Neuronal apoptosis induced by pharmacological concentrations of 3- hydroxykynurenine: Characterization and protection by dantrolene and Bcl-2 overexpression

Journal of Neurochemistry

Volumn 75, Issue 1, 2000, Pages 81-90

  Wei, Huafeng ^b   Leeds, Peter ^b   Chen, Ren Wu ^b   Wei, Wenlin ^b   Leng, Yan ^b   Bredesen, Dale E ^a   Chuang, De Maw ^b  

^a BURNHAM INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

3 Hydroxykynurenine; Apoptosis; Bcl 2; Dantrolene; Hydrogen peroxide; Neuroprotection

Indexed keywords

3 HYDROXYKYNURENINE; CATALASE; DANTROLENE; DEFEROXAMINE; FLUORESCEIN DERIVATIVE; HYDROGEN PEROXIDE; MANGANESE DERIVATIVE; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA CLEAVAGE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GRANULE CELL; NERVE CELL; NEUROPROTECTION; NEUROSECRETORY CELL; NEUROTOXICITY; NEWBORN; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CEREBELLUM; CHROMATIN; DANTROLENE; DNA FRAGMENTATION; DRUG SYNERGISM; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GENE EXPRESSION; IRON CHELATING AGENTS; KYNURENINE; METALLOPORPHYRINS; NEURONS; PC12 CELLS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMALIA;

EID: 0034051381     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0750081.x     Document Type: Article

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