N-methyl-d-aspartate receptor-mediated processing of β-amyloid precursor protein in rat hippocampal slices: In vitro-superfusion study

Folia Neuropathologica

Volumn 40, Issue 1, 2002, Pages 13-17

  Gordon Krajcer, Wanda ^a   Salińska, Elzbieta ^a   Łazarewicz, Jerzy W ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Calcium; NMDA receptors; Secretase; Amyloid precursor protein

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN DERIVATIVE; CALCIUM CHLORIDE; CALCIUM ION; DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN SLICE; CALCIUM METABOLISM; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DIALYSATE; DOSE RESPONSE; DRUG EXPOSURE; HIPPOCAMPUS; IMMUNOREACTIVITY; IN VITRO STUDY; INHIBITION KINETICS; MALE; METABOLIC ACTIVATION; NONHUMAN; PERFUSION AND SUPERFUSION; PHARMACOLOGICAL BLOCKING; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN SECRETION; RAT; RECEPTOR SOLUBILIZATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; WESTERN BLOTTING;

EID: 0036377690     PISSN: 00283894     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Neuronal models to study amyloid precursor protein expression and processing in vitro
2. Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat
3. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer β/A4 amyloid protein precursor
4. Alzheimer's α-secretase may be calcium-dependent protease
5. Cleavage of amyloid beta peptide during constitutive processing of its precursor
6. Potentially amyloidogenic carboxyl-terminal derivatives of the amyloid protein precursor
7. 2+ account for poor pyramidal cell structure in hippocampal slices
8. Processing of the amyloid protein precursor to potentially amyloidogenic derivative
9. Targeting of cell-surface β-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
10. Amyloid β-peptide is produced by cultured cells during normal metabolism
11. Altered processing of Alzheimer amyloid precursor protein in response to neuronal degeneration
12. β-Amyloid protein increases the vulnerability of cultured cortical neurones to excitotoxic damage
13. Cleavage of structural proteins during the assembly of the head of bacteriophage
14. 2+ can cause nonspecific damage
15. Protein measurement with the Folin phenol reagent
16. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
17. Amyloid β-protein precursor deposition in rat hippocampus lesioned by ibotenic acid injection
18. Release of amyloid β-protein precursor derivatives by electrical depolarization of rat hippocampal slices
19. Production of the Alzheimer amyloid β-protein by normal proteolytic processing
20. Alzheimer's amyloid precursor protein α-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: Similarities to the angiotensin converting enzyme secretase
21. Cleavage of Alzheimer's amyloid precursor protein by α-secretase occurs at the surface of neuronal cells
22. Production of the Alzheimer amyloid β-protein by normal proteolytic processing
23. Evidence that β-amyloid protein in Alzheimer's disease is not derived by normal processing
24. Protein kinase C-dependent α-secretase competes with beta-secretase for cleavage of amyloid-β precursor protein in the trans-golgi network
25. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
26. Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides