Simultaneous novel BCR-ABL gene mutation and increased expression of BCR-ABL mRNA caused clinical resistance to STI571 in double-Ph-positive acute biphenotypic leukemia [2]

International Journal of Hematology

Volumn 78, Issue 2, 2003, Pages 173-175

  Inami, Mitsuharu ^a   Inokuchi, Koiti ^a,b   Nakayama, Kazutaka ^a   Tamura, Hideto ^a   Shimad, Takashi ^b   Dan, Kazuo ^a  

^a Division of Hematology   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; GENE PRODUCT; IMATINIB; MESSENGER RNA;

ACUTE LEUKEMIA; ADULT; CANCER REGRESSION; CASE REPORT; CHRONIC MYELOID LEUKEMIA; CORRELATION ANALYSIS; CYTOGENETICS; GENE AMPLIFICATION; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; KARYOTYPE; LETTER; MALE; PHENOTYPE; PHILADELPHIA 1 CHROMOSOME; POINT MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0042389716     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02983390     Document Type: Letter

References (6)

1. Hocchaus A, Kreil S, AS Corbin, et al. Molecular and chromosomal mechanisms of resistance to imanitab (STI571) therapy. Leukemia. 2002;16:2190-2196.
2. Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293:8768-8780.
3. von Bubnoff N, Schneller F, Peschel C, Duyster J. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet. 2002;359:487-491.
4. Branford S, Rudzki Z, Walsh S, et al. High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance. Blood. 2002;99:3472-3475.
5. Hofmann WK, Jones LC, Lemp NA, et al. Ph+ acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation. Blood. 2002;99:1860-1862.
6. Abo J, Inokuchi K, Dan K, et al. p53 and N-ras mutations in two new leukemia cell lines established from a patient with multilineage CD7-positive acute leukemia. Blood. 1993;82:2829-2836.