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Volumn 43, Issue 4, 2005, Pages 322-339

The role of excitotoxicity in neurodegeneration

Author keywords

Calcium; Excitatory amino acid receptors; Neurodegeneration; NO; Oxidative stress

Indexed keywords

2,4 DIAMINO 5 (2,3,5 TRICHLOROPHENYL)PYRIMIDINE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMINO ACID RECEPTOR; AMPA RECEPTOR ANTAGONIST; APTIGANEL; CALCIUM; CP 283097; DEXTROMETHORPHAN; DIZOCILPINE; FLUNARIZINE; GAVESTINEL; GLUTAMATE RECEPTOR ANTAGONIST; IFENPRODIL; IONOTROPIC RECEPTOR; LAMOTRIGINE; MEMANTINE; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NITRIC OXIDE; REMACEMIDE; RILUZOLE; RO 256981; SIPATRIGINE; TRAXOPRODIL; UNCLASSIFIED DRUG;

EID: 30944463613     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (106)

References (226)
  • 2
    • 0031020308 scopus 로고    scopus 로고
    • Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury
    • Agrawal SK, Fehlings MG. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J Neurosci 1997; 17: 1055-1063.
    • (1997) J Neurosci , vol.17 , pp. 1055-1063
    • Agrawal, S.K.1    Fehlings, M.G.2
  • 5
    • 0042536473 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    • Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003; 34: 325-337.
    • (2003) Cell Calcium , vol.34 , pp. 325-337
    • Arundine, M.1    Tymianski, M.2
  • 6
    • 23644442109 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis
    • Baskys A, Bayazitov I, Fang L, Blaabjerg M, Poulsen FR, Zimmer J. Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis. Neuropharmacology 2005; 49 (Suppl 1): 146-156.
    • (2005) Neuropharmacology , vol.49 , Issue.SUPPL. 1 , pp. 146-156
    • Baskys, A.1    Bayazitov, I.2    Fang, L.3    Blaabjerg, M.4    Poulsen, F.R.5    Zimmer, J.6
  • 8
    • 0027477946 scopus 로고
    • Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
    • Beal MF, Hyman BT, Koroshetz W. Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases? Trends Neurosci 1993; 16: 125-135.
    • (1993) Trends Neurosci , vol.16 , pp. 125-135
    • Beal, M.F.1    Hyman, B.T.2    Koroshetz, W.3
  • 10
    • 0028097839 scopus 로고
    • A controlled trial of riluzole in amyotrophic lateral sclerosis
    • ALS/Riluzole Study Group
    • Bensimon G, Lacomblez L, Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N Engl J Med 1994; 330: 585-591.
    • (1994) N Engl J Med , vol.330 , pp. 585-591
    • Bensimon, G.1    Lacomblez, L.2    Meininger, V.3
  • 11
    • 0021707433 scopus 로고
    • Elevation of extracellular concentrations of glutamate in rat hippocampus during transient cerebral ischaemia monitored by intracerebral microdialysis
    • Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of extracellular concentrations of glutamate in rat hippocampus during transient cerebral ischaemia monitored by intracerebral microdialysis. J Neurochem 1984; 43: 1369-1374.
    • (1984) J Neurochem , vol.43 , pp. 1369-1374
    • Benveniste, H.1    Drejer, J.2    Schousboe, A.3    Diemer, N.H.4
  • 12
    • 0029890682 scopus 로고    scopus 로고
    • Traumatic brain damage prevented by the non-n-methyl-d-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline
    • Bernert H, Turski L. Traumatic brain damage prevented by the non-n-methyl-d-aspartate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]quinoxaline. Proc Natl Acad Sci USA 1996; 93: 5235-5240.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5235-5240
    • Bernert, H.1    Turski, L.2
  • 13
    • 0032531818 scopus 로고    scopus 로고
    • Calcium - A life and death signal
    • Berridge MJ, Bootman MD, Lipp P. Calcium - a life and death signal. Nature 1998; 395: 645-648.
    • (1998) Nature , vol.395 , pp. 645-648
    • Berridge, M.J.1    Bootman, M.D.2    Lipp, P.3
  • 14
    • 0031786468 scopus 로고    scopus 로고
    • Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model
    • Bezard E, Stutzmann JM, Imbert C, Boraud T, Boireau A, Gross CE. Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model. Eur J Pharmacol 1998; 356: 101-104.
    • (1998) Eur J Pharmacol , vol.356 , pp. 101-104
    • Bezard, E.1    Stutzmann, J.M.2    Imbert, C.3    Boraud, T.4    Boireau, A.5    Gross, C.E.6
  • 15
    • 0031950985 scopus 로고    scopus 로고
    • Prospects of glutamate antagonists in the therapy of Parkinson's disease
    • Blandini F, Greenamyre JT. Prospects of glutamate antagonists in the therapy of Parkinson's disease. Fund Clin Pharmacol 1998; 12: 4-12.
    • (1998) Fund Clin Pharmacol , vol.12 , pp. 4-12
    • Blandini, F.1    Greenamyre, J.T.2
  • 16
    • 0032801648 scopus 로고    scopus 로고
    • Sodium/calcium exchange: Its physiological implications
    • Blaustein MP, Lederer WJ. Sodium/calcium exchange: its physiological implications. Physiol Rev 1999; 79: 763-854.
    • (1999) Physiol Rev , vol.79 , pp. 763-854
    • Blaustein, M.P.1    Lederer, W.J.2
  • 20
    • 0032822044 scopus 로고    scopus 로고
    • LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia
    • Bond A, Ragumoorthy N, Monn JA, Hicks CA, Ward MA, Lodge D, O'Neill MJ. LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia. Neurosci Lett 1999; 273: 191-194.
    • (1999) Neurosci Lett , vol.273 , pp. 191-194
    • Bond, A.1    Ragumoorthy, N.2    Monn, J.A.3    Hicks, C.A.4    Ward, M.A.5    Lodge, D.6    O'Neill, M.J.7
  • 21
    • 0027302430 scopus 로고
    • The relationship between excitotoxicity and oxidative stress in the central nervous system
    • Bondy SC, LeBel CP. The relationship between excitotoxicity and oxidative stress in the central nervous system. Free Radic Biol Med 1993; 14: 633-642.
    • (1993) Free Radic Biol Med , vol.14 , pp. 633-642
    • Bondy, S.C.1    LeBel, C.P.2
  • 26
    • 0028806656 scopus 로고
    • Massive persistent release of excitatory amino acids following human occlusive stroke
    • Bullock R, Zauner A, Woodward J, Young HF. Massive persistent release of excitatory amino acids following human occlusive stroke. Stroke 1995; 26: 2187-2189.
    • (1995) Stroke , vol.26 , pp. 2187-2189
    • Bullock, R.1    Zauner, A.2    Woodward, J.3    Young, H.F.4
  • 27
    • 0002171705 scopus 로고    scopus 로고
    • Cellular interactions that regulate programmed cell death in the developing vertebrate nervous system
    • Koliatsos VE, Ratan RR (eds.). Humana Press Inc Totowa NJ
    • Burek MJ, Oppenheim RW. Cellular interactions that regulate programmed cell death in the developing vertebrate nervous system. In: Koliatsos VE, Ratan RR (eds.). Cell Death and Diseases of the Nervous System. Humana Press Inc Totowa NJ 1999, pp. 145-179.
    • (1999) Cell Death and Diseases of the Nervous System , pp. 145-179
    • Burek, M.J.1    Oppenheim, R.W.2
  • 28
    • 0030176244 scopus 로고    scopus 로고
    • Calcium permeability of glutamate-gated channels in the central nervous system
    • Burnashev N. Calcium permeability of glutamate-gated channels in the central nervous system. Current Opinion in Neurobiology 1996; 6: 311-317.
    • (1996) Current Opinion in Neurobiology , vol.6 , pp. 311-317
    • Burnashev, N.1
  • 29
    • 0024321139 scopus 로고
    • Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor
    • Carter C, Rivy J-P, Scatton B. Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor. Eur J Pharmacol 1989; 164: 611-612.
    • (1989) Eur J Pharmacol , vol.164 , pp. 611-612
    • Carter, C.1    Rivy, J.-P.2    Scatton, B.3
  • 30
    • 0030810685 scopus 로고    scopus 로고
    • Glutamate is a marker for cerebral ischemia in cortical but not deep infarcts
    • Castillo J, Davalos A, Lema M, Serena J, Noya M. Glutamate is a marker for cerebral ischemia in cortical but not deep infarcts. Cerebrovasc Dis 1997; 7: 245-250.
    • (1997) Cerebrovasc Dis , vol.7 , pp. 245-250
    • Castillo, J.1    Davalos, A.2    Lema, M.3    Serena, J.4    Noya, M.5
  • 31
    • 0019188479 scopus 로고
    • Transient formation of superoxide radicals on polyunsaturated fatty-acid induced brain swelling
    • Chan PH, Fishman RA. Transient formation of superoxide radicals on polyunsaturated fatty-acid induced brain swelling. J Neurochem 1980; 35: 1004-1007.
