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The biological activity presented for efavirenz is that of the single enantiomer and, unless reported otherwise, the activity reported for all other compounds is that of the racemate.
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The racemates contain only 50% of the active enantiomer, and the incorrect enantiomers (the R-isomer) are essentially inactive in the biological assays. Therefore, the activity of the single enantiomers would be expected to be approximately one-half that of the racemic values.
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The racemates contain only 50% of the active enantiomer, and the incorrect enantiomers (the R-isomer) are essentially inactive in the biological assays. Therefore, the activity of the single enantiomers would be expected to be approximately one-half that of the racemic values.
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