-
1
-
-
0036655769
-
Treatment of acute myeloid leukemia: State-of-the-art and future directions
-
Stone RM. Treatment of acute myeloid leukemia: state-of-the-art and future directions. Semin Hematol. 2002;39(suppl 2):4-10.
-
(2002)
Semin Hematol
, vol.39
, Issue.SUPPL. 2
, pp. 4-10
-
-
Stone, R.M.1
-
2
-
-
16944365287
-
Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: A study on a large series of patients and cell lines
-
Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies: a study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
-
(1997)
Leukemia
, vol.11
, pp. 1605-1609
-
-
Yokota, S.1
Kiyoi, H.2
Nakao, M.3
-
3
-
-
0035871889
-
Activating mutation of D835 within the activation loop of FLT3 in human hematological malignancies
-
Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematological malignancies. Blood. 2001;97:2434-2439.
-
(2001)
Blood
, vol.97
, pp. 2434-2439
-
-
Yamamoto, Y.1
Kiyoi, H.2
Nakano, Y.3
-
4
-
-
0033758958
-
FLT3 internal tandem duplication mutations in adult acute myeloid leukemia define a high-risk group
-
Abu-Duhier FM, Goodeve AC, Wilson GA, et al. FLT3 internal tandem duplication mutations in adult acute myeloid leukemia define a high-risk group. Br J Haematol. 2000;111:190-195.
-
(2000)
Br J Haematol
, vol.111
, pp. 190-195
-
-
Abu-Duhier, F.M.1
Goodeve, A.C.2
Wilson, G.A.3
-
5
-
-
0035885955
-
The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
-
Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
-
(2001)
Blood
, vol.98
, pp. 1752-1759
-
-
Kottaridis, P.D.1
Gale, R.E.2
Frew, M.E.3
-
6
-
-
0037097716
-
Analysis of FLT-3-activating mutations in 979 patients acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
-
Thiede C, Steudel C, Mohr B, et al. Analysis of FLT-3-activating mutations in 979 patients acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
-
(2002)
Blood
, vol.99
, pp. 4326-4335
-
-
Thiede, C.1
Steudel, C.2
Mohr, B.3
-
7
-
-
0036624916
-
A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
-
Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99:3885-3891.
-
(2002)
Blood
, vol.99
, pp. 3885-3891
-
-
Levis, M.1
Allebach, J.2
Tse, K.F.3
-
8
-
-
0013102301
-
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
-
Kelly LM, Yu JC, Boulton CL, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell. 2002;1:421-432.
-
(2002)
Cancer Cell
, vol.1
, pp. 421-432
-
-
Kelly, L.M.1
Yu, J.C.2
Boulton, C.L.3
-
9
-
-
0038156174
-
Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor
-
Grundler R, Thiede C, Miething C, et al. Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor. Blood. 2003;102:646-651.
-
(2003)
Blood
, vol.102
, pp. 646-651
-
-
Grundler, R.1
Thiede, C.2
Miething, C.3
-
10
-
-
1842420032
-
Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
-
Smith BD, Levis M, Beran M, et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood. 2004;103:3669-3676.
-
(2004)
Blood
, vol.103
, pp. 3669-3676
-
-
Smith, B.D.1
Levis, M.2
Beran, M.3
-
11
-
-
0141993064
-
A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia
-
Fiedler W, Mesters R, Tinnefeid H, et al. A phase 2 clinical study of SU5416 In patients with refractory acute myeloid leukemia. Blood. 2003;102:2763-2767.
-
(2003)
Blood
, vol.102
, pp. 2763-2767
-
-
Fiedler, W.1
Mesters, R.2
Tinnefeid, H.3
-
12
-
-
0141465061
-
The role of FLT3 in haematopoietic malignancies
-
Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650-666.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 650-666
-
-
Stirewalt, D.L.1
Radich, J.P.2
-
13
-
-
0037108298
-
SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
-
Yee KW, O'Farrell AM, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood. 2002l;100:2941-2949.
