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Volumn 4, Issue 10, 2004, Pages 1045-1057

Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

4 CYCLOPROPYLETHYNYL 5,6 DIFLUORO 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; 5 NITROIMIDAZOLE DERIVATIVE; 6 CHLORO 4 (2 CYCLOPROPYLVINYL) 3,4 DIHYDRO 4 TRIFLUOROMETHYL 2(1H) QUINAZOLINONE; ABACAVIR; ANTIRETROVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; BENZONITRILE; BENZOPHENONE DERIVATIVE; BENZOTHIADIAZINE DERIVATIVE; CALANOLIDE A; CAPRAVIRINE; DAPIVIRINE; DELAVIRDINE; EFAVIRENZ; EMIVIRINE; EMTRICITABINE; ETRAVIRINE; INDAZOLE DERIVATIVE; LAMIVUDINE PLUS ZIDOVUDINE; NELFINAVIR; NEVIRAPINE; PLACEBO; PROTEINASE INHIBITOR; PYRIDONE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

EID: 3042760870     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568026043388295     Document Type: Review
Times cited : (51)

References (79)
  • 1
    • 0028271687 scopus 로고
    • Structure of the Binding Site for Nonnucleoside Inhibitors of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1 1 Proc. Natl. Acad. Sci. USA
    • Smerdon, S.; Jager, J.; Wang, J.; Kohlstaedt, L.; Chirino, A.; Friedman, J.; Rice, P.; Steitz, T. Structure of the Binding Site for Nonnucleoside Inhibitors of the Reverse Transcriptase of Human Immunodeficiency Virus Type 1. Proc. Natl. Acad. Sci. USA 1994, 91, 3911-3915.
    • (1994) , vol.91 , pp. 3911-3915
    • Smerdon, S.1    Jager, J.2    Wang, J.3    Kohlstaedt, L.4    Chirino, A.5    Friedman, J.6    Rice, P.7    Steitz, T.8
  • 5
    • 18044404926 scopus 로고    scopus 로고
    • What are the Perceived Advantages and Disadvantages of Non-Nucleoside Reverse Transcriptase Inhibitors as First-line Therapy?
    • Gazzard, B. J. What are the Perceived Advantages and Disadvantages of Non-Nucleoside Reverse Transcriptase Inhibitors as First-line Therapy? HIV Medicine 2000, 1(S1), 11-14.
    • (2000) HIV Medicine , vol.1 , Issue.S1 , pp. 11-14
    • Gazzard B., J.1
  • 6
    • 0034103473 scopus 로고    scopus 로고
    • Evaluation of Lymph Node Virus Burden in Human Immunodeficiency Virus-infected Patients Receiving Efavirenz Based Protease Inhibitor Sparing Highly Active Antiretroviral Therapy
    • Dybul, M.; Chun, T.; Ward, D.; Hertogs, K.; Larder, B.; Fox, C.; Orenstein, J.; Baird, B.; Li, Y.; Green, L.; Engel, D.; Liu, S.; Mican, J.; Fauci, A. Evaluation of Lymph Node Virus Burden in Human Immunodeficiency Virus-infected Patients Receiving Efavirenz Based Protease Inhibitor Sparing Highly Active Antiretroviral Therapy. J. Infect. Dis. 2000, 181, 1273-1279.
    • (2000) J. Infect. Dis. , vol.181 , pp. 1273-1279
    • Dybul, M.1    Chun, T.2    Ward, D.3    Hertogs, K.4    Larder, B.5    Fox, C.6    Orenstein, J.7    Baird, B.8    Li, Y.9    Green, L.10    Engel, D.11    Liu, S.12    Mican, J.13    Fauci, A.14
  • 7
    • 0033081564 scopus 로고    scopus 로고
    • Resistance to Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase
    • Bacheler, L. Resistance to Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. Drug Resistance Updates 1999, 2, 56-67.
