메뉴 건너뛰기




Volumn 6, Issue SUPPL. 5, 2001, Pages 32-39

The vascular endothelial growth factor (VEGF) signaling pathway: A therapeutic target in patients with hematologic malignancies

Author keywords

Angiogenesis; Leukemia; Lymphoma; SU5416; VEGF

Indexed keywords

3 [(4,5 DIMETHYL 1H PYRROL 2 YL)METHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MATRIX METALLOPROTEINASE; PROTEIN TYROSINE KINASE; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR;

EID: 0035168739     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.6-suppl_5-32     Document Type: Conference Paper
Times cited : (87)

References (57)
  • 1
    • 0034241233 scopus 로고    scopus 로고
    • Intensive chemotherapy for patients with high-risk myelodysplastic syndrome
    • (2000) Int J Hematol , vol.72 , pp. 139-150
    • Beran, M.1
  • 2
    • 0033897401 scopus 로고    scopus 로고
    • Multifaceted approach to the diagnosis and classification of acute leukemias
    • (2000) Clin Chem , vol.46 , pp. 1252-1259
    • McKenna, R.W.1
  • 3
    • 0035070384 scopus 로고    scopus 로고
    • Prognostic factors in acute myelogenous leukemia
    • (2001) Leukemia , vol.15 , pp. 670-672
    • Estey, E.H.1
  • 6
    • 0034242218 scopus 로고    scopus 로고
    • World Health Organization classification of the acute leukemias and myelodysplasfic syndrome
    • (2000) Int J Hematol , vol.72 , pp. 131-133
    • Bennett, J.M.1
  • 9
    • 0034655957 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma
    • (2000) Blood , vol.95 , pp. 2630-2636
    • Dankbar, B.1    Padró, T.2    Leo, R.3
  • 21
    • 0035793623 scopus 로고    scopus 로고
    • Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants
    • (2001) J Biol Chem , vol.276 , pp. 3222-3230
    • Gille, H.1    Kowalski, J.2    Li, B.3
  • 22
    • 0029929716 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
    • (1996) J Biol Chem , vol.271 , pp. 17629-17634
    • Clauss, M.1    Weich, H.2    Breier, G.3
  • 24
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR
    • (1994) J Biol Chem , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3
  • 29
    • 84975525035 scopus 로고
    • Seminars in medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis
    • (1995) N Engl J Med , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 30
    • 0035863552 scopus 로고    scopus 로고
    • Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival
    • (2001) J Clin Oncol , vol.19 , pp. 577-583
    • Ugurel, S.1    Rappl, G.2    Tilgen, W.3
  • 31
    • 0034489116 scopus 로고    scopus 로고
    • Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma
    • (2000) Clin Cancer Res , vol.6 , pp. 4874-4884
    • Inoue, K.1    Slaton, J.W.2    Perrotte, P.3
  • 33
  • 34
    • 0034548821 scopus 로고    scopus 로고
    • Simultaneous elevation in the serum concentrations of the angiogenic growth factors VEGF and bFGF is an independent predictor of poor prognosis in non-Hodgkin lymphoma: A single-institution study of 200 patients
    • (2000) Blood , vol.96 , pp. 3712-3718
    • Salven, P.1    Orpana, A.2    Teerenhovi, L.3
  • 35
    • 0033485961 scopus 로고    scopus 로고
    • Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia
    • (1999) Blood , vol.94 , pp. 3717-3721
    • Aguayo, A.1    Estey, E.2    Kantarjian, H.3
  • 36
    • 18344413014 scopus 로고    scopus 로고
    • Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia
    • (2000) Blood , vol.96 , pp. 768-770
    • Aguayo, A.1    O'Brien, S.2    Keating, M.3
  • 37
    • 0032705222 scopus 로고    scopus 로고
    • Increased serum levels of vascular endothelial growth factor predict risk of progression in early B-cell chronic lymphocytic leukaemia
    • (1999) Br J Haematol , vol.107 , pp. 605-610
    • Molica, S.1    Vitelli, G.2    Levato, D.3
  • 38
    • 0027444652 scopus 로고
    • A predictive model for aggressive non-Hodgkin's lymphoma
    • (1993) N Engl J Med , vol.329 , pp. 987-994
  • 39
  • 42
  • 45
  • 46
    • 0033527584 scopus 로고    scopus 로고
    • Selection and analysis of an optimized anti-VEGF antibody: Crystal structure of an affinity-matured Fab in complex with antigen
    • (1999) J Mol Biol , vol.293 , pp. 865-881
    • Chen, Y.1    Wiesmann, C.2    Fuh, G.3
  • 50
    • 0034097928 scopus 로고    scopus 로고
    • Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)
    • (2000) Exp Hematol , vol.28 , pp. 660-671
    • Blair, A.1    Sutherland, H.J.2
  • 52
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.T.1    Shawver, L.K.2    Sun, L.3
  • 53
    • 0033231069 scopus 로고    scopus 로고
    • Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
    • (1999) Cancer Res , vol.59 , pp. 5412-5416
    • Shaheen, R.M.1    Davis, D.W.2    Liu, W.3
  • 54
    • 0035282940 scopus 로고    scopus 로고
    • The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.D.1    Yuen, H.A.2    West, K.A.3
  • 56
    • 0035412371 scopus 로고    scopus 로고
    • Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia
    • (2001) Blood , vol.98 , pp. 241-243
    • Mesters, R.M.1    Padro, T.2    Bieker, R.3
  • 57
    • 0033994955 scopus 로고    scopus 로고
    • Clinical strategy for the development of angiogenesis inhibitors
    • (2000) The Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 51-54
    • Carter, S.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.