    • (1980) J Neurochem , vol.35 , pp. 1004-1007
    • Chan, P.H.1    Fishman, R.A.2
  • 32
    • 0023137252 scopus 로고
    • Ionic dependence of glutamate neurotoxicity in cortical cell culture
    • Choi DW. Ionic dependence of glutamate neurotoxicity in cortical cell culture. J Neurosci 1985; 7: 369-379.
    • (1985) J Neurosci , vol.7 , pp. 369-379
    • Choi, D.W.1
  • 33
    • 0021961417 scopus 로고
    • Glutamate neurotoxicity in cortical cell culture is calcium dependent
    • Choi DW. Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett 1985; 58: 293-297.
    • (1985) Neurosci Lett , vol.58 , pp. 293-297
    • Choi, D.W.1
  • 34
    • 0023870521 scopus 로고
    • Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
    • Choi DW, Koh JY, Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J Neurosci 1988; 8: 185-196.
    • (1988) J Neurosci , vol.8 , pp. 185-196
    • Choi, D.W.1    Koh, J.Y.2    Peters, S.3
  • 36
    • 0028799654 scopus 로고
    • Calcium: Still center-stage in hypoxic-ischemic neuronal death
    • Choi DW. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci 1987; 18: 58-60.
    • (1987) Trends Neurosci , vol.18 , pp. 58-60
    • Choi, D.W.1
  • 37
    • 0028831997 scopus 로고
    • Calcium signaling
    • Clapham DE. Calcium signaling. Cell 1995; 80: 259-268.
    • (1995) Cell , vol.80 , pp. 259-268
    • Clapham, D.E.1
  • 39
    • 0027397195 scopus 로고
    • Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors
    • Couratier P, Hugon J, Sindou P, Vallat JM, Dumas M. Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors. Lancet 1993; 341: 265-268.
    • (1993) Lancet , vol.341 , pp. 265-268
    • Couratier, P.1    Hugon, J.2    Sindou, P.3    Vallat, J.M.4    Dumas, M.5
  • 40
    • 0347631873 scopus 로고
    • The excitation and depression of spinal neurons by structurally related amino acids
    • Curtis DR, Watkins JC. The excitation and depression of spinal neurons by structurally related amino acids. J Neurochem 1960; 6: 117-141.
    • (1960) J Neurochem , vol.6 , pp. 117-141
    • Curtis, D.R.1    Watkins, J.C.2
  • 41
    • 0345653848 scopus 로고
    • Acidic amino acids with strong excitatory actions on mammalian neurons
    • Curtis DR, Watkins JC. Acidic amino acids with strong excitatory actions on mammalian neurons. J Physiol 1963; 66: 1-14.
    • (1963) J Physiol , vol.66 , pp. 1-14
    • Curtis, D.R.1    Watkins, J.C.2
  • 42
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • Danbolt NC. Glutamate uptake. Prog Neurobiol 2001; 65: 1-105.
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 43
    • 0032429754 scopus 로고    scopus 로고
    • Glycine and N-methyl-D-aspartate receptors: Physiological significance and possible therapeutic applications
    • Danysz W, Parsons CG. Glycine and N-methyl-D-aspartate receptors: Physiological significance and possible therapeutic applications. Pharmacol Rev 1998; 50: 597-664.
    • (1998) Pharmacol Rev , vol.50 , pp. 597-664
    • Danysz, W.1    Parsons, C.G.2
  • 44
    • 0141707078 scopus 로고    scopus 로고
    • The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease preclinical evidence
    • Danysz W, Parsons CG. The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease preclinical evidence. International Journal of Geriatric Psychiatry 2003; 18: S23-S32.
    • (2003) International Journal of Geriatric Psychiatry , vol.18
    • Danysz, W.1    Parsons, C.G.2
  • 45
    • 0029115634 scopus 로고
    • Glutamate in CNS disorders: A revived target for drug development?
    • Danysz W, Parsons CG, Bresink I, Quack G. Glutamate in CNS disorders: a revived target for drug development? DN&P 1995; 8: 261-277.
    • (1995) DN&P , vol.8 , pp. 261-277
    • Danysz, W.1    Parsons, C.G.2    Bresink, I.3    Quack, G.4
  • 48
    • 0027453536 scopus 로고
    • Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity
    • Dawson TM, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci USA 1993; 90: 3256-3259.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3256-3259
    • Dawson, T.M.1    Steiner, J.P.2    Dawson, V.L.3    Dinerman, J.L.4    Uhl, G.R.5    Snyder, S.H.6
  • 49
    • 0034520063 scopus 로고    scopus 로고
    • Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats
    • Dempsey RJ, Baskaya MK, Dogan A. Attenuation of brain edema, blood-brain barrier breakdown, and injury volume by ifenprodil, a polyamine-site N-methyl-D-aspartate receptor antagonist, after experimental traumatic brain injury in rats. Neurosurgery 2000, 47: 399-404.
    • (2000) Neurosurgery , vol.47 , pp. 399-404
    • Dempsey, R.J.1    Baskaya, M.K.2    Dogan, A.3
  • 52
    • 0032967382 scopus 로고    scopus 로고
    • The role of excitotoxicity in neurodegenerative disease: Implications for therapy
    • Doble A. The role of excitotoxicity in neurodegenerative disease: Implications for therapy. Pharmacol Ther 1999; 18: 163-221.
    • (1999) Pharmacol Ther , vol.18 , pp. 163-221
    • Doble, A.1
  • 53
    • 1842405463 scopus 로고    scopus 로고
    • Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia
    • Dogan A, Rao AM, Baskaya MK, Rao VLR, Rastl J, Donaldson D, Dempsey RJ. Effects of ifenprodil, a polyamine site NMDA receptor antagonist, on reperfusion injury after transient focal cerebral ischemia. J Neurosurg 1997; 87: 921-926.
    • (1997) J Neurosurg , vol.87 , pp. 921-926
    • Dogan, A.1    Rao, A.M.2    Baskaya, M.K.3    Rao, V.L.R.4    Rastl, J.5    Donaldson, D.6    Dempsey, R.J.7
  • 54
    • 0026093663 scopus 로고
    • Intracellular calcium concentration during "chemical hypoxia" and excitotoxic neuronal injury
    • Dubinsky JM, Rothman SM. Intracellular calcium concentration during "chemical hypoxia" and excitotoxic neuronal injury. J Neurosci 1991; 11: 2545-2551.
    • (1991) J Neurosci , vol.11 , pp. 2545-2551
    • Dubinsky, J.M.1    Rothman, S.M.2
  • 55
    • 0029876024 scopus 로고    scopus 로고
    • Neuroprotection by dextromethorphan in acute experimental subdural hematoma in the rat
    • Duhaime AC, Gennarelli LM, Boardman C. Neuroprotection by dextromethorphan in acute experimental subdural hematoma in the rat. J Neurotrauma 1996; 13: 79-84.
    • (1996) J Neurotrauma , vol.13 , pp. 79-84
    • Duhaime, A.C.1    Gennarelli, L.M.2    Boardman, C.3
  • 56
    • 0031307181 scopus 로고    scopus 로고
    • Are age-related neurodegenerative diseases linked with various types of magnesium depletion?
    • Durlach J, Bac P, Durlach V, Durlach A, Bara M, Guiet-Bara A. Are age-related neurodegenerative diseases linked with various types of magnesium depletion? Magnes Res 1997; 10: 339-353.
    • (1997) Magnes Res , vol.10 , pp. 339-353
    • Durlach, J.1    Bac, P.2    Durlach, V.3    Durlach, A.4    Bara, M.5    Guiet-Bara, A.6
  • 57
    • 0001916922 scopus 로고    scopus 로고
    • Free radicals and mitochondria dysfunction in excitotoxicity and neurodegenerative disease
    • Koliatsos VE, Ratan RR (eds). Humana Press, Totowa NJ
    • Dykens JA. Free radicals and mitochondria dysfunction in excitotoxicity and neurodegenerative disease. In: Koliatsos VE, Ratan RR (eds). Cell Death and Diseases of the Nervous System. Humana Press, Totowa NJ 1999; pp. 45-68.
    • (1999) Cell Death and Diseases of the Nervous System , pp. 45-68
    • Dykens, J.A.1
  • 58
    • 0028097733 scopus 로고
    • The quantity of calcium that appears to induce neuronal death
    • Eimerl S, Schramm M. The quantity of calcium that appears to induce neuronal death. J Neurochem 1994; 62: 1223-1226.
    • (1994) J Neurochem , vol.62 , pp. 1223-1226
    • Eimerl, S.1    Schramm, M.2
  • 59
    • 0027759524 scopus 로고
    • Anti-glutamate therapy in amyotrophic lateral sclerosis - A trial using lamotrigine
    • Eisen A, Stewart H, Schulzer M, Cameron D. Anti-glutamate therapy in amyotrophic lateral sclerosis - a trial using lamotrigine. Can J Neurol Sci 1993, 20: 297-301.