    • (1999) Drug Resistance Updates , vol.2 , pp. 56-67
    • Bacheler, L.1
  • 9
    • 0036174444 scopus 로고    scopus 로고
    • Extent of Cross-resistance Between Agents Used to Treat Human Immunodeficiency Virus Type 1 Infection in Clinically Dervied Isolates
    • Harrigan, P.; Larder, B. Extent of Cross-resistance Between Agents Used to Treat Human Immunodeficiency Virus Type 1 Infection in Clinically Dervied Isolates. Antimicrob. Agents Chemother. 2002, 46, 909-912.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 909-912
    • Harrigan, P.1    Larder, B.2
  • 14
    • 0034081772 scopus 로고    scopus 로고
    • Patterns of Resistance Mutations Selected by Treatmnet of Human Immunodeficiency Virus Type 1 Infection with Zidovudine, Didanosine, and Nevirapine
    • Hanna, G.; Johnson, V.; Kuritzkes, D.; Richman, D.; Leigh Brown, A.; Savara, A.; Hazelwood, J.; D'Aquila, R. Patterns of Resistance Mutations Selected by Treatmnet of Human Immunodeficiency Virus Type 1 Infection with Zidovudine, Didanosine, and Nevirapine. J. Infect. Dis. 2000, 181, 904-911.
    • (2000) J. Infect. Dis. , vol.181 , pp. 904-911
    • Hanna, G.1    Johnson, V.2    Kuritzkes, D.3    Richman, D.4    Leigh Brown, A.5    Savara, A.6    Hazelwood, J.7    D'Aquila, R.8
  • 15
    • 0035292858 scopus 로고    scopus 로고
    • Nonnucleoside Reverse Transcriptase Inhibitor Resistance
    • Deeks, S.G. Nonnucleoside Reverse Transcriptase Inhibitor Resistance. JAIDS J. Acquir. Immune Defic. Syndr. 2001, 26, S25-S33.
    • (2001) JAIDS J. Acquir. Immune Defic. Syndr. , vol.26
    • Deeks, S.G.1
  • 16
    • 0034899570 scopus 로고    scopus 로고
    • Non-Nucleoside Reverse Transcriptase Inhibitors: Perspectives on Novel Therapeutic Compounds and Strategies for the Treatment of HIV Infection
    • Buckheit, R. W., Jr. Non-Nucleoside Reverse Transcriptase Inhibitors: Perspectives on Novel Therapeutic Compounds and Strategies for the Treatment of HIV Infection. Expert Opin. Investig. Drugs 2001, 10, 1423-1442.
    • (2001) Expert Opin. Investig. Drugs , vol.10 , pp. 1423-1442
    • Buckheit Jr., R.W.1
  • 17
    • 0035138694 scopus 로고    scopus 로고
    • The Emerging Roles of Non-Nucleoside Reverse Transcriptase Inhibitors in Antiretroviral Therapy
    • Moyle, G. The Emerging Roles of Non-Nucleoside Reverse Transcriptase Inhibitors in Antiretroviral Therapy. Drugs 2001, 61, 19-26.
    • (2001) Drugs , vol.61 , pp. 19-26
    • Moyle, G.1
  • 18
    • 0035271620 scopus 로고    scopus 로고
    • New Developments in Anti-HIV Therapy
    • De Clerq, E. New Developments in Anti-HIV Therapy. Farmaco 2001, 56, 3-12.
    • (2001) Farmaco , vol.56 , pp. 3-12
    • De Clerq, E.1
  • 19
    • 0345135410 scopus 로고    scopus 로고
    • A Review of Recent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Research Activity
    • Corbett, J. W. A Review of Recent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor Research Activity. Curr. Med. Chem.: Anti-Infective Agents 2002, 1, 119-140.
    • (2002) Curr. Med. Chem.: Anti-Infective Agents , vol.1 , pp. 119-140
    • Corbett, J.W.1
  • 20
    • 18744433652 scopus 로고    scopus 로고
    • Why Switch from Protease Inhibitors (PI) to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)?
