Iodoacetate produces striatal excitotoxic lesions

Journal of Neurochemistry

Volumn 69, Issue 1, 1997, Pages 285-289

  Matthews, Russell T ^c   Ferrante, Robert J ^a,b   Jenkins, Bruce G ^c   Browne, Susan E ^c   Goetz, Katrine ^c   Berger, Stephanie ^c   Chen, Iris Y C ^c   Beal, M Flint ^c  

^a VA Medical Center   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Excitotoxicity; Huntington's disease; Oxidative damage; Peroxynitrite

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IODOACETIC ACID; PEROXYNITRITE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUNTINGTON CHOREA; MALE; NERVE FIBER DEGENERATION; NEUROTOXICITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PUTAMEN; RAT;

ANIMALIA;

EID: 0030983165     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69010285.x     Document Type: Article

References (22)

1. Albin R. L. and Greenamyre J. T. (1992) Alternative excitotoxic hypotheses. Neurology 42, 733.
2. Beal M. F. (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119-130.
3. Beal M. F., Ferrante R. J., Swartz K. J., and Kowall N. W. (1991) Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. J. Neurosci. 11, 1649-1659.
4. Beal M. F., Brouillet E., Jenkins B. G., Ferrante R. J., Kowall N. W., Miller J. M., Storey E., Srivastava R., Rosen B. R., and Hyman B. (1993) Neurochemical and histologic characterization of excitotoxic lesions produced by the mitochondrial toxin 3-nitro-propionic acid. J. Neurosci. 13, 4181-4191.
5. Brouillet E., Hantraye P., Ferrante R. J., Dolan R., Leroy-Willig A., Kowall N. W., and Beal M. F. (1995) Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates. Proc. Natl. Acad. Sci. USA 92, 7105-7109.
6. Burke J. R., Enghild J. J., Martin M. E., Jou Y.-S., Myers R. M., Roses A. D., Vance J. M., and Strittmatter W. J. (1996) Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat. Med. 2, 347-350.
7. DiFiglia M., Sapp E., Chase K., Schwarz C., Meloni A., Young C., Martin E., Vonsattel J.-P., Carraway R., Reeves S. A., Boyce F. M., and Aronin N. (1995) Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons. Neuron 14, 1075-1081.
8. Duyao M. P., Auerbach A. B., Ryan A., Persichetti F., Barnes G. T., McNeil S. M., Ge P., Vonsattel J.-P., Gusella J. F., Joyner A. L., and MacDonald M. E. (1995) Inactivation of the mouse Huntington's disease gene homolog Hdh. Science 269, 407-410.
9. Floyd R. A., Watson J. J., and Wong P. K. (1984) Sensitive assay of hydroxyl radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J. Biochem. Biophys. Methods 10, 221-235.
10. Gutekunst C.-A., Levey A. I., Heilman C. J., Whaley W. L., Yi H., Nash N. R., Rees H. D., Madden J. J., and Hersch S. M. (1995) Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc. Natl. Acad. Sci. USA 92, 8710-8714.
11. Heinz F. and Freimuller B. (1982) Glyceraldehyde-3-phosphate dehydrogenase from human tissues. Methods Enzymol. 89, 301-309.
12. Huntington's Disease Collaborative Group (1993) The novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971-983.
13. Jenkins B., Koroshetz W., Beal M. F., and Rosen B. (1993) Evidence for an energy metabolism defect in Huntington's disease using localized proton spectroscopy. Neurology 43, 2689-2695.
14. Jenkins B. G., Brouillet E., Chen Y.-C. I., Storey E., Schulz J. B., Kirschner P., Beal M. F., and Rosen B. R. (1996) Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. J. Cereb. Blood Flow Metab. 16, 450-461.
15. Roses A. D. (1996) From genes to mechanisms to therapies: lessons to be learned from neurological disorders. Nat. Med. 2, 267-269.
16. Sabri M. I. and Ochs S. (1971) Inhibition of glyceraldehyde-3-phosphate dehydrogenase in mammalian nerve by iodoacetic acid. J. Neurochem. 18, 1509-1514.
17. Schulz J. B., Matthews R. T., Jenkins B. G., Ferrante R. J., Siwek D., Henshaw D. R., Cipolloni P. B., Mecocci P., Kowall N. W., Rosen B. R., and Beal M. F. (1995) Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J. Neurosci. 15, 8419-8429.
18. Webb J. L. (1966) Enzyme and Metabolic Inhibitors, Vol. 2. Academic Press, New York.
19. Zeevalk G. D. and Nicklas W. J. (1990) Chemically induced hypoglycemia and anoxia: relationship to glutamate receptor-mediated toxicity in retina. J. Pharmacol. Exp. Ther. 253, 1285-1292.
20. Zeevalk G. D. and Nicklas W. J. (1991) Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition. J. Pharmacol. Exp. Ther. 257, 870-878.
21. 2+ block at the N-methyl-D-aspartate receptor underlies receptor activation during inhibition of neuronal metabolism. J. Neurochem. 59, 1211-1220.
22. Zeitlin S., Liu J.-P., Chapman D. L., Papaioannou V. E., and Efstratiadis A. (1995) Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nat. Genet. 11, 155-163.