    • (1993) Can J Neurol Sci , vol.20 , pp. 297-301
    • Eisen, A.1    Stewart, H.2    Schulzer, M.3    Cameron, D.4
  • 60
    • 0026601969 scopus 로고
    • Dynorphin Increases Extracellular Levels of Excitatory Amino Acids in the Brain Through a Non-Opioid Mechanism
    • Faden AI. Dynorphin Increases Extracellular Levels of Excitatory Amino Acids in the Brain Through a Non-Opioid Mechanism. J Neurosci 1992; 12: 425-429.
    • (1992) J Neurosci , vol.12 , pp. 425-429
    • Faden, A.I.1
  • 61
    • 0031443289 scopus 로고    scopus 로고
    • Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro
    • Fischer G, Mutel V, Trube G, Malherbe P, Kew JNC, Mohacsi E, Heitz MP, Kemp JA. Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro. J Pharmacol Exp Ther 1997; 283: 1285-1292.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1285-1292
    • Fischer, G.1    Mutel, V.2    Trube, G.3    Malherbe, P.4    Kew, J.N.C.5    Mohacsi, E.6    Heitz, M.P.7    Kemp, J.A.8
  • 62
    • 0345460317 scopus 로고    scopus 로고
    • The neuroprotective activity of Ro 25-6981, a NMDA receptor NR2B subtype selective blocker
    • Fischer G, Bourson A, Kemp JA Lorez HP. The neuroprotective activity of Ro 25-6981, a NMDA receptor NR2B subtype selective blocker. Soc Neurosci Abstr 1996; 22 (part III): 1760.
    • (1996) Soc Neurosci Abstr , vol.22 , Issue.PART III , pp. 1760
    • Fischer, G.1    Bourson, A.2    Kemp, J.A.3    Lorez, H.P.4
  • 63
    • 0021434352 scopus 로고
    • Acidic amino acid binding sites in mammalian neuronal membranes: Their characteristics and relationship to synaptic receptors
    • Foster AC, Fagg GE. Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptors. Brain Res Rev 1984; 7: 103-164.
    • (1984) Brain Res Rev , vol.7 , pp. 103-164
    • Foster, A.C.1    Fagg, G.E.2
  • 64
    • 0026572466 scopus 로고
    • Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionate and kainate in cultured cerebral cortical neurons
    • Frandsen A, Schousboe A. Mobilization of dantrolene-sensitive intracellular calcium pools is involved in the cytotoxicity induced by quisqualate and N-methyl-D-aspartate but not by 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl) propionate and kainate in cultured cerebral cortical neurons. Proc Natl Acad Sci USA 1992; 89: 2590-2594.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2590-2594
    • Frandsen, A.1    Schousboe, A.2
  • 65
    • 0023244774 scopus 로고
    • The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
    • Gallo V, Kingsbury A, Balazs R, Jorgensen OS. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J Neurosci 1987; 7: 2203-2213.
    • (1987) J Neurosci , vol.7 , pp. 2203-2213
    • Gallo, V.1    Kingsbury, A.2    Balazs, R.3    Jorgensen, O.S.4
  • 66
    • 0022476629 scopus 로고
    • Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices
    • Garthwaite G, Hajos F, Garthwaite J. Ionic requirements for neurotoxic effects of excitatory amino acid analogues in rat cerebellar slices. Neuroscience 1986; 18: 437-447.
    • (1986) Neuroscience , vol.18 , pp. 437-447
    • Garthwaite, G.1    Hajos, F.2    Garthwaite, J.3
  • 67
    • 0026077959 scopus 로고
    • Glutamate, nitric oxide and cell-cell signaling in the nervous system
    • Garthwaite J. Glutamate, nitric oxide and cell-cell signaling in the nervous system. Trends Neurosci 1991; 14: 60-67.
    • (1991) Trends Neurosci , vol.14 , pp. 60-67
    • Garthwaite, J.1
  • 68
    • 0028987937 scopus 로고
    • Calcium signaling in neurons: Molecular mechanisms and cellular consequences
    • Ghosh A, Greenberg ME. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 1995; 268: 239-247.
    • (1995) Science , vol.268 , pp. 239-247
    • Ghosh, A.1    Greenberg, M.E.2
  • 70
    • 84970313210 scopus 로고
    • Neuroprotection in brain ischemia: An update (part I)
    • Ginsberg MD. Neuroprotection in brain ischemia: an update (part I). The Neuroscientist 1995; 1: 95-103.
    • (1995) The Neuroscientist , vol.1 , pp. 95-103
    • Ginsberg, M.D.1
  • 71
    • 84970398628 scopus 로고
    • Neuroprotection in brain ischemia: An update (part II)
    • Ginsberg MD. Neuroprotection in brain ischemia: an update (part II). The Neuroscientist 1995; 1: 164-175.
    • (1995) The Neuroscientist , vol.1 , pp. 164-175
    • Ginsberg, M.D.1
  • 73
    • 0023723433 scopus 로고
    • Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and β-aminobutyric acid studied in intracerebral microdialysis
    • Globus MYT, Busto R, Dietrich WD, Martinez E, Valdes I, Ginsberg MD. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and β-aminobutyric acid studied in intracerebral microdialysis.J Neurochem 1988; 51: 1455-1464.
    • (1988) J Neurochem , vol.51 , pp. 1455-1464
    • Globus, M.Y.T.1    Busto, R.2    Dietrich, W.D.3    Martinez, E.4    Valdes, I.5    Ginsberg, M.D.6
  • 74
    • 0036377690 scopus 로고    scopus 로고
    • N-methyl-d-aspartate receptor-mediated processing of beta-amyloid precursor protein in rat hippocampal slices: In vitro-superfusion study
    • Gordon-Krajcer W, Salinska E, Lazarewicz JW. N-methyl-d-aspartate receptor-mediated processing of beta-amyloid precursor protein in rat hippocampal slices: in vitro-superfusion study. Folia Neuropathol 2002; 40 (1): 13-7.
    • (2002) Folia Neuropathol , vol.40 , Issue.1 , pp. 13-17
    • Gordon-Krajcer, W.1    Salinska, E.2    Lazarewicz, J.W.3
  • 76
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1311.
    • (1998) Science , vol.281 , pp. 1309-1311
    • Green, D.R.1    Reed, J.C.2
  • 78
    • 0026005169 scopus 로고
    • N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease
    • Greenamyre JT, O'Brien CF. N-methyl-D-aspartate antagonists in the treatment of Parkinson's disease. Arch Neurol 1991; 48: 977-981.
    • (1991) Arch Neurol , vol.48 , pp. 977-981
    • Greenamyre, J.T.1    O'Brien, C.F.2
  • 79
    • 0028836272 scopus 로고
    • Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate
    • Greene JG, Greenamyre JT. Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate. J Neurochem 1995; 64: 430-436.
    • (1995) J Neurochem , vol.64 , pp. 430-436
    • Greene, J.G.1    Greenamyre, J.T.2
  • 80
    • 0030756917 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis
    • Hajimohammadreza I, Raser KJ, Nath R, Nadimpalli R, Scott M, Wang KKW. Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis. J Neurochem 1997; 69: 1006-1013.
    • (1997) J Neurochem , vol.69 , pp. 1006-1013
    • Hajimohammadreza, I.1    Raser, K.J.2    Nath, R.3    Nadimpalli, R.4    Scott, M.5    Wang, K.K.W.6
  • 81
    • 0027474041 scopus 로고
    • 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration
    • 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J Neurosci 1993; 13: 1993-2000.
    • (1993) J Neurosci , vol.13 , pp. 1993-2000
    • Hartley, D.M.1    Kurth, M.C.2    Bjerkness, L.3
  • 82
    • 0030850891 scopus 로고    scopus 로고
    • Free D-aspartate and D-serine in the mammalian brain and periphery
    • Hashimoto A, Oka T. Free D-aspartate and D-serine in the mammalian brain and periphery. Prog Neurobiol 1997; 52: 325-353.
    • (1997) Prog Neurobiol , vol.52 , pp. 325-353
    • Hashimoto, A.1    Oka, T.2
  • 83
    • 0030911911 scopus 로고    scopus 로고
    • 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes
    • Hazell AS, Itzhak Y, Liu HP, Norenberg MD. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreases glutamate uptake in cultured astrocytes. J Neurochem 1997; 68: 2216-2219.
    • (1997) J Neurochem , vol.68 , pp. 2216-2219
    • Hazell, A.S.1    Itzhak, Y.2    Liu, H.P.3    Norenberg, M.D.4
  • 84
    • 0034742610 scopus 로고    scopus 로고
    • 26+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons
    • 26+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons. Eur J Neurosci 2001; 14: 73-82.
    • (2001) Eur J Neurosci , vol.14 , pp. 73-82
    • Hirai, H.1
  • 86
    • 0024454210 scopus 로고
    • Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord
    • Hugon J, Vallat JM, Spencer PS, Leboutet Ml, Barthe D. Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord. Neurosci Lett 1989; 104: 258-262.