    • Pozniak, A. Why Switch from Protease Inhibitors (PI) to Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)? HIV Medicine 2000, 1(S1), 7-10.
    • (2000) HIV Medicine , vol.1 , Issue.SUPPL. 1 , pp. 7-10
    • Pozniak, A.1
  • 21
    • 0034100184 scopus 로고    scopus 로고
    • Nonnucleoside Reverse Transcriptase Inhibitors
    • Hajós, G.; Riedl, Z.; Molnár, J.; Szabó, D. Nonnucleoside Reverse Transcriptase Inhibitors, Drugs Fut. 2000, 25, 47-62.
    • (2000) Drugs Fut. , vol.25 , pp. 47-62
    • Hajós, G.1    Riedl, Z.2    Molnár, J.3    Szabó, D.4
  • 22
    • 0033900830 scopus 로고    scopus 로고
    • HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors
    • Högberg, M.; Morrison, I. HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. Expert Opin. Ther. Patents 2000, 10, 1189-1199.
    • (2000) Expert Opin. Ther. Patents , vol.10 , pp. 1189-1199
    • Högberg, M.1    Morrison, I.2
  • 24
    • 0034640387 scopus 로고    scopus 로고
    • Binding of the Second Generation Non-Nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding
    • Ren, J.; Nichols, C.; Bird, L. E.; Fujiwara, T.; Sugimoto, H.; Stuart, D.I.; Stammers, D.K. Binding of the Second Generation Non-Nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding. J. Biol. Chem. 2000, 275, 14316-14320.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14316-14320
    • Ren, J.1    Nichols, C.2    Bird, L.E.3    Fujiwara, T.4    Sugimoto, H.5    Stuart, D.I.6    Stammers, D.K.7
  • 25
    • 0003235190 scopus 로고    scopus 로고
    • Short-course Monotherapy with AG1549, a Novel Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), in Antiretroviral Naïve Patients
    • January 20-February 4, San Francisco, CA
    • Hernandez, J.; Amador, L.; Amantea, M.; Chao, H.; Hawley, P.; Paradiso, L. Short-course Monotherapy with AG1549, a Novel Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), in Antiretroviral Naïve Patients. 7th Conference on Retroviruses and Opportunistic Infections, January 20-February 4, 2000, San Francisco, CA.
    • (2000) 7th Conference on Retroviruses and Opportunistic Infections
    • Hernandez, J.1    Amador, L.2    Amantea, M.3    Chao, H.4    Hawley, P.5    Paradiso, L.6
  • 26
    • 0011079213 scopus 로고    scopus 로고
    • Safety and Efficacy of Capravirine Versus Placebo in HIV-Infected Patient Failing a Non-Nucleoside Reverse Transcriptase Inhibitor Containing Regimen: Results of a Phase II, Double-blind, Placebo-controlled Study
    • February 4-8, Chicago, IL
    • Wolfe, P.; Hawley, P.; Boccia, G.; Clendenin, N; Paradiso, L.; Shaw, T.; Chi-burris, K. Safety and Efficacy of Capravirine Versus Placebo in HIV-Infected Patient Failing a Non-Nucleoside Reverse Transcriptase Inhibitor Containing Regimen: Results of a Phase II, Double-blind, Placebo-controlled Study. 8th Conference on Retroviruses and Opportunistic Infections, February 4-8, 2001, Chicago, IL.
