Targeting leukemic fusion proteins with small interfering RNAs: Recent advances and therapeutic potentials

Acta Pharmacologica Sinica

Volumn 27, Issue 3, 2006, Pages 273-281

  Thomas, Maria ^a   Greil, Johann ^b   Heidenreich, Olaf ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b Paediatric University Hospital   (Germany)

Author keywords

Leukemia; Leukemic fusion genes; RNA interference; Small hairpin RNA; Small interfering RNA

Indexed keywords

AML1 MTG8 FUSION PROTEIN; ANAPLASTIC LYMPHOMA KINASE; BCR ABL PROTEIN; FLT3 LIGAND; HYBRID PROTEIN; IMATINIB; MIXED LINEAGE LEUKEMIA PROTEIN; MLL AF4 FUSION PROTEIN; NUCLEOPLASMIN; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; RAPAMYCIN; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; STEROID RECEPTOR COACTIVATOR 1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL TRANSFORMATION; CHROMOSOME TRANSLOCATION; CHROMOSOME TRANSLOCATION 11; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 21; CHROMOSOME TRANSLOCATION 4; CHROMOSOME TRANSLOCATION 5; CHROMOSOME TRANSLOCATION 8; CHRONIC MYELOID LEUKEMIA; DRUG EFFECT; DRUG EFFICACY; DRUG SPECIFICITY; GENE DELIVERY SYSTEM; GENE MUTATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; LARGE CELL LYMPHOMA; LENTIVIRUS VECTOR; LEUKEMIA; LYMPHATIC LEUKEMIA; MYELOID LEUKEMIA; MYELOMONOCYTIC LEUKEMIA; REVIEW; RNA DEGRADATION; RNA INTERFERENCE; TRANSLATION REGULATION; TREATMENT OUTCOME;

ANIMALS; CORE BINDING FACTOR ALPHA 2 SUBUNIT; FUSION PROTEINS, BCR-ABL; GENE SILENCING; GENE TARGETING; GENE THERAPY; HUMANS; LEUKEMIA; ONCOGENE PROTEINS, FUSION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSLOCATION, GENETIC;

EID: 33644830569     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00282.x     Document Type: Review

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