Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 6, 1998, Pages 1063-1066

  Lagrèze, Wolf A ^a,b   Knörle, Rainer ^a   Bach, Michael ^a   Feuerstein, Thomas J ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTAMIC ACID; GLYCINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; INTRAOCULAR HYPERTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; RETINA ISCHEMIA; SUBCUTANEOUS DRUG ADMINISTRATION; VITREOUS BODY;

EID: 0345072185     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994;330:613-622.
2. Louzada-Junior P, Dias JJ, Santos WF, et al. Glutamate release in experimental ischaemia of the retina: an approach using microdialysis. J Neurochem. 1992;59:358-363.
3. Choi D. Glutamate neurotoxicity in cortical cell culture is calcium dependent. Neurosci Lett. 1985;58:293-297.
4. Vorwerk CK, Lipton SA, Zurakowski D, Hyman BT, Sabel BA, Dreyer EB. Chronic low-dose glutamate is toxic to retinal ganglion cells. Invest Ophthalmol Vis Sci. 1996;37:1618-1624.
5. Pellegrini JW, Lipton SA. Delayed administration of memantine prevents NMDA-receptor mediated neurotoxicity. Ann Neurol. 1993;33:403-407.
6. Osborne NN, Quack G. Memantine stimulates inositol phosphate production in neurons and nullifies N-methyl-D-aspartate-induced destruction of retinal neurons. Neurochem Int. 1992;21:329-336.
7. Hughes WF. Quantification of ischemic damage in the rat retina. Exp Eye Res. 1991;53:573-582.
8. Wesemann W, Sontag K, Maj J. Zur Pharmakodynamik und Pharmakokinetik des Memantin. Arzneimittelforschung. 1983;33: 1122-1134.
9. Perry VH. Evidence for an amacrine cell system in the ganglion cell layer of the rat retina. Neuroscience. 1981;6:931-944.
10. Brandstätter JH, Hartveit E, Sassoe-Pognetto M, Wässle H. Expression of NMDA and high affinity kainate receptor subunit mRNAs in the adult rat retina. Eur J Neurosci. 1994;6:1100-1112.
11. Kornhuber J, Quack G. Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man. Neurosci Lett. 1995;195:137-139.