    • (2001) 8th Conference on Retroviruses and Opportunistic Infections
    • Wolfe, P.1    Hawley, P.2    Boccia, G.3    Clendenin, N.4    Paradiso, L.5    Shaw, T.6    Chi-burris, K.7
  • 27
    • 3042829303 scopus 로고    scopus 로고
    • Absence of Risk of Vasculitis in a HIV Population Taking Capravirine - Results of an Active Monitoring Plan
    • July 7-12, Barcelona, Spain
    • Hawley, P.; Diniz-Piraino, S.; Paxton, W.; Pesano, R.; Chikami, G. Absence of Risk of Vasculitis in a HIV Population Taking Capravirine - Results of an Active Monitoring Plan. XIV International AIDS Conference, July 7-12, 2002, Barcelona, Spain.
    • (2002) XIV International AIDS Conference
    • Hawley, P.1    Diniz-Piraino, S.2    Paxton, W.3    Pesano, R.4    Chikami, G.5
  • 30
    • 0036987892 scopus 로고    scopus 로고
    • Discovery of Second Generation Quinazolinone Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1
    • Corbett, J.; Rodgers, J. Discovery of Second Generation Quinazolinone Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1. Progress in Medicinal Chemistry, 2002, 40, 63-105.
    • (2002) Progress in Medicinal Chemistry , vol.40 , pp. 63-105
    • Corbett, J.1    Rodgers, J.2
  • 37
  • 42
    • 0030434064 scopus 로고    scopus 로고
    • Kinetic Analysis of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by (+)-Calanolide A
    • Currens, M.; Mariner, J.; McMahon, J.; Boyd, M. Kinetic Analysis of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by (+)-Calanolide A. J. Pharmacol. Exp. Ther. 1996, 279, 646-651.
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 646-651
    • Currens, M.1    Mariner, J.2    McMahon, J.3    Boyd, M.4
  • 43
    • 0035037065 scopus 로고    scopus 로고
    • Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Nautally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects
    • Creagh, T.; Ruckle, J.; Tolbert, D.; Giltner, J.; Eiznhamer, D.; Dutta, B.; Flavin, M.; Xu, Z. Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Nautally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects. Antimicrob. Agents Chemother. 2001, 45, 1379-1386.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1379-1386
    • Creagh, T.1    Ruckle, J.2    Tolbert, D.3    Giltner, J.4    Eiznhamer, D.5    Dutta, B.6    Flavin, M.7    Xu, Z.8
  • 47
    • 0035847679 scopus 로고    scopus 로고
    • Trifluoromethyl-Containing 3-Alkoxymethyl- and 3-Aryloxymethyl-2-pyridones are Potent Inhibitors of HIV-1 Non-nucleoside Reverse Transcriptase
    • Corbett, J.; Kresge, K.; Pan, S.; Cordova, B.; Klabe, R.; Rodgers, J.; Erickson-Viitanen, S. Trifluoromethyl-Containing 3-Alkoxymethyl- and 3-Aryloxymethyl-2-pyridones are Potent Inhibitors of HIV-1 Non-nucleoside Reverse Transcriptase. Bioorg. Med. Chem. Lett. 2001, 11, 309-312.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 309-312
    • Corbett, J.1    Kresge, K.2    Pan, S.3    Cordova, B.4    Klabe, R.5    Rodgers, J.6    Erickson-Viitanen, S.7
  • 51
  • 52
    • 0037061639 scopus 로고    scopus 로고
    • Syntheisi, Biological Evaluation and Binding Mode of Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles Targeted at the HIV-1 Reverse Transcriptase
    • Silvestri, R.; Artico, M.; De Martino, G.; Ragno, R.; Massa, S.; Loddo, R.; Murfioni, C.; Loi, A.; La Colla, P.; Pani, A. Syntheisi, Biological Evaluation and Binding Mode of Novel 1-[2-(Diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles Targeted at the HIV-1 Reverse Transcriptase. J. Med. Chem. 2002, 45, 1567-1576.