    • (1989) Neurosci Lett , vol.104 , pp. 258-262
    • Hugon, J.1    Vallat, J.M.2    Spencer, P.S.3    Leboutet, M.J.4    Barthe, D.5
  • 87
    • 0029977724 scopus 로고    scopus 로고
    • Prevention of trauma-induced neurodegeneration in infant and adult rat brain: Glutamate antagonists
    • Ikonomidou C, Turski L. Prevention of trauma-induced neurodegeneration in infant and adult rat brain: glutamate antagonists. Metab Brain Dis 1996; 11: 125-141.
    • (1996) Metab Brain Dis , vol.11 , pp. 125-141
    • Ikonomidou, C.1    Turski, L.2
  • 88
    • 0033550927 scopus 로고    scopus 로고
    • Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists
    • Johnson MP, Chamberlain M, Kelly GM. Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists. Brain Res 1999; 821: 539-545.
    • (1999) Brain Res , vol.821 , pp. 539-545
    • Johnson, M.P.1    Chamberlain, M.2    Kelly, G.M.3
  • 89
    • 0029080310 scopus 로고
    • Clinical evaluation of extracellular amino acids in severe head trauma by intracerebral in vivo microdialysis
    • Kanthan R, Shuaib A. Clinical evaluation of extracellular amino acids in severe head trauma by intracerebral in vivo microdialysis. J Neurol Neurosurg Psychiatry 1995; 59: 326-327.
    • (1995) J Neurol Neurosurg Psychiatry , vol.59 , pp. 326-327
    • Kanthan, R.1    Shuaib, A.2
  • 90
    • 0031037335 scopus 로고    scopus 로고
    • Neuroprotective effects of the glutamate release inhibitor 619C89 in temporary middle cerebral artery occlusion
    • Kawaguchi K, Graham SH (1997) Neuroprotective effects of the glutamate release inhibitor 619C89 in temporary middle cerebral artery occlusion. Brain Res, 749: 131-134.
    • (1997) Brain Res , vol.749 , pp. 131-134
    • Kawaguchi, K.1    Graham, S.H.2
  • 91
    • 85009226418 scopus 로고    scopus 로고
    • Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharm. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease
    • Kew JN, Kemp JA. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharm. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001; 57: 397-404.
    • (2001) Neurology , vol.57 , pp. 397-404
    • Kew, J.N.1    Kemp, J.A.2
  • 92
    • 0028256101 scopus 로고
    • Glutamate impairs neuronal calcium extrusion while reducing sodium gradient
    • Kiedrowski L, Brooker G, Costa E, Wroblewski JT. Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron 1994; 12: 295-300.
    • (1994) Neuron , vol.12 , pp. 295-300
    • Kiedrowski, L.1    Brooker, G.2    Costa, E.3    Wroblewski, J.T.4
  • 93
    • 3042811085 scopus 로고    scopus 로고
    • Differential contribution of plasmalemmal Na/Ca exchange isoforms to sodium-dependent calcium influx and NMDA excitotoxicity in depolarized neurons
    • Kiedrowski L, Czyz A, Baranauskas G, Li XF, Lytton J. Differential contribution of plasmalemmal Na/Ca exchange isoforms to sodium-dependent calcium influx and NMDA excitotoxicity in depolarized neurons. J Neurochem 2004; 90: 117-128.
    • (2004) J Neurochem , vol.90 , pp. 117-128
    • Kiedrowski, L.1    Czyz, A.2    Baranauskas, G.3    Li, X.F.4    Lytton, J.5
  • 96
    • 0028325880 scopus 로고
    • Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient
    • Koch RA, Barish ME. Perturbation of intracellular calcium and hydrogen ion regulation in cultured mouse hippocampal neurons by reduction of the sodium ion concentration gradient. Neurosci 1994; 14: 2585-2593.
    • (1994) Neurosci , vol.14 , pp. 2585-2593
    • Koch, R.A.1    Barish, M.E.2
  • 97
    • 0027943804 scopus 로고
    • Calcium stores in neurons and glia
    • Kostyuk P, Verkhratsky A. calcium stores in neurons and glia. Neurosci 1994; 63: 381-404.
    • (1994) Neurosci , vol.63 , pp. 381-404
    • Kostyuk, P.1    Verkhratsky, A.2
  • 98
    • 0024320804 scopus 로고
    • Autophosphorylation of the type II calmodulin-dependent protein kinase is essesntial for the formation of a proteolysic fragment with catalytic activity. Implication for the long-term synaptic potentiation
    • Kwiatkowski AP, King MM. Autophosphorylation of the type II calmodulin-dependent protein kinase is essesntial for the formation of a proteolysic fragment with catalytic activity. Implication for the long-term synaptic potentiation. Biochemistry 1989; 28: 5380-5385.
    • (1989) Biochemistry , vol.28 , pp. 5380-5385
    • Kwiatkowski, A.P.1    King, M.M.2
  • 99
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis
    • Amyotrophic Lateral Sclerosis/Riluzole Study Group II
    • Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet 1996; 347: 1425-1431.
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Leigh, P.N.3    Guillet, P.4    Meininger, V.5
  • 100
    • 0345072185 scopus 로고    scopus 로고
    • Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia
    • Lagreze WA, Knorle R, Bach M, Feuerstein TJ. Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. Invest Ophthalmol Vis Sci 1998, 39: 1063-1066.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1063-1066
    • Lagreze, W.A.1    Knorle, R.2    Bach, M.3    Feuerstein, T.J.4
  • 101
    • 0030991790 scopus 로고    scopus 로고
    • Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit
    • Laube B, Hirai H, Sturgess M, Betz H, Kuhse J. Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit. Neuron 1997, 18: 493-503.
    • (1997) Neuron , vol.18 , pp. 493-503
    • Laube, B.1    Hirai, H.2    Sturgess, M.3    Betz, H.4    Kuhse, J.5
  • 103
    • 0028321004 scopus 로고
    • Cyclic ADP Ribose: Metabolism and calcium mobilizing function
    • Lee HC, Galione A, Walseth TF. Cyclic ADP Ribose: Metabolism and calcium mobilizing function. Vit Horm 1994; 48: 199-257.
    • (1994) Vit Horm , vol.48 , pp. 199-257
    • Lee, H.C.1    Galione, A.2    Walseth, T.F.3
  • 104
    • 0033600277 scopus 로고    scopus 로고
    • The changing landscape of ischaemic brain injury mechanisms
    • Lee JM, Zipfel GJ, Choi DW. The changing landscape of ischaemic brain injury mechanisms. Nature 1999; 399: A7-14.
    • (1999) Nature , vol.399
    • Lee, J.M.1    Zipfel, G.J.2    Choi, D.W.3
  • 106
    • 0033629142 scopus 로고    scopus 로고
    • Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: Evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy
    • Lee WT, Shen YZ, Cheng C. Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: Evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy. Neurosc 2000; 95: 89-95.
    • (2000) Neurosc , vol.95 , pp. 89-95
    • Lee, W.T.1    Shen, Y.Z.2    Cheng, C.3
  • 107
    • 0034059343 scopus 로고    scopus 로고
    • Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders
    • Lees GJ. Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders. Drugs 2000; 59: 33-78.
    • (2000) Drugs , vol.59 , pp. 33-78
    • Lees, G.J.1
  • 108
    • 0034600485 scopus 로고    scopus 로고
    • Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: A randomised controlled trial
    • GAIN International Investigators
    • Lees KR, Asplund K, Carolei A, Davis SM, Diener HC, Kaste M, Orgogozo JM, Whitehead J. Glycine antagonist (gavestinel) in neuroprotection (GAIN International) in patients with acute stroke: a randomised controlled trial. GAIN International Investigators. Lancet 2000; 355: 1949-1954.
    • (2000) Lancet , vol.355 , pp. 1949-1954
    • Lees, K.R.1    Asplund, K.2    Carolei, A.3    Davis, S.M.4    Diener, H.C.5    Kaste, M.6    Orgogozo, J.M.7    Whitehead, J.8
  • 111
    • 0031816414 scopus 로고    scopus 로고
    • Apoptosis, Excitotoxicity, and Neuropathology
    • Leist M, Nicotera P. Apoptosis, Excitotoxicity, and Neuropathology. Exp Cell Res 1998; 239: 183-201.
    • (1998) Exp Cell Res , vol.239 , pp. 183-201
    • Leist, M.1    Nicotera, P.2
  • 112
    • 0031059975 scopus 로고    scopus 로고
    • Glutamate receptors of the kainate type and synaptic transmission
    • Lerma J, Morales M, Vicente MA, Herreras O. Glutamate receptors of the kainate type and synaptic transmission. Trends Neurosci 1997; 20: 9-12.
    • (1997) Trends Neurosci , vol.20 , pp. 9-12
    • Lerma, J.1    Morales, M.2    Vicente, M.A.3    Herreras, O.4
  • 113
    • 0030872412 scopus 로고    scopus 로고
    • Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
    • Li S, Mallory M, Alford M, Tanaka S, Masliah E. Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression. J Neuropathol Exp Neurol 1997, 56: 901-911.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 901-911
    • Li, S.1    Mallory, M.2    Alford, M.3    Tanaka, S.4    Masliah, E.5
  • 114
    • 0031824965 scopus 로고    scopus 로고
    • Neuroprotective vs. neurodestructive effects of NO-related species
    • Lipton H, Choi YB, Sucher NJ, Chen HS. Neuroprotective vs. neurodestructive effects of NO-related species. Biofactors 1998; 8: 33-40.