-
(2002)
Blood
, vol.100
, pp. 2941-2949
-
-
Yee, K.W.1
O'Farrell, A.M.2
Smolich, B.D.3
-
14
-
-
0031985201
-
DNA cross-linker-induced G2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function
-
Heinrich MC, Hoatlin ME, Zigler AJ, et al. DNA cross-linker-induced G2/M arrest in group C Fanconi anemia lymphoblasts reflects normal checkpoint function. Blood. 1998;91:275-287.
-
(1998)
Blood
, vol.91
, pp. 275-287
-
-
Heinrich, M.C.1
Hoatlin, M.E.2
Zigler, A.J.3
-
15
-
-
16944367543
-
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23)
-
Matsuo Y, MacLeod RA, Uphoff CC, et al. Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23). Leukemia. 1997;11:1469-1477.
-
(1997)
Leukemia
, vol.11
, pp. 1469-1477
-
-
Matsuo, Y.1
MacLeod, R.A.2
Uphoff, C.C.3
-
16
-
-
0034605042
-
Essential role of signal transducer and activator of transcription (Stat)5a but not Stat 5b for Flt-3 dependent signaling
-
Zhang S, Fukuda S, Lee Y, et al. Essential role of signal transducer and activator of transcription (Stat)5a but not Stat 5b for Flt-3 dependent signaling. J Exp Med. 2000;192:719-728.
-
(2000)
J Exp Med
, vol.192
, pp. 719-728
-
-
Zhang, S.1
Fukuda, S.2
Lee, Y.3
-
17
-
-
0037838661
-
Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
-
Spiekermann K, Bagrintseva K, Schwab R, et al. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res. 2003;9:2140-2150.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2140-2150
-
-
Spiekermann, K.1
Bagrintseva, K.2
Schwab, R.3
-
18
-
-
0035203382
-
Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
-
Birkenkamp KU, Geugien M, Lemmink HH, et al. Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. Leukemia. 2001;15:1923-1931.
-
(2001)
Leukemia
, vol.15
, pp. 1923-1931
-
-
Birkenkamp, K.U.1
Geugien, M.2
Lemmink, H.H.3
-
19
-
-
0042744837
-
Survival of acute myeloid leukemia cells requires PI3 kinase activation
-
Xu Q, Simpson SE, Scialla TJ, et al. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood. 2003;102:972-980.
-
(2003)
Blood
, vol.102
, pp. 972-980
-
-
Xu, Q.1
Simpson, S.E.2
Scialla, T.J.3
-
20
-
-
1242285048
-
Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
-
Zhao S, Konopleva M, Cabreira-Hansen M, et al. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia. 2004;18:267-275.
-
(2004)
Leukemia
, vol.18
, pp. 267-275
-
-
Zhao, S.1
Konopleva, M.2
Cabreira-Hansen, M.3
-
21
-
-
0348140591
-
Mechanisms and implications of imatinib resistance mutations in BCR-ABL
-
Nardi V, Azam M, Daley GQ. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Curr Opin Hematol. 2004;11:35-43.
-
(2004)
Curr Opin Hematol
, vol.11
, pp. 35-43
-
-
Nardi, V.1
Azam, M.2
Daley, G.Q.3
-
22
-
-
2942530436
-
Inhibition of influenza virus production in virus-infected mice by RNA interference
-
Ge Q, Filip L, Bai A, et al. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci U S A. 2004;101:8676-8681.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8676-8681
-
-
Ge, Q.1
Filip, L.2
Bai, A.3
-
23
-
-
0037348329
-
RNA interference targeting Fas protects mice from fulminant hepatitis
-
Song E, Lee SK, Wang J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 2003;9:347-351.
-
(2003)
Nat Med
, vol.9
, pp. 347-351
-
-
Song, E.1
Lee, S.K.2
Wang, J.3
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