Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study)

FEBS Letters

Volumn 570, Issue 1-3, 2004, Pages 195-204

  Zhelev, Zhivko ^a   Bakalova, Rumiana ^a   Ohba, Hideki ^a   Ewis, Ashraf ^a   Ishikawa, Mitsuru ^a   Shinohara, Yasuo ^a,b   Baba, Yoshinobu ^a,b  

^a AIST Shikoku   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; IMATINIB; INTERFERON; INTERLEUKIN 6; PROTEIN C JUN; PROTEIN INHIBITOR; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; STAT PROTEIN; TRANSCRIPTION ELONGATION FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ARTICLE; CELL PROLIFERATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA MICROARRAY; DRUG EFFECT; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LYMPHOCYTE TRANSFORMATION TEST; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; ONCOGENE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA SEQUENCE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL DIVISION; CELL SURVIVAL; DNA, COMPLEMENTARY; ENZYME INHIBITORS; FLUORESCEIN; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; LYMPHOCYTES; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 3142634525     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.06.048     Document Type: Article

References (22)

1. Van Etten R.A. Studying the pathogenesis of Bcr-Abl+ leukemia in mice. Oncogene. 21:2002;8643-8651
2. O'Dwyer M.E., Mauro M.J., Druker B.J. Recent advancements in the treatment of chronic myelogenous leukemia. Annu. Rev. Med. 53:2002;369-381
3. Wisniewski D., Lambek C.L., Liu C., Strife A., Veach D.R., et al. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinase. Cancer Res. 62:2002;4244-4255
4. Fabbro D., Ruetz S., Buchdunger E., Cowan-Jacob S.W., Fendrich G., et al. Protein kinases as targets for anticancer agents: from inhibitors to useful drugs. Pharmacol. Ther. 93:2002;78-98
5. Wilda M., Fuchs U., Wossmann W., Borkhardt A. Killing of leukemic cells with a bcr/abl fusion gene by RNA interference (RNAi). Oncogene. 21:2002;5716-5724
6. Scherr M., Battmer K., Winkler T., Heidenreich O., Gasner A., Eder M. Specific inhibition of bcr-abl gene expression by small interfering RNA. Blood. 101(4):2003;1566-1569
7. Wohlbold L., van der Kuip H., Mieting C., Vornlocher H.-P., Knabbe C., Duyster J., Aulitzky W.E. Inhibition of bcr-abl gene expression by small interfering RNA sensitizes for imatinib mesylate (STI571). Blood. 102(6):2003;2236-2239
8. Bakalova R., Ohba H., Zhelev Z., Ishikawa M., Shinohara Y., Baba Y. Cross-talk between BCR-ABL tyrosine kinase, protein kinase C and telomerase - a potential reason for resistance to Glivec in chronic myelogenous leukemia. Biochem. Pharmacol. 66(10):2003;1879-1884
9. Bakalova R., Ohba H., Zhelev Z., Kubo T., Fujii M., Ishikawa M., Shinohara Y., Baba Y. Antisense inhibition of bcr-abl/c-abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells. FEBS Lett. 564:2004;73-84
10. Von Bubnoff N., Schneller F., Peschel S., Duyster J. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet. 359:2002;487-491
11. Hofmann W.K., Jones L.C., Lemp N.A., De Vos S., Gschaidmeier H., Hoelzer D., Ottmann O.G., Koeffler H.P. Ph (+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood. 99(5):2002;1860-1862
12. Paddison P.J., Caudy A.A., Hannon G.J. Stable suppression of gene expression by RNAi in mammalian cells. Proc. Natl. Acad. Sci. USA. 99:2002;1443-1448
13. Elbashir S.M., Harbort J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411(6836):2001;494-498
14. Montgomery M.K., Xu S., Fire A. RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 95:1998;15502-15507
15. Baulcombe D.C. Fast forward genetics based on virus-induced gene silencing. Curr. Opin. Plant. Biol. 2:1999;109-113
16. Kennerdell J.R., Carthew R.W. Heritable gene silencing in Drosophila using double-stranded RNA. Nat. Biotechnol. 18:2000;869-898
17. Scherr M., Morgan M.A., Eder M. Gene silencing mediated by small interfering RNAs in mammalian cells. Curr. Med. Chem. 10(3):2003;245-256
18. Saunders L.R., Barber G.N. The dsRNA binding protein family: critical roles, diverse cellular functions. FASEB J. 17(9):2003;961-983
19. Ardelt B., Ardelt W., Darzynkiewicz Z. Cytotoxic ribonucleases and RNA interference (RNAi). Cell Cycle. 2(1):2003;22-24
20. Wall N. Snall RNA: can RNA interference be exploited for therapy. Lancet. 362:2003;1401-1403
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65:1983;55-63
22. Brummendorf T.H., Ersoz I., Hartmann U., Balabanov S., Wolke H., Paschka P., Lahaye T., Berner B., Bartolovic K., Kreil S., Berger U., Gschaidmeier H., Bokemeyer C., Hehlmann R., Dietz K., Lansdorp P.M., Kanz L., Hochhaus A. Ann. N.Y. Acad. Sci. 996:2003;26-38