., Venkataraghavan R., J. Med. Chem., 29, 899-906 (1986).
14. Barlow R. B., Johnson O., Br. J. Pharmacol., 98, 799-808 (1989).
15. Glennon R. A., Maarouf A., Fahmy S., Martin B., Fan F., Yousif M., Shafik R. M., Dukat M., Med. Chem. Res., 2, 2, 546-551 (1993).
16. Roano C., Goldstein A., Science, 210, 647-650 (1980).
17. Ikushima S., Muramatsu I., Sakakibara Y., Yokotani K., Fujiwara M., J. Pharmacol. Exp. Ther., 22, 22, 463-470 (1982).
18. Reavill C., Jenner P., Kumar R., Stolerman I. P., Neuropharmacology, 27, 235-241 (1988).
19. Counsell R. E., Ice R. D., "Drug Design," ed. by Ariens E., Academic Press, New York, 1975, pp. 172-259.
20. Magata Y., Saji H., Arano Y., Horiuchi K., Torizuka K., Yokoyama A., Nucl. Med. Biol., 14, 7-13 (1987).
21. Eckelman W. C., "Radiopharmaceuticals," ed. by Nunn A. D., Marcel Dekker, New York, 1992, pp. 167-219.
22. Roe A., Hawkins G. F., J. Am. Chem. Soc., 69, 2443-2444 (1947).
23. Rondahl L., Acta Pharm. Suec., 14, 113-118 (1977).
24. Chan S. M., Basmadjian G. P., Marten D. F., Sadek S. A., Magarian R. A., Grunder J. R., Ice R. D., J. Label. Comp. Radiopharm., 20, 1017-1025 (1983).
25. Leete E., Bodem G. B., Manuel M. F., Photochemistry, 10, 2687-2692 (1971).
26. Jacob P., III J. Org. Chem., 47, 4165-4167 (1982).
27. Oldendorf W. H., Proc. Soc. Exp. Biol. Med., 147, 813-816 (1974).
28. Pardridge W. M., Landaw E., J. Clin. Invest., 74, 745-752 (1984).
29. Shimohara S., Taniguchi T., Fujiwara M., Kameyama M., J. Neurochem., 45, 604-610 (1985).
30. Wonnacott S., Human Toxicol., 6, 343-353 (1987).
31. Broussolle E. P., Wong D. F., Fanelli R. J., London E. D., Life Sci., 44, 1123-1132 (1989).
32. Flesher J. E., Scheffel U., London E. D., Frost J. J., Life Sci., 54, 1883-1890 (1994).
33. London E. D., Waller S. B., Wamsley J. K., Neurosci. Lett., 53, 179-184 (1985).
34. Laduron P. M., Verwimp M., Leysen J. E., J. Neurochem., 32, 421-427 (1979).
35. Barlow R. B., McLeod L. J., Br. J. Pharmac., 35, 161-174 (1969).
36. Bedran de Castro M. T., Crystal G. J., Downey H. F., Bashour F. A., Stroke, 15, 690-694 (1984).
37. Pabreza L. A., Dhawan S., Kellar K., Mol. Pharmacol., 39, 9-12 (1991).
38. Cheng Y. C., Prusoff W. H., Biochem. Pharmacol., 22, 3099-3108 (1973).
39. Oldendorf W. H., Brain Res., 24, 372-376 (1970).
40. Saji H., Iida Y., Takahashi M., Sasa M., Serikawa T., Yamada J., Yokoyama A., Brain Res., 601, 76-79 (1993).