p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

Oncogene

Volumn 21, Issue 34, 2002, Pages 5325-5334

  Horton, Lynn E ^a   Bushell, Martin ^c,d   Barth Baus, Diane ^a   Tilleray, Vivienne J ^c   Clemens, Michael J ^c   Hensold, Jack O ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Veterans Affairs Medical Center   (United Kingdom)

^c ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Growth inhibition; MTOR; P53; Polypeptide chain initiation; Protein synthesis

Indexed keywords

BINDING PROTEIN; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; PROTEIN P53; S6 KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROLEUKEMIA CELL; GENE ACTIVATION; GENE INACTIVATION; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RIBOSOME; TEMPERATURE SENSITIVITY; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; TRANSLATION REGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACIDS; CARRIER PROTEINS; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA-BINDING PROTEINS; ERYTHROCYTES; EUKARYOTIC INITIATION FACTOR-4E; GENE EXPRESSION REGULATION; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; RIBOSOMES; TEMPERATURE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MURINAE;

EID: 0037043851     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205662     Document Type: Article

References (82)