HIV-1 non-nucleoside reverse transcriptase inhibitors

Expert Opinion on Therapeutic Patents

Volumn 10, Issue 8, 2000, Pages 1189-1199

  Hogberg, M ^a   Morrison, I ^a  

^a GE Healthcare Bio Sciences AB   (Sweden)

Author keywords

Allosteric; Calanolide; Delavirdine; DPC 961; DPC 963; Efavirenz; HIV 1 RT; Loviride; Nevirapine; NNRTI; Non nucleoside inhibitors; NSC 667952; PETT; PNU 142721; S DABO; Trovirdine

Indexed keywords

6 CHLORO 2 [(1 FURO[2,3 C]PYRIDIN 5 YLETHYL)THIO] 4 PYRIMIDINAMINE; AZEPINE DERIVATIVE; BENZALDEHYDE DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BIFLAVONOID; CALANOLIDE A; DELAVIRDINE; EFAVIRENZ; EMIVIRINE; HETEROCYCLIC COMPOUND; LOVIRIDE; MACROLIDE; MKC 447; NAPHTHOL DERIVATIVE; NEVIRAPINE; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PLANT EXTRACT; PYRIDONE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; SULFONE DERIVATIVE; TRIAZINE DERIVATIVE; TROVIRDINE; UREA DERIVATIVE;

ANTIVIRAL ACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG FORMULATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MINIMUM INHIBITORY CONCENTRATION; MUTATION; PATENT; REVIEW;

EID: 0033900830     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.10.8.1189     Document Type: Review

References (27)

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14. Novel 2,2-dioxide-4,4-disubstituted-1,3-H-2,1,3-benzothiadia zines as non-nucleoside reverse transcriptase inhibitors
15. The PETT series, a new class of potent nonucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase
16. Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs
17. Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues
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19. Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent nonnucleoside inhibitors of HIV-1 reverse transcriptase
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