Role of group I metabotropic glutamate receptors and NMDA receptors in homocysteine-evoked acute neurodegeneration of cultured cerebellar granule neurones

Neurochemistry International

Volumn 43, Issue 4-5, 2003, Pages 481-492

  Ziemińska, Elzbieta ^a   Stafiej, Aleksandra ^a   Łazarewicz, Jerzy W ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Calcium; Cerebellar granule neurones; Homocysteine; mGluRs; Neurotoxicity; NMDA receptors

Indexed keywords

4 CARBOXY 2 METHYLPHENYLGLYCINE; CALCIUM; CARBOXYLIC ACID DERIVATIVE; DIZOCILPINE; GLYCINE; HOMOCYSTEINE; MAGNESIUM ION; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTOXIN; PROPIDIUM IODIDE;

ANIMAL CELL; ANIMAL TISSUE; BRAIN NERVE CELL; BRAIN PROTECTION; CALCIUM TRANSPORT; CELL CULTURE; CEREBELLUM; CONCENTRATION RESPONSE; CONFERENCE PAPER; CYTOTOXICITY; DRUG EFFECT; GRANULE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; STAINING;

EID: 0038664379     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(03)00038-X     Document Type: Conference Paper

References (77)

1. Ango F., Prezeau L., Muller T., Tu J.C., Xiao B., Worley P.F., Pin J.P., Bockaert J., Fagni L. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature. 411:2001;962-965.
2. Ankarcrona M., Dypbukt J.M., Orrenius S., Nicotera P. Calcium and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett. 394:1996;321-324.
3. Aramori I., Nakanishi S. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron. 8:1992;757-765.
4. Berridge M.J., Bootman M.D., Lipp P. Calcium - a life and death signal. Nature. 395:1998;645-648.
5. Berridge M.J., Lipp P., Bootman M.D. The versatility and universality of calcium signalling. Nat. Rev. Mol. Cell Biol. 1:2000;11-21.
6. Bond A., O'Neill M.J., Hicks C.A., Monn J.A., Lodge D. Neuroprotective effects of a systemically active group II metabotropic glutamate receptor agonist LY354740 in a gerbil model of global ischemia. NeuroReport. 9:1998;1191-1193.
7. Bond A., Jones N.M., Hicks C.A., Whiffin G.M., Ward M.A., O'Neill M.F., Kingston A.E., Monn J.A., Ornstein P.L., Schoepp D.D., Lodge D., O'Neill M.J. Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanism of action in vivo. J. Pharmacol. Exp. Ther. 294:2000;800-809.
8. Bootman M.D., Berridge M.J., Roderick H.L. Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate. Proc. Natl. Acad. Sci. U.S.A. 99:2002;7320-7322.
9. Brakeman P.R., Lanahan A.A., O'Brien R., Roche K., Barnes C.A., Huganir R.L., Worley P.F. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 386:1997;284-288.
10. Cai Z., Xiao F., Fratkin J.D., Rhodes P.G. Protection of neonatal rat brain from hypoxic-ischemic injury by LY379268, a group II metabotropic glutamate receptor agonist. NeuroReport. 10:1999;3927-3931.
11. Cambonie G., Laplanche L., Kamenka J.M., Barbanel G. N-Methyl-D-aspartate but not glutamate induces the release of hydroxyl radicals in the neonatal rat: modulation by group I metabotropic glutamate receptors. J. Neurosci. 62:2000;84-90.
12. Choi D.W. Ionic dependence of glutamate neurotoxicity. J. Neurosci. 7:1987;369-379.
13. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
14. Choi D.W. Calcium and excitotoxic neuronal injury. Ann. N. Y. Acad. Sci. 747:1994;162-171.
15. Choi D.W. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18:1995;58-60.
16. Ciruela F., Soloviev M.M., Chan W.Y., McIlhinney R.A. Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring function. Mol. Cell. Neurosci. 15:2000;36-50.
17. Conn P.J., Pin J.P. Pharmacology and functions of metabotropic glutamate receptors. Annu. Rev. Pharmacol. Toxicol. 37:1997;205-237.
18. Contractor A., Gereau R.W. IV, Green T., Heinemann S.F. Direct effects of metabotropic glutamate receptor compounds on native and recombinant N-methyl-D-aspartate receptors. Proc. Natl. Acad. Sci. U.S.A. 95:1998;8969-8974.
19. Croucher M.J., Thomas L.S., Ahmadi H., Lawrence V., Harris J.R. Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system. Br. J. Pharmacol. 133:2001;815-824.
20. D'Emilia D.M., Lipton S.A. Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures. Neurosci. Lett. 265:1999;103-106.
21. Do K.Q., Mattenberger M., Streit P., Cuenod M. In vitro release of endogenous excitatory sulfur-containing amino acids from various rat brain regions. J. Neurochem. 46:1986;779-786.
22. Duan W., Ladenheim B., Cutler R.G., Kruman I.I., Cadet J.L., Mattson M.P. Dietary foliate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease. J. Neurochem. 80:2002;101-110.
23. 3H ]aminobutyric acid release from cultured mouse cerebral cortex neurons by sulphur-containing excitatory amino acid transmitter candidates: receptor activation mediates two distinct mechanisms of release J. Neurochem. 57:1991;1388-1397.