    • (1998) Biofactors , vol.8 , pp. 33-40
    • Lipton, H.1    Choi, Y.B.2    Sucher, N.J.3    Chen, H.S.4
  • 115
    • 0026755602 scopus 로고
    • Memantine prevents HIV coat protein induced neuronal injury in vitro
    • Lipton SA. Memantine prevents HIV coat protein induced neuronal injury in vitro. Neurology 1992a; 42: 1403-1405.
    • (1992) Neurology , vol.42 , pp. 1403-1405
    • Lipton, S.A.1
  • 116
    • 0026569410 scopus 로고
    • Models of Neuronal Injury in AIDS - Another Role for the NMDA Receptor
    • Lipton SA. Models of Neuronal Injury in AIDS - Another Role for the NMDA Receptor. Trends Neurosci 1992b; 15: 75-79.
    • (1992) Trends Neurosci , vol.15 , pp. 75-79
    • Lipton, S.A.1
  • 118
    • 0033920335 scopus 로고    scopus 로고
    • Neuroprotection in stroke - Analysis of failure, and alternative strategies
    • Lodder J (2000) Neuroprotection in stroke - Analysis of failure, and alternative strategies. Neurosci Res Commun, 26: 173-179.
    • (2000) Neurosci Res Commun , vol.26 , pp. 173-179
    • Lodder, J.1
  • 120
    • 84948011844 scopus 로고
    • The toxic activity of sodium-L-glutamate on the inner layers of the retina
    • Lucas DR and Newhouse JP. The toxic activity of sodium-L-glutamate on the inner layers of the retina. Arch Opthamol 1957; 58: 193-201.
    • (1957) Arch Opthamol , vol.58 , pp. 193-201
    • Lucas, D.R.1    Newhouse, J.P.2
  • 122
    • 0025674468 scopus 로고
    • N-methyl-D-aspartate-mediated arachidonic acid release in primary cultures of cerebellar granule cells
    • Łazarewicz JW, Wróblewski JT, Costa E. N-methyl-D-aspartate-mediated arachidonic acid release in primary cultures of cerebellar granule cells. J Neurochem 1990; 55: 1875-1881.
    • (1990) J Neurochem , vol.55 , pp. 1875-1881
    • Łazarewicz, J.W.1    Wróblewski, J.T.2    Costa, E.3
  • 123
    • 0023933548 scopus 로고
    • Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells
    • Łazarewicz JW, Wróblewski JT, Palmer MR, Costa E. Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells. Neuropharmacology 1988; 27: 765-769.
    • (1988) Neuropharmacology , vol.27 , pp. 765-769
    • Łazarewicz, J.W.1    Wróblewski, J.T.2    Palmer, M.R.3    Costa, E.4
  • 126
    • 0002771858 scopus 로고
    • Hypoxic neural injury in cell culture: Calcium accumulation blockade and neuroprotection by NMDA antagonists but not calcium channel antagonists
    • MD, Dietrich WD (eds.). Raven. New York
    • Marcoux FW, Probert AW, Weber ML. Hypoxic neural injury in cell culture: calcium accumulation blockade and neuroprotection by NMDA antagonists but not calcium channel antagonists. In: Gisberg MD, Dietrich WD (eds.). Cerebrovascular disease: Sixteenth Princeton Conference. Raven. New York 1989; pp. 135-141.
    • (1989) Cerebrovascular Disease: Sixteenth Princeton Conference , pp. 135-141
    • Marcoux, F.W.1    Probert, A.W.2    Weber, M.L.3
  • 129
    • 0026570528 scopus 로고
    • Beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-389.
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 130
    • 17344366821 scopus 로고    scopus 로고
    • The mode of spinal motor neurons degeneration in a model of slow glutamate excitotoxicity in vitro
    • Matyja E, Naganska E, Taraszewska A, Rafalowska J. The mode of spinal motor neurons degeneration in a model of slow glutamate excitotoxicity in vitro. Folia Neuropathol 2005; 43 (1): 7-13.
    • (2005) Folia Neuropathol , vol.43 , Issue.1 , pp. 7-13
    • Matyja, E.1    Naganska, E.2    Taraszewska, A.3    Rafalowska, J.4
  • 132
    • 0037146905 scopus 로고    scopus 로고
    • Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40)
    • Miguel-Hidalgo J J, Alvarez XA, Cacabelos R, Quack G. Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain Res 2002; 958: 210-221.
    • (2002) Brain Res , vol.958 , pp. 210-221
    • Miguel-Hidalgo, J.J.1    Alvarez, X.A.2    Cacabelos, R.3    Quack, G.4
  • 133
    • 0029848165 scopus 로고    scopus 로고
    • Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice
    • Mikawa S, Kinouchi H, Kamii H, Gobbel GT, Chen SF, Carlson E, Epstein CJ, Chan PH. Attenuation of acute and chronic damage following traumatic brain injury in copper, zinc-superoxide dismutase transgenic mice. J Neurosurg 1996; 85: 885-891.
    • (1996) J Neurosurg , vol.85 , pp. 885-891
    • Mikawa, S.1    Kinouchi, H.2    Kamii, H.3    Gobbel, G.T.4    Chen, S.F.5    Carlson, E.6    Epstein, C.J.7    Chan, P.H.8
  • 134
  • 136
    • 0038103656 scopus 로고    scopus 로고
    • Nitric oxide and S-nitrosylation: Excitotoxic and cell signaling mechanism
    • Nelson EJ, Connolly J, McArthur P. Nitric oxide and S-nitrosylation: excitotoxic and cell signaling mechanism, Biol Cell 2003; 95: 3-8.
    • (2003) Biol Cell , vol.95 , pp. 3-8
    • Nelson, E.J.1    Connolly, J.2    McArthur, P.3
  • 139
    • 1842430709 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures
    • Nicholls DG. Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Curr Mol Med 2004; 4: 149-177.
    • (2004) Curr Mol Med , vol.4 , pp. 149-177
    • Nicholls, D.G.1
  • 140
    • 0023895734 scopus 로고
    • Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced
    • Novelli A, Relly JA, Lysko PG, Henneberry RC. Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced. Brain Res 1988; 451: 205-212.
    • (1988) Brain Res , vol.451 , pp. 205-212
    • Novelli, A.1    Relly, J.A.2    Lysko, P.G.3    Henneberry, R.C.4
  • 141
    • 0028836161 scopus 로고
    • The sodium channel blocker and glutamate release inhibitor BW1003c87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat
    • Okiyama K, Smith DH, Gennarelli TA, Simon RP, Leach M, McIntosh TK. The sodium channel blocker and glutamate release inhibitor BW1003c87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat. J Neurochem 1995; 64: 802-809.
    • (1995) J Neurochem , vol.64 , pp. 802-809
    • Okiyama, K.1    Smith, D.H.2    Gennarelli, T.A.3    Simon, R.P.4    Leach, M.5    McIntosh, T.K.6
  • 142
    • 0030925812 scopus 로고    scopus 로고
    • Effects of the novel NMDA antagonists CP-98,113, CP-101,581 and CP-101,606 on cognitive function and regional cerebral edema following experimental brain injury in the rat
    • Okiyama K, Smith DH, White WF, Richter K, McIntosh TK. Effects of the novel NMDA antagonists CP-98,113, CP-101,581 and CP-101,606 on cognitive function and regional cerebral edema following experimental brain injury in the rat. J Neurotrauma 1997; 14: 211-222.
    • (1997) J Neurotrauma , vol.14 , pp. 211-222
    • Okiyama, K.1    Smith, D.H.2    White, W.F.3    Richter, K.4    McIntosh, T.K.5
  • 143
  • 144
    • 0001933595 scopus 로고
    • Neurotoxicity of excitatory amino acids
    • McGeer EG, Olney JW, McGeer PL (eds.). Raven Press, New York
    • Olney JW. Neurotoxicity of excitatory amino acids. In: McGeer EG, Olney JW, McGeer PL (eds.). Kainic Acid as a Tool in Neurobiology. Raven Press, New York 1978; pp. 95-112.
    • (1978) Kainic Acid As a Tool in Neurobiology , pp. 95-112
    • Olney, J.W.1
  • 145
    • 0032191984 scopus 로고    scopus 로고
    • Decahydroisoquinolines: Novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia
    • O'Neill MJ, Bond A, Ornstein PL, Ward MA, Hicks CA, Hoo K, Bleakman D, Lodge D. Decahydroisoquinolines: novel competitive AMPA/kainate antagonists with neuroprotective effects in global cerebral ischaemia. Neuropharmacol 1998, 37: 1211-1222.