    • (2002) J. Med. Chem. , vol.45 , pp. 1567-1576
    • Silvestri, R.1    Artico, M.2    De Martino, G.3    Ragno, R.4    Massa, S.5    Loddo, R.6    Murfioni, C.7    Loi, A.8    La Colla, P.9    Pani, A.10
  • 54
    • 0035823172 scopus 로고    scopus 로고
    • Solid-Phase Synthesis of the Alkenyldiarylmethane (ADAM) Series of Non-nucleoside Reverse Transcriptase Inhibitors
    • Xu, G.; Loftus, T.; Wargo, H.; Turpin, J.; Buckeit, R.; Cushman, M. Solid-Phase Synthesis of the Alkenyldiarylmethane (ADAM) Series of Non-nucleoside Reverse Transcriptase Inhibitors. J. Org. Chem. 2001, 66, 5958-5964.
    • (2001) J. Org. Chem. , vol.66 , pp. 5958-5964
    • Xu, G.1    Loftus, T.2    Wargo, H.3    Turpin, J.4    Buckeit, R.5    Cushman, M.6
  • 55
    • 0036132217 scopus 로고    scopus 로고
    • Synthesis of Alkenyidiarylmethane (ADAM) Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors with Non-identical Aromatic Rings
    • Xu, G.; Hartman, T.; Wargo, H.; Turpin, J.; Buckheit, R.; Cushman, M. Synthesis of Alkenyidiarylmethane (ADAM) Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors with Non-identical Aromatic Rings. Bioorg. Med. Chem. 2002, 10, 283-290.
    • (2002) Bioorg. Med. Chem. , vol.10 , pp. 283-290
    • Xu, G.1    Hartman, T.2    Wargo, H.3    Turpin, J.4    Buckheit, R.5    Cushman, M.6
  • 56
    • 0035952259 scopus 로고    scopus 로고
    • Anti-HIV Activity of Aromatic and Heterocyclic Thiazolyl Thiourea Compounds
    • Venkathachalam, T.; Sudbeck, E.; Mao, C.; Uckun, F. Anti-HIV Activity of Aromatic and Heterocyclic Thiazolyl Thiourea Compounds. Bioorg. Med. Chem. Lett. 2001, 11, 523-528.
    • (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 523-528
    • Venkathachalam, T.1    Sudbeck, E.2    Mao, C.3    Uckun, F.4
  • 58
    • 0035797356 scopus 로고    scopus 로고
    • Structure-based Design, Synthesis and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin- 4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase
    • Mai, A.; Sbardella, G.; Artico, M.; Ragno, R.; Massa, S.; Novellino, E.; Greco, G.; Lavecchia, A.; Musiu, C.; La Colla, M; Murgiono, C.; La Colla, P.; Loddo, R. Structure-based Design, Synthesis and Biological Evaluation of Conformationally Restricted Novel 2-Alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin- 4(3H)-ones as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase. J. Med. Chem. 2001, 44, 2544-2554.
    • (2001) J. Med. Chem. , vol.44 , pp. 2544-2554
    • Mai, A.1    Sbardella, G.2    Artico, M.3    Ragno, R.4    Massa, S.5    Novellino, E.6    Greco, G.7    Lavecchia, A.8    Musiu, C.9    La Colla, M.10    Murgiono, C.11    La Colla, P.12    Loddo, R.13
  • 61
    • 1842866611 scopus 로고    scopus 로고
    • Synthesis and anti-HIV Activity of 1-(2,6 -Difluorophenyl)-1H,3H-Thiazolo[3,4-a]benzamidazole Structurally-related 1,2-Disubstituted Benzimidazoles
    • Rao, A.; Chimirri, A.; De Clercq; E.; Monforte, A.; Monforte, P.; Pannecouque, C.; Zappala, M. Synthesis and anti-HIV Activity of 1-(2,6 -Difluorophenyl)-1H,3H-Thiazolo[3,4-a]benzamidazole Structurally-related 1,2-Disubstituted Benzimidazoles. Farmaco 2002, 57, 819-823.