24. 3H ]aspartate from cultured cerebellar granule cells: the role of glutamate receptor activation coupled to reversal of the acidic amino acid plasma membrane carrier Neuroscience. 50:1992;107-115.
25. Ehlers M.D. Synapse structure: glutamate receptors connected by the shanks. Curr. Biol. 9:1999;R848-R850.
26. Eimerl S., Schramm M. The quantity of calcium that appears to induce neuronal death. J. Neurochem. 62:1994;1223-1226.
27. Fagni, L., Ango, F., Prezeau, L., Muller, T., Tu, J.C., Xiao, B., Worley, P.F., Pin, J.P., Bockaert, J., 2002. Role of Homer proteins in neuronal localisation and constitutive activity of metabotropic glutamate receptors (mGluRs). FENS Forum 2002, Paris, Abstracts 062.4.
28. Folbergrova J. Cerebral energy state of neonatal rats during seizures induced by homocysteine. Physiol. Res. 42:1993;155-160.
29. Folbergrova J. Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. Exp. Neurol. 145:1997;442-450.
30. Folbergrova J., Haugvicova R., Mares P. Attenuation of seizures induced by homocysteic acid in immature rats by metabotropic glutamate group II and group III receptor agonists. Brain Res. 908:2001;120-129.
31. 2+ and cGMP concentrations of sulphur-containing excitatory amino acids in cultured cerebral cortical neurons. J. Neurosci. Res. 34:1993;331-339.
32. Gorman A., Griffiths R. Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors. Neuroscience. 59:1994;299-308.
33. Gosh A., Greenberg M.E. Calcium signalling in neurons: molecular mechanisms and cellular consequences. Science. 268:1995;239-247.
34. Grieve A., Dunlop J., Schousboe A., Griffiths R. Kinetic characterisation of excitatory sulphur amino acid transport in synaptosomes and in primary cultures of different brain cells. Biochem. Soc. Trans. 19:1991;5S.
35. Griffiths R. Cysteine sulphinate (CSA) as an excitatory amino acid transmitter candidate in the mammalian central nervous system. Progr. Neurobiol. 35:1990;313-323.
36. Griffiths R., Grieve A., Dunlop J., Damgaard I., Fosmark H., Schousboe A. Inhibition by excitatory sulphur amino acids of the high-affinity L-glutamate transporter in synaptosomes and in primary cultures of cortical astrocytes and cerebellar neurons. Neurochem. Res. 14:1989;333-343.
37. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration. J. Neurosci. 13:1993;1993-2000.
38. Kim W.-K. S-Nitrosation ameliorates homocysteine-induced neurotoxicity and calcium responses in primary culture of rat cortical neurons. Neurosci. Lett. 265:1999;99-102.
39. Kim W.-K., Pae Y.-S. Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci. Lett. 216:1996;117-120.
40. Kingston A.E., Lowndes J., Evans N., Clark B., Tomlinson R., Burnett J.P., Mayne N.G., Cockerham S.L., Lodge D. Sulphur-containing amino acids are agonists for group I metabotropic receptors expressed in clonal RGT cell lines. Neuropharmacology. 37:1998;277-287.
41. Klein J., Reymann K.G., Riedel G. Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist t-ADA. Neuropharmacology. 36:1997;261-263.
42. Kozikowski A.P., Tuckmantel W., Liao Y., Manev H., Ikonomovic S., Wroblewski J.T. Synthesis and metabotropic receptor activity of the novel rigidified glutamate analogues (+) and (-)-trans-azetidine-2,4-dicarboxylic acid and their N-methyl derivatives. J. Med. Chem. 36:1993;2706-2708.
43. Kruman I.I., Culmsee C., Chan S.L., Kruman Y., Guo Z., Penix L., Mattson M.P. Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J. Neurosci. 20:2000;6920-6926.
44. Kruman I.I., Kumaravel T.S., Lohani A., Pedersen W.A., Cutler R.G., Kruman Y., Haughey N., Lee J., Evans M., Mattson M.P. Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease. J. Neurosci. 22:2002;1752-1762.
45. Lipton S.A., Kim W.-K., Choi Y.-B., Kumar S., D'Emilia D.M., Rayudu P.V., Arnelle D.R., Stamler J.S. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. U.S.A. 94:1997;5923-5928.
46. 2+ influx underlies potent induction of injury. J. Neurosci. 16:1996;5457-5465.
47. 45Ca release in the rabbit hippocampus is mediated both by NMDA and group I metabotropic glutamate receptors: in vivo microdialysis study. Neurochem. Res. 28, 259-269.
48. Manahan-Vaughan D., Reymann K.G. Metabotropic glutamate receptor subtype agonists facilitate long-term potentiation within a distinct time window in the dentate gyrus in vivo. Neuroscience. 74:1996;723-731.
49. Manahan-Vaughan D., Reiser M., Pin J.P., Wilsch V., Reymann K.G., Riedel G. Physiological and pharmacological profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience. 72:1996;999-1008.