    • (1998) Neuropharmacol , vol.37 , pp. 1211-1222
    • O'Neill, M.J.1    Bond, A.2    Ornstein, P.L.3    Ward, M.A.4    Hicks, C.A.5    Hoo, K.6    Bleakman, D.7    Lodge, D.8
  • 146
    • 0028586835 scopus 로고
    • Increased transmitter amino acid concentration in human ventricular CSF after brain trauma
    • Palmer AM, Marion DW, Botscheller ML, Bowen DM, Dekosky S. Increased transmitter amino acid concentration in human ventricular CSF after brain trauma. Neuroreport 1994; 6: 153-156.
    • (1994) Neuroreport , vol.6 , pp. 153-156
    • Palmer, A.M.1    Marion, D.W.2    Botscheller, M.L.3    Bowen, D.M.4    Dekosky, S.5
  • 147
    • 0025162091 scopus 로고
    • Alterations in extracellular amino acids after traumatic spinal injury
    • Panter SS, Yum SW, Faden AI. Alterations in extracellular amino acids after traumatic spinal injury. Ann Neurol 1990; 27: 96-99.
    • (1990) Ann Neurol , vol.27 , pp. 96-99
    • Panter, S.S.1    Yum, S.W.2    Faden, A.I.3
  • 148
    • 0032467053 scopus 로고    scopus 로고
    • Glutamate in CNS Disorders as a target for drug development. An update
    • Parsons CG, Danysz W, Quack G. Glutamate in CNS Disorders as a target for drug development. An update. Drug News Perspect 1998; 11: 523-569.
    • (1998) Drug News Perspect , vol.11 , pp. 523-569
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 149
    • 0027715150 scopus 로고
    • Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin-A
    • Partin KM, Patneau DK, Winters CA, Mayer ML, Buonanno A. Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin-A. Neuron 1993; 11: 1069-1082.
    • (1993) Neuron , vol.11 , pp. 1069-1082
    • Partin, K.M.1    Patneau, D.K.2    Winters, C.A.3    Mayer, M.L.4    Buonanno, A.5
  • 150
    • 0043037253 scopus 로고    scopus 로고
    • Endoplasmic reticulum: A primary target in various acute disorders and degenerative diseases of the brain
    • Paschen W. Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain. Cell Calcium 2003; 34: 365-383.
    • (2003) Cell Calcium , vol.34 , pp. 365-383
    • Paschen, W.1
  • 151
    • 0032979420 scopus 로고    scopus 로고
    • Disturbances of the functioning of endoplasmic reticulum: A key mechanism underlying neuronal cell injury?
    • Paschen W, Doutheil J. Disturbances of the functioning of endoplasmic reticulum: A key mechanism underlying neuronal cell injury? J Cereb Blood Flow Metab 1999; 19: 1-18.
    • (1999) J Cereb Blood Flow Metab , vol.19 , pp. 1-18
    • Paschen, W.1    Doutheil, J.2
  • 153
    • 0025187798 scopus 로고
    • Structural and functional aspects of calcium homeostasis in eucaryotic cells
    • Pietribon D, Di Virgilio F, Pozzan T (1990) Structural and functional aspects of calcium homeostasis in eucaryotic cells. Eur J Biochem, 193: 599-622.
    • (1990) Eur J Biochem , vol.193 , pp. 599-622
    • Pietribon, D.1    Di Virgilio, F.2    Pozzan, T.3
  • 154
    • 0001050066 scopus 로고    scopus 로고
    • The metabotropic glutamate receptors: Structure, activation mechanism and pharmacology
    • Pin JP, Acher F. The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Target CNS Neurol Disord 2002; 1: 297-317.
    • (2002) Curr Drug Target CNS Neurol Disord , vol.1 , pp. 297-317
    • Pin, J.P.1    Acher, F.2
  • 155
    • 0025566990 scopus 로고
    • Calcium-binding proteins in normal and transformed cells
    • Pochet R, Lawson DEM, Heizmann CW. Calcium-binding proteins in normal and transformed cells. Adv Exp Med Biol 1990; 269: 1-223.
    • (1990) Adv Exp Med Biol , vol.269 , pp. 1-223
    • Pochet, R.1    Lawson, D.E.M.2    Heizmann, C.W.3
  • 156
    • 0031762340 scopus 로고    scopus 로고
    • Glutamate antagonists in therapy of stroke
    • Prass K, Dirnagl U. Glutamate antagonists in therapy of stroke. Restor Neurol Neurosci 1998; 13: 3-10.
    • (1998) Restor Neurol Neurosci , vol.13 , pp. 3-10
    • Prass, K.1    Dirnagl, U.2
  • 158
    • 0025325042 scopus 로고
    • In vitro ischemia and protein synthesis in the rat hippocampal slice: The role of calcium and NMDA receptor activation
    • Raley-Susman KM, Lipton P. In vitro ischemia and protein synthesis in the rat hippocampal slice: the role of calcium and NMDA receptor activation. Brain Res 1990; 515: 27-38.
    • (1990) Brain Res , vol.515 , pp. 27-38
    • Raley-Susman, K.M.1    Lipton, P.2
  • 159
    • 0002854860 scopus 로고    scopus 로고
    • Antioxidants and the treatment of neurological disease
    • Koliatsos VE, Ratan RR (eds.). Humana Press, Totowa NJ
    • Ratan RR. Antioxidants and the treatment of neurological disease. In: Koliatsos VE, Ratan RR (eds.). Cell Death and Diseases of the Nervous System. Humana Press, Totowa NJ 1999; pp. 649-666.
    • (1999) Cell Death and Diseases of the Nervous System , pp. 649-666
    • Ratan, R.R.1
  • 161
    • 0031732811 scopus 로고    scopus 로고
    • Intracellular calcium and magnesium: Critical determinants of excitotoxicity?
    • Reynolds IJ. Intracellular calcium and magnesium: Critical determinants of excitotoxicity? Progress in Brain Res 1998; 116: 225-243.
    • (1998) Progress in Brain Res , vol.116 , pp. 225-243
    • Reynolds, I.J.1
  • 162
    • 0028871039 scopus 로고
    • Failure of neuronal ion exchange, not potentiated excitation, causes excitotoxicity after inhibition of oxidative phosphorylation
    • Riepe MW, Hori N, Ludolph AC, Carpenter DO. Failure of neuronal ion exchange, not potentiated excitation, causes excitotoxicity after inhibition of oxidative phosphorylation. Neuroscience 1995; 64: 91-97.
    • (1995) Neuroscience , vol.64 , pp. 91-97
    • Riepe, M.W.1    Hori, N.2    Ludolph, A.C.3    Carpenter, D.O.4
  • 163
    • 0030561276 scopus 로고    scopus 로고
    • Mechanisms of glutamate release from rat hippocampal slices during in vitro ischemia
    • Roettger V, Lipton P. Mechanisms of glutamate release from rat hippocampal slices during in vitro ischemia. Neuroscience 1996; 75: 677-685.
    • (1996) Neuroscience , vol.75 , pp. 677-685
    • Roettger, V.1    Lipton, P.2
  • 164
    • 0020585505 scopus 로고
    • Synaptic activity mediates death of hypoxic neurons
    • Rothman SM. Synaptic activity mediates death of hypoxic neurons. Science 1983; 220: 536-537.
    • (1983) Science , vol.220 , pp. 536-537
    • Rothman, S.M.1
  • 165
    • 0021125414 scopus 로고
    • Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
    • Rothman SM. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J Neurosci 1984; 4: 1884-1891.
    • (1984) J Neurosci , vol.4 , pp. 1884-1891
    • Rothman, S.M.1
  • 166
    • 0021880922 scopus 로고
    • The neurotoxicity of excitatory amino acids is produced by passive chloride influx
    • Rothman SM. The neurotoxicity of excitatory amino acids is produced by passive chloride influx. J Neurosci 1985; 5: 1483-1489.
    • (1985) J Neurosci , vol.5 , pp. 1483-1489
    • Rothman, S.M.1
  • 167
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 1993; 90: 6591-6595.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 168
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992; 326: 1464-1468.
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 170
    • 0027474051 scopus 로고
    • Widespread activation of calcium activated neutral protease (calpain) in the brain in Alzheimer disease: A potential, molecular basis for neuronal degeneration
    • Saito K-I, Elce JS, Homos JE, Nixon RA. Widespread activation of calcium activated neutral protease (calpain) in the brain in Alzheimer disease: a potential, molecular basis for neuronal degeneration. Proc Natl Acad Sci USA 1993; 90: 2628-2632.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2628-2632
    • Saito, K.-I.1    Elce, J.S.2    Homos, J.E.3    Nixon, R.A.4
  • 172
    • 0031792791 scopus 로고    scopus 로고
    • Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity
    • Sattler R, Charlton MP, Hafner M, Tymianski M. Distinct influx pathways, not calcium load, determine neuronal vulnerability to calcium neurotoxicity. J Neurochem 1998; 71: 2349-2364.
    • (1998) J Neurochem , vol.71 , pp. 2349-2364
    • Sattler, R.1    Charlton, M.P.2    Hafner, M.3    Tymianski, M.4
  • 173
    • 0034023864 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent excitotoxicity
    • Sattler R, Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med 2000; 78: 3-13.