    • (2002) Farmaco , vol.57 , pp. 819-823
    • Rao, A.1    Chimirri, A.2    De Clercq, E.3    Monforte, A.4    Monforte, P.5    Pannecouque, C.6    Zappala, M.7
  • 63
    • 3042759567 scopus 로고    scopus 로고
    • Imidazole Derivatives for the Treatment of Viral Diseases
    • PCT Pat. Apl. WO02/42279 Nov. 12
    • Dymock, B.; Jones, P.; Merrett, J.; Parkes. K.; Parrratt, M.; Walter, D. Imidazole Derivatives for the Treatment of Viral Diseases. PCT Pat. Apl. WO02/42279, Nov. 12, 2001.
    • (2001)
    • Dymock, B.1    Jones, P.2    Merrett, J.3    Parkes, K.4    Parrratt, M.5    Walter, D.6
  • 64
    • 3042759567 scopus 로고    scopus 로고
    • Pyrazole Derivatives for the Treatment of Viral Diseases
    • PCT Pat. Apl. WO02/30907, Oct
    • Dymock, B.; Jones, P.; Merrett, J.; Parkes. K.; Parrratt, M. Pyrazole Derivatives for the Treatment of Viral Diseases. PCT Pat. Apl. WO02/30907, Oct. 4, 2001.
    • (2001) , vol.4
    • Dymock, B.1    Jones, P.2    Merrett, J.3    Parkes, K.4    Parrratt, M.5
  • 65
    • 3042750315 scopus 로고    scopus 로고
    • Pyrrole Derivatives for Treating
    • AIDS PCT Pat. Apl. WO02/025424, Apr
    • Dymock, B.; Jones, P.; Merrett, J.; Parkes. K.; Parrratt, M. Pyrrole Derivatives for Treating AIDS. PCT Pat. Apl. WO02/025424, Apr. 30, 2001.
    • (2001) , vol.30
    • Dymock, B.1    Jones, P.2    Merrett, J.3    Parkes, K.4    Parrratt, M.5
  • 66
  • 67
    • 3042788803 scopus 로고    scopus 로고
    • Phenoxy-Thiourea-Pyridine Compounds and Their Use for the Treatment of HIV Infections
    • PCT Pat. Apl. WO02/32873, Oct. 18
    • Uckun, F.; Venkatachalam, T. Phenoxy-Thiourea-Pyridine Compounds and Their Use for the Treatment of HIV Infections. PCT Pat. Apl. WO02/32873, Oct. 18, 2000.
    • (2000)
    • Uckun, F.1    Venkatachalam, T.2
  • 68
    • 3042833937 scopus 로고    scopus 로고
    • Aromatic and Heterocyclic Thiazolyl Thiourea Compounds and
    • Use PCT Pat. Apl. W002/32889, Oct. 19
    • Uckun, F.; Venkatachalam, T. Aromatic and Heterocyclic Thiazolyl Thiourea Compounds and Use. PCT Pat. Apl. W002/32889, Oct. 19, 2000.
    • (2000)
    • Uckun, F.1    Venkatachalam, T.2
  • 72
    • 70349091289 scopus 로고    scopus 로고
    • Non-nucleoside Reverse Transcriptase Inhibitors
    • PCT Pat. Apt. WO01/96338, Jun. 14
    • Simoneau, B. Non-nucleoside Reverse Transcriptase Inhibitors. PCT Pat. Apt. WO01/96338, Jun. 14, 2001.
    • (2001)
    • Simoneau, B.1
  • 73
    • 3042709284 scopus 로고    scopus 로고
    • Non-nucleoside Reverse Transcriptase Inhibitors
    • PCT Pat. Apl. WO02/07682, Mar. 21
    • Ogilvie, W.; Dezeil, R.; Naud, J.; O'Meara, J. Non-nucleoside Reverse Transcriptase Inhibitors. PCT Pat. Apl. WO02/07682, Mar. 21, 2002.
    • (2002)
    • Ogilvie, W.1    Dezeil, R.2    Naud, J.3    O'Meara, J.4
  • 74
    • 3042798114 scopus 로고    scopus 로고
    • Novel 3-Nitropyridine Derivatives and the Pharmaceutical Compositions Containing Said Derivatives
    • PCT Pat. Apl. WO01/38306, Nov. 27
    • Yoon, S.; Lee, S.; Kim, N.; Park, Y.; Lee, G.; Kim, J.; Park, S.; Park, H.; Shin, D. Novel 3-Nitropyridine Derivatives and the Pharmaceutical Compositions Containing Said Derivatives. PCT Pat. Apl. WO01/38306, Nov. 27, 2000.
    • (2000)
    • Yoon, S.1    Lee, S.2    Kim, N.3    Park, Y.4    Lee, G.5    Kim, J.6    Park, S.7    Park, H.8    Shin, D.9
  • 75
    • 3042798114 scopus 로고    scopus 로고
    • Novel 5-Pyrimidinecarboxamide Derivatives and the Pharmaceutical Compositions Containing Said Derivatives
    • PCT Pat. Apl. WO01/38308, Nov. 27
    • Yoon, S.; Lee, S.; Kim, N.; Park, Y.; Lee, G.; Kim, J.; Park, S.; Park, H.; Jang, H. Novel 5-Pyrimidinecarboxamide Derivatives and the Pharmaceutical Compositions Containing Said Derivatives. PCT Pat. Apl. WO01/38308, Nov. 27, 2000.
    • (2000)
    • Yoon, S.1    Lee, S.2    Kim, N.3    Park, Y.4    Lee, G.5    Kim, J.6    Park, S.7    Park, H.8    Jang, H.9
  • 76
    • 3042714028 scopus 로고    scopus 로고
    • Benzophenones as Inhibitors of Reverse Transcriptase
    • PCT Pat. Apl. WO01/17982, Aug. 31
    • Andrews, C.; Chan, J.; Freeman, G.; Romines, K.; Tidwell, J. Benzophenones as Inhibitors of Reverse Transcriptase. PCT Pat. Apl. WO01/17982, Aug. 31, 2000.
    • (2000)
    • Andrews, C.1    Chan, J.2    Freeman, G.3    Romines, K.4    Tidwell, J.5
  • 77
    • 3042750316 scopus 로고    scopus 로고
    • Benzophenones as Inhibitors of Reverse Transcriptase
    • PCT Pat. Apl. WO02/07470, Sept. 12
    • Chan, J. Benzophenones as Inhibitors of Reverse Transcriptase. PCT Pat. Apl. WO02/07470, Sept. 12, 2002.
    • (2002)
    • Chan, J.1
  • 78
    • 3042711646 scopus 로고    scopus 로고
    • Tricyclic 2-Pyridone Compounds Useful as HIV Reverse Transcriptase Inhibitors
    • PCT Pat. Apl. WO02/08226, July 20
    • Rodgers, J.; Wang, H.; Patel, M.; Arvanitis, A.; Cocuzza, A. Tricyclic 2-Pyridone Compounds Useful as HIV Reverse Transcriptase Inhibitors. PCT Pat. Apl. WO02/08226, July 20, 2001.
    • (2001)
    • Rodgers, J.1    Wang, H.2    Patel, M.3    Arvanitis, A.4    Cocuzza, A.5
  • 79
    • 3042709285 scopus 로고    scopus 로고
    • Tricyclic Compounds Useful as HIV Reverse Transcriptase Inhibitors
    • PCT Pat. Apl. WO01/29037, Oct. 19
    • Johnson, B.; Patel, M.; Rodgers, J.; Wang, H. Tricyclic Compounds Useful as HIV Reverse Transcriptase Inhibitors. PCT Pat. Apl. WO01/29037, Oct. 19, 2000.
    • (2000)
    • Johnson, B.1    Patel, M.2    Rodgers, J.3    Wang, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.