50. Mannaioni G., Marino M.J., Valenti O., Traynelis S.F., Conn P.J. Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J. Neurosci. 21:2001;5925-5934.
51. Masgrau R., Servitja J.M., Young K.W., Pardo R., Sarri E., Nahorski S.R., Picatoste F. Characterization of the metabotropic glutamate receptors mediating phospholipase C activation and calcium release in cerebellar granule cells: calcium-dependence of the phospholipase C response. Eur. J. Neurosci. 13:2001;248-256.
52. Mayer M.L., Westbrook G.L. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons. J. Physiol. 394:1987;500-527.
53. Michaels R.L., Rothman S.M. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10:1990;283-292.
54. Miniaci M.C., Tempia F., Strata P., Pisani A. Presynaptic modulation by group III metabotropic glutamate receptors (mGluRs) of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells. Neurosci. Lett. 310:2001;61-65.
55. Molloy, A.M., Weir, D.G., 2001. Homocysteine and the nervous system. In: Carmel, R., Jacobsen, D.W. (Eds.), Homocysteine in Health and Disease. Cambridge University Press, Cambridge, pp. 183-197.
56. Monaghan D.T., Cotman C.W. Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes. Proc. Natl. Acad. Sci. U.S.A. 83:1986;7532-7536.
57. Monaghan D.T., Bridges R.J., Cotman C.W. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:1989;365-402.
58. Montoliu C., Llansola M., Cucarella C., Grisolia S., Felipo V. Activation of the metabotropic glutamate receptor mGluR5 prevents glutamate toxicity in primary cultures of cerebellar neurons. J. Pharmacol. Exp. Ther. 281:1997;643-647.
59. 2+ release evoked by metabotropic agonists and backpropagating action potentials in hippocampal CA1 pyramidal neurons. J. Neurosci. 20:2000;8365-8376.
60. Nicoletti F., Canonico P.L. Glycine potentiates the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in primary cultures of cerebellar neurons. J. Neurochem. 53:1989;724-727.
61. Perry I.J., Refsum H., Morris R.W., Ebrahim S.B., Ueland P.M., Shaper A.G. Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men. Lancet. 346:1995;1395-1398.
62. Pisani A., Gubellini P., Bonsi P., Conquet F., Picconi B., Centonze D., Bernardi G., Calabresi P. Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 106:2001;579-587.
63. Porter R.H.P., Roberts P.J. Glutamate metabotropic receptor activation in neonatal rat cerebral cortex by sulphur-containing excitatory amino acids. Neurosci. Lett. 154:1993;78-80.
64. Pullan L.M., Olney J.W., Price M.T., Compton R.P., Hood W.F., Michel J., Monahan J.B. Excitatory amino acid receptor potency and subclass specificity of sulphur containing amino acids. J. Neurochem. 49:1987;1301-1307.
65. Refsum H., Ueland P.M., Nygard O., Vollset S.E. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49:1998;31-62.
66. Sala C., Piech V., Wilson N.R., Passafaro M., Liu G., Sheng M. Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron. 31:2001;115-130.
67. Schoepp D.D., Jane D.E., Monn J.A. Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 38:1999;1431-1476.
68. Schousboe A., Drejer J., Hansen G.M., Meier E. Cultured neurons as model systems for biochemical and pharmacological studies on receptors for neurotransmitter amino acids. Dev. Neurosci. 7:1985;252-262.
69. Scott J.M., Weir D.G. Folic acid, homocysteine, and one-carbon metabolism: a review of the essential biochemistry. J. Cardiovasc. Risk. 5:1998;223-227.
70. Serge A., Fourgeaud L., Hemar A., Choquet D. Receptor activation and Homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane. J. Neurosci. 22:2002;3910-3920.
71. Seshadri S., Beiser A., Selhub J., Jacques P.F., Rosenberg I.H., D'Agostino R.B., Wilson P.W.F., Wolf P.A. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N. Engl. J. Med. 346:2002;476-483.
72. Stampfer M.J., Malinow M.R., Willett W.C., Newcomer L.M., Upson B., Ullmann D., Tishler P.V., Hennekens C.H. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. J. Am. Med. Assoc. 268:1992;877-881.
73. Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 23:1999;583-592.
74. van den Berg M., van der Knaap M.S., Boers G.H., Stehouwer C.D., Rauwerda J.A., Valk J. Hyperhomocysteinaemia with reference to its neuroradiological aspects. Neuroradiology. 37:1995;403-411.
75. Watkins D., Rosenblatt D.S. Functional methionine synthase deficiency (cdIE and cbIG): clinical and biochemical heterogeneity. Am. J. Med. Genet. 34:1989;427-434.
76. 2+ release channels. Proc. Natl. Acad. Sci. U.S.A. 99:2002;7711-7716.
77. Yudkoff, M., 1999. Diseases of amino acid metabolism. In: Siegel, G.J. (Ed.), Basic Neurochemistry: Molecular, Cellular and Medical Aspects, Sixth ed. Williams & Northgate, Philadelphia, pp. 887-915.