    • (2000) J Mol Med , vol.78 , pp. 3-13
    • Sattler, R.1    Tymianski, M.2
  • 174
    • 0033546347 scopus 로고    scopus 로고
    • Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein
    • Sattler R, Xiong Z, Lu WY, Hafner M, MacDonald JF, Tymianski M. Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein. Science 1999; 284: 1845-1848.
    • (1999) Science , vol.284 , pp. 1845-1848
    • Sattler, R.1    Xiong, Z.2    Lu, W.Y.3    Hafner, M.4    MacDonald, J.F.5    Tymianski, M.6
  • 175
    • 0025022509 scopus 로고
    • Excitatory amino acids and Parkinson's disease
    • Schmidt WJ, Bubser M, Hauber W. Excitatory amino acids and Parkinson's disease. Trends Neurosci 1990; 13: 46-47.
    • (1990) Trends Neurosci , vol.13 , pp. 46-47
    • Schmidt, W.J.1    Bubser, M.2    Hauber, W.3
  • 176
    • 0032834028 scopus 로고    scopus 로고
    • Pharmacological agents acting at subtypes of metabotropic glutamate receptors
    • Schoepp DD, Jane DE, Monn JA. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 1999; 38: 1431-1476.
    • (1999) Neuropharmacology , vol.38 , pp. 1431-1476
    • Schoepp, D.D.1    Jane, D.E.2    Monn, J.A.3
  • 177
    • 0029879056 scopus 로고    scopus 로고
    • Neuroprotective strategies for the treatment of lesions produced by mitochondrial toxins: Implications for neurodegenerative diseases
    • Schulz JB, Matthews RT, Henshaw DR, Beal MF. Neuroprotective strategies for the treatment of lesions produced by mitochondrial toxins: implications for neurodegenerative diseases. Neurosci 1996, 71: 1043-1048.
    • (1996) Neurosci , vol.71 , pp. 1043-1048
    • Schulz, J.B.1    Matthews, R.T.2    Henshaw, D.R.3    Beal, M.F.4
  • 178
    • 0020591879 scopus 로고
    • Differential vulnerability of central neurons of the rat to quinolinic acid
    • Schwarcz R, Köhler C. Differential vulnerability of central neurons of the rat to quinolinic acid. Neurosci Lett 1983; 38: 85-90.
    • (1983) Neurosci Lett , vol.38 , pp. 85-90
    • Schwarcz, R.1    Köhler, C.2
  • 180
    • 0027234701 scopus 로고
    • The TINS/TIPS lecture - The molecular biology of mammalian glutamate receptor channels
    • Seeburg PH. The TINS/TIPS lecture - the molecular biology of mammalian glutamate receptor channels. Trends Neurosci 1993; 16: 359-365.
    • (1993) Trends Neurosci , vol.16 , pp. 359-365
    • Seeburg, P.H.1
  • 181
    • 0024556434 scopus 로고
    • Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: A unifying hypothesis
    • Siesjö BK, Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis. J Cereb Blood Flow Metab 1989; 9: 127-140.
    • (1989) J Cereb Blood Flow Metab , vol.9 , pp. 127-140
    • Siesjö, B.K.1    Bengtsson, F.2
  • 182
  • 183
    • 0027283953 scopus 로고
    • 2+ response to N-methyl-D-aspartate and depolarization in cerebelar granule cells
    • 2+ response to N-methyl-D-aspartate and depolarization in cerebelar granule cells. J Neurochem 1993; 61: 760-763.
    • (1993) J Neurochem , vol.61 , pp. 760-763
    • Simpson, P.B.1    Challiss, R.A.J.2    Nahorski, S.R.3
  • 185
    • 0030044586 scopus 로고    scopus 로고
    • Mechanisms of cerebral ischemia: Intracellular cascades and therapeutic interventions
    • Small DL, Buchan AM. Mechanisms of cerebral ischemia: intracellular cascades and therapeutic interventions. J Cardiothorac Vasc Anesth 1996; 10: 139-146.
    • (1996) J Cardiothorac Vasc Anesth , vol.10 , pp. 139-146
    • Small, D.L.1    Buchan, A.M.2
  • 186
    • 0026669125 scopus 로고
    • Nitric oxide: First in a new class of neurotransmitters?
    • Snyder SH. Nitric oxide: first in a new class of neurotransmitters? Science 1992; 257: 494-496.
    • (1992) Science , vol.257 , pp. 494-496
    • Snyder, S.H.1
  • 188
    • 0026033799 scopus 로고
    • Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice
    • Sonsalla PK, Riordan DE, Heikkila RE. Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice. J Pharmacol Exp Ther 1991; 256: 506-512.
    • (1991) J Pharmacol Exp Ther , vol.256 , pp. 506-512
    • Sonsalla, P.K.1    Riordan, D.E.2    Heikkila, R.E.3
  • 189
    • 0042868860 scopus 로고    scopus 로고
    • Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: Behavioural characterization and implications for the treatment of CNS disorders
    • Spooren W, Ballard T, Gasparini F, Amalric M, Mutel V, Schreiber R. Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders. Behav Pharmacol 2003; 14: 257-77.
    • (2003) Behav Pharmacol , vol.14 , pp. 257-277
    • Spooren, W.1    Ballard, T.2    Gasparini, F.3    Amalric, M.4    Mutel, V.5    Schreiber, R.6
  • 190
    • 0027177628 scopus 로고
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment - A stereological estimate of neuronal loss
    • +) nigral toxicity in the rat by prior decortication or MK-801 treatment - a stereological estimate of neuronal loss. Neurobiol Aging 1993; 14: 295-301.
    • (1993) Neurobiol Aging , vol.14 , pp. 295-301
    • Srivastava, R.1    Brouillet, E.2    Beal, M.F.3    Storey, E.4    Hyman, B.T.5
  • 191
    • 0032752054 scopus 로고    scopus 로고
    • Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis
    • Takuma H, Kwak S, Yoshizawa T, Kanazawa I. Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis. Ann Neurol 1999; 46: 806-815.
    • (1999) Ann Neurol , vol.46 , pp. 806-815
    • Takuma, H.1    Kwak, S.2    Yoshizawa, T.3    Kanazawa, I.4
  • 192
    • 0027256475 scopus 로고
    • Regulation of intracellular free calcium concentration in acutely dissociated neurones from rat nucleus basalis
    • Tatsumi H, Katayama Y. Regulation of intracellular free calcium concentration in acutely dissociated neurones from rat nucleus basalis. J Physiol Lond 1993; 464: 165-181.
    • (1993) J Physiol Lond , vol.464 , pp. 165-181
    • Tatsumi, H.1    Katayama, Y.2
  • 193
    • 0025886184 scopus 로고
    • Extrusion of calcium from a single isolated neuron of the snail Helix pomatioa
    • Tepikin AV, Kostyuk PG, Snitsarev VA, Belan PV. Extrusion of calcium from a single isolated neuron of the snail Helix pomatioa. J Membrane Biol 1991; 123: 43-47.
    • (1991) J Membrane Biol , vol.123 , pp. 43-47
    • Tepikin, A.V.1    Kostyuk, P.G.2    Snitsarev, V.A.3    Belan, P.V.4
  • 194
    • 0025331705 scopus 로고
    • Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro
    • Thayer SA, Miller RJ. Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro. J Physiol Lond 1990; 425: 85-115.
    • (1990) J Physiol Lond , vol.425 , pp. 85-115
    • Thayer, S.A.1    Miller, R.J.2
  • 195
    • 0030059754 scopus 로고    scopus 로고
    • Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine
    • Toggas SM, Masliah E, Mucke L. Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res 1996; 706: 303-307.
    • (1996) Brain Res , vol.706 , pp. 303-307
    • Toggas, S.M.1    Masliah, E.2    Mucke, L.3
  • 196
    • 0030832277 scopus 로고    scopus 로고
    • The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat
    • Tsuchida E, Rice M, Bullock R. The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat. J Neurotrauma 1997; 14: 409-417.
    • (1997) J Neurotrauma , vol.14 , pp. 409-417
    • Tsuchida, E.1    Rice, M.2    Bullock, R.3
  • 198
    • 0027497936 scopus 로고
    • Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons
    • Tymianski M, Charlton MP, Carlen PL. Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons. J Neurosci, 13 1993; 2085-2104.
    • (1993) J Neurosci , vol.13 , pp. 2085-2104
    • Tymianski, M.1    Charlton, M.P.2    Carlen, P.L.3
  • 200
    • 0025949127 scopus 로고
    • Aminooxyacetic acid produces excitotoxic lesions in the rat striatum
    • Urbańska E, Ikonomidou C, Sieklucka M, Turski WA. Aminooxyacetic acid produces excitotoxic lesions in the rat striatum. Synapse 1991; 9: 129-135.
    • (1991) Synapse , vol.9 , pp. 129-135
    • Urbańska, E.1    Ikonomidou, C.2    Sieklucka, M.3    Turski, W.A.4
  • 203
    • 0030915422 scopus 로고    scopus 로고
    • Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury
    • Wahl F, Renou E, Mary V, Stutzmann JM. Riluzole reduces brain lesions and improves neurological function in rats after a traumatic brain injury. Brain Res 1997; 756: 247-255.
    • (1997) Brain Res , vol.756 , pp. 247-255
    • Wahl, F.1    Renou, E.2    Mary, V.3    Stutzmann, J.M.4
  • 204
    • 0032055671 scopus 로고    scopus 로고
    • 2+ channels: Role in channel function
    • 2+ channels: role in channel function. Trends Neurosci 1998; 21: 148-154.
    • (1998) Trends Neurosci , vol.21 , pp. 148-154
    • Walker, D.1    De Waard, M.2
  • 205
    • 0030008498 scopus 로고    scopus 로고
    • Memantine abrogates neurological deficits, but not CNS inflammation, in lewis rat experimental autoimmune encephalomyelitis
    • Wallstrom E, Diener P, Ljungdahl A, Khademi M, Nilsson CG, Olsson T. Memantine abrogates neurological deficits, but not CNS inflammation, in lewis rat experimental autoimmune encephalomyelitis. J Neurol Sci 1996; 137: 89-96.
    • (1996) J Neurol Sci , vol.137 , pp. 89-96
    • Wallstrom, E.1    Diener, P.2    Ljungdahl, A.3    Khademi, M.4    Nilsson, C.G.5    Olsson, T.6
  • 208
    • 0034051381 scopus 로고    scopus 로고
    • Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: Characterisation and protection by dantrolene and Bcl-2 overexpression
    • Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE, Chuang DM. Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: Characterisation and protection by dantrolene and Bcl-2 overexpression. J Neurochem 2000; 75: 81-90.
    • (2000) J Neurochem , vol.75 , pp. 81-90
    • Wei, H.1    Leeds, P.2    Chen, R.W.3    Wei, W.4    Leng, Y.5    Bredesen, D.E.6    Chuang, D.M.7
  • 209
    • 0028048433 scopus 로고
    • Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat
    • Wenk GL, Danysz W, Mobley SL. Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat. Brain Res 1994; 655: 7-11.
    • (1994) Brain Res , vol.655 , pp. 7-11
    • Wenk, G.L.1    Danysz, W.2    Mobley, S.L.3
  • 210
    • 0028980903 scopus 로고
    • MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis
    • Wenk GL, Danysz W, Mobley SL. MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis. Eur J Pharmac Env Tox Pharmacol 1995; 293: 267-270.
    • (1995) Eur J Pharmac Env Tox Pharmacol , vol.293 , pp. 267-270
    • Wenk, G.L.1    Danysz, W.2    Mobley, S.L.3
  • 211
    • 0029743772 scopus 로고    scopus 로고
    • The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis
    • Wenk GL, Danysz W, Roice DD. The effects of mitochondrial failure upon cholinergic toxicity in the nucleus basalis. Neuroreport, 7: 1453-1456.
    • Neuroreport , vol.7 , pp. 1453-1456
    • Wenk, G.L.1    Danysz, W.2    Roice, D.D.3
  • 212
    • 0033856448 scopus 로고    scopus 로고
    • The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition
    • (2000)
    • Willard LB, Hauss-Wegrzyniak B, Danysz W, Wenk GL (2000) The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition. Exp Brain Res 1996, 134: 58-65.
    • (1996) Exp Brain Res , vol.134 , pp. 58-65
    • Willard, L.B.1    Hauss-Wegrzyniak, B.2    Danysz, W.3    Wenk, G.L.4
  • 213
    • 0030853492 scopus 로고    scopus 로고
    • Interactions of polyamines with ion channels
    • Williams K. Interactions of polyamines with ion channels. Biochem J 1997; 325: 289-297.
    • (1997) Biochem J , vol.325 , pp. 289-297
    • Williams, K.1
  • 214
    • 0028340993 scopus 로고
    • Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits
    • Williams K, Zappia AM, Pritchett DB, Shen YM, Molinoff PB. Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. Mol Pharmacol 1994; 45: 803-809.
    • (1994) Mol Pharmacol , vol.45 , pp. 803-809
    • Williams, K.1    Zappia, A.M.2    Pritchett, D.B.3    Shen, Y.M.4    Molinoff, P.B.5
  • 215
    • 45949119755 scopus 로고
    • 2+ and ionophore A23187 on protein synthesis in intac rabbit reticulocytes
    • 2+ and ionophore A23187 on protein synthesis in intac rabbit reticulocytes. Int J Biochem 1991; 23: 605-608.
    • (1991) Int J Biochem , vol.23 , pp. 605-608
    • Wong, W.L.1    Brostrom, M.A.2    Brostrom, C.O.3
  • 216
    • 0030054133 scopus 로고    scopus 로고
    • Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-n-methyl-d-aspartate receptors
    • Wrathall JR, Teng YD, Choiniere D. Amelioration of functional deficits from spinal cord trauma with systemically administered NBQX, an antagonist of non-n-methyl-d-aspartate receptors. Exp Neurol 1996; 137: 119-126.
    • (1996) Exp Neurol , vol.137 , pp. 119-126
    • Wrathall, J.R.1    Teng, Y.D.2    Choiniere, D.3
  • 217
    • 0026649325 scopus 로고
    • Evidence That Local Non-NMDA Receptors Contribute to Functional Deficits in Contusive Spinal Cord Injury
    • Wrathall JR, Teng YD, Choiniere D, Mundt DJ. Evidence That Local Non-NMDA Receptors Contribute to Functional Deficits in Contusive Spinal Cord Injury. Brain Res 1992; 586: 140-143.
    • (1992) Brain Res , vol.586 , pp. 140-143
    • Wrathall, J.R.1    Teng, Y.D.2    Choiniere, D.3    Mundt, D.J.4
  • 218
    • 0342813092 scopus 로고    scopus 로고
    • Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma
    • Wrathall JR, Teng YD, Marriott R. Delayed antagonism of AMPA/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma. Exp Neurol 1997; 145: 565-573.
    • (1997) Exp Neurol , vol.145 , pp. 565-573
    • Wrathall, J.R.1    Teng, Y.D.2    Marriott, R.3
  • 219
    • 0029417021 scopus 로고
    • Beta-amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus
    • Wu JQ, Anwyl R, Rowan MJ. beta-amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus. Neuroreport 1995; 6: 2409-2413.
    • (1995) Neuroreport , vol.6 , pp. 2409-2413
    • Wu, J.Q.1    Anwyl, R.2    Rowan, M.J.3
  • 220
    • 3242756951 scopus 로고    scopus 로고
    • Calpain as proposed target for neuroprotective treatment of brain ischemia
    • Review
    • Zalewska T. Calpain as proposed target for neuroprotective treatment of brain ischemia. Folia Neuropathol 1996; 34 (3): 121-7. Review.
    • (1996) Folia Neuropathol , vol.34 , Issue.3 , pp. 121-127
    • Zalewska, T.1
  • 221
    • 0028786448 scopus 로고
    • The role of excitatory amino acids in severe brain trauma: Opportunities for therapy: A review
    • Zauner A, Bullock R. The role of excitatory amino acids in severe brain trauma: opportunities for therapy: a review. J Neurotrauma 1995; 12: 547-554.
    • (1995) J Neurotrauma , vol.12 , pp. 547-554
    • Zauner, A.1    Bullock, R.2
  • 222
    • 0344971308 scopus 로고
    • Chemically induced hypoglucemia and anoxia: Relationship to glutamate receptor-mediated toxicity in retina
    • Zeevalk GD, Nicklas WJ. Chemically induced hypoglucemia and anoxia: Relationship to glutamate receptor-mediated toxicity in retina. J Pharmacol Exp Ther 1990; 257: 870-878.
    • (1990) J Pharmacol Exp Ther , vol.257 , pp. 870-878
    • Zeevalk, G.D.1    Nicklas, W.J.2
  • 224
    • 0038664379 scopus 로고    scopus 로고
    • Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones
    • Ziemińska E, Stafiej A, Łazarewicz JW. Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones. Neurochem Int 2003; 43: 481-492.
    • (2003) Neurochem Int , vol.43 , pp. 481-492
    • Ziemińska, E.1    Stafiej, A.2    Łazarewicz, J.W.3
  • 225
    • 0026752794 scopus 로고
    • MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates
    • Zuddas A, Oberto G, Vaglini F, Fascetti F, Fornai F, Corsini GU. MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates. J Neurochem 1992; 59: 733-739.
    • (1992) J Neurochem , vol.59 , pp. 733-739
    • Zuddas, A.1    Oberto, G.2    Vaglini, F.3    Fascetti, F.4    Fornai, F.5    Corsini, G.U.6
  • 226
    • 0029073172 scopus 로고
    • Alternatively spliced isoforms of the NMDARI receptor subunit
    • Zukin RS, Bennett MVL. Alternatively spliced isoforms of the NMDARI receptor subunit. Trends Neurosci 1995; 18: 306-313.
    • (1995) Trends Neurosci , vol.18 , pp. 306-313
    • Zukin, R.S.1    Bennett, M